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Protein

Undecaprenyl-phosphate 4-deoxy-4-formamido-L-arabinose transferase

Gene

arnC

Organism
Pseudomonas aeruginosa (strain ATCC 15692 / DSM 22644 / CIP 104116 / JCM 14847 / LMG 12228 / 1C / PRS 101 / PAO1)
Status
Reviewed-Annotation score: -Protein inferred from homologyi

Functioni

Catalyzes the transfer of 4-deoxy-4-formamido-L-arabinose from UDP to undecaprenyl phosphate. The modified arabinose is attached to lipid A and is required for resistance to polymyxin and cationic antimicrobial peptides.UniRule annotation

Catalytic activityi

UDP-4-deoxy-4-formamido-beta-L-arabinose + ditrans,octacis-undecaprenyl phosphate = UDP + 4-deoxy-4-formamido-alpha-L-arabinose ditrans,octacis-undecaprenyl phosphate.UniRule annotation

Pathwayi: 4-amino-4-deoxy-alpha-L-arabinose undecaprenyl phosphate biosynthesis

This protein is involved in step 1 of the subpathway that synthesizes 4-amino-4-deoxy-alpha-L-arabinose undecaprenyl phosphate from UDP-4-deoxy-4-formamido-beta-L-arabinose and undecaprenyl phosphate.UniRule annotation
Proteins known to be involved in the 2 steps of the subpathway in this organism are:
  1. Undecaprenyl-phosphate 4-deoxy-4-formamido-L-arabinose transferase (arnC)
  2. Probable 4-deoxy-4-formamido-L-arabinose-phosphoundecaprenol deformylase ArnD (arnD)
This subpathway is part of the pathway 4-amino-4-deoxy-alpha-L-arabinose undecaprenyl phosphate biosynthesis, which is itself part of Glycolipid biosynthesis.
View all proteins of this organism that are known to be involved in the subpathway that synthesizes 4-amino-4-deoxy-alpha-L-arabinose undecaprenyl phosphate from UDP-4-deoxy-4-formamido-beta-L-arabinose and undecaprenyl phosphate, the pathway 4-amino-4-deoxy-alpha-L-arabinose undecaprenyl phosphate biosynthesis and in Glycolipid biosynthesis.

Pathwayi: lipopolysaccharide biosynthesis

This protein is involved in the pathway lipopolysaccharide biosynthesis, which is part of Bacterial outer membrane biogenesis.UniRule annotation
View all proteins of this organism that are known to be involved in the pathway lipopolysaccharide biosynthesis and in Bacterial outer membrane biogenesis.

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionGlycosyltransferase, Transferase
Biological processAntibiotic resistance, Lipid A biosynthesis, Lipid biosynthesis, Lipid metabolism, Lipopolysaccharide biosynthesis

Enzyme and pathway databases

BioCyciPAER208964:G1FZ6-3621-MONOMER
UniPathwayiUPA00030
UPA00036; UER00495

Protein family/group databases

CAZyiGT2 Glycosyltransferase Family 2

Names & Taxonomyi

Protein namesi
Recommended name:
Undecaprenyl-phosphate 4-deoxy-4-formamido-L-arabinose transferaseUniRule annotation (EC:2.4.2.53UniRule annotation)
Alternative name(s):
Undecaprenyl-phosphate Ara4FN transferaseUniRule annotation
Short name:
Ara4FN transferaseUniRule annotation
Gene namesi
Name:arnCUniRule annotation
Ordered Locus Names:PA3553
OrganismiPseudomonas aeruginosa (strain ATCC 15692 / DSM 22644 / CIP 104116 / JCM 14847 / LMG 12228 / 1C / PRS 101 / PAO1)
Taxonomic identifieri208964 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaPseudomonadalesPseudomonadaceaePseudomonas
Proteomesi
  • UP000002438 Componenti: Chromosome

Organism-specific databases

PseudoCAPiPA3553

Subcellular locationi

  • Cell inner membrane UniRule annotation; Multi-pass membrane protein UniRule annotation

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Transmembranei235 – 255HelicalUniRule annotationAdd BLAST21
Transmembranei269 – 289HelicalUniRule annotationAdd BLAST21

GO - Cellular componenti

Keywords - Cellular componenti

Cell inner membrane, Cell membrane, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00003802631 – 339Undecaprenyl-phosphate 4-deoxy-4-formamido-L-arabinose transferaseAdd BLAST339

Proteomic databases

PaxDbiQ9HY64
PRIDEiQ9HY64

Interactioni

Protein-protein interaction databases

STRINGi208964.PA3553

Structurei

3D structure databases

ProteinModelPortaliQ9HY64
SMRiQ9HY64
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the glycosyltransferase 2 family.UniRule annotation

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiENOG4105CKK Bacteria
COG0463 LUCA
HOGENOMiHOG000283251
InParanoidiQ9HY64
KOiK10012
OMAiDLVSGWK
PhylomeDBiQ9HY64

Family and domain databases

Gene3Di3.90.550.10, 1 hit
HAMAPiMF_01164 ArnC_transfer, 1 hit
InterProiView protein in InterPro
IPR022857 ArnC_tfrase
IPR001173 Glyco_trans_2-like
IPR029044 Nucleotide-diphossugar_trans
PfamiView protein in Pfam
PF00535 Glycos_transf_2, 1 hit
SUPFAMiSSF53448 SSF53448, 1 hit

Sequencei

Sequence statusi: Complete.

Q9HY64-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MKPYPIDLVS VVIPVYNEEA SLPELLRRTE AACLELGRAF EIVLVDDGSR
60 70 80 90 100
DRSAELLQAA AERDGSAVVA VILNRNYGQH AAILAGFEQS RGDLVITLDA
110 120 130 140 150
DLQNPPEEIP RLVERAAQGY DVVGSIRAER QDSAWRRWPS RLVNLAVQRS
160 170 180 190 200
TGVAMHDYGC MLRAYRRSIV EAMLACRERS TFIPILANGF ARHTCEIRVA
210 220 230 240 250
HAERAHGESK YSAMRLLNLM FDLVTCMTTT PLRLLSLVGG GMALAGFLFA
260 270 280 290 300
LFLLVLRLAF GAAWAGNGLF VLFAVLFMFS GVQLLGMGLL GEYLGRMYSD
310 320 330
VRARPRFFIE RVVRATPSAL PSALQRAGFT SSSSEPSTP
Length:339
Mass (Da):37,296
Last modified:March 1, 2001 - v1
Checksum:iB045790966F26AC9
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AE004091 Genomic DNA Translation: AAG06941.1
PIRiD83201
RefSeqiNP_252243.1, NC_002516.2
WP_003112880.1, NC_002516.2

Genome annotation databases

EnsemblBacteriaiAAG06941; AAG06941; PA3553
GeneIDi878472
KEGGipae:PA3553
PATRICifig|208964.12.peg.3718

Similar proteinsi

Entry informationi

Entry nameiARNC_PSEAE
AccessioniPrimary (citable) accession number: Q9HY64
Entry historyiIntegrated into UniProtKB/Swiss-Prot: July 28, 2009
Last sequence update: March 1, 2001
Last modified: April 25, 2018
This is version 101 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome
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Main funding by: National Institutes of Health