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Protein

Undecaprenyl-phosphate 4-deoxy-4-formamido-L-arabinose transferase

Gene

arnC

Organism
Pseudomonas aeruginosa (strain ATCC 15692 / DSM 22644 / CIP 104116 / JCM 14847 / LMG 12228 / 1C / PRS 101 / PAO1)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Protein inferred from homologyi

Functioni

Catalyzes the transfer of 4-deoxy-4-formamido-L-arabinose from UDP to undecaprenyl phosphate. The modified arabinose is attached to lipid A and is required for resistance to polymyxin and cationic antimicrobial peptides.UniRule annotation

Catalytic activityi

UDP-4-deoxy-4-formamido-beta-L-arabinose + ditrans,octacis-undecaprenyl phosphate = UDP + 4-deoxy-4-formamido-alpha-L-arabinose ditrans,octacis-undecaprenyl phosphate.UniRule annotation

Pathwayi: 4-amino-4-deoxy-alpha-L-arabinose undecaprenyl phosphate biosynthesis

This protein is involved in step 1 of the subpathway that synthesizes 4-amino-4-deoxy-alpha-L-arabinose undecaprenyl phosphate from UDP-4-deoxy-4-formamido-beta-L-arabinose and undecaprenyl phosphate.UniRule annotation
Proteins known to be involved in the 2 steps of the subpathway in this organism are:
  1. Undecaprenyl-phosphate 4-deoxy-4-formamido-L-arabinose transferase (arnC)
  2. Probable 4-deoxy-4-formamido-L-arabinose-phosphoundecaprenol deformylase ArnD (arnD)
This subpathway is part of the pathway 4-amino-4-deoxy-alpha-L-arabinose undecaprenyl phosphate biosynthesis, which is itself part of Glycolipid biosynthesis.
View all proteins of this organism that are known to be involved in the subpathway that synthesizes 4-amino-4-deoxy-alpha-L-arabinose undecaprenyl phosphate from UDP-4-deoxy-4-formamido-beta-L-arabinose and undecaprenyl phosphate, the pathway 4-amino-4-deoxy-alpha-L-arabinose undecaprenyl phosphate biosynthesis and in Glycolipid biosynthesis.

Pathwayi: lipopolysaccharide biosynthesis

This protein is involved in the pathway lipopolysaccharide biosynthesis, which is part of Bacterial outer membrane biogenesis.UniRule annotation
View all proteins of this organism that are known to be involved in the pathway lipopolysaccharide biosynthesis and in Bacterial outer membrane biogenesis.

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Glycosyltransferase, Transferase

Keywords - Biological processi

Antibiotic resistance, Lipid A biosynthesis, Lipid biosynthesis, Lipid metabolism, Lipopolysaccharide biosynthesis

Enzyme and pathway databases

UniPathwayiUPA00030.
UPA00036; UER00495.

Protein family/group databases

CAZyiGT2. Glycosyltransferase Family 2.

Names & Taxonomyi

Protein namesi
Recommended name:
Undecaprenyl-phosphate 4-deoxy-4-formamido-L-arabinose transferaseUniRule annotation (EC:2.4.2.53UniRule annotation)
Alternative name(s):
Undecaprenyl-phosphate Ara4FN transferaseUniRule annotation
Short name:
Ara4FN transferaseUniRule annotation
Gene namesi
Name:arnCUniRule annotation
Ordered Locus Names:PA3553
OrganismiPseudomonas aeruginosa (strain ATCC 15692 / DSM 22644 / CIP 104116 / JCM 14847 / LMG 12228 / 1C / PRS 101 / PAO1)
Taxonomic identifieri208964 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaPseudomonadalesPseudomonadaceaePseudomonas
Proteomesi
  • UP000002438 Componenti: Chromosome

Organism-specific databases

PseudoCAPiPA3553.

Subcellular locationi

  • Cell inner membrane UniRule annotation; Multi-pass membrane protein UniRule annotation

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Transmembranei235 – 25521HelicalUniRule annotationAdd
BLAST
Transmembranei269 – 28921HelicalUniRule annotationAdd
BLAST

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Cell inner membrane, Cell membrane, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 339339Undecaprenyl-phosphate 4-deoxy-4-formamido-L-arabinose transferasePRO_0000380263Add
BLAST

Proteomic databases

PaxDbiQ9HY64.

Interactioni

Protein-protein interaction databases

STRINGi208964.PA3553.

Structurei

3D structure databases

ProteinModelPortaliQ9HY64.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the glycosyltransferase 2 family.UniRule annotation

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiENOG4105CKK. Bacteria.
COG0463. LUCA.
HOGENOMiHOG000283251.
InParanoidiQ9HY64.
KOiK10012.
OMAiYGQTPAM.
PhylomeDBiQ9HY64.

Family and domain databases

Gene3Di3.90.550.10. 1 hit.
HAMAPiMF_01164. ArnC_transfer. 1 hit.
InterProiIPR022857. ArnC_tfrase.
IPR001173. Glyco_trans_2-like.
IPR029044. Nucleotide-diphossugar_trans.
[Graphical view]
PfamiPF00535. Glycos_transf_2. 1 hit.
[Graphical view]
SUPFAMiSSF53448. SSF53448. 1 hit.

Sequencei

Sequence statusi: Complete.

Q9HY64-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MKPYPIDLVS VVIPVYNEEA SLPELLRRTE AACLELGRAF EIVLVDDGSR
60 70 80 90 100
DRSAELLQAA AERDGSAVVA VILNRNYGQH AAILAGFEQS RGDLVITLDA
110 120 130 140 150
DLQNPPEEIP RLVERAAQGY DVVGSIRAER QDSAWRRWPS RLVNLAVQRS
160 170 180 190 200
TGVAMHDYGC MLRAYRRSIV EAMLACRERS TFIPILANGF ARHTCEIRVA
210 220 230 240 250
HAERAHGESK YSAMRLLNLM FDLVTCMTTT PLRLLSLVGG GMALAGFLFA
260 270 280 290 300
LFLLVLRLAF GAAWAGNGLF VLFAVLFMFS GVQLLGMGLL GEYLGRMYSD
310 320 330
VRARPRFFIE RVVRATPSAL PSALQRAGFT SSSSEPSTP
Length:339
Mass (Da):37,296
Last modified:March 1, 2001 - v1
Checksum:iB045790966F26AC9
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AE004091 Genomic DNA. Translation: AAG06941.1.
PIRiD83201.
RefSeqiNP_252243.1. NC_002516.2.
WP_003112880.1. NZ_ASJY01000574.1.

Genome annotation databases

EnsemblBacteriaiAAG06941; AAG06941; PA3553.
GeneIDi878472.
KEGGipae:PA3553.
PATRICi19841721. VBIPseAer58763_3718.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AE004091 Genomic DNA. Translation: AAG06941.1.
PIRiD83201.
RefSeqiNP_252243.1. NC_002516.2.
WP_003112880.1. NZ_ASJY01000574.1.

3D structure databases

ProteinModelPortaliQ9HY64.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi208964.PA3553.

Protein family/group databases

CAZyiGT2. Glycosyltransferase Family 2.

Proteomic databases

PaxDbiQ9HY64.

Protocols and materials databases

DNASUi878472.
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaiAAG06941; AAG06941; PA3553.
GeneIDi878472.
KEGGipae:PA3553.
PATRICi19841721. VBIPseAer58763_3718.

Organism-specific databases

PseudoCAPiPA3553.

Phylogenomic databases

eggNOGiENOG4105CKK. Bacteria.
COG0463. LUCA.
HOGENOMiHOG000283251.
InParanoidiQ9HY64.
KOiK10012.
OMAiYGQTPAM.
PhylomeDBiQ9HY64.

Enzyme and pathway databases

UniPathwayiUPA00030.
UPA00036; UER00495.

Family and domain databases

Gene3Di3.90.550.10. 1 hit.
HAMAPiMF_01164. ArnC_transfer. 1 hit.
InterProiIPR022857. ArnC_tfrase.
IPR001173. Glyco_trans_2-like.
IPR029044. Nucleotide-diphossugar_trans.
[Graphical view]
PfamiPF00535. Glycos_transf_2. 1 hit.
[Graphical view]
SUPFAMiSSF53448. SSF53448. 1 hit.
ProtoNetiSearch...

Entry informationi

Entry nameiARNC_PSEAE
AccessioniPrimary (citable) accession number: Q9HY64
Entry historyi
Integrated into UniProtKB/Swiss-Prot: July 28, 2009
Last sequence update: March 1, 2001
Last modified: September 7, 2016
This is version 92 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.