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Protein

Undecaprenyl phosphate-alpha-4-amino-4-deoxy-L-arabinose arabinosyl transferase

Gene

arnT

Organism
Pseudomonas aeruginosa (strain ATCC 15692 / DSM 22644 / CIP 104116 / JCM 14847 / LMG 12228 / 1C / PRS 101 / PAO1)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Protein inferred from homologyi

Functioni

Catalyzes the transfer of the L-Ara4N moiety of the glycolipid undecaprenyl phosphate-alpha-L-Ara4N to lipid A. The modified arabinose is attached to lipid A and is required for resistance to polymyxin and cationic antimicrobial peptides.UniRule annotation

Catalytic activityi

4-amino-4-deoxy-alpha-L-arabinopyranosyl di-trans,octa-cis-undecaprenyl phosphate + lipid IV(A) = lipid II(A) + di-trans,octa-cis-undecaprenyl phosphate.UniRule annotation

Pathwayi: 4-amino-4-deoxy-beta-L-arabinose-lipid A biosynthesis

This protein is involved in the pathway 4-amino-4-deoxy-beta-L-arabinose-lipid A biosynthesis, which is part of Lipopolysaccharide metabolism.UniRule annotation
View all proteins of this organism that are known to be involved in the pathway 4-amino-4-deoxy-beta-L-arabinose-lipid A biosynthesis and in Lipopolysaccharide metabolism.

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Glycosyltransferase, Transferase

Keywords - Biological processi

Lipid A biosynthesis, Lipid biosynthesis, Lipid metabolism, Lipopolysaccharide biosynthesis

Enzyme and pathway databases

UniPathwayiUPA00037.

Protein family/group databases

CAZyiGT83. Glycosyltransferase Family 83.

Names & Taxonomyi

Protein namesi
Recommended name:
Undecaprenyl phosphate-alpha-4-amino-4-deoxy-L-arabinose arabinosyl transferaseUniRule annotation (EC:2.4.2.43UniRule annotation)
Alternative name(s):
4-amino-4-deoxy-L-arabinose lipid A transferaseUniRule annotation
Lipid IV(A) 4-amino-4-deoxy-L-arabinosyltransferaseUniRule annotation
Undecaprenyl phosphate-alpha-L-Ara4N transferaseUniRule annotation
Gene namesi
Name:arnTUniRule annotation
Ordered Locus Names:PA3556
OrganismiPseudomonas aeruginosa (strain ATCC 15692 / DSM 22644 / CIP 104116 / JCM 14847 / LMG 12228 / 1C / PRS 101 / PAO1)
Taxonomic identifieri208964 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaPseudomonadalesPseudomonadaceaePseudomonas
Proteomesi
  • UP000002438 Componenti: Chromosome

Organism-specific databases

PseudoCAPiPA3556.

Subcellular locationi

  • Cell inner membrane UniRule annotation; Multi-pass membrane protein UniRule annotation

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Transmembranei9 – 29HelicalUniRule annotationAdd BLAST21
Transmembranei80 – 100HelicalUniRule annotationAdd BLAST21
Transmembranei112 – 132HelicalUniRule annotationAdd BLAST21
Transmembranei136 – 156HelicalUniRule annotationAdd BLAST21
Transmembranei176 – 196HelicalUniRule annotationAdd BLAST21
Transmembranei204 – 224HelicalUniRule annotationAdd BLAST21
Transmembranei256 – 276HelicalUniRule annotationAdd BLAST21
Transmembranei288 – 308HelicalUniRule annotationAdd BLAST21
Transmembranei312 – 332HelicalUniRule annotationAdd BLAST21
Transmembranei346 – 366HelicalUniRule annotationAdd BLAST21
Transmembranei376 – 396HelicalUniRule annotationAdd BLAST21
Transmembranei402 – 422HelicalUniRule annotationAdd BLAST21

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Cell inner membrane, Cell membrane, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00003800181 – 549Undecaprenyl phosphate-alpha-4-amino-4-deoxy-L-arabinose arabinosyl transferaseAdd BLAST549

Proteomic databases

PaxDbiQ9HY61.
PRIDEiQ9HY61.

Interactioni

Protein-protein interaction databases

STRINGi208964.PA3556.

Structurei

3D structure databases

ProteinModelPortaliQ9HY61.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the glycosyltransferase 83 family.UniRule annotation

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiENOG4105SA9. Bacteria.
COG1807. LUCA.
HOGENOMiHOG000273002.
InParanoidiQ9HY61.
KOiK07264.
OMAiAWRIFRD.
PhylomeDBiQ9HY61.

Family and domain databases

HAMAPiMF_01165. ArnT_transfer. 1 hit.
InterProiIPR022839. ArnT_tfrase.
IPR003342. Glyco_trans_39/83.
[Graphical view]
PfamiPF02366. PMT. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q9HY61-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MSRRQTCSLL LIAFGLFYLV PLSNHGLWIP DETRYAQISQ AMLLGGDWVS
60 70 80 90 100
PHFLGLRYFE KPVAGYWMIA LGQAVFGENL FGVRIASVVA TALSVLLAYL
110 120 130 140 150
LARRLWRDPR TSLACALLYA SFGLIAGQSG YANLDPQFTF WVNLSLVALW
160 170 180 190 200
HALDAGSRRA RLLGWTLLGL ACGMGFLTKG FLAWLLPVLV ALPYMLWQRR
210 220 230 240 250
WRELLGYGAL AVLAALLVCL PWALAVHARE ADYWRFFFWH EHIRRFAGED
260 270 280 290 300
AQHSRPWWFY LPLLAVACLP WSGLLPSALR QAWHERRQAP VVFLALWLLL
310 320 330 340 350
PLAFFSLSRG KLPTYIMPCL LPLALLMGHA LVQRLRLGNS VALRGNGLLN
360 370 380 390 400
LGLALLALAA LAYLQLRKPV YQEEPFELFL VLLVIGAWAA AGLAQWRYPL
410 420 430 440 450
RAWAAPLLAS WVLIALLPAA MPNHVVQNKT PDLFVAEHLD ELTGARHLLS
460 470 480 490 500
NDLGAASALA WRLRRSDVTL YDTRGELKYG LSYPEHSQRS VPLADIRQWL
510 520 530 540
WRARQDGSIA VLLRINSASD RYQLALLPGD GERYRNGNLV LAILPQVRP
Length:549
Mass (Da):61,728
Last modified:March 1, 2001 - v1
Checksum:i2E8A6ABC8E06638C
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AE004091 Genomic DNA. Translation: AAG06944.1.
PIRiG83201.
RefSeqiNP_252246.1. NC_002516.2.
WP_003112877.1. NZ_ASJY01000576.1.

Genome annotation databases

EnsemblBacteriaiAAG06944; AAG06944; PA3556.
GeneIDi879122.
KEGGipae:PA3556.
PATRICi19841727. VBIPseAer58763_3721.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AE004091 Genomic DNA. Translation: AAG06944.1.
PIRiG83201.
RefSeqiNP_252246.1. NC_002516.2.
WP_003112877.1. NZ_ASJY01000576.1.

3D structure databases

ProteinModelPortaliQ9HY61.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi208964.PA3556.

Protein family/group databases

CAZyiGT83. Glycosyltransferase Family 83.

Proteomic databases

PaxDbiQ9HY61.
PRIDEiQ9HY61.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaiAAG06944; AAG06944; PA3556.
GeneIDi879122.
KEGGipae:PA3556.
PATRICi19841727. VBIPseAer58763_3721.

Organism-specific databases

PseudoCAPiPA3556.

Phylogenomic databases

eggNOGiENOG4105SA9. Bacteria.
COG1807. LUCA.
HOGENOMiHOG000273002.
InParanoidiQ9HY61.
KOiK07264.
OMAiAWRIFRD.
PhylomeDBiQ9HY61.

Enzyme and pathway databases

UniPathwayiUPA00037.

Family and domain databases

HAMAPiMF_01165. ArnT_transfer. 1 hit.
InterProiIPR022839. ArnT_tfrase.
IPR003342. Glyco_trans_39/83.
[Graphical view]
PfamiPF02366. PMT. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiARNT_PSEAE
AccessioniPrimary (citable) accession number: Q9HY61
Entry historyi
Integrated into UniProtKB/Swiss-Prot: July 28, 2009
Last sequence update: March 1, 2001
Last modified: November 2, 2016
This is version 86 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.