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Q9HXY8

- LPXB_PSEAE

UniProt

Q9HXY8 - LPXB_PSEAE

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Protein

Lipid-A-disaccharide synthase

Gene

lpxB

Organism
Pseudomonas aeruginosa (strain ATCC 15692 / PAO1 / 1C / PRS 101 / LMG 12228)
Status
Reviewed - Annotation score: 2 out of 5- Protein inferred from homologyi

Functioni

Condensation of UDP-2,3-diacylglucosamine and 2,3-diacylglucosamine-1-phosphate to form lipid A disaccharide, a precursor of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell.By similarity

Catalytic activityi

UDP-2,3-bis(3-hydroxytetradecanoyl)glucosamine + 2,3-bis(3-hydroxytetradecanoyl)-beta-D-glucosaminyl 1-phosphate = UDP + 2,3-bis(3-hydroxytetradecanoyl)-D-glucosaminyl-1,6-beta-D-2,3-bis(3-hydroxytetradecanoyl)-beta-D-glucosaminyl 1-phosphate.

Pathwayi

GO - Molecular functioni

  1. lipid-A-disaccharide synthase activity Source: UniProtKB-EC

GO - Biological processi

  1. lipid A biosynthetic process Source: UniProtKB-KW
Complete GO annotation...

Keywords - Molecular functioni

Glycosyltransferase, Transferase

Keywords - Biological processi

Lipid A biosynthesis, Lipid biosynthesis, Lipid metabolism

Enzyme and pathway databases

UniPathwayiUPA00359; UER00481.

Protein family/group databases

CAZyiGT19. Glycosyltransferase Family 19.

Names & Taxonomyi

Protein namesi
Recommended name:
Lipid-A-disaccharide synthase (EC:2.4.1.182)
Gene namesi
Name:lpxB
Ordered Locus Names:PA3643
OrganismiPseudomonas aeruginosa (strain ATCC 15692 / PAO1 / 1C / PRS 101 / LMG 12228)
Taxonomic identifieri208964 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaPseudomonadalesPseudomonadaceaePseudomonas
ProteomesiUP000002438: Chromosome

Organism-specific databases

PseudoCAPiPA3643.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 378378Lipid-A-disaccharide synthasePRO_0000190177Add
BLAST

Interactioni

Protein-protein interaction databases

STRINGi208964.PA3643.

Structurei

3D structure databases

ProteinModelPortaliQ9HXY8.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the LpxB family.Curated

Phylogenomic databases

eggNOGiCOG0763.
HOGENOMiHOG000018004.
InParanoidiQ9HXY8.
KOiK00748.
OMAiVSPITYR.
OrthoDBiEOG6FBWZR.
PhylomeDBiQ9HXY8.

Family and domain databases

HAMAPiMF_00392. LpxB.
InterProiIPR003835. Glyco_trans_19.
[Graphical view]
PfamiPF02684. LpxB. 1 hit.
[Graphical view]
TIGRFAMsiTIGR00215. lpxB. 1 hit.

Sequencei

Sequence statusi: Complete.

Q9HXY8-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MADGLRVALV AGEASGDILG SGLMQALRAR HPDIEFIGVG GPRMEAEGLS
60 70 80 90 100
SYFPMERLSV MGLVEVLGRL PELLRRRKRL IRTLIEARPD VMIGIDAPDF
110 120 130 140 150
TLGVEHKLRQ AGLRTVHYVS PSVWAWRQKR VLKIREACDL MLALFPFEAR
160 170 180 190 200
FYEEHGVPVR FVGHPLANTI PLQADRAAAR ARLGLPADGQ VLALMPGSRG
210 220 230 240 250
GEVGKLGALF LDTAQRLLVE RPGLRFVLPC ASAARREQIE QMLQGREPLP
260 270 280 290 300
LTLLDGASHE ALAACDAVLI ASGTATLEAL LYKRPMVVAY RVAGLTYRIL
310 320 330 340 350
KRLVKSPYIS LPNLLAGRLL VPELIQDAAT PQALAATLSP LLDDGSQQVE
360 370
FFDAIHRALR QDASAQAAEA VLQLVERR
Length:378
Mass (Da):41,294
Last modified:March 1, 2001 - v1
Checksum:i46DB015E89C9874D
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AE004091 Genomic DNA. Translation: AAG07031.1.
PIRiC83190.
RefSeqiNP_252333.1. NC_002516.2.

Genome annotation databases

EnsemblBacteriaiAAG07031; AAG07031; PA3643.
GeneIDi880521.
KEGGipae:PA3643.
PATRICi19841909. VBIPseAer58763_3812.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AE004091 Genomic DNA. Translation: AAG07031.1 .
PIRi C83190.
RefSeqi NP_252333.1. NC_002516.2.

3D structure databases

ProteinModelPortali Q9HXY8.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 208964.PA3643.

Protein family/group databases

CAZyi GT19. Glycosyltransferase Family 19.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai AAG07031 ; AAG07031 ; PA3643 .
GeneIDi 880521.
KEGGi pae:PA3643.
PATRICi 19841909. VBIPseAer58763_3812.

Organism-specific databases

PseudoCAPi PA3643.

Phylogenomic databases

eggNOGi COG0763.
HOGENOMi HOG000018004.
InParanoidi Q9HXY8.
KOi K00748.
OMAi VSPITYR.
OrthoDBi EOG6FBWZR.
PhylomeDBi Q9HXY8.

Enzyme and pathway databases

UniPathwayi UPA00359 ; UER00481 .

Family and domain databases

HAMAPi MF_00392. LpxB.
InterProi IPR003835. Glyco_trans_19.
[Graphical view ]
Pfami PF02684. LpxB. 1 hit.
[Graphical view ]
TIGRFAMsi TIGR00215. lpxB. 1 hit.
ProtoNeti Search...

Publicationsi

  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: ATCC 15692 / PAO1 / 1C / PRS 101 / LMG 12228.

Entry informationi

Entry nameiLPXB_PSEAE
AccessioniPrimary (citable) accession number: Q9HXY8
Entry historyi
Integrated into UniProtKB/Swiss-Prot: June 1, 2001
Last sequence update: March 1, 2001
Last modified: October 29, 2014
This is version 73 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3