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Protein

3-hydroxyacyl-[acyl-carrier-protein] dehydratase FabZ

Gene

fabZ

Organism
Pseudomonas aeruginosa (strain ATCC 15692 / DSM 22644 / CIP 104116 / JCM 14847 / LMG 12228 / 1C / PRS 101 / PAO1)
Status
Reviewed-Annotation score: Annotation score: 2 out of 5-Experimental evidence at protein leveli

Functioni

Involved in unsaturated fatty acids biosynthesis. Catalyzes the dehydration of short chain beta-hydroxyacyl-ACPs and long chain saturated and unsaturated beta-hydroxyacyl-ACPs.UniRule annotation

Catalytic activityi

A (3R)-3-hydroxyacyl-[acyl-carrier protein] = a trans-2-enoyl-[acyl-carrier protein] + H2O.UniRule annotation

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Active sitei49UniRule annotation1

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Lyase

Keywords - Biological processi

Lipid A biosynthesis, Lipid biosynthesis, Lipid metabolism

Names & Taxonomyi

Protein namesi
Recommended name:
3-hydroxyacyl-[acyl-carrier-protein] dehydratase FabZUniRule annotation (EC:4.2.1.59UniRule annotation)
Alternative name(s):
(3R)-hydroxymyristoyl-[acyl-carrier-protein] dehydrataseUniRule annotation
Short name:
(3R)-hydroxymyristoyl-ACP dehydraseUniRule annotation
Beta-hydroxyacyl-ACP dehydrataseUniRule annotation
Gene namesi
Name:fabZUniRule annotation
Ordered Locus Names:PA3645
OrganismiPseudomonas aeruginosa (strain ATCC 15692 / DSM 22644 / CIP 104116 / JCM 14847 / LMG 12228 / 1C / PRS 101 / PAO1)
Taxonomic identifieri208964 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaPseudomonadalesPseudomonadaceaePseudomonas
Proteomesi
  • UP000002438 Componenti: Chromosome

Organism-specific databases

PseudoCAPiPA3645.

Subcellular locationi

  • Cytoplasm UniRule annotation

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000917131 – 1463-hydroxyacyl-[acyl-carrier-protein] dehydratase FabZAdd BLAST146

Proteomic databases

PaxDbiQ9HXY7.
PRIDEiQ9HXY7.

Interactioni

Protein-protein interaction databases

STRINGi208964.PA3645.

Structurei

Secondary structure

1146
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details
Feature keyPosition(s)DescriptionActionsGraphical viewLength
Helixi4 – 7Combined sources4
Turni8 – 10Combined sources3
Beta strandi22 – 27Combined sources6
Turni28 – 31Combined sources4
Beta strandi32 – 38Combined sources7
Helixi46 – 48Combined sources3
Helixi58 – 77Combined sources20
Beta strandi86 – 97Combined sources12
Beta strandi106 – 117Combined sources12
Beta strandi120 – 129Combined sources10
Beta strandi132 – 144Combined sources13

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
1U1ZX-ray2.50A/B/C/D/E/F1-146[»]
ProteinModelPortaliQ9HXY7.
SMRiQ9HXY7.
ModBaseiSearch...
MobiDBiSearch...

Miscellaneous databases

EvolutionaryTraceiQ9HXY7.

Family & Domainsi

Sequence similaritiesi

Belongs to the thioester dehydratase family. FabZ subfamily.UniRule annotation

Phylogenomic databases

eggNOGiENOG4108YXN. Bacteria.
COG0764. LUCA.
HOGENOMiHOG000277829.
InParanoidiQ9HXY7.
KOiK02372.
OMAiNGHFPHH.
PhylomeDBiQ9HXY7.

Family and domain databases

Gene3Di3.10.129.10. 1 hit.
HAMAPiMF_00406. FabZ. 1 hit.
InterProiIPR013114. FabA_FabZ.
IPR010084. FabZ.
IPR029069. HotDog_dom.
[Graphical view]
PfamiPF07977. FabA. 1 hit.
[Graphical view]
SUPFAMiSSF54637. SSF54637. 1 hit.
TIGRFAMsiTIGR01750. fabZ. 1 hit.

Sequencei

Sequence statusi: Complete.

Q9HXY7-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MMDINEIREY LPHRYPFLLV DRVVELDIEG KRIRAYKNVS INEPFFNGHF
60 70 80 90 100
PEHPIMPGVL IIEAMAQAAG ILGFKMLDVK PADGTLYYFV GSDKLRFRQP
110 120 130 140
VLPGDQLQLH AKFISVKRSI WKFDCHATVD DKPVCSAEII CAERKL
Length:146
Mass (Da):16,774
Last modified:March 1, 2001 - v1
Checksum:iBC7D53E61F5E44CB
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AE004091 Genomic DNA. Translation: AAG07033.1.
PIRiE83190.
RefSeqiNP_252335.1. NC_002516.2.
WP_003092375.1. NZ_ASJY01000591.1.

Genome annotation databases

EnsemblBacteriaiAAG07033; AAG07033; PA3645.
GeneIDi880494.
KEGGipae:PA3645.
PATRICi19841913. VBIPseAer58763_3814.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AE004091 Genomic DNA. Translation: AAG07033.1.
PIRiE83190.
RefSeqiNP_252335.1. NC_002516.2.
WP_003092375.1. NZ_ASJY01000591.1.

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
1U1ZX-ray2.50A/B/C/D/E/F1-146[»]
ProteinModelPortaliQ9HXY7.
SMRiQ9HXY7.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi208964.PA3645.

Proteomic databases

PaxDbiQ9HXY7.
PRIDEiQ9HXY7.

Protocols and materials databases

DNASUi880494.
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaiAAG07033; AAG07033; PA3645.
GeneIDi880494.
KEGGipae:PA3645.
PATRICi19841913. VBIPseAer58763_3814.

Organism-specific databases

PseudoCAPiPA3645.

Phylogenomic databases

eggNOGiENOG4108YXN. Bacteria.
COG0764. LUCA.
HOGENOMiHOG000277829.
InParanoidiQ9HXY7.
KOiK02372.
OMAiNGHFPHH.
PhylomeDBiQ9HXY7.

Miscellaneous databases

EvolutionaryTraceiQ9HXY7.

Family and domain databases

Gene3Di3.10.129.10. 1 hit.
HAMAPiMF_00406. FabZ. 1 hit.
InterProiIPR013114. FabA_FabZ.
IPR010084. FabZ.
IPR029069. HotDog_dom.
[Graphical view]
PfamiPF07977. FabA. 1 hit.
[Graphical view]
SUPFAMiSSF54637. SSF54637. 1 hit.
TIGRFAMsiTIGR01750. fabZ. 1 hit.
ProtoNetiSearch...

Entry informationi

Entry nameiFABZ_PSEAE
AccessioniPrimary (citable) accession number: Q9HXY7
Entry historyi
Integrated into UniProtKB/Swiss-Prot: June 20, 2001
Last sequence update: March 1, 2001
Last modified: November 2, 2016
This is version 96 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.