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Protein

Phosphoenolpyruvate carboxylase

Gene

ppc

Organism
Pseudomonas aeruginosa (strain ATCC 15692 / PAO1 / 1C / PRS 101 / LMG 12228)
Status
Reviewed-Annotation score: Annotation score: 2 out of 5-Protein inferred from homologyi

Functioni

Forms oxaloacetate, a four-carbon dicarboxylic acid source for the tricarboxylic acid cycle.UniRule annotation

Catalytic activityi

Phosphate + oxaloacetate = H2O + phosphoenolpyruvate + HCO3-.UniRule annotation

Cofactori

Mg2+UniRule annotation

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Active sitei140 – 1401UniRule annotation
Active sitei545 – 5451UniRule annotation

GO - Molecular functioni

  1. magnesium ion binding Source: UniProtKB-HAMAP
  2. phosphoenolpyruvate carboxylase activity Source: UniProtKB-HAMAP

GO - Biological processi

  1. carbon fixation Source: UniProtKB-HAMAP
  2. oxaloacetate metabolic process Source: UniProtKB-HAMAP
  3. tricarboxylic acid cycle Source: InterPro
Complete GO annotation...

Keywords - Molecular functioni

Lyase

Keywords - Biological processi

Carbon dioxide fixation

Keywords - Ligandi

Magnesium

Names & Taxonomyi

Protein namesi
Recommended name:
Phosphoenolpyruvate carboxylaseUniRule annotation (EC:4.1.1.31UniRule annotation)
Short name:
PEPCUniRule annotation
Short name:
PEPCaseUniRule annotation
Gene namesi
Name:ppcUniRule annotation
Ordered Locus Names:PA3687
OrganismiPseudomonas aeruginosa (strain ATCC 15692 / PAO1 / 1C / PRS 101 / LMG 12228)
Taxonomic identifieri208964 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaPseudomonadalesPseudomonadaceaePseudomonas
ProteomesiUP000002438 Componenti: Chromosome

Organism-specific databases

PseudoCAPiPA3687.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 878878Phosphoenolpyruvate carboxylasePRO_0000166613Add
BLAST

Proteomic databases

PRIDEiQ9HXV3.

Interactioni

Protein-protein interaction databases

STRINGi208964.PA3687.

Structurei

3D structure databases

ProteinModelPortaliQ9HXV3.
SMRiQ9HXV3. Positions 8-878.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the PEPCase type 1 family.UniRule annotation

Phylogenomic databases

eggNOGiCOG2352.
HOGENOMiHOG000238648.
InParanoidiQ9HXV3.
KOiK01595.
OMAiCGMGVIA.
OrthoDBiEOG6TJ7T8.
PhylomeDBiQ9HXV3.

Family and domain databases

HAMAPiMF_00595. PEPcase_type1.
InterProiIPR021135. PEP_COase.
IPR018129. PEP_COase_AS.
IPR022805. PEP_COase_bac/pln-type.
IPR015813. Pyrv/PenolPyrv_Kinase-like_dom.
[Graphical view]
PfamiPF00311. PEPcase. 1 hit.
[Graphical view]
PRINTSiPR00150. PEPCARBXLASE.
SUPFAMiSSF51621. SSF51621. 1 hit.
PROSITEiPS00781. PEPCASE_1. 1 hit.
PS00393. PEPCASE_2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q9HXV3-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MPEIDARLRE DVHQLGELLG DTIREQYGPR FLDKIELIRK GAKAARRGSA
60 70 80 90 100
EGAQQLTATL DGLEEDELLP VARAFNQFLN LANIAEQYHR IRRRRPNEPE
110 120 130 140 150
PFENLVLEEL LGRLKDAGHA PGQLARQLAG LEIELVLTAH PTEVARRTLI
160 170 180 190 200
QKYDAITAQL AAKDHADLLP EERSRIQQRL QRLVAEAWHT DEIRKVRPTP
210 220 230 240 250
VDEAKWGFAV IEHSLWQALP NVLRHVDEVL LRSTGERLPL TAAPLRFASW
260 270 280 290 300
MGGDRDGNPN VTASVTREVL LLARWMAADL YLRDIDRLAA ELSMQQASPQ
310 320 330 340 350
LLARVGDSAE PYRALLKQLR ERLRVTRNWT HQALAGEVPA AEGVLEHNRD
360 370 380 390 400
LVEPLQLCHE SLHACGMGVI ADGALLDCLR RAATFGLFLV RLDVRQDSAR
410 420 430 440 450
HAAALSEITE YLELGSYDEW DEKTRLEFLL EELNSRRPLL PAHYQPSADT
460 470 480 490 500
AEVLATCRAI AAAPPASLGS YVISMAGQPS DVLAVQLLLK ESGVDWPMRV
510 520 530 540 550
VPLFETLDDL DNAGPCMERL LTLPGYRSRL SGVQEVMIGY SDSAKDAGTL
560 570 580 590 600
TAAWAQYRAQ EKLVEICRQH EVELLLFHGR GGTVGRGGGP AHAAILSQPP
610 620 630 640 650
GSVAGRFRVT EQGEMIRFKF GLPDIAEQNL NLYLAAVLEA TLMPPPAPEP
660 670 680 690 700
AWRAQMDRLA KDALLAYRRV VRDDPQFVEY FRLATPEQEL GRLPLGSRPA
710 720 730 740 750
KRREGGVESL RAIPWIFAWT QTRLMLPAWL GWETALLNAI ERGEGALLGQ
760 770 780 790 800
MREQWPFFTT RIDMLEMVLA KADADIARLY DERLVPLELR PLGRRLRDLL
810 820 830 840 850
SQAVRVVLGL TGQSLLLAHA SETRESISVR NSYLDPLHLL QAELLARSRR
860 870
CRGDACGGLE QALLVTVAGV AAGLRNTG
Length:878
Mass (Da):97,840
Last modified:February 28, 2001 - v1
Checksum:i51D1309A70425BDA
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AE004091 Genomic DNA. Translation: AAG07075.1.
PIRiH83184.
RefSeqiNP_252377.1. NC_002516.2.

Genome annotation databases

EnsemblBacteriaiAAG07075; AAG07075; PA3687.
GeneIDi879083.
KEGGipae:PA3687.
PATRICi19841997. VBIPseAer58763_3856.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AE004091 Genomic DNA. Translation: AAG07075.1.
PIRiH83184.
RefSeqiNP_252377.1. NC_002516.2.

3D structure databases

ProteinModelPortaliQ9HXV3.
SMRiQ9HXV3. Positions 8-878.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi208964.PA3687.

Proteomic databases

PRIDEiQ9HXV3.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaiAAG07075; AAG07075; PA3687.
GeneIDi879083.
KEGGipae:PA3687.
PATRICi19841997. VBIPseAer58763_3856.

Organism-specific databases

PseudoCAPiPA3687.

Phylogenomic databases

eggNOGiCOG2352.
HOGENOMiHOG000238648.
InParanoidiQ9HXV3.
KOiK01595.
OMAiCGMGVIA.
OrthoDBiEOG6TJ7T8.
PhylomeDBiQ9HXV3.

Family and domain databases

HAMAPiMF_00595. PEPcase_type1.
InterProiIPR021135. PEP_COase.
IPR018129. PEP_COase_AS.
IPR022805. PEP_COase_bac/pln-type.
IPR015813. Pyrv/PenolPyrv_Kinase-like_dom.
[Graphical view]
PfamiPF00311. PEPcase. 1 hit.
[Graphical view]
PRINTSiPR00150. PEPCARBXLASE.
SUPFAMiSSF51621. SSF51621. 1 hit.
PROSITEiPS00781. PEPCASE_1. 1 hit.
PS00393. PEPCASE_2. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: ATCC 15692 / PAO1 / 1C / PRS 101 / LMG 12228.

Entry informationi

Entry nameiCAPP_PSEAE
AccessioniPrimary (citable) accession number: Q9HXV3
Entry historyi
Integrated into UniProtKB/Swiss-Prot: November 7, 2002
Last sequence update: February 28, 2001
Last modified: January 6, 2015
This is version 83 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.