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Protein

Probable nicotinate-nucleotide adenylyltransferase

Gene

nadD

Organism
Pseudomonas aeruginosa (strain ATCC 15692 / DSM 22644 / CIP 104116 / JCM 14847 / LMG 12228 / 1C / PRS 101 / PAO1)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at protein leveli

Functioni

Catalyzes the reversible adenylation of nicotinate mononucleotide (NaMN) to nicotinic acid adenine dinucleotide (NaAD).By similarity

Catalytic activityi

ATP + beta-nicotinate-D-ribonucleotide = diphosphate + deamido-NAD+.

Pathwayi: NAD(+) biosynthesis

This protein is involved in step 1 of the subpathway that synthesizes deamido-NAD(+) from nicotinate D-ribonucleotide.
Proteins known to be involved in this subpathway in this organism are:
  1. Probable nicotinate-nucleotide adenylyltransferase (nadD)
This subpathway is part of the pathway NAD(+) biosynthesis, which is itself part of Cofactor biosynthesis.
View all proteins of this organism that are known to be involved in the subpathway that synthesizes deamido-NAD(+) from nicotinate D-ribonucleotide, the pathway NAD(+) biosynthesis and in Cofactor biosynthesis.

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Nucleotidyltransferase, Transferase

Keywords - Biological processi

Pyridine nucleotide biosynthesis

Keywords - Ligandi

ATP-binding, NAD, Nucleotide-binding

Enzyme and pathway databases

BRENDAi2.7.7.18. 5087.
UniPathwayiUPA00253; UER00332.

Names & Taxonomyi

Protein namesi
Recommended name:
Probable nicotinate-nucleotide adenylyltransferase (EC:2.7.7.18)
Alternative name(s):
Deamido-NAD(+) diphosphorylase
Deamido-NAD(+) pyrophosphorylase
Nicotinate mononucleotide adenylyltransferase
Short name:
NaMN adenylyltransferase
Gene namesi
Name:nadD
Ordered Locus Names:PA4006
OrganismiPseudomonas aeruginosa (strain ATCC 15692 / DSM 22644 / CIP 104116 / JCM 14847 / LMG 12228 / 1C / PRS 101 / PAO1)
Taxonomic identifieri208964 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaPseudomonadalesPseudomonadaceaePseudomonas
Proteomesi
  • UP000002438 Componenti: Chromosome

Organism-specific databases

PseudoCAPiPA4006.

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001814321 – 214Probable nicotinate-nucleotide adenylyltransferaseAdd BLAST214

Proteomic databases

PaxDbiQ9HX21.

Interactioni

Protein-protein interaction databases

STRINGi208964.PA4006.

Structurei

Secondary structure

1214
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details
Feature keyPosition(s)DescriptionActionsGraphical viewLength
Beta strandi4 – 10Combined sources7
Helixi17 – 30Combined sources14
Beta strandi33 – 39Combined sources7
Helixi44 – 46Combined sources3
Helixi53 – 64Combined sources12
Beta strandi70 – 72Combined sources3
Helixi75 – 78Combined sources4
Beta strandi79 – 82Combined sources4
Helixi85 – 95Combined sources11
Beta strandi101 – 107Combined sources7
Helixi108 – 111Combined sources4
Helixi112 – 116Combined sources5
Helixi120 – 122Combined sources3
Turni124 – 126Combined sources3
Beta strandi128 – 133Combined sources6
Beta strandi135 – 137Combined sources3
Helixi143 – 145Combined sources3
Helixi146 – 152Combined sources7
Helixi157 – 159Combined sources3
Beta strandi162 – 164Combined sources3
Beta strandi167 – 171Combined sources5
Helixi179 – 187Combined sources9
Helixi198 – 206Combined sources9
Turni207 – 210Combined sources4

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
1YULX-ray2.00A1-214[»]
1YUMX-ray1.70A/B/C/D1-214[»]
1YUNX-ray2.00A/B1-214[»]
ProteinModelPortaliQ9HX21.
SMRiQ9HX21.
ModBaseiSearch...
MobiDBiSearch...

Miscellaneous databases

EvolutionaryTraceiQ9HX21.

Family & Domainsi

Sequence similaritiesi

Belongs to the NadD family.Curated

Phylogenomic databases

eggNOGiENOG4108Z1W. Bacteria.
COG1057. LUCA.
HOGENOMiHOG000262781.
InParanoidiQ9HX21.
KOiK00969.
OMAiFLLLGWD.
PhylomeDBiQ9HX21.

Family and domain databases

Gene3Di3.40.50.620. 1 hit.
HAMAPiMF_00244. NaMN_adenylyltr. 1 hit.
InterProiIPR004821. Cyt_trans-like.
IPR005248. NAMN_adtrnsfrase.
IPR014729. Rossmann-like_a/b/a_fold.
[Graphical view]
PANTHERiPTHR12039. PTHR12039. 1 hit.
PfamiPF01467. CTP_transf_like. 1 hit.
[Graphical view]
TIGRFAMsiTIGR00125. cyt_tran_rel. 1 hit.
TIGR00482. TIGR00482. 1 hit.

Sequencei

Sequence statusi: Complete.

Q9HX21-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MGKRIGLFGG TFDPVHIGHM RSAVEMAEQF ALDELRLLPN ARPPHRETPQ
60 70 80 90 100
VSAAQRLAMV ERAVAGVERL TVDPRELQRD KPSYTIDTLE SVRAELAADD
110 120 130 140 150
QLFMLIGWDA FCGLPTWHRW EALLDHCHIV VLQRPDADSE PPESLRDLLA
160 170 180 190 200
ARSVADPQAL KGPGGQITFV WQTPLAVSAT QIRALLGAGR SVRFLVPDAV
210
LNYIEAHHLY RAPH
Length:214
Mass (Da):23,801
Last modified:March 1, 2001 - v1
Checksum:i95FF8237AD0C3A69
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AE004091 Genomic DNA. Translation: AAG07393.1.
PIRiB83147.
RefSeqiNP_252695.1. NC_002516.2.
WP_003093199.1. NZ_ASJY01000638.1.

Genome annotation databases

EnsemblBacteriaiAAG07393; AAG07393; PA4006.
GeneIDi878969.
KEGGipae:PA4006.
PATRICi19842683. VBIPseAer58763_4198.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AE004091 Genomic DNA. Translation: AAG07393.1.
PIRiB83147.
RefSeqiNP_252695.1. NC_002516.2.
WP_003093199.1. NZ_ASJY01000638.1.

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
1YULX-ray2.00A1-214[»]
1YUMX-ray1.70A/B/C/D1-214[»]
1YUNX-ray2.00A/B1-214[»]
ProteinModelPortaliQ9HX21.
SMRiQ9HX21.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi208964.PA4006.

Proteomic databases

PaxDbiQ9HX21.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaiAAG07393; AAG07393; PA4006.
GeneIDi878969.
KEGGipae:PA4006.
PATRICi19842683. VBIPseAer58763_4198.

Organism-specific databases

PseudoCAPiPA4006.

Phylogenomic databases

eggNOGiENOG4108Z1W. Bacteria.
COG1057. LUCA.
HOGENOMiHOG000262781.
InParanoidiQ9HX21.
KOiK00969.
OMAiFLLLGWD.
PhylomeDBiQ9HX21.

Enzyme and pathway databases

UniPathwayiUPA00253; UER00332.
BRENDAi2.7.7.18. 5087.

Miscellaneous databases

EvolutionaryTraceiQ9HX21.

Family and domain databases

Gene3Di3.40.50.620. 1 hit.
HAMAPiMF_00244. NaMN_adenylyltr. 1 hit.
InterProiIPR004821. Cyt_trans-like.
IPR005248. NAMN_adtrnsfrase.
IPR014729. Rossmann-like_a/b/a_fold.
[Graphical view]
PANTHERiPTHR12039. PTHR12039. 1 hit.
PfamiPF01467. CTP_transf_like. 1 hit.
[Graphical view]
TIGRFAMsiTIGR00125. cyt_tran_rel. 1 hit.
TIGR00482. TIGR00482. 1 hit.
ProtoNetiSearch...

Entry informationi

Entry nameiNADD_PSEAE
AccessioniPrimary (citable) accession number: Q9HX21
Entry historyi
Integrated into UniProtKB/Swiss-Prot: June 1, 2001
Last sequence update: March 1, 2001
Last modified: November 2, 2016
This is version 105 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  2. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  3. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.