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Protein

Probable nicotinate-nucleotide adenylyltransferase

Gene

nadD

Organism
Pseudomonas aeruginosa (strain ATCC 15692 / DSM 22644 / CIP 104116 / JCM 14847 / LMG 12228 / 1C / PRS 101 / PAO1)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at protein leveli

Functioni

Catalyzes the reversible adenylation of nicotinate mononucleotide (NaMN) to nicotinic acid adenine dinucleotide (NaAD).By similarity

Catalytic activityi

ATP + beta-nicotinate-D-ribonucleotide = diphosphate + deamido-NAD+.

Pathwayi: NAD(+) biosynthesis

This protein is involved in step 1 of the subpathway that synthesizes deamido-NAD(+) from nicotinate D-ribonucleotide.
Proteins known to be involved in this subpathway in this organism are:
  1. Probable nicotinate-nucleotide adenylyltransferase (nadD)
This subpathway is part of the pathway NAD(+) biosynthesis, which is itself part of Cofactor biosynthesis.
View all proteins of this organism that are known to be involved in the subpathway that synthesizes deamido-NAD(+) from nicotinate D-ribonucleotide, the pathway NAD(+) biosynthesis and in Cofactor biosynthesis.

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Nucleotidyltransferase, Transferase

Keywords - Biological processi

Pyridine nucleotide biosynthesis

Keywords - Ligandi

ATP-binding, NAD, Nucleotide-binding

Enzyme and pathway databases

BRENDAi2.7.7.18. 5087.
UniPathwayiUPA00253; UER00332.

Names & Taxonomyi

Protein namesi
Recommended name:
Probable nicotinate-nucleotide adenylyltransferase (EC:2.7.7.18)
Alternative name(s):
Deamido-NAD(+) diphosphorylase
Deamido-NAD(+) pyrophosphorylase
Nicotinate mononucleotide adenylyltransferase
Short name:
NaMN adenylyltransferase
Gene namesi
Name:nadD
Ordered Locus Names:PA4006
OrganismiPseudomonas aeruginosa (strain ATCC 15692 / DSM 22644 / CIP 104116 / JCM 14847 / LMG 12228 / 1C / PRS 101 / PAO1)
Taxonomic identifieri208964 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaPseudomonadalesPseudomonadaceaePseudomonas
Proteomesi
  • UP000002438 Componenti: Chromosome

Organism-specific databases

PseudoCAPiPA4006.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 214214Probable nicotinate-nucleotide adenylyltransferasePRO_0000181432Add
BLAST

Proteomic databases

PaxDbiQ9HX21.

Interactioni

Protein-protein interaction databases

STRINGi208964.PA4006.

Structurei

Secondary structure

1
214
Legend: HelixTurnBeta strand
Show more details
Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Beta strandi4 – 107Combined sources
Helixi17 – 3014Combined sources
Beta strandi33 – 397Combined sources
Helixi44 – 463Combined sources
Helixi53 – 6412Combined sources
Beta strandi70 – 723Combined sources
Helixi75 – 784Combined sources
Beta strandi79 – 824Combined sources
Helixi85 – 9511Combined sources
Beta strandi101 – 1077Combined sources
Helixi108 – 1114Combined sources
Helixi112 – 1165Combined sources
Helixi120 – 1223Combined sources
Turni124 – 1263Combined sources
Beta strandi128 – 1336Combined sources
Beta strandi135 – 1373Combined sources
Helixi143 – 1453Combined sources
Helixi146 – 1527Combined sources
Helixi157 – 1593Combined sources
Beta strandi162 – 1643Combined sources
Beta strandi167 – 1715Combined sources
Helixi179 – 1879Combined sources
Helixi198 – 2069Combined sources
Turni207 – 2104Combined sources

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
EntryMethodResolution (Å)ChainPositionsPDBsum
1YULX-ray2.00A1-214[»]
1YUMX-ray1.70A/B/C/D1-214[»]
1YUNX-ray2.00A/B1-214[»]
ProteinModelPortaliQ9HX21.
SMRiQ9HX21. Positions 2-213.
ModBaseiSearch...
MobiDBiSearch...

Miscellaneous databases

EvolutionaryTraceiQ9HX21.

Family & Domainsi

Sequence similaritiesi

Belongs to the NadD family.Curated

Phylogenomic databases

eggNOGiENOG4108Z1W. Bacteria.
COG1057. LUCA.
HOGENOMiHOG000262781.
InParanoidiQ9HX21.
KOiK00969.
OMAiFLLLGWD.
PhylomeDBiQ9HX21.

Family and domain databases

Gene3Di3.40.50.620. 1 hit.
HAMAPiMF_00244. NaMN_adenylyltr. 1 hit.
InterProiIPR004821. Cyt_trans-like.
IPR005248. NAMN_adtrnsfrase.
IPR014729. Rossmann-like_a/b/a_fold.
[Graphical view]
PANTHERiPTHR12039. PTHR12039. 1 hit.
PfamiPF01467. CTP_transf_like. 1 hit.
[Graphical view]
TIGRFAMsiTIGR00125. cyt_tran_rel. 1 hit.
TIGR00482. TIGR00482. 1 hit.

Sequencei

Sequence statusi: Complete.

Q9HX21-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MGKRIGLFGG TFDPVHIGHM RSAVEMAEQF ALDELRLLPN ARPPHRETPQ
60 70 80 90 100
VSAAQRLAMV ERAVAGVERL TVDPRELQRD KPSYTIDTLE SVRAELAADD
110 120 130 140 150
QLFMLIGWDA FCGLPTWHRW EALLDHCHIV VLQRPDADSE PPESLRDLLA
160 170 180 190 200
ARSVADPQAL KGPGGQITFV WQTPLAVSAT QIRALLGAGR SVRFLVPDAV
210
LNYIEAHHLY RAPH
Length:214
Mass (Da):23,801
Last modified:March 1, 2001 - v1
Checksum:i95FF8237AD0C3A69
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AE004091 Genomic DNA. Translation: AAG07393.1.
PIRiB83147.
RefSeqiNP_252695.1. NC_002516.2.
WP_003093199.1. NZ_ASJY01000638.1.

Genome annotation databases

EnsemblBacteriaiAAG07393; AAG07393; PA4006.
GeneIDi878969.
KEGGipae:PA4006.
PATRICi19842683. VBIPseAer58763_4198.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AE004091 Genomic DNA. Translation: AAG07393.1.
PIRiB83147.
RefSeqiNP_252695.1. NC_002516.2.
WP_003093199.1. NZ_ASJY01000638.1.

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
EntryMethodResolution (Å)ChainPositionsPDBsum
1YULX-ray2.00A1-214[»]
1YUMX-ray1.70A/B/C/D1-214[»]
1YUNX-ray2.00A/B1-214[»]
ProteinModelPortaliQ9HX21.
SMRiQ9HX21. Positions 2-213.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi208964.PA4006.

Proteomic databases

PaxDbiQ9HX21.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaiAAG07393; AAG07393; PA4006.
GeneIDi878969.
KEGGipae:PA4006.
PATRICi19842683. VBIPseAer58763_4198.

Organism-specific databases

PseudoCAPiPA4006.

Phylogenomic databases

eggNOGiENOG4108Z1W. Bacteria.
COG1057. LUCA.
HOGENOMiHOG000262781.
InParanoidiQ9HX21.
KOiK00969.
OMAiFLLLGWD.
PhylomeDBiQ9HX21.

Enzyme and pathway databases

UniPathwayiUPA00253; UER00332.
BRENDAi2.7.7.18. 5087.

Miscellaneous databases

EvolutionaryTraceiQ9HX21.

Family and domain databases

Gene3Di3.40.50.620. 1 hit.
HAMAPiMF_00244. NaMN_adenylyltr. 1 hit.
InterProiIPR004821. Cyt_trans-like.
IPR005248. NAMN_adtrnsfrase.
IPR014729. Rossmann-like_a/b/a_fold.
[Graphical view]
PANTHERiPTHR12039. PTHR12039. 1 hit.
PfamiPF01467. CTP_transf_like. 1 hit.
[Graphical view]
TIGRFAMsiTIGR00125. cyt_tran_rel. 1 hit.
TIGR00482. TIGR00482. 1 hit.
ProtoNetiSearch...

Entry informationi

Entry nameiNADD_PSEAE
AccessioniPrimary (citable) accession number: Q9HX21
Entry historyi
Integrated into UniProtKB/Swiss-Prot: June 1, 2001
Last sequence update: March 1, 2001
Last modified: September 7, 2016
This is version 103 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  2. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  3. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.