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Q9HWT0

- Q9HWT0_PSEAE

UniProt

Q9HWT0 - Q9HWT0_PSEAE

Protein
Submitted name:

Probable short-chain dehydrogenase

Gene

PA4098

Organism
Pseudomonas aeruginosa (strain ATCC 15692 / PAO1 / 1C / PRS 101 / LMG 12228)
Status
Unreviewed - Annotation score: 1 out of 5- Experimental evidence at protein leveli
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    • History
      Entry version 89 (01 Oct 2014)
      Sequence version 1 (01 Mar 2001)
      Previous versions | rss
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    Functioni

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Binding sitei42 – 421NAD; via amide nitrogenImported
    Binding sitei84 – 841NAD; via carbonyl oxygenImported
    Binding sitei146 – 1461NADImported
    Binding sitei150 – 1501NADImported

    Regions

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Nucleotide bindingi17 – 226NADImported
    Nucleotide bindingi61 – 622NADImported
    Nucleotide bindingi176 – 1816NADImported

    GO - Molecular functioni

    1. nucleotide binding Source: UniProtKB-KW
    2. oxidoreductase activity Source: InterPro

    Keywords - Ligandi

    NADImported, Nucleotide-bindingImported

    Names & Taxonomyi

    Protein namesi
    Submitted name:
    Probable short-chain dehydrogenaseImported
    Gene namesi
    Ordered Locus Names:PA4098Imported
    OrganismiPseudomonas aeruginosa (strain ATCC 15692 / PAO1 / 1C / PRS 101 / LMG 12228)Imported
    Taxonomic identifieri208964 [NCBI]
    Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaPseudomonadalesPseudomonadaceaePseudomonas
    ProteomesiUP000002438: Chromosome

    Organism-specific databases

    PseudoCAPiPA4098.

    Interactioni

    Protein-protein interaction databases

    STRINGi208964.PA4098.

    Structurei

    3D structure databases

    Select the link destinations:
    PDBe
    RCSB PDB
    PDBj
    Links Updated
    EntryMethodResolution (Å)ChainPositionsPDBsum
    4AVYX-ray2.00A/B1-241[»]
    4B79X-ray1.98A/B1-241[»]
    ProteinModelPortaliQ9HWT0.
    SMRiQ9HWT0. Positions 1-241.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Sequence similaritiesi

    Belongs to the short-chain dehydrogenases/reductases (SDR) family.UniRule annotation

    Phylogenomic databases

    OMAiIQTDFSQ.
    OrthoDBiEOG6N3CR8.
    PhylomeDBiQ9HWT0.

    Family and domain databases

    Gene3Di3.40.50.720. 1 hit.
    InterProiIPR002198. DH_sc/Rdtase_SDR.
    IPR002347. Glc/ribitol_DH.
    IPR016040. NAD(P)-bd_dom.
    IPR020904. Sc_DH/Rdtase_CS.
    [Graphical view]
    PfamiPF00106. adh_short. 1 hit.
    [Graphical view]
    PRINTSiPR00081. GDHRDH.
    PR00080. SDRFAMILY.
    PROSITEiPS00061. ADH_SHORT. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Q9HWT0-1 [UniParc]FASTAAdd to Basket

    « Hide

    MVFQHDIYAG QQVLVTGGSS GIGAAIAMQF AELGAEVVAL GLDADGVHAP    50
    RHPRIRREEL DITDSQRLQR LFEALPRLDV LVNNAGISRD REEYDLATFE 100
    RVLRLNLSAA MLASQLARPL LAQRGGSILN IASMYSTFGS ADRPAYSASK 150
    GAIVQLTRSL ACEYAAERIR VNAIAPGWID TPLGAGLKAD VEATRRIMQR 200
    TPLARWGEAP EVASAAAFLC GPGASFVTGA VLAVDGGYLC A 241
    Length:241
    Mass (Da):25,622
    Last modified:March 1, 2001 - v1
    Checksum:i879AAD48E36F19CE
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AE004091 Genomic DNA. Translation: AAG07485.1.
    PIRiC83133.
    RefSeqiNP_252787.1. NC_002516.2.

    Genome annotation databases

    EnsemblBacteriaiAAG07485; AAG07485; PA4098.
    GeneIDi878798.
    KEGGipae:PA4098.
    PATRICi19842870. VBIPseAer58763_4291.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AE004091 Genomic DNA. Translation: AAG07485.1 .
    PIRi C83133.
    RefSeqi NP_252787.1. NC_002516.2.

    3D structure databases

    Select the link destinations:
    PDBe
    RCSB PDB
    PDBj
    Links Updated
    Entry Method Resolution (Å) Chain Positions PDBsum
    4AVY X-ray 2.00 A/B 1-241 [» ]
    4B79 X-ray 1.98 A/B 1-241 [» ]
    ProteinModelPortali Q9HWT0.
    SMRi Q9HWT0. Positions 1-241.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 208964.PA4098.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    EnsemblBacteriai AAG07485 ; AAG07485 ; PA4098 .
    GeneIDi 878798.
    KEGGi pae:PA4098.
    PATRICi 19842870. VBIPseAer58763_4291.

    Organism-specific databases

    PseudoCAPi PA4098.

    Phylogenomic databases

    OMAi IQTDFSQ.
    OrthoDBi EOG6N3CR8.
    PhylomeDBi Q9HWT0.

    Family and domain databases

    Gene3Di 3.40.50.720. 1 hit.
    InterProi IPR002198. DH_sc/Rdtase_SDR.
    IPR002347. Glc/ribitol_DH.
    IPR016040. NAD(P)-bd_dom.
    IPR020904. Sc_DH/Rdtase_CS.
    [Graphical view ]
    Pfami PF00106. adh_short. 1 hit.
    [Graphical view ]
    PRINTSi PR00081. GDHRDH.
    PR00080. SDRFAMILY.
    PROSITEi PS00061. ADH_SHORT. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: ATCC 15692 / PAO1 / 1C / PRS 101 / LMG 12228Imported.
    2. "The AEROPATH project targeting Pseudomonas aeruginosa: crystallographic studies for assessment of potential targets in early-stage drug discovery."
      Moynie L., Schnell R., McMahon S.A., Sandalova T., Boulkerou W.A., Schmidberger J.W., Alphey M., Cukier C., Duthie F., Kopec J., Liu H., Jacewicz A., Hunter W.N., Naismith J.H., Schneider G.
      Acta Crystallogr. F 69:25-34(2013) [PubMed] [Europe PMC] [Abstract]
      Cited for: X-RAY CRYSTALLOGRAPHY (1.98 ANGSTROMS) IN COMPLEX WITH NAD.

    Entry informationi

    Entry nameiQ9HWT0_PSEAE
    AccessioniPrimary (citable) accession number: Q9HWT0
    Entry historyi
    Integrated into UniProtKB/TrEMBL: March 1, 2001
    Last sequence update: March 1, 2001
    Last modified: October 1, 2014
    This is version 89 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiUnreviewed (UniProtKB/TrEMBL)

    Miscellaneousi

    Keywords - Technical termi

    3D-structureImported, Complete proteome, Reference proteomeImported

    External Data

    Dasty 3