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Protein
Submitted name:

Probable short-chain dehydrogenase

Gene

PA4098

Organism
Pseudomonas aeruginosa (strain ATCC 15692 / PAO1 / 1C / PRS 101 / LMG 12228)
Status
Unreviewed-Annotation score: Annotation score: 1 out of 5-Experimental evidence at protein leveli

Functioni

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Binding sitei42 – 421NAD; via amide nitrogenCombined sources
Binding sitei84 – 841NAD; via carbonyl oxygenCombined sources
Binding sitei146 – 1461NADCombined sources
Binding sitei150 – 1501NADCombined sources

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Nucleotide bindingi17 – 226NADCombined sources
Nucleotide bindingi61 – 622NADCombined sources
Nucleotide bindingi176 – 1816NADCombined sources

GO - Molecular functioni

Complete GO annotation...

Keywords - Ligandi

NADCombined sources, Nucleotide-bindingCombined sources

Names & Taxonomyi

Protein namesi
Submitted name:
Probable short-chain dehydrogenaseImported
Gene namesi
Ordered Locus Names:PA4098Imported
OrganismiPseudomonas aeruginosa (strain ATCC 15692 / PAO1 / 1C / PRS 101 / LMG 12228)Imported
Taxonomic identifieri208964 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaPseudomonadalesPseudomonadaceaePseudomonas
ProteomesiUP000002438 Componenti: Chromosome

Organism-specific databases

PseudoCAPiPA4098.

Interactioni

Protein-protein interaction databases

STRINGi208964.PA4098.

Structurei

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
EntryMethodResolution (Å)ChainPositionsPDBsum
4AVYX-ray2.00A/B1-241[»]
4B79X-ray1.98A/B1-241[»]
ProteinModelPortaliQ9HWT0.
SMRiQ9HWT0. Positions 1-241.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the short-chain dehydrogenases/reductases (SDR) family.UniRule annotation

Phylogenomic databases

InParanoidiQ9HWT0.
OMAiKIVNVNI.
OrthoDBiEOG6N3CR8.
PhylomeDBiQ9HWT0.

Family and domain databases

Gene3Di3.40.50.720. 1 hit.
InterProiIPR002198. DH_sc/Rdtase_SDR.
IPR002347. Glc/ribitol_DH.
IPR016040. NAD(P)-bd_dom.
IPR020904. Sc_DH/Rdtase_CS.
[Graphical view]
PfamiPF00106. adh_short. 1 hit.
[Graphical view]
PRINTSiPR00081. GDHRDH.
PR00080. SDRFAMILY.
PROSITEiPS00061. ADH_SHORT. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q9HWT0-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MVFQHDIYAG QQVLVTGGSS GIGAAIAMQF AELGAEVVAL GLDADGVHAP
60 70 80 90 100
RHPRIRREEL DITDSQRLQR LFEALPRLDV LVNNAGISRD REEYDLATFE
110 120 130 140 150
RVLRLNLSAA MLASQLARPL LAQRGGSILN IASMYSTFGS ADRPAYSASK
160 170 180 190 200
GAIVQLTRSL ACEYAAERIR VNAIAPGWID TPLGAGLKAD VEATRRIMQR
210 220 230 240
TPLARWGEAP EVASAAAFLC GPGASFVTGA VLAVDGGYLC A
Length:241
Mass (Da):25,622
Last modified:March 1, 2001 - v1
Checksum:i879AAD48E36F19CE
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AE004091 Genomic DNA. Translation: AAG07485.1.
PIRiC83133.
RefSeqiNP_252787.1. NC_002516.2.
WP_003093405.1. NC_002516.2.

Genome annotation databases

EnsemblBacteriaiAAG07485; AAG07485; PA4098.
GeneIDi878798.
KEGGipae:PA4098.
PATRICi19842870. VBIPseAer58763_4291.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AE004091 Genomic DNA. Translation: AAG07485.1.
PIRiC83133.
RefSeqiNP_252787.1. NC_002516.2.
WP_003093405.1. NC_002516.2.

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
EntryMethodResolution (Å)ChainPositionsPDBsum
4AVYX-ray2.00A/B1-241[»]
4B79X-ray1.98A/B1-241[»]
ProteinModelPortaliQ9HWT0.
SMRiQ9HWT0. Positions 1-241.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi208964.PA4098.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaiAAG07485; AAG07485; PA4098.
GeneIDi878798.
KEGGipae:PA4098.
PATRICi19842870. VBIPseAer58763_4291.

Organism-specific databases

PseudoCAPiPA4098.

Phylogenomic databases

InParanoidiQ9HWT0.
OMAiKIVNVNI.
OrthoDBiEOG6N3CR8.
PhylomeDBiQ9HWT0.

Family and domain databases

Gene3Di3.40.50.720. 1 hit.
InterProiIPR002198. DH_sc/Rdtase_SDR.
IPR002347. Glc/ribitol_DH.
IPR016040. NAD(P)-bd_dom.
IPR020904. Sc_DH/Rdtase_CS.
[Graphical view]
PfamiPF00106. adh_short. 1 hit.
[Graphical view]
PRINTSiPR00081. GDHRDH.
PR00080. SDRFAMILY.
PROSITEiPS00061. ADH_SHORT. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: ATCC 15692 / PAO1 / 1C / PRS 101 / LMG 12228Imported.
  2. "The AEROPATH project targeting Pseudomonas aeruginosa: crystallographic studies for assessment of potential targets in early-stage drug discovery."
    Moynie L., Schnell R., McMahon S.A., Sandalova T., Boulkerou W.A., Schmidberger J.W., Alphey M., Cukier C., Duthie F., Kopec J., Liu H., Jacewicz A., Hunter W.N., Naismith J.H., Schneider G.
    Acta Crystallogr. F 69:25-34(2013) [PubMed] [Europe PMC] [Abstract]
    Cited for: X-RAY CRYSTALLOGRAPHY (1.98 ANGSTROMS) IN COMPLEX WITH NAD.

Entry informationi

Entry nameiQ9HWT0_PSEAE
AccessioniPrimary (citable) accession number: Q9HWT0
Entry historyi
Integrated into UniProtKB/TrEMBL: March 1, 2001
Last sequence update: March 1, 2001
Last modified: July 22, 2015
This is version 93 of the entry and version 1 of the sequence. [Complete history]
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Keywords - Technical termi

3D-structureCombined sources, Complete proteome, Reference proteomeImported

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.