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Protein

Bacteriophytochrome

Gene

bphP

Organism
Pseudomonas aeruginosa (strain ATCC 15692 / DSM 22644 / CIP 104116 / JCM 14847 / LMG 12228 / 1C / PRS 101 / PAO1)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Photoreceptor which exists in two forms that are reversibly interconvertible by light: the R form that absorbs maximally in the red region of the spectrum and the FR form that absorbs maximally in the far-red region.By similarity

Catalytic activityi

ATP + protein L-histidine = ADP + protein N-phospho-L-histidine.

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Binding sitei12Tetrapyrrole chromophore (covalent; via 1 link)By similarity1

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionKinase, Photoreceptor protein, Receptor, Transferase
Biological processSensory transduction
LigandATP-binding, Chromophore, Nucleotide-binding

Enzyme and pathway databases

BioCyciPAER208964:G1FZ6-4190-MONOMER
BRENDAi2.7.13.3 5087

Names & Taxonomyi

Protein namesi
Recommended name:
Bacteriophytochrome (EC:2.7.13.3)
Alternative name(s):
Phytochrome-like protein
Gene namesi
Name:bphP
Ordered Locus Names:PA4117
OrganismiPseudomonas aeruginosa (strain ATCC 15692 / DSM 22644 / CIP 104116 / JCM 14847 / LMG 12228 / 1C / PRS 101 / PAO1)
Taxonomic identifieri208964 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaPseudomonadalesPseudomonadaceaePseudomonas
Proteomesi
  • UP000002438 Componenti: Chromosome

Organism-specific databases

PseudoCAPiPA4117

Subcellular locationi

GO - Cellular componenti

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001720001 – 728BacteriophytochromeAdd BLAST728

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei513Phosphohistidine; by autocatalysisPROSITE-ProRule annotation1

Post-translational modificationi

Contains one covalently linked tetrapyrrole chromophore.By similarity

Keywords - PTMi

Phosphoprotein

Proteomic databases

PaxDbiQ9HWR3
PRIDEiQ9HWR3

Interactioni

Binary interactionsi

WithEntry#Exp.IntActNotes
itself4EBI-15729881,EBI-15729881

GO - Molecular functioni

  • identical protein binding Source: IntAct

Protein-protein interaction databases

DIPiDIP-46175N
STRINGi208964.PA4117

Structurei

Secondary structure

1728
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details
Feature keyPosition(s)DescriptionActionsGraphical viewLength
Turni9 – 11Combined sources3
Helixi12 – 14Combined sources3
Beta strandi21 – 23Combined sources3
Beta strandi27 – 32Combined sources6
Beta strandi36 – 42Combined sources7
Helixi45 – 49Combined sources5
Helixi61 – 76Combined sources16
Beta strandi85 – 88Combined sources4
Beta strandi90 – 93Combined sources4
Beta strandi95 – 102Combined sources8
Beta strandi105 – 112Combined sources8
Helixi121 – 136Combined sources16
Helixi140 – 155Combined sources16
Beta strandi158 – 165Combined sources8
Turni167 – 169Combined sources3
Beta strandi171 – 178Combined sources8
Helixi192 – 194Combined sources3
Helixi197 – 205Combined sources9
Beta strandi207 – 212Combined sources6
Beta strandi219 – 225Combined sources7
Turni227 – 229Combined sources3
Beta strandi230 – 232Combined sources3
Helixi235 – 237Combined sources3
Beta strandi239 – 241Combined sources3
Helixi245 – 254Combined sources10
Beta strandi258 – 265Combined sources8
Beta strandi267 – 280Combined sources14
Helixi286 – 332Combined sources47
Helixi335 – 340Combined sources6
Turni342 – 344Combined sources3
Helixi346 – 349Combined sources4
Beta strandi353 – 359Combined sources7
Beta strandi362 – 368Combined sources7
Helixi371 – 382Combined sources12
Beta strandi388 – 393Combined sources6
Beta strandi410 – 417Combined sources8
Turni418 – 421Combined sources4
Beta strandi422 – 428Combined sources7
Beta strandi434 – 440Combined sources7
Helixi452 – 454Combined sources3
Helixi456 – 467Combined sources12
Helixi476 – 493Combined sources18

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
3C2WX-ray2.90A/B/C/D/E/F/G/H1-497[»]
3G6OX-ray2.85A/B1-497[»]
3IBRX-ray2.97A/B1-497[»]
3NHQX-ray2.55A/B/C/D/E/F/G/H1-497[»]
3NOPX-ray2.80C1-497[»]
3NOTX-ray2.70C1-497[»]
3NOUX-ray3.00C1-497[»]
ProteinModelPortaliQ9HWR3
SMRiQ9HWR3
ModBaseiSearch...
MobiDBiSearch...

Miscellaneous databases

EvolutionaryTraceiQ9HWR3

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini139 – 303GAFAdd BLAST165
Domaini510 – 721Histidine kinasePROSITE-ProRule annotationAdd BLAST212

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Regioni17 – 495Chromophore binding domainAdd BLAST479

Sequence similaritiesi

In the N-terminal section; belongs to the phytochrome family.Curated

Phylogenomic databases

eggNOGiENOG4105BZU Bacteria
ENOG410XNMH LUCA
HOGENOMiHOG000030537
InParanoidiQ9HWR3
OMAiYMRNIGM
PhylomeDBiQ9HWR3

Family and domain databases

CDDicd00075 HATPase_c, 1 hit
cd00082 HisKA, 1 hit
Gene3Di3.30.450.40, 4 hits
3.30.565.10, 1 hit
InterProiView protein in InterPro
IPR003018 GAF
IPR029016 GAF-like_dom_sf
IPR003594 HATPase_C
IPR036890 HATPase_C_sf
IPR005467 His_kinase_dom
IPR003661 HisK_dim/P
IPR036097 HisK_dim/P_sf
IPR035965 PAS-like_dom_sf
IPR013654 PAS_2
IPR016132 Phyto_chromo_attachment
IPR001294 Phytochrome
IPR013515 Phytochrome_cen-reg
PfamiView protein in Pfam
PF01590 GAF, 1 hit
PF02518 HATPase_c, 1 hit
PF00512 HisKA, 1 hit
PF08446 PAS_2, 1 hit
PF00360 PHY, 1 hit
PRINTSiPR01033 PHYTOCHROME
SMARTiView protein in SMART
SM00065 GAF, 1 hit
SM00387 HATPase_c, 1 hit
SM00388 HisKA, 1 hit
SUPFAMiSSF47384 SSF47384, 1 hit
SSF55785 SSF55785, 1 hit
SSF55874 SSF55874, 1 hit
PROSITEiView protein in PROSITE
PS50109 HIS_KIN, 1 hit
PS50046 PHYTOCHROME_2, 1 hit

Sequencei

Sequence statusi: Complete.

Q9HWR3-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MTSITPVTLA NCEDEPIHVP GAIQPHGALV TLRADGMVLA ASENIQALLG
60 70 80 90 100
FVASPGSYLT QEQVGPEVLR MLEEGLTGNG PWSNSVETRI GEHLFDVIGH
110 120 130 140 150
SYKEVFYLEF EIRTADTLSI TSFTLNAQRI IAQVQLHNDT ASLLSNVTDE
160 170 180 190 200
LRRMTGYDRV MAYRFRHDDS GEVVAESRRE DLESYLGQRY PASDIPAQAR
210 220 230 240 250
RLYIQNPIRL IADVAYTPMR VFPALNPETN ESFDLSYSVL RSVSPIHCEY
260 270 280 290 300
LTNMGVRASM SISIVVGGKL WGLFSCHHMS PKLIPYPVRM SFQIFSQVCS
310 320 330 340 350
AIVERLEQGR IAELLRVSTE RRLALARRAR DADDLFGALA HPDDGIAALI
360 370 380 390 400
PCDGALVMLG GRTLSIRGDF ERQAGNVLQR LQRDPERDIY HTDNWPQPSE
410 420 430 440 450
DSPDGGDCCG VLAIRFHRQE SGWIFWFRHE EVHRIRWGGK PEKLLTIGPS
460 470 480 490 500
GPRLTPRGSF EAWEEVVRGH STPWSETDLA IAEKLRLDLM ELCLNHAAEV
510 520 530 540 550
DRMRQRLIAV LGHDLRNPLQ SISMAAALLS SSDTRTTELR QHISASSSRM
560 570 580 590 600
ERLVSQILDM SRLQSGIGLT VNPVDTDVSQ LVRQIVCETD VAYPGLVIEI
610 620 630 640 650
AIDPQVRAVV DPDRYAQVAA NLLSNARHHG LPGRPVLVTL TRQGDEVCLS
660 670 680 690 700
VLNETSGLSE AQLANLFEPF KRESADNQRN RNGLGIGLYI SQAIAQAHQG
710 720
RIDVDCRDDV ITFCLRLPVR QAETGSSS
Length:728
Mass (Da):80,931
Last modified:January 11, 2001 - v1
Checksum:iEEE9259392E5C4B0
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AE004091 Genomic DNA Translation: AAG07504.1
PIRiB83131
RefSeqiNP_252806.1, NC_002516.2
WP_003101278.1, NC_002516.2

Genome annotation databases

EnsemblBacteriaiAAG07504; AAG07504; PA4117
GeneIDi880365
KEGGipae:PA4117
PATRICifig|208964.12.peg.4314

Similar proteinsi

Entry informationi

Entry nameiBPHY_PSEAE
AccessioniPrimary (citable) accession number: Q9HWR3
Entry historyiIntegrated into UniProtKB/Swiss-Prot: January 11, 2001
Last sequence update: January 11, 2001
Last modified: May 23, 2018
This is version 132 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

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