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Protein

Bacteriophytochrome

Gene

bphP

Organism
Pseudomonas aeruginosa (strain ATCC 15692 / DSM 22644 / CIP 104116 / JCM 14847 / LMG 12228 / 1C / PRS 101 / PAO1)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at protein leveli

Functioni

Photoreceptor which exists in two forms that are reversibly interconvertible by light: the R form that absorbs maximally in the red region of the spectrum and the FR form that absorbs maximally in the far-red region.By similarity

Catalytic activityi

ATP + protein L-histidine = ADP + protein N-phospho-L-histidine.

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Binding sitei12Tetrapyrrole chromophore (covalent; via 1 link)By similarity1

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Kinase, Photoreceptor protein, Receptor, Transferase

Keywords - Biological processi

Sensory transduction

Keywords - Ligandi

ATP-binding, Chromophore, Nucleotide-binding

Enzyme and pathway databases

BRENDAi2.7.13.3. 5087.

Names & Taxonomyi

Protein namesi
Recommended name:
Bacteriophytochrome (EC:2.7.13.3)
Alternative name(s):
Phytochrome-like protein
Gene namesi
Name:bphP
Ordered Locus Names:PA4117
OrganismiPseudomonas aeruginosa (strain ATCC 15692 / DSM 22644 / CIP 104116 / JCM 14847 / LMG 12228 / 1C / PRS 101 / PAO1)
Taxonomic identifieri208964 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaPseudomonadalesPseudomonadaceaePseudomonas
Proteomesi
  • UP000002438 Componenti: Chromosome

Organism-specific databases

PseudoCAPiPA4117.

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001720001 – 728BacteriophytochromeAdd BLAST728

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei513Phosphohistidine; by autocatalysisPROSITE-ProRule annotation1

Post-translational modificationi

Contains one covalently linked tetrapyrrole chromophore.By similarity

Keywords - PTMi

Phosphoprotein

Proteomic databases

PaxDbiQ9HWR3.

Interactioni

Protein-protein interaction databases

DIPiDIP-46175N.
STRINGi208964.PA4117.

Structurei

Secondary structure

1728
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details
Feature keyPosition(s)DescriptionActionsGraphical viewLength
Turni9 – 11Combined sources3
Helixi12 – 14Combined sources3
Beta strandi21 – 23Combined sources3
Beta strandi27 – 32Combined sources6
Beta strandi36 – 42Combined sources7
Helixi45 – 49Combined sources5
Helixi61 – 76Combined sources16
Beta strandi85 – 88Combined sources4
Beta strandi90 – 93Combined sources4
Beta strandi95 – 102Combined sources8
Beta strandi105 – 112Combined sources8
Helixi121 – 136Combined sources16
Helixi140 – 155Combined sources16
Beta strandi158 – 165Combined sources8
Turni167 – 169Combined sources3
Beta strandi171 – 178Combined sources8
Helixi192 – 194Combined sources3
Helixi197 – 205Combined sources9
Beta strandi207 – 212Combined sources6
Beta strandi219 – 225Combined sources7
Turni227 – 229Combined sources3
Beta strandi230 – 232Combined sources3
Helixi235 – 237Combined sources3
Beta strandi239 – 241Combined sources3
Helixi245 – 254Combined sources10
Beta strandi258 – 265Combined sources8
Beta strandi267 – 280Combined sources14
Helixi286 – 332Combined sources47
Helixi335 – 340Combined sources6
Turni342 – 344Combined sources3
Helixi346 – 349Combined sources4
Beta strandi353 – 359Combined sources7
Beta strandi362 – 368Combined sources7
Helixi371 – 382Combined sources12
Beta strandi388 – 393Combined sources6
Beta strandi410 – 417Combined sources8
Turni418 – 421Combined sources4
Beta strandi422 – 428Combined sources7
Beta strandi434 – 440Combined sources7
Helixi452 – 454Combined sources3
Helixi456 – 467Combined sources12
Helixi476 – 493Combined sources18

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
3C2WX-ray2.90A/B/C/D/E/F/G/H1-497[»]
3G6OX-ray2.85A/B1-497[»]
3IBRX-ray2.97A/B1-497[»]
3NHQX-ray2.55A/B/C/D/E/F/G/H1-497[»]
3NOPX-ray2.80C1-497[»]
3NOTX-ray2.70C1-497[»]
3NOUX-ray3.00C1-497[»]
ProteinModelPortaliQ9HWR3.
SMRiQ9HWR3.
ModBaseiSearch...
MobiDBiSearch...

Miscellaneous databases

EvolutionaryTraceiQ9HWR3.

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini139 – 303GAFAdd BLAST165
Domaini510 – 721Histidine kinasePROSITE-ProRule annotationAdd BLAST212

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Regioni17 – 495Chromophore binding domainAdd BLAST479

Sequence similaritiesi

In the N-terminal section; belongs to the phytochrome family.Curated
Contains 1 GAF domain.Curated
Contains 1 histidine kinase domain.PROSITE-ProRule annotation

Phylogenomic databases

eggNOGiENOG4105BZU. Bacteria.
ENOG410XNMH. LUCA.
HOGENOMiHOG000030537.
InParanoidiQ9HWR3.
OMAiANCADEP.
PhylomeDBiQ9HWR3.

Family and domain databases

Gene3Di1.10.287.130. 1 hit.
3.30.450.40. 1 hit.
3.30.565.10. 1 hit.
InterProiIPR003018. GAF.
IPR029016. GAF_dom-like.
IPR003594. HATPase_C.
IPR005467. His_kinase_dom.
IPR003661. HisK_dim/P.
IPR000014. PAS.
IPR013654. PAS_2.
IPR016132. Phyto_chromo_attachment.
IPR001294. Phytochrome.
IPR013515. Phytochrome_cen-reg.
[Graphical view]
PfamiPF01590. GAF. 1 hit.
PF02518. HATPase_c. 1 hit.
PF00512. HisKA. 1 hit.
PF08446. PAS_2. 1 hit.
PF00360. PHY. 1 hit.
[Graphical view]
PRINTSiPR01033. PHYTOCHROME.
SMARTiSM00065. GAF. 1 hit.
SM00387. HATPase_c. 1 hit.
SM00388. HisKA. 1 hit.
[Graphical view]
SUPFAMiSSF47384. SSF47384. 1 hit.
SSF55781. SSF55781. 2 hits.
SSF55785. SSF55785. 1 hit.
SSF55874. SSF55874. 1 hit.
PROSITEiPS50109. HIS_KIN. 1 hit.
PS50046. PHYTOCHROME_2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q9HWR3-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MTSITPVTLA NCEDEPIHVP GAIQPHGALV TLRADGMVLA ASENIQALLG
60 70 80 90 100
FVASPGSYLT QEQVGPEVLR MLEEGLTGNG PWSNSVETRI GEHLFDVIGH
110 120 130 140 150
SYKEVFYLEF EIRTADTLSI TSFTLNAQRI IAQVQLHNDT ASLLSNVTDE
160 170 180 190 200
LRRMTGYDRV MAYRFRHDDS GEVVAESRRE DLESYLGQRY PASDIPAQAR
210 220 230 240 250
RLYIQNPIRL IADVAYTPMR VFPALNPETN ESFDLSYSVL RSVSPIHCEY
260 270 280 290 300
LTNMGVRASM SISIVVGGKL WGLFSCHHMS PKLIPYPVRM SFQIFSQVCS
310 320 330 340 350
AIVERLEQGR IAELLRVSTE RRLALARRAR DADDLFGALA HPDDGIAALI
360 370 380 390 400
PCDGALVMLG GRTLSIRGDF ERQAGNVLQR LQRDPERDIY HTDNWPQPSE
410 420 430 440 450
DSPDGGDCCG VLAIRFHRQE SGWIFWFRHE EVHRIRWGGK PEKLLTIGPS
460 470 480 490 500
GPRLTPRGSF EAWEEVVRGH STPWSETDLA IAEKLRLDLM ELCLNHAAEV
510 520 530 540 550
DRMRQRLIAV LGHDLRNPLQ SISMAAALLS SSDTRTTELR QHISASSSRM
560 570 580 590 600
ERLVSQILDM SRLQSGIGLT VNPVDTDVSQ LVRQIVCETD VAYPGLVIEI
610 620 630 640 650
AIDPQVRAVV DPDRYAQVAA NLLSNARHHG LPGRPVLVTL TRQGDEVCLS
660 670 680 690 700
VLNETSGLSE AQLANLFEPF KRESADNQRN RNGLGIGLYI SQAIAQAHQG
710 720
RIDVDCRDDV ITFCLRLPVR QAETGSSS
Length:728
Mass (Da):80,931
Last modified:January 11, 2001 - v1
Checksum:iEEE9259392E5C4B0
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AE004091 Genomic DNA. Translation: AAG07504.1.
PIRiB83131.
RefSeqiNP_252806.1. NC_002516.2.
WP_003101278.1. NZ_ASJY01000659.1.

Genome annotation databases

EnsemblBacteriaiAAG07504; AAG07504; PA4117.
GeneIDi880365.
KEGGipae:PA4117.
PATRICi19842916. VBIPseAer58763_4314.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AE004091 Genomic DNA. Translation: AAG07504.1.
PIRiB83131.
RefSeqiNP_252806.1. NC_002516.2.
WP_003101278.1. NZ_ASJY01000659.1.

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
3C2WX-ray2.90A/B/C/D/E/F/G/H1-497[»]
3G6OX-ray2.85A/B1-497[»]
3IBRX-ray2.97A/B1-497[»]
3NHQX-ray2.55A/B/C/D/E/F/G/H1-497[»]
3NOPX-ray2.80C1-497[»]
3NOTX-ray2.70C1-497[»]
3NOUX-ray3.00C1-497[»]
ProteinModelPortaliQ9HWR3.
SMRiQ9HWR3.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

DIPiDIP-46175N.
STRINGi208964.PA4117.

Proteomic databases

PaxDbiQ9HWR3.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaiAAG07504; AAG07504; PA4117.
GeneIDi880365.
KEGGipae:PA4117.
PATRICi19842916. VBIPseAer58763_4314.

Organism-specific databases

PseudoCAPiPA4117.

Phylogenomic databases

eggNOGiENOG4105BZU. Bacteria.
ENOG410XNMH. LUCA.
HOGENOMiHOG000030537.
InParanoidiQ9HWR3.
OMAiANCADEP.
PhylomeDBiQ9HWR3.

Enzyme and pathway databases

BRENDAi2.7.13.3. 5087.

Miscellaneous databases

EvolutionaryTraceiQ9HWR3.

Family and domain databases

Gene3Di1.10.287.130. 1 hit.
3.30.450.40. 1 hit.
3.30.565.10. 1 hit.
InterProiIPR003018. GAF.
IPR029016. GAF_dom-like.
IPR003594. HATPase_C.
IPR005467. His_kinase_dom.
IPR003661. HisK_dim/P.
IPR000014. PAS.
IPR013654. PAS_2.
IPR016132. Phyto_chromo_attachment.
IPR001294. Phytochrome.
IPR013515. Phytochrome_cen-reg.
[Graphical view]
PfamiPF01590. GAF. 1 hit.
PF02518. HATPase_c. 1 hit.
PF00512. HisKA. 1 hit.
PF08446. PAS_2. 1 hit.
PF00360. PHY. 1 hit.
[Graphical view]
PRINTSiPR01033. PHYTOCHROME.
SMARTiSM00065. GAF. 1 hit.
SM00387. HATPase_c. 1 hit.
SM00388. HisKA. 1 hit.
[Graphical view]
SUPFAMiSSF47384. SSF47384. 1 hit.
SSF55781. SSF55781. 2 hits.
SSF55785. SSF55785. 1 hit.
SSF55874. SSF55874. 1 hit.
PROSITEiPS50109. HIS_KIN. 1 hit.
PS50046. PHYTOCHROME_2. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiBPHY_PSEAE
AccessioniPrimary (citable) accession number: Q9HWR3
Entry historyi
Integrated into UniProtKB/Swiss-Prot: January 11, 2001
Last sequence update: January 11, 2001
Last modified: November 2, 2016
This is version 123 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.