Flavin-containing monooxygenase - Pseudomonas aeruginosa (strain ATCC 15692 / PAO1 / 1C / PRS 101 / LMG 12228)

Preferred order of sections

Names and origin

Protein names

Submitted name:
Flavin-containing monooxygenase EMBL AAG07605.1

Gene names

Name:	phzS EMBL AAG07605.1
Ordered Locus Names:	PA4217

Organism

Pseudomonas aeruginosa (strain ATCC 15692 / PAO1 / 1C / PRS 101 / LMG 12228)

Taxonomic identifier

208964 [NCBI]

Taxonomic lineage

Bacteria › Proteobacteria › Gammaproteobacteria › Pseudomonadales › Pseudomonadaceae › Pseudomonas

Protein attributes

Sequence length	402 AA.
Sequence status	Complete.
Protein existence	Evidence at protein level

Ontologies

Keywords
Ligand	FAD PDB 2RGJ PDB 3C96 Flavoprotein PDB 2RGJ PDB 3C96 Nucleotide-binding PDB 2RGJ PDB 3C96
Molecular function	Monooxygenase EMBL AAG07605.1 Oxidoreductase
Technical term	3D-structure PDB 2RGJ PDB 3C96 Complete proteome Reference proteome
Gene Ontology (GO)
Molecular function	monooxygenase activity Inferred from electronic annotation. Source: UniProtKB-KW nucleotide binding Inferred from electronic annotation. Source: UniProtKB-KW
Complete GO annotation...

Sequence annotation (Features)

Feature key

Position(s)

Length

Description

Graphical view

Feature identifier

Regions

Nucleotide binding

14 – 15

2

FAD PDB 2RGJ PDB 3C96

Nucleotide binding

35 – 36

2

FAD PDB 2RGJ PDB 3C96

Nucleotide binding

43 – 45

3

FAD PDB 2RGJ PDB 3C96

Sites

Binding site

106

1

FAD PDB 2RGJ PDB 3C96

Binding site

132

1

FAD; via amide nitrogen and carbonyl oxygen PDB 2RGJ PDB 3C96

Binding site

191

1

FAD PDB 2RGJ PDB 3C96

Binding site

253

1

FAD PDB 2RGJ PDB 3C96

Binding site

310

1

FAD PDB 2RGJ PDB 3C96

Binding site

323

1

FAD; via amide nitrogen PDB 2RGJ

Sequences

Sequence

Length

Mass (Da)

Tools

Q9HWG9 [UniParc].

Last modified March 1, 2001. Version 1.
Checksum: F2BB36662ABAC790
Show »

FASTA

402

43,645

        10         20         30         40         50         60 
MSEPIDILIA GAGIGGLSCA LALHQAGIGK VTLLESSSEI RPLGVGINIQ PAAVEALAEL 

        70         80         90        100        110        120 
GLGPALAATA IPTHELRYID QSGATVWSEP RGVEAGNAYP QYSIHRGELQ MILLAAVRER 

       130        140        150        160        170        180 
LGQQAVRTGL GVERIEERDG RVLIGARDGH GKPQALGADV LVGADGIHSA VRAHLHPDQR 

       190        200        210        220        230        240 
PLSHGGITMW RGVTEFDRFL DGKTMIVAND EHWSRLVAYP ISARHAAEGK SLVNWVCMVP 

       250        260        270        280        290        300 
SAAVGQLDNE ADWNRDGRLE DVLPFFADWD LGWFDIRDLL TRNQLILQYP MVDRDPLPHW 

       310        320        330        340        350        360 
GRGRITLLGD AAHLMYPMGA NGASQAILDG IELAAALARN ADVAAALREY EEARRPTANK 

       370        380        390        400 
IILANREREK EEWAAASRPK TEKSAALEAI TGSYRNQVER PR

« Hide

References

	« Hide 'large scale' referencesShow 'large scale' references »
[1]	"Complete genome sequence of Pseudomonas aeruginosa PAO1, an opportunistic pathogen." Stover C.K., Pham X.Q., Erwin A.L., Mizoguchi S.D., Warrener P., Hickey M.J., Brinkman F.S., Hufnagle W.O., Kowalik D.J., Lagrou M., Garber R.L., Goltry L., Tolentino E., Westbrock-Wadman S., Yuan Y., Brody L.L., Coulter S.N., Folger K.R. Olson M.V. Nature 406:959-964(2000) [PubMed: 10984043] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: ATCC 15692 / PAO1 / 1C / PRS 101 / LMG 12228.
[2]	"Crystal structure of the flavin-containing monooxygenase phzS from Pseudomonas aeruginosa." Vorobiev S.M., Chen Y., Seetharaman J., Wang D., Mao L., Xiao R., Acton T.B., Montelione G.T., Tong L., Hunt J.F. Submitted (FEB-2008) to the PDB data bank Cited for: X-RAY CRYSTALLOGRAPHY (1.90 ANGSTROMS) IN COMPLEX WITH FAD.
[3]	"Crystal structure of the pyocyanin biosynthetic protein PhzS." Greenhagen B.T., Shi K., Robinson H., Gamage S., Bera A.K., Ladner J.E., Parsons J.F. Biochemistry 47:5281-5289(2008) [PubMed: 18416536] [Abstract] Cited for: X-RAY CRYSTALLOGRAPHY (2.40 ANGSTROMS) IN COMPLEX WITH FAD.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ

AE004091 Genomic DNA. Translation: AAG07605.1.

PIR

E83119.

RefSeq

NP_252907.1. NC_002516.2.

3D structure databases

PDBe
RCSB PDB
PDBj

Entry	Method	Resolution (Å)	Chain	Positions	PDBsum
2RGJ	X-ray	2.40	A	1-402	[»]
3C96	X-ray	1.90	A	1-402	[»]

ProteinModelPortal

Q9HWG9.

SMR

Q9HWG9. Positions 4-379.

ModBase

Search...

Protocols and materials databases

StructuralBiologyKnowledgebase

Search...

Genome annotation databases

GeneID

881836.

GenomeReviews

Gene locus PA4217 in contig AE004091_GR.

KEGG

pae:PA4217.

NMPDR

fig|208964.1.peg.4217.

PATRIC

19843124. VBIPseAer58763_4418.

Organism-specific databases

PseudoCAP

PA4217.

Phylogenomic databases

HOGENOM

HBG294561.

OMA

YWSSGRV.

ProtClustDB

PRK07538.

Enzyme and pathway databases

BioCyc

PAER208964:PA4217-MONOMER.

Family and domain databases

InterPro

IPR002938. mOase_FAD-bd.
IPR003042. Rng_hydrolase-like.
[Graphical view]

Pfam

PF01494. FAD_binding_3. 2 hits.
[Graphical view]

PRINTS

PR00420. RNGMNOXGNASE.

ProtoNet

Search...

Entry information

Entry name

Q9HWG9_PSEAE

Accession

Primary (citable) accession number: Q9HWG9

Entry history

Integrated into UniProtKB/TrEMBL:	March 1, 2001
Last sequence update:	March 1, 2001
Last modified:	December 14, 2011
This is version 59 of the entry and version 1 of the sequence. [Complete history]

Entry status

Unreviewed (UniProtKB/TrEMBL)