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Q9HWF9

- BFR_PSEAE

UniProt

Q9HWF9 - BFR_PSEAE

Protein

Bacterioferritin

Gene

bfr

Organism
Pseudomonas aeruginosa (strain ATCC 15692 / PAO1 / 1C / PRS 101 / LMG 12228)
Status
Reviewed - Annotation score: 3 out of 5- Experimental evidence at protein leveli
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    • History
      Entry version 85 (01 Oct 2014)
      Sequence version 1 (01 Mar 2001)
      Previous versions | rss
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    Functioni

    Iron-storage protein, whose ferroxidase center binds Fe2+ ions, oxidizes them by dioxygen to Fe3+, and participates in the subsequent Fe3+ oxide mineral core formation within the central cavity of the protein complex.By similarity

    Catalytic activityi

    4 Fe2+ + 4 H+ + O2 = 4 Fe3+ + 2 H2O.

    Cofactori

    Binds 1 heme B (iron-protoporphyrin IX) group per dimer.Curated
    Binds 2 iron ions per subunit. The catalytic dinuclear iron-binding site within each subunit is known as the ferroxidase center By similarity.By similarity

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Metal bindingi18 – 181Iron 1PROSITE-ProRule annotation
    Metal bindingi48 – 481Iron (heme axial ligand); shared with dimeric partnerPROSITE-ProRule annotation
    Metal bindingi51 – 511Iron 1PROSITE-ProRule annotation
    Metal bindingi51 – 511Iron 2PROSITE-ProRule annotation
    Metal bindingi54 – 541Iron 1PROSITE-ProRule annotation
    Metal bindingi93 – 931Iron 2PROSITE-ProRule annotation
    Metal bindingi127 – 1271Iron 1PROSITE-ProRule annotation
    Metal bindingi127 – 1271Iron 2PROSITE-ProRule annotation
    Metal bindingi130 – 1301Iron 2PROSITE-ProRule annotation

    GO - Molecular functioni

    1. ferric iron binding Source: InterPro
    2. ferroxidase activity Source: UniProtKB-EC

    GO - Biological processi

    1. intracellular sequestering of iron ion Source: PseudoCAP
    2. iron ion transport Source: PseudoCAP

    Keywords - Molecular functioni

    Oxidoreductase

    Keywords - Biological processi

    Iron storage

    Keywords - Ligandi

    Heme, Iron, Metal-binding

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Bacterioferritin (EC:1.16.3.1)
    Short name:
    BFR
    Gene namesi
    Name:bfr
    Synonyms:bfrA
    Ordered Locus Names:PA4235
    OrganismiPseudomonas aeruginosa (strain ATCC 15692 / PAO1 / 1C / PRS 101 / LMG 12228)
    Taxonomic identifieri208964 [NCBI]
    Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaPseudomonadalesPseudomonadaceaePseudomonas
    ProteomesiUP000002438: Chromosome

    Organism-specific databases

    PseudoCAPiPA4235.

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 154154BacterioferritinPRO_0000287751Add
    BLAST

    Interactioni

    Subunit structurei

    Homooligomer of 24 subunits, arranged as 12 dimers, that are packed together to form an approximately spherical molecule with a central cavity, in which large amounts of iron can be deposited.By similarity

    Protein-protein interaction databases

    STRINGi208964.PA4235.

    Structurei

    Secondary structure

    1
    154
    Legend: HelixTurnBeta strand
    Show more details
    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Helixi5 – 3430
    Helixi38 – 6427
    Helixi82 – 10928
    Helixi113 – 12816
    Helixi130 – 14415
    Helixi146 – 1527

    3D structure databases

    Select the link destinations:
    PDBe
    RCSB PDB
    PDBj
    Links Updated
    EntryMethodResolution (Å)ChainPositionsPDBsum
    3R2HX-ray1.70A1-154[»]
    3R2KX-ray1.55A1-154[»]
    3R2LX-ray1.85A1-154[»]
    3R2MX-ray1.80A1-154[»]
    3R2OX-ray1.95A1-154[»]
    3R2RX-ray1.65A1-154[»]
    3R2SX-ray2.10A1-154[»]
    ProteinModelPortaliQ9HWF9.
    SMRiQ9HWF9. Positions 1-154.
    ModBaseiSearch...
    MobiDBiSearch...

    Miscellaneous databases

    EvolutionaryTraceiQ9HWF9.

    Family & Domainsi

    Domains and Repeats

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Domaini1 – 145145Ferritin-like diironPROSITE-ProRule annotationAdd
    BLAST

    Sequence similaritiesi

    Belongs to the bacterioferritin family.Curated
    Contains 1 ferritin-like diiron domain.PROSITE-ProRule annotation

    Phylogenomic databases

    eggNOGiCOG2193.
    HOGENOMiHOG000262383.
    KOiK03594.
    OMAiYESREIL.
    OrthoDBiEOG6WDSKP.
    PhylomeDBiQ9HWF9.

    Family and domain databases

    Gene3Di1.20.1260.10. 1 hit.
    InterProiIPR002024. Bacterioferritin.
    IPR009040. Ferritin-like_diiron.
    IPR009078. Ferritin-like_SF.
    IPR012347. Ferritin-rel.
    IPR008331. Ferritin_DPS_dom.
    [Graphical view]
    PfamiPF00210. Ferritin. 1 hit.
    [Graphical view]
    PIRSFiPIRSF002560. Bacterioferritin. 1 hit.
    PRINTSiPR00601. BACFERRITIN.
    SUPFAMiSSF47240. SSF47240. 1 hit.
    TIGRFAMsiTIGR00754. bfr. 1 hit.
    PROSITEiPS00549. BACTERIOFERRITIN. 1 hit.
    PS50905. FERRITIN_LIKE. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Q9HWF9-1 [UniParc]FASTAAdd to Basket

    « Hide

    MQGHPEVIDY LNTLLTGELA ARDQYFIHSR MYEDWGFSKL YERLNHEMEE    50
    ETQHADALLR RILLLEGTPR MRPDDIHPGT TVPEMLEADL KLERHVRAAL 100
    AKGIALCEQH KDFVSRDILK AQLADTEEDH AYWLEQQLGL IARMGLENYL 150
    QSQI 154
    Length:154
    Mass (Da):17,940
    Last modified:March 1, 2001 - v1
    Checksum:iDFD36D0DB9518343
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AE004091 Genomic DNA. Translation: AAG07623.1.
    PIRiA83113.
    RefSeqiNP_252925.1. NC_002516.2.

    Genome annotation databases

    EnsemblBacteriaiAAG07623; AAG07623; PA4235.
    GeneIDi881830.
    KEGGipae:PA4235.
    PATRICi19843161. VBIPseAer58763_4436.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AE004091 Genomic DNA. Translation: AAG07623.1 .
    PIRi A83113.
    RefSeqi NP_252925.1. NC_002516.2.

    3D structure databases

    Select the link destinations:
    PDBe
    RCSB PDB
    PDBj
    Links Updated
    Entry Method Resolution (Å) Chain Positions PDBsum
    3R2H X-ray 1.70 A 1-154 [» ]
    3R2K X-ray 1.55 A 1-154 [» ]
    3R2L X-ray 1.85 A 1-154 [» ]
    3R2M X-ray 1.80 A 1-154 [» ]
    3R2O X-ray 1.95 A 1-154 [» ]
    3R2R X-ray 1.65 A 1-154 [» ]
    3R2S X-ray 2.10 A 1-154 [» ]
    ProteinModelPortali Q9HWF9.
    SMRi Q9HWF9. Positions 1-154.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 208964.PA4235.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    EnsemblBacteriai AAG07623 ; AAG07623 ; PA4235 .
    GeneIDi 881830.
    KEGGi pae:PA4235.
    PATRICi 19843161. VBIPseAer58763_4436.

    Organism-specific databases

    PseudoCAPi PA4235.

    Phylogenomic databases

    eggNOGi COG2193.
    HOGENOMi HOG000262383.
    KOi K03594.
    OMAi YESREIL.
    OrthoDBi EOG6WDSKP.
    PhylomeDBi Q9HWF9.

    Miscellaneous databases

    EvolutionaryTracei Q9HWF9.

    Family and domain databases

    Gene3Di 1.20.1260.10. 1 hit.
    InterProi IPR002024. Bacterioferritin.
    IPR009040. Ferritin-like_diiron.
    IPR009078. Ferritin-like_SF.
    IPR012347. Ferritin-rel.
    IPR008331. Ferritin_DPS_dom.
    [Graphical view ]
    Pfami PF00210. Ferritin. 1 hit.
    [Graphical view ]
    PIRSFi PIRSF002560. Bacterioferritin. 1 hit.
    PRINTSi PR00601. BACFERRITIN.
    SUPFAMi SSF47240. SSF47240. 1 hit.
    TIGRFAMsi TIGR00754. bfr. 1 hit.
    PROSITEi PS00549. BACTERIOFERRITIN. 1 hit.
    PS50905. FERRITIN_LIKE. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: ATCC 15692 / PAO1 / 1C / PRS 101 / LMG 12228.

    Entry informationi

    Entry nameiBFR_PSEAE
    AccessioniPrimary (citable) accession number: Q9HWF9
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: May 15, 2007
    Last sequence update: March 1, 2001
    Last modified: October 1, 2014
    This is version 85 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programProkaryotic Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    3D-structure, Complete proteome, Reference proteome

    Documents

    1. PDB cross-references
      Index of Protein Data Bank (PDB) cross-references
    2. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3