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Q9HWF9

- BFR_PSEAE

UniProt

Q9HWF9 - BFR_PSEAE

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Protein
Bacterioferritin
Gene
bfr, bfrA, PA4235
Organism
Pseudomonas aeruginosa (strain ATCC 15692 / PAO1 / 1C / PRS 101 / LMG 12228)
Status
Reviewed - Annotation score: 3 out of 5 - Experimental evidence at protein leveli

Functioni

Iron-storage protein, whose ferroxidase center binds Fe2+ ions, oxidizes them by dioxygen to Fe3+, and participates in the subsequent Fe3+ oxide mineral core formation within the central cavity of the protein complex By similarity.

Catalytic activityi

4 Fe2+ + 4 H+ + O2 = 4 Fe3+ + 2 H2O.

Cofactori

Binds 1 heme B (iron-protoporphyrin IX) group per dimer Reviewed prediction.
Binds 2 iron ions per subunit. The catalytic dinuclear iron-binding site within each subunit is known as the ferroxidase center By similarity.

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Metal bindingi18 – 181Iron 1 By similarity
Metal bindingi48 – 481Iron (heme axial ligand); shared with dimeric partner Reviewed prediction
Metal bindingi51 – 511Iron 1 By similarity
Metal bindingi51 – 511Iron 2 By similarity
Metal bindingi54 – 541Iron 1 By similarity
Metal bindingi93 – 931Iron 2 By similarity
Metal bindingi127 – 1271Iron 1 By similarity
Metal bindingi127 – 1271Iron 2 By similarity
Metal bindingi130 – 1301Iron 2 By similarity

GO - Molecular functioni

  1. ferric iron binding Source: InterPro
  2. ferroxidase activity Source: UniProtKB-EC

GO - Biological processi

  1. intracellular sequestering of iron ion Source: PseudoCAP
  2. iron ion transport Source: PseudoCAP
Complete GO annotation...

Keywords - Molecular functioni

Oxidoreductase

Keywords - Biological processi

Iron storage

Keywords - Ligandi

Heme, Iron, Metal-binding

Names & Taxonomyi

Protein namesi
Recommended name:
Bacterioferritin (EC:1.16.3.1)
Short name:
BFR
Gene namesi
Name:bfr
Synonyms:bfrA
Ordered Locus Names:PA4235
OrganismiPseudomonas aeruginosa (strain ATCC 15692 / PAO1 / 1C / PRS 101 / LMG 12228)
Taxonomic identifieri208964 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaPseudomonadalesPseudomonadaceaePseudomonas
ProteomesiUP000002438: Chromosome

Organism-specific databases

PseudoCAPiPA4235.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 154154Bacterioferritin
PRO_0000287751Add
BLAST

Interactioni

Subunit structurei

Homooligomer of 24 subunits, arranged as 12 dimers, that are packed together to form an approximately spherical molecule with a central cavity, in which large amounts of iron can be deposited By similarity.

Protein-protein interaction databases

STRINGi208964.PA4235.

Structurei

Secondary structure

Legend: HelixTurnBeta strand
Show more details
Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Helixi5 – 3430
Helixi38 – 6427
Helixi82 – 10928
Helixi113 – 12816
Helixi130 – 14415
Helixi146 – 1527

3D structure databases

Select the link destinations:
PDBe
RCSB PDB
PDBj
Links Updated
EntryMethodResolution (Å)ChainPositionsPDBsum
3R2HX-ray1.70A1-154[»]
3R2KX-ray1.55A1-154[»]
3R2LX-ray1.85A1-154[»]
3R2MX-ray1.80A1-154[»]
3R2OX-ray1.95A1-154[»]
3R2RX-ray1.65A1-154[»]
3R2SX-ray2.10A1-154[»]
ProteinModelPortaliQ9HWF9.
SMRiQ9HWF9. Positions 1-154.

Miscellaneous databases

EvolutionaryTraceiQ9HWF9.

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini1 – 145145Ferritin-like diiron
Add
BLAST

Sequence similaritiesi

Belongs to the bacterioferritin family.

Phylogenomic databases

eggNOGiCOG2193.
HOGENOMiHOG000262383.
KOiK03594.
OMAiYESREIL.
OrthoDBiEOG6WDSKP.
PhylomeDBiQ9HWF9.

Family and domain databases

Gene3Di1.20.1260.10. 1 hit.
InterProiIPR002024. Bacterioferritin.
IPR009040. Ferritin-like_diiron.
IPR009078. Ferritin-like_SF.
IPR012347. Ferritin-rel.
IPR008331. Ferritin_DPS_dom.
[Graphical view]
PfamiPF00210. Ferritin. 1 hit.
[Graphical view]
PIRSFiPIRSF002560. Bacterioferritin. 1 hit.
PRINTSiPR00601. BACFERRITIN.
SUPFAMiSSF47240. SSF47240. 1 hit.
TIGRFAMsiTIGR00754. bfr. 1 hit.
PROSITEiPS00549. BACTERIOFERRITIN. 1 hit.
PS50905. FERRITIN_LIKE. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q9HWF9-1 [UniParc]FASTAAdd to Basket

« Hide

MQGHPEVIDY LNTLLTGELA ARDQYFIHSR MYEDWGFSKL YERLNHEMEE    50
ETQHADALLR RILLLEGTPR MRPDDIHPGT TVPEMLEADL KLERHVRAAL 100
AKGIALCEQH KDFVSRDILK AQLADTEEDH AYWLEQQLGL IARMGLENYL 150
QSQI 154
Length:154
Mass (Da):17,940
Last modified:March 1, 2001 - v1
Checksum:iDFD36D0DB9518343
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AE004091 Genomic DNA. Translation: AAG07623.1.
PIRiA83113.
RefSeqiNP_252925.1. NC_002516.2.

Genome annotation databases

EnsemblBacteriaiAAG07623; AAG07623; PA4235.
GeneIDi881830.
KEGGipae:PA4235.
PATRICi19843161. VBIPseAer58763_4436.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AE004091 Genomic DNA. Translation: AAG07623.1 .
PIRi A83113.
RefSeqi NP_252925.1. NC_002516.2.

3D structure databases

Select the link destinations:
PDBe
RCSB PDB
PDBj
Links Updated
Entry Method Resolution (Å) Chain Positions PDBsum
3R2H X-ray 1.70 A 1-154 [» ]
3R2K X-ray 1.55 A 1-154 [» ]
3R2L X-ray 1.85 A 1-154 [» ]
3R2M X-ray 1.80 A 1-154 [» ]
3R2O X-ray 1.95 A 1-154 [» ]
3R2R X-ray 1.65 A 1-154 [» ]
3R2S X-ray 2.10 A 1-154 [» ]
ProteinModelPortali Q9HWF9.
SMRi Q9HWF9. Positions 1-154.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 208964.PA4235.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai AAG07623 ; AAG07623 ; PA4235 .
GeneIDi 881830.
KEGGi pae:PA4235.
PATRICi 19843161. VBIPseAer58763_4436.

Organism-specific databases

PseudoCAPi PA4235.

Phylogenomic databases

eggNOGi COG2193.
HOGENOMi HOG000262383.
KOi K03594.
OMAi YESREIL.
OrthoDBi EOG6WDSKP.
PhylomeDBi Q9HWF9.

Miscellaneous databases

EvolutionaryTracei Q9HWF9.

Family and domain databases

Gene3Di 1.20.1260.10. 1 hit.
InterProi IPR002024. Bacterioferritin.
IPR009040. Ferritin-like_diiron.
IPR009078. Ferritin-like_SF.
IPR012347. Ferritin-rel.
IPR008331. Ferritin_DPS_dom.
[Graphical view ]
Pfami PF00210. Ferritin. 1 hit.
[Graphical view ]
PIRSFi PIRSF002560. Bacterioferritin. 1 hit.
PRINTSi PR00601. BACFERRITIN.
SUPFAMi SSF47240. SSF47240. 1 hit.
TIGRFAMsi TIGR00754. bfr. 1 hit.
PROSITEi PS00549. BACTERIOFERRITIN. 1 hit.
PS50905. FERRITIN_LIKE. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: ATCC 15692 / PAO1 / 1C / PRS 101 / LMG 12228.

Entry informationi

Entry nameiBFR_PSEAE
AccessioniPrimary (citable) accession number: Q9HWF9
Entry historyi
Integrated into UniProtKB/Swiss-Prot: May 15, 2007
Last sequence update: March 1, 2001
Last modified: July 9, 2014
This is version 84 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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