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Protein

30S ribosomal protein S12

Gene

rpsL

Organism
Pseudomonas aeruginosa (strain ATCC 15692 / DSM 22644 / CIP 104116 / JCM 14847 / LMG 12228 / 1C / PRS 101 / PAO1)
Status
Reviewed-Annotation score: Annotation score: 2 out of 5-Protein inferred from homologyi

Functioni

With S4 and S5 plays an important role in translational accuracy.UniRule annotation
Interacts with and stabilizes bases of the 16S rRNA that are involved in tRNA selection in the A site and with the mRNA backbone. Located at the interface of the 30S and 50S subunits, it traverses the body of the 30S subunit contacting proteins on the other side and probably holding the rRNA structure together. The combined cluster of proteins S8, S12 and S17 appears to hold together the shoulder and platform of the 30S subunit.UniRule annotation

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionRibonucleoprotein, Ribosomal protein, RNA-binding, rRNA-binding, tRNA-binding

Names & Taxonomyi

Protein namesi
Recommended name:
30S ribosomal protein S12UniRule annotation
Gene namesi
Name:rpsLUniRule annotation
Ordered Locus Names:PA4268
OrganismiPseudomonas aeruginosa (strain ATCC 15692 / DSM 22644 / CIP 104116 / JCM 14847 / LMG 12228 / 1C / PRS 101 / PAO1)
Taxonomic identifieri208964 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaPseudomonadalesPseudomonadaceaePseudomonas
Proteomesi
  • UP000002438 Componenti: Chromosome

Organism-specific databases

PseudoCAPiPA4268.

Subcellular locationi

GO - Cellular componenti

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001462901 – 12330S ribosomal protein S12Add BLAST123

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei893-methylthioaspartic acidBy similarity1

Keywords - PTMi

Methylation

Proteomic databases

PaxDbiQ9HWD0.

Interactioni

Subunit structurei

Part of the 30S ribosomal subunit. Contacts proteins S8 and S17. May interact with IF1 in the 30S initiation complex.UniRule annotation

Protein-protein interaction databases

STRINGi208964.PA4268.

Structurei

3D structure databases

ProteinModelPortaliQ9HWD0.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the universal ribosomal protein uS12 family.UniRule annotation

Phylogenomic databases

eggNOGiENOG4108UKE. Bacteria.
COG0048. LUCA.
HOGENOMiHOG000040063.
InParanoidiQ9HWD0.
KOiK02950.
OMAiKRGVCTA.
PhylomeDBiQ9HWD0.

Family and domain databases

CDDicd03368. Ribosomal_S12. 1 hit.
HAMAPiMF_00403_B. Ribosomal_S12_B. 1 hit.
InterProiView protein in InterPro
IPR012340. NA-bd_OB-fold.
IPR006032. Ribosomal_S12/S23.
IPR005679. Ribosomal_S12_bac.
PANTHERiPTHR11652. PTHR11652. 1 hit.
PfamiView protein in Pfam
PF00164. Ribosom_S12_S23. 1 hit.
PIRSFiPIRSF002133. Ribosomal_S12/S23. 1 hit.
PRINTSiPR01034. RIBOSOMALS12.
SUPFAMiSSF50249. SSF50249. 1 hit.
TIGRFAMsiTIGR00981. rpsL_bact. 1 hit.
PROSITEiView protein in PROSITE
PS00055. RIBOSOMAL_S12. 1 hit.

Sequencei

Sequence statusi: Complete.

Q9HWD0-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MATINQLVRK PRKRMVDKSD VPALQNCPQR RGVCTRVYTT TPKKPNSALR
60 70 80 90 100
KVCRVRLTNG FEVSSYIGGE GHNLQEHSVV LIRGGRVKDL PGVRYHTVRG
110 120
SLDTSGVKDR KQGRSKYGAK RPK
Length:123
Mass (Da):13,799
Last modified:March 1, 2001 - v1
Checksum:iB1583256AC9BC7FF
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AE004091 Genomic DNA. Translation: AAG07656.1.
PIRiF83112.
RefSeqiNP_252958.1. NC_002516.2.
WP_003093744.1. NC_002516.2.

Genome annotation databases

EnsemblBacteriaiAAG07656; AAG07656; PA4268.
GeneIDi881709.
KEGGipae:PA4268.
PATRICifig|208964.12.peg.4469.

Similar proteinsi

Entry informationi

Entry nameiRS12_PSEAE
AccessioniPrimary (citable) accession number: Q9HWD0
Entry historyiIntegrated into UniProtKB/Swiss-Prot: June 20, 2001
Last sequence update: March 1, 2001
Last modified: November 22, 2017
This is version 107 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Ribosomal proteins
    Ribosomal proteins families and list of entries
  2. SIMILARITY comments
    Index of protein domains and families