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Protein

Formyltetrahydrofolate deformylase

Gene

purU1

Organism
Pseudomonas aeruginosa (strain ATCC 15692 / PAO1 / 1C / PRS 101 / LMG 12228)
Status
Unreviewed-Annotation score: Annotation score: 3 out of 5-Protein inferred from homologyi

Functioni

Catalyzes the hydrolysis of 10-formyltetrahydrofolate (formyl-FH4) to formate and tetrahydrofolate (FH4).UniRule annotation

Catalytic activityi

10-formyltetrahydrofolate + H2O = formate + tetrahydrofolate.UniRule annotation

Pathwayi: IMP biosynthesis via de novo pathway

This protein is involved in step 1 of the subpathway that synthesizes formate from 10-formyl-5,6,7,8-tetrahydrofolate.UniRule annotation
Proteins known to be involved in this subpathway in this organism are:
  1. Formyltetrahydrofolate deformylase (purU1), Formyltetrahydrofolate deformylase (purU2)
This subpathway is part of the pathway IMP biosynthesis via de novo pathway, which is itself part of Purine metabolism.
View all proteins of this organism that are known to be involved in the subpathway that synthesizes formate from 10-formyl-5,6,7,8-tetrahydrofolate, the pathway IMP biosynthesis via de novo pathway and in Purine metabolism.

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Active sitei227 – 2271UniRule annotation

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

HydrolaseUniRule annotation

Keywords - Biological processi

One-carbon metabolismUniRule annotation, Purine biosynthesisUniRule annotation

Enzyme and pathway databases

UniPathwayiUPA00074; UER00170.

Names & Taxonomyi

Protein namesi
Recommended name:
Formyltetrahydrofolate deformylaseUniRule annotation (EC:3.5.1.10UniRule annotation)
Alternative name(s):
Formyl-FH(4) hydrolaseUniRule annotation
Gene namesi
Name:purU1Imported
Synonyms:purUUniRule annotation
Ordered Locus Names:PA4314Imported
OrganismiPseudomonas aeruginosa (strain ATCC 15692 / PAO1 / 1C / PRS 101 / LMG 12228)Imported
Taxonomic identifieri208964 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaPseudomonadalesPseudomonadaceaePseudomonas
Proteomesi
  • UP000002438 Componenti: Chromosome

Organism-specific databases

PseudoCAPiPA4314.

PTM / Processingi

Proteomic databases

PaxDbiQ9HW87.

Interactioni

Protein-protein interaction databases

STRINGi208964.PA4314.

Structurei

3D structure databases

ProteinModelPortaliQ9HW87.
SMRiQ9HW87. Positions 1-283.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini5 – 8581ACTUniRule annotationAdd
BLAST
Domaini87 – 261175Formyl_trans_NInterPro annotationAdd
BLAST

Sequence similaritiesi

Belongs to the PurU family.UniRule annotation
Contains 1 ACT domain.UniRule annotation

Phylogenomic databases

eggNOGiENOG4105CIY. Bacteria.
COG0788. LUCA.
HOGENOMiHOG000033576.
InParanoidiQ9HW87.
KOiK01433.
OMAiIQDTLPI.
OrthoDBiEOG615VP4.
PhylomeDBiQ9HW87.

Family and domain databases

Gene3Di3.40.50.170. 1 hit.
HAMAPiMF_01927. PurU.
InterProiIPR002376. Formyl_transf_N.
IPR004810. PurU.
[Graphical view]
PANTHERiPTHR10520:SF7. PTHR10520:SF7. 1 hit.
PfamiPF00551. Formyl_trans_N. 1 hit.
[Graphical view]
PRINTSiPR01575. FFH4HYDRLASE.
SUPFAMiSSF53328. SSF53328. 1 hit.
TIGRFAMsiTIGR00655. PurU. 1 hit.

Sequencei

Sequence statusi: Complete.

Q9HW87-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MRTFRLVIAC PDGVGIVAKV SNFLATYNGW ITEASHHSDN DNGWFFMRHE
60 70 80 90 100
IRADSLPFDL DGFRQAFAPI AREFSMEWRI TDSEVKKRVV LMASKESHCL
110 120 130 140 150
ADLLHRWHSG ELDCEIPCVI ANHDDLRSMV EWHGIPYFHV PVDPQDKQPA
160 170 180 190 200
FDEVSRLIDE HGADCIVLAR YMQILPPDLC RKYAHQVINI HHSFLPSFIG
210 220 230 240 250
AKPYHQASKR GVKLIGATSH YVTEELDAGP IIEQDVVRVT HRDNVEDMVR
260 270 280
LGKDVEKLVL ARGLRYHLED RVLVHGNKTV VFD
Length:283
Mass (Da):32,410
Last modified:March 1, 2001 - v1
Checksum:i902AE0AD3C897E0B
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AE004091 Genomic DNA. Translation: AAG07702.1.
PIRiC83105.
RefSeqiNP_253004.1. NC_002516.2.
WP_003101174.1. NZ_ASJY01000714.1.

Genome annotation databases

EnsemblBacteriaiAAG07702; AAG07702; PA4314.
GeneIDi881557.
KEGGipae:PA4314.
PATRICi19843345. VBIPseAer58763_4519.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AE004091 Genomic DNA. Translation: AAG07702.1.
PIRiC83105.
RefSeqiNP_253004.1. NC_002516.2.
WP_003101174.1. NZ_ASJY01000714.1.

3D structure databases

ProteinModelPortaliQ9HW87.
SMRiQ9HW87. Positions 1-283.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi208964.PA4314.

Proteomic databases

PaxDbiQ9HW87.

Protocols and materials databases

DNASUi881557.
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaiAAG07702; AAG07702; PA4314.
GeneIDi881557.
KEGGipae:PA4314.
PATRICi19843345. VBIPseAer58763_4519.

Organism-specific databases

PseudoCAPiPA4314.

Phylogenomic databases

eggNOGiENOG4105CIY. Bacteria.
COG0788. LUCA.
HOGENOMiHOG000033576.
InParanoidiQ9HW87.
KOiK01433.
OMAiIQDTLPI.
OrthoDBiEOG615VP4.
PhylomeDBiQ9HW87.

Enzyme and pathway databases

UniPathwayiUPA00074; UER00170.

Family and domain databases

Gene3Di3.40.50.170. 1 hit.
HAMAPiMF_01927. PurU.
InterProiIPR002376. Formyl_transf_N.
IPR004810. PurU.
[Graphical view]
PANTHERiPTHR10520:SF7. PTHR10520:SF7. 1 hit.
PfamiPF00551. Formyl_trans_N. 1 hit.
[Graphical view]
PRINTSiPR01575. FFH4HYDRLASE.
SUPFAMiSSF53328. SSF53328. 1 hit.
TIGRFAMsiTIGR00655. PurU. 1 hit.
ProtoNetiSearch...

Publicationsi

  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: ATCC 15692 / PAO1 / 1C / PRS 101 / LMG 12228Imported.

Entry informationi

Entry nameiQ9HW87_PSEAE
AccessioniPrimary (citable) accession number: Q9HW87
Entry historyi
Integrated into UniProtKB/TrEMBL: March 1, 2001
Last sequence update: March 1, 2001
Last modified: March 16, 2016
This is version 88 of the entry and version 1 of the sequence. [Complete history]
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteomeImported

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.