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Protein

Formyltetrahydrofolate deformylase

Gene

purU1

Organism
Pseudomonas aeruginosa (strain ATCC 15692 / DSM 22644 / CIP 104116 / JCM 14847 / LMG 12228 / 1C / PRS 101 / PAO1)
Status
Unreviewed-Annotation score: -Protein inferred from homologyi

Functioni

Catalyzes the hydrolysis of 10-formyltetrahydrofolate (formyl-FH4) to formate and tetrahydrofolate (FH4).UniRule annotation

Catalytic activityi

10-formyltetrahydrofolate + H2O = formate + tetrahydrofolate.UniRule annotation

Pathwayi: IMP biosynthesis via de novo pathway

This protein is involved in step 1 of the subpathway that synthesizes formate from 10-formyl-5,6,7,8-tetrahydrofolate.UniRule annotation
Proteins known to be involved in this subpathway in this organism are:
  1. Formyltetrahydrofolate deformylase (purU1), Formyltetrahydrofolate deformylase (purU2)
This subpathway is part of the pathway IMP biosynthesis via de novo pathway, which is itself part of Purine metabolism.
View all proteins of this organism that are known to be involved in the subpathway that synthesizes formate from 10-formyl-5,6,7,8-tetrahydrofolate, the pathway IMP biosynthesis via de novo pathway and in Purine metabolism.

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Active sitei227UniRule annotation1

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionHydrolaseUniRule annotation
Biological processOne-carbon metabolismUniRule annotation, Purine biosynthesisUniRule annotation

Enzyme and pathway databases

BioCyciPAER208964:G1FZ6-4399-MONOMER
UniPathwayiUPA00074; UER00170

Names & Taxonomyi

Protein namesi
Recommended name:
Formyltetrahydrofolate deformylaseUniRule annotation (EC:3.5.1.10UniRule annotation)
Alternative name(s):
Formyl-FH(4) hydrolaseUniRule annotation
Gene namesi
Name:purU1Imported
Synonyms:purUUniRule annotation
Ordered Locus Names:PA4314Imported
OrganismiPseudomonas aeruginosa (strain ATCC 15692 / DSM 22644 / CIP 104116 / JCM 14847 / LMG 12228 / 1C / PRS 101 / PAO1)Imported
Taxonomic identifieri208964 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaPseudomonadalesPseudomonadaceaePseudomonas
Proteomesi

Organism-specific databases

PseudoCAPiPA4314

PTM / Processingi

Proteomic databases

PaxDbiQ9HW87

Interactioni

Protein-protein interaction databases

STRINGi208964.PA4314

Structurei

3D structure databases

ProteinModelPortaliQ9HW87
SMRiQ9HW87
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini87 – 261Formyl_trans_NInterPro annotationAdd BLAST175

Sequence similaritiesi

Belongs to the PurU family.UniRule annotation

Phylogenomic databases

eggNOGiENOG4105CIY Bacteria
COG0788 LUCA
HOGENOMiHOG000033576
InParanoidiQ9HW87
KOiK01433
OMAiHADHHTD
PhylomeDBiQ9HW87

Family and domain databases

HAMAPiMF_01927 PurU, 1 hit
InterProiView protein in InterPro
IPR002376 Formyl_transf_N
IPR036477 Formyl_transf_N_sf
IPR004810 PurU
PANTHERiPTHR42706 PTHR42706, 1 hit
PfamiView protein in Pfam
PF00551 Formyl_trans_N, 1 hit
PRINTSiPR01575 FFH4HYDRLASE
SUPFAMiSSF53328 SSF53328, 1 hit
TIGRFAMsiTIGR00655 PurU, 1 hit

Sequencei

Sequence statusi: Complete.

Q9HW87-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MRTFRLVIAC PDGVGIVAKV SNFLATYNGW ITEASHHSDN DNGWFFMRHE
60 70 80 90 100
IRADSLPFDL DGFRQAFAPI AREFSMEWRI TDSEVKKRVV LMASKESHCL
110 120 130 140 150
ADLLHRWHSG ELDCEIPCVI ANHDDLRSMV EWHGIPYFHV PVDPQDKQPA
160 170 180 190 200
FDEVSRLIDE HGADCIVLAR YMQILPPDLC RKYAHQVINI HHSFLPSFIG
210 220 230 240 250
AKPYHQASKR GVKLIGATSH YVTEELDAGP IIEQDVVRVT HRDNVEDMVR
260 270 280
LGKDVEKLVL ARGLRYHLED RVLVHGNKTV VFD
Length:283
Mass (Da):32,410
Last modified:March 1, 2001 - v1
Checksum:i902AE0AD3C897E0B
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AE004091 Genomic DNA Translation: AAG07702.1
PIRiC83105
RefSeqiNP_253004.1, NC_002516.2
WP_003101174.1, NC_002516.2

Genome annotation databases

EnsemblBacteriaiAAG07702; AAG07702; PA4314
GeneIDi881557
KEGGipae:PA4314
PATRICifig|208964.12.peg.4519

Similar proteinsi

Entry informationi

Entry nameiQ9HW87_PSEAE
AccessioniPrimary (citable) accession number: Q9HW87
Entry historyiIntegrated into UniProtKB/TrEMBL: March 1, 2001
Last sequence update: March 1, 2001
Last modified: March 28, 2018
This is version 103 of the entry and version 1 of the sequence. See complete history.
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteomeImported

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