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Q9HW26

- PNCB2_PSEAE

UniProt

Q9HW26 - PNCB2_PSEAE

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Protein

Nicotinate phosphoribosyltransferase 2

Gene

pncB2

Organism
Pseudomonas aeruginosa (strain ATCC 15692 / PAO1 / 1C / PRS 101 / LMG 12228)
Status
Reviewed - Annotation score: 2 out of 5- Experimental evidence at protein leveli

Functioni

Catalyzes the synthesis of beta-nicotinate D-ribonucleotide from nicotinate and 5-phospho-D-ribose 1-phosphate at the expense of ATP.UniRule annotation

Catalytic activityi

Nicotinate + 5-phospho-alpha-D-ribose 1-diphosphate + ATP + H2O = beta-nicotinate D-ribonucleotide + diphosphate + ADP + phosphate.UniRule annotation

Pathwayi

GO - Molecular functioni

  1. ligase activity Source: UniProtKB-KW
  2. nicotinate-nucleotide diphosphorylase (carboxylating) activity Source: InterPro
  3. nicotinate phosphoribosyltransferase activity Source: InterPro

GO - Biological processi

  1. NAD biosynthetic process Source: UniProtKB-UniPathway
  2. nicotinate nucleotide biosynthetic process Source: InterPro
Complete GO annotation...

Keywords - Molecular functioni

Ligase, Transferase

Keywords - Biological processi

Pyridine nucleotide biosynthesis

Enzyme and pathway databases

UniPathwayiUPA00253; UER00457.

Names & Taxonomyi

Protein namesi
Recommended name:
Nicotinate phosphoribosyltransferase 2UniRule annotation (EC:6.3.4.21UniRule annotation)
Short name:
NAPRTase 2UniRule annotation
Gene namesi
Name:pncB2UniRule annotation
Ordered Locus Names:PA4376
OrganismiPseudomonas aeruginosa (strain ATCC 15692 / PAO1 / 1C / PRS 101 / LMG 12228)
Taxonomic identifieri208964 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaPseudomonadalesPseudomonadaceaePseudomonas
ProteomesiUP000002438: Chromosome

Organism-specific databases

PseudoCAPiPA4376.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 398398Nicotinate phosphoribosyltransferase 2PRO_0000205838Add
BLAST

Proteomic databases

PRIDEiQ9HW26.

Interactioni

Protein-protein interaction databases

STRINGi208964.PA4376.

Structurei

Secondary structure

1
398
Legend: HelixTurnBeta strand
Show more details
Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Beta strandi16 – 183
Helixi19 – 3113
Beta strandi36 – 438
Helixi50 – 523
Helixi53 – 6513
Helixi70 – 778
Helixi84 – 929
Helixi97 – 993
Beta strandi100 – 1056
Beta strandi108 – 1169
Helixi117 – 1204
Helixi121 – 1233
Helixi124 – 13916
Helixi145 – 16016
Helixi165 – 1684
Beta strandi172 – 1754
Helixi184 – 19714
Beta strandi199 – 2079
Helixi208 – 2136
Helixi224 – 23310
Helixi237 – 2393
Helixi240 – 25213
Beta strandi258 – 2614
Helixi266 – 2727
Helixi275 – 2806
Beta strandi283 – 2864
Helixi291 – 30515
Helixi309 – 3113
Beta strandi312 – 3165
Helixi322 – 33211
Turni333 – 3353
Beta strandi336 – 3427
Helixi344 – 3474
Beta strandi358 – 3658
Helixi386 – 39510

3D structure databases

Select the link destinations:
PDBe
RCSB PDB
PDBj
Links Updated
EntryMethodResolution (Å)ChainPositionsPDBsum
1YIRX-ray2.10A/B/C/D2-398[»]
ProteinModelPortaliQ9HW26.
SMRiQ9HW26. Positions 1-397.
ModBaseiSearch...
MobiDBiSearch...

Miscellaneous databases

EvolutionaryTraceiQ9HW26.

Family & Domainsi

Sequence similaritiesi

Belongs to the NAPRTase family.UniRule annotation

Phylogenomic databases

eggNOGiCOG1488.
HOGENOMiHOG000284928.
InParanoidiQ9HW26.
KOiK00763.
OMAiDWTYEGQ.
OrthoDBiEOG6X10XB.
PhylomeDBiQ9HW26.

Family and domain databases

HAMAPiMF_00570. NAPRTase.
InterProiIPR006406. Nic_PRibTrfase.
IPR007229. Nic_PRibTrfase-Fam.
IPR002638. Quinolinate_PRibosylTrfase_C.
[Graphical view]
PANTHERiPTHR11098. PTHR11098. 1 hit.
PfamiPF04095. NAPRTase. 1 hit.
[Graphical view]
PIRSFiPIRSF000484. NAPRT. 1 hit.
SUPFAMiSSF51690. SSF51690. 1 hit.
TIGRFAMsiTIGR01514. NAPRTase. 1 hit.

Sequencei

Sequence statusi: Complete.

Q9HW26-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MAESAFSERI VQNLLDTDFY KLTMMQAVLH NYPNAEVEWE FRCRNQEDLR
60 70 80 90 100
LYLPAIREQL EYLAGLAISD EQLAFLERIP FLAPDFIRFL GLFRFNPRYV
110 120 130 140 150
QTGIENDEFF LRLKGPWLHV ILFEVPLLAM ISEVRNRARY PAATVEQARE
160 170 180 190 200
RLQEKFDWLR REASAEELAG FKMADFGTRR RFSYRVHEAV VSGLKEDFPG
210 220 230 240 250
CFVGTSNVHL ARKLDLKPLG TMAHEWLMAH QQLGPRLIDS QSAALDCWVR
260 270 280 290 300
EYRGLLGIAL TDCITTDAFL RDFDLYFAKL FDGLRHDSGD PLLWAEKTIA
310 320 330 340 350
HYLKLGIDPL TKTLVFSDGL DLPRALKIYR ALQGRINVSF GIGTHFTCDL
360 370 380 390
PGVEPMNIVV KMSACNGHPV AKISDTPGKA QCRDPDFIHY LKHVFQVA
Length:398
Mass (Da):45,691
Last modified:March 1, 2001 - v1
Checksum:i526899B1B705C37F
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AE004091 Genomic DNA. Translation: AAG07764.1.
PIRiF83099.
RefSeqiNP_253066.1. NC_002516.2.

Genome annotation databases

EnsemblBacteriaiAAG07764; AAG07764; PA4376.
GeneIDi881378.
KEGGipae:PA4376.
PATRICi19843473. VBIPseAer58763_4583.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AE004091 Genomic DNA. Translation: AAG07764.1 .
PIRi F83099.
RefSeqi NP_253066.1. NC_002516.2.

3D structure databases

Select the link destinations:
PDBe
RCSB PDB
PDBj
Links Updated
Entry Method Resolution (Å) Chain Positions PDBsum
1YIR X-ray 2.10 A/B/C/D 2-398 [» ]
ProteinModelPortali Q9HW26.
SMRi Q9HW26. Positions 1-397.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 208964.PA4376.

Proteomic databases

PRIDEi Q9HW26.

Protocols and materials databases

DNASUi 881378.
Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai AAG07764 ; AAG07764 ; PA4376 .
GeneIDi 881378.
KEGGi pae:PA4376.
PATRICi 19843473. VBIPseAer58763_4583.

Organism-specific databases

PseudoCAPi PA4376.

Phylogenomic databases

eggNOGi COG1488.
HOGENOMi HOG000284928.
InParanoidi Q9HW26.
KOi K00763.
OMAi DWTYEGQ.
OrthoDBi EOG6X10XB.
PhylomeDBi Q9HW26.

Enzyme and pathway databases

UniPathwayi UPA00253 ; UER00457 .

Miscellaneous databases

EvolutionaryTracei Q9HW26.

Family and domain databases

HAMAPi MF_00570. NAPRTase.
InterProi IPR006406. Nic_PRibTrfase.
IPR007229. Nic_PRibTrfase-Fam.
IPR002638. Quinolinate_PRibosylTrfase_C.
[Graphical view ]
PANTHERi PTHR11098. PTHR11098. 1 hit.
Pfami PF04095. NAPRTase. 1 hit.
[Graphical view ]
PIRSFi PIRSF000484. NAPRT. 1 hit.
SUPFAMi SSF51690. SSF51690. 1 hit.
TIGRFAMsi TIGR01514. NAPRTase. 1 hit.
ProtoNeti Search...

Publicationsi

  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: ATCC 15692 / PAO1 / 1C / PRS 101 / LMG 12228.

Entry informationi

Entry nameiPNCB2_PSEAE
AccessioniPrimary (citable) accession number: Q9HW26
Entry historyi
Integrated into UniProtKB/Swiss-Prot: July 11, 2002
Last sequence update: March 1, 2001
Last modified: October 29, 2014
This is version 102 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  2. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  3. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3