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Protein

Nicotinate phosphoribosyltransferase 2

Gene

pncB2

Organism
Pseudomonas aeruginosa (strain ATCC 15692 / PAO1 / 1C / PRS 101 / LMG 12228)
Status
Reviewed-Annotation score: Annotation score: 2 out of 5-Experimental evidence at protein leveli

Functioni

Catalyzes the synthesis of beta-nicotinate D-ribonucleotide from nicotinate and 5-phospho-D-ribose 1-phosphate at the expense of ATP.UniRule annotation

Catalytic activityi

Nicotinate + 5-phospho-alpha-D-ribose 1-diphosphate + ATP + H2O = beta-nicotinate D-ribonucleotide + diphosphate + ADP + phosphate.UniRule annotation

Pathwayi

GO - Molecular functioni

  1. ligase activity Source: UniProtKB-KW
  2. nicotinate-nucleotide diphosphorylase (carboxylating) activity Source: InterPro
  3. nicotinate phosphoribosyltransferase activity Source: UniProtKB-HAMAP

GO - Biological processi

  1. NAD biosynthetic process Source: UniProtKB-HAMAP
  2. nicotinate nucleotide biosynthetic process Source: InterPro
Complete GO annotation...

Keywords - Molecular functioni

Ligase, Transferase

Keywords - Biological processi

Pyridine nucleotide biosynthesis

Enzyme and pathway databases

UniPathwayiUPA00253; UER00457.

Names & Taxonomyi

Protein namesi
Recommended name:
Nicotinate phosphoribosyltransferase 2UniRule annotation (EC:6.3.4.21UniRule annotation)
Short name:
NAPRTase 2UniRule annotation
Gene namesi
Name:pncB2UniRule annotation
Ordered Locus Names:PA4376
OrganismiPseudomonas aeruginosa (strain ATCC 15692 / PAO1 / 1C / PRS 101 / LMG 12228)
Taxonomic identifieri208964 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaPseudomonadalesPseudomonadaceaePseudomonas
ProteomesiUP000002438 Componenti: Chromosome

Organism-specific databases

PseudoCAPiPA4376.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 398398Nicotinate phosphoribosyltransferase 2PRO_0000205838Add
BLAST

Proteomic databases

PRIDEiQ9HW26.

Interactioni

Protein-protein interaction databases

STRINGi208964.PA4376.

Structurei

Secondary structure

1
398
Legend: HelixTurnBeta strand
Show more details
Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Beta strandi16 – 183Combined sources
Helixi19 – 3113Combined sources
Beta strandi36 – 438Combined sources
Helixi50 – 523Combined sources
Helixi53 – 6513Combined sources
Helixi70 – 778Combined sources
Helixi84 – 929Combined sources
Helixi97 – 993Combined sources
Beta strandi100 – 1056Combined sources
Beta strandi108 – 1169Combined sources
Helixi117 – 1204Combined sources
Helixi121 – 1233Combined sources
Helixi124 – 13916Combined sources
Helixi145 – 16016Combined sources
Helixi165 – 1684Combined sources
Beta strandi172 – 1754Combined sources
Helixi184 – 19714Combined sources
Beta strandi199 – 2079Combined sources
Helixi208 – 2136Combined sources
Helixi224 – 23310Combined sources
Helixi237 – 2393Combined sources
Helixi240 – 25213Combined sources
Beta strandi258 – 2614Combined sources
Helixi266 – 2727Combined sources
Helixi275 – 2806Combined sources
Beta strandi283 – 2864Combined sources
Helixi291 – 30515Combined sources
Helixi309 – 3113Combined sources
Beta strandi312 – 3165Combined sources
Helixi322 – 33211Combined sources
Turni333 – 3353Combined sources
Beta strandi336 – 3427Combined sources
Helixi344 – 3474Combined sources
Beta strandi358 – 3658Combined sources
Helixi386 – 39510Combined sources

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
EntryMethodResolution (Å)ChainPositionsPDBsum
1YIRX-ray2.10A/B/C/D2-398[»]
ProteinModelPortaliQ9HW26.
SMRiQ9HW26. Positions 1-397.
ModBaseiSearch...
MobiDBiSearch...

Miscellaneous databases

EvolutionaryTraceiQ9HW26.

Family & Domainsi

Sequence similaritiesi

Belongs to the NAPRTase family.UniRule annotation

Phylogenomic databases

eggNOGiCOG1488.
HOGENOMiHOG000284928.
InParanoidiQ9HW26.
KOiK00763.
OMAiTPGKGMC.
OrthoDBiEOG6X10XB.
PhylomeDBiQ9HW26.

Family and domain databases

HAMAPiMF_00570. NAPRTase.
InterProiIPR006406. Nic_PRibTrfase.
IPR007229. Nic_PRibTrfase-Fam.
IPR002638. Quinolinate_PRibosylTrfase_C.
[Graphical view]
PANTHERiPTHR11098. PTHR11098. 1 hit.
PfamiPF04095. NAPRTase. 1 hit.
[Graphical view]
PIRSFiPIRSF000484. NAPRT. 1 hit.
SUPFAMiSSF51690. SSF51690. 1 hit.
TIGRFAMsiTIGR01514. NAPRTase. 1 hit.

Sequencei

Sequence statusi: Complete.

Q9HW26-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MAESAFSERI VQNLLDTDFY KLTMMQAVLH NYPNAEVEWE FRCRNQEDLR
60 70 80 90 100
LYLPAIREQL EYLAGLAISD EQLAFLERIP FLAPDFIRFL GLFRFNPRYV
110 120 130 140 150
QTGIENDEFF LRLKGPWLHV ILFEVPLLAM ISEVRNRARY PAATVEQARE
160 170 180 190 200
RLQEKFDWLR REASAEELAG FKMADFGTRR RFSYRVHEAV VSGLKEDFPG
210 220 230 240 250
CFVGTSNVHL ARKLDLKPLG TMAHEWLMAH QQLGPRLIDS QSAALDCWVR
260 270 280 290 300
EYRGLLGIAL TDCITTDAFL RDFDLYFAKL FDGLRHDSGD PLLWAEKTIA
310 320 330 340 350
HYLKLGIDPL TKTLVFSDGL DLPRALKIYR ALQGRINVSF GIGTHFTCDL
360 370 380 390
PGVEPMNIVV KMSACNGHPV AKISDTPGKA QCRDPDFIHY LKHVFQVA
Length:398
Mass (Da):45,691
Last modified:March 1, 2001 - v1
Checksum:i526899B1B705C37F
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AE004091 Genomic DNA. Translation: AAG07764.1.
PIRiF83099.
RefSeqiNP_253066.1. NC_002516.2.

Genome annotation databases

EnsemblBacteriaiAAG07764; AAG07764; PA4376.
GeneIDi881378.
KEGGipae:PA4376.
PATRICi19843473. VBIPseAer58763_4583.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AE004091 Genomic DNA. Translation: AAG07764.1.
PIRiF83099.
RefSeqiNP_253066.1. NC_002516.2.

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
EntryMethodResolution (Å)ChainPositionsPDBsum
1YIRX-ray2.10A/B/C/D2-398[»]
ProteinModelPortaliQ9HW26.
SMRiQ9HW26. Positions 1-397.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi208964.PA4376.

Proteomic databases

PRIDEiQ9HW26.

Protocols and materials databases

DNASUi881378.
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaiAAG07764; AAG07764; PA4376.
GeneIDi881378.
KEGGipae:PA4376.
PATRICi19843473. VBIPseAer58763_4583.

Organism-specific databases

PseudoCAPiPA4376.

Phylogenomic databases

eggNOGiCOG1488.
HOGENOMiHOG000284928.
InParanoidiQ9HW26.
KOiK00763.
OMAiTPGKGMC.
OrthoDBiEOG6X10XB.
PhylomeDBiQ9HW26.

Enzyme and pathway databases

UniPathwayiUPA00253; UER00457.

Miscellaneous databases

EvolutionaryTraceiQ9HW26.

Family and domain databases

HAMAPiMF_00570. NAPRTase.
InterProiIPR006406. Nic_PRibTrfase.
IPR007229. Nic_PRibTrfase-Fam.
IPR002638. Quinolinate_PRibosylTrfase_C.
[Graphical view]
PANTHERiPTHR11098. PTHR11098. 1 hit.
PfamiPF04095. NAPRTase. 1 hit.
[Graphical view]
PIRSFiPIRSF000484. NAPRT. 1 hit.
SUPFAMiSSF51690. SSF51690. 1 hit.
TIGRFAMsiTIGR01514. NAPRTase. 1 hit.
ProtoNetiSearch...

Publicationsi

  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: ATCC 15692 / PAO1 / 1C / PRS 101 / LMG 12228.

Entry informationi

Entry nameiPNCB2_PSEAE
AccessioniPrimary (citable) accession number: Q9HW26
Entry historyi
Integrated into UniProtKB/Swiss-Prot: July 11, 2002
Last sequence update: March 1, 2001
Last modified: March 4, 2015
This is version 106 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  2. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  3. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.