Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Basket 0
(max 400 entries)x

Your basket is currently empty.

Select item(s) and click on "Add to basket" to create your own collection here
(400 entries max)

Q9HW26

- PNCB2_PSEAE

UniProt

Q9HW26 - PNCB2_PSEAE

Protein

Nicotinate phosphoribosyltransferase 2

Gene

pncB2

Organism
Pseudomonas aeruginosa (strain ATCC 15692 / PAO1 / 1C / PRS 101 / LMG 12228)
Status
Reviewed - Annotation score: 2 out of 5- Experimental evidence at protein leveli
    • BLAST
    • Align
    • Format
    • Add to basket
    • History
      Entry version 101 (01 Oct 2014)
      Sequence version 1 (01 Mar 2001)
      Previous versions | rss
    • Help video
    • Feedback
    • Comment

    Functioni

    Catalyzes the synthesis of beta-nicotinate D-ribonucleotide from nicotinate and 5-phospho-D-ribose 1-phosphate at the expense of ATP.UniRule annotation

    Catalytic activityi

    Nicotinate + 5-phospho-alpha-D-ribose 1-diphosphate + ATP + H2O = beta-nicotinate D-ribonucleotide + diphosphate + ADP + phosphate.UniRule annotation

    Pathwayi

    GO - Molecular functioni

    1. ligase activity Source: UniProtKB-KW
    2. nicotinate-nucleotide diphosphorylase (carboxylating) activity Source: InterPro
    3. nicotinate phosphoribosyltransferase activity Source: InterPro

    GO - Biological processi

    1. NAD biosynthetic process Source: UniProtKB-UniPathway
    2. nicotinate nucleotide biosynthetic process Source: InterPro

    Keywords - Molecular functioni

    Ligase, Transferase

    Keywords - Biological processi

    Pyridine nucleotide biosynthesis

    Enzyme and pathway databases

    UniPathwayiUPA00253; UER00457.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Nicotinate phosphoribosyltransferase 2UniRule annotation (EC:6.3.4.21UniRule annotation)
    Short name:
    NAPRTase 2UniRule annotation
    Gene namesi
    Name:pncB2UniRule annotation
    Ordered Locus Names:PA4376
    OrganismiPseudomonas aeruginosa (strain ATCC 15692 / PAO1 / 1C / PRS 101 / LMG 12228)
    Taxonomic identifieri208964 [NCBI]
    Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaPseudomonadalesPseudomonadaceaePseudomonas
    ProteomesiUP000002438: Chromosome

    Organism-specific databases

    PseudoCAPiPA4376.

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 398398Nicotinate phosphoribosyltransferase 2PRO_0000205838Add
    BLAST

    Proteomic databases

    PRIDEiQ9HW26.

    Interactioni

    Protein-protein interaction databases

    STRINGi208964.PA4376.

    Structurei

    Secondary structure

    1
    398
    Legend: HelixTurnBeta strand
    Show more details
    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Beta strandi16 – 183
    Helixi19 – 3113
    Beta strandi36 – 438
    Helixi50 – 523
    Helixi53 – 6513
    Helixi70 – 778
    Helixi84 – 929
    Helixi97 – 993
    Beta strandi100 – 1056
    Beta strandi108 – 1169
    Helixi117 – 1204
    Helixi121 – 1233
    Helixi124 – 13916
    Helixi145 – 16016
    Helixi165 – 1684
    Beta strandi172 – 1754
    Helixi184 – 19714
    Beta strandi199 – 2079
    Helixi208 – 2136
    Helixi224 – 23310
    Helixi237 – 2393
    Helixi240 – 25213
    Beta strandi258 – 2614
    Helixi266 – 2727
    Helixi275 – 2806
    Beta strandi283 – 2864
    Helixi291 – 30515
    Helixi309 – 3113
    Beta strandi312 – 3165
    Helixi322 – 33211
    Turni333 – 3353
    Beta strandi336 – 3427
    Helixi344 – 3474
    Beta strandi358 – 3658
    Helixi386 – 39510

    3D structure databases

    Select the link destinations:
    PDBe
    RCSB PDB
    PDBj
    Links Updated
    EntryMethodResolution (Å)ChainPositionsPDBsum
    1YIRX-ray2.10A/B/C/D2-398[»]
    ProteinModelPortaliQ9HW26.
    SMRiQ9HW26. Positions 1-397.
    ModBaseiSearch...
    MobiDBiSearch...

    Miscellaneous databases

    EvolutionaryTraceiQ9HW26.

    Family & Domainsi

    Sequence similaritiesi

    Belongs to the NAPRTase family.UniRule annotation

    Phylogenomic databases

    eggNOGiCOG1488.
    HOGENOMiHOG000284928.
    KOiK00763.
    OMAiDWTYEGQ.
    OrthoDBiEOG6X10XB.
    PhylomeDBiQ9HW26.

    Family and domain databases

    HAMAPiMF_00570. NAPRTase.
    InterProiIPR006406. Nic_PRibTrfase.
    IPR007229. Nic_PRibTrfase-Fam.
    IPR002638. Quinolinate_PRibosylTrfase_C.
    [Graphical view]
    PANTHERiPTHR11098. PTHR11098. 1 hit.
    PfamiPF04095. NAPRTase. 1 hit.
    [Graphical view]
    PIRSFiPIRSF000484. NAPRT. 1 hit.
    SUPFAMiSSF51690. SSF51690. 1 hit.
    TIGRFAMsiTIGR01514. NAPRTase. 1 hit.

    Sequencei

    Sequence statusi: Complete.

    Q9HW26-1 [UniParc]FASTAAdd to Basket

    « Hide

    MAESAFSERI VQNLLDTDFY KLTMMQAVLH NYPNAEVEWE FRCRNQEDLR    50
    LYLPAIREQL EYLAGLAISD EQLAFLERIP FLAPDFIRFL GLFRFNPRYV 100
    QTGIENDEFF LRLKGPWLHV ILFEVPLLAM ISEVRNRARY PAATVEQARE 150
    RLQEKFDWLR REASAEELAG FKMADFGTRR RFSYRVHEAV VSGLKEDFPG 200
    CFVGTSNVHL ARKLDLKPLG TMAHEWLMAH QQLGPRLIDS QSAALDCWVR 250
    EYRGLLGIAL TDCITTDAFL RDFDLYFAKL FDGLRHDSGD PLLWAEKTIA 300
    HYLKLGIDPL TKTLVFSDGL DLPRALKIYR ALQGRINVSF GIGTHFTCDL 350
    PGVEPMNIVV KMSACNGHPV AKISDTPGKA QCRDPDFIHY LKHVFQVA 398
    Length:398
    Mass (Da):45,691
    Last modified:March 1, 2001 - v1
    Checksum:i526899B1B705C37F
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AE004091 Genomic DNA. Translation: AAG07764.1.
    PIRiF83099.
    RefSeqiNP_253066.1. NC_002516.2.

    Genome annotation databases

    EnsemblBacteriaiAAG07764; AAG07764; PA4376.
    GeneIDi881378.
    KEGGipae:PA4376.
    PATRICi19843473. VBIPseAer58763_4583.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AE004091 Genomic DNA. Translation: AAG07764.1 .
    PIRi F83099.
    RefSeqi NP_253066.1. NC_002516.2.

    3D structure databases

    Select the link destinations:
    PDBe
    RCSB PDB
    PDBj
    Links Updated
    Entry Method Resolution (Å) Chain Positions PDBsum
    1YIR X-ray 2.10 A/B/C/D 2-398 [» ]
    ProteinModelPortali Q9HW26.
    SMRi Q9HW26. Positions 1-397.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 208964.PA4376.

    Proteomic databases

    PRIDEi Q9HW26.

    Protocols and materials databases

    DNASUi 881378.
    Structural Biology Knowledgebase Search...

    Genome annotation databases

    EnsemblBacteriai AAG07764 ; AAG07764 ; PA4376 .
    GeneIDi 881378.
    KEGGi pae:PA4376.
    PATRICi 19843473. VBIPseAer58763_4583.

    Organism-specific databases

    PseudoCAPi PA4376.

    Phylogenomic databases

    eggNOGi COG1488.
    HOGENOMi HOG000284928.
    KOi K00763.
    OMAi DWTYEGQ.
    OrthoDBi EOG6X10XB.
    PhylomeDBi Q9HW26.

    Enzyme and pathway databases

    UniPathwayi UPA00253 ; UER00457 .

    Miscellaneous databases

    EvolutionaryTracei Q9HW26.

    Family and domain databases

    HAMAPi MF_00570. NAPRTase.
    InterProi IPR006406. Nic_PRibTrfase.
    IPR007229. Nic_PRibTrfase-Fam.
    IPR002638. Quinolinate_PRibosylTrfase_C.
    [Graphical view ]
    PANTHERi PTHR11098. PTHR11098. 1 hit.
    Pfami PF04095. NAPRTase. 1 hit.
    [Graphical view ]
    PIRSFi PIRSF000484. NAPRT. 1 hit.
    SUPFAMi SSF51690. SSF51690. 1 hit.
    TIGRFAMsi TIGR01514. NAPRTase. 1 hit.
    ProtoNeti Search...

    Publicationsi

    1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: ATCC 15692 / PAO1 / 1C / PRS 101 / LMG 12228.

    Entry informationi

    Entry nameiPNCB2_PSEAE
    AccessioniPrimary (citable) accession number: Q9HW26
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: July 11, 2002
    Last sequence update: March 1, 2001
    Last modified: October 1, 2014
    This is version 101 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programProkaryotic Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    3D-structure, Complete proteome, Reference proteome

    Documents

    1. PATHWAY comments
      Index of metabolic and biosynthesis pathways
    2. PDB cross-references
      Index of Protein Data Bank (PDB) cross-references
    3. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3