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Q9HW09

- PANE_PSEAE

UniProt

Q9HW09 - PANE_PSEAE

Protein

Probable 2-dehydropantoate 2-reductase

Gene

panE

Organism
Pseudomonas aeruginosa (strain ATCC 15692 / PAO1 / 1C / PRS 101 / LMG 12228)
Status
Reviewed - Annotation score: 3 out of 5- Protein inferred from homologyi
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    • History
      Entry version 92 (01 Oct 2014)
      Sequence version 1 (01 Mar 2001)
      Previous versions | rss
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    Functioni

    Catalyzes the NADPH-dependent reduction of ketopantoate into pantoic acid.

    Catalytic activityi

    (R)-pantoate + NADP+ = 2-dehydropantoate + NADPH.

    Pathwayi

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Binding sitei31 – 311NADP; via amide nitrogenBy similarity
    Binding sitei103 – 1031NADP; via amide nitrogenBy similarity
    Binding sitei103 – 1031SubstrateBy similarity
    Binding sitei129 – 1291NADP; via amide nitrogen and carbonyl oxygenBy similarity
    Active sitei182 – 1821Proton donorBy similarity
    Binding sitei186 – 1861SubstrateBy similarity
    Binding sitei190 – 1901SubstrateBy similarity
    Binding sitei200 – 2001SubstrateBy similarity
    Binding sitei247 – 2471SubstrateBy similarity
    Binding sitei250 – 2501SubstrateBy similarity
    Binding sitei262 – 2621NADPBy similarity

    Regions

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Nucleotide bindingi7 – 126NADPBy similarity

    GO - Molecular functioni

    1. 2-dehydropantoate 2-reductase activity Source: UniProtKB-EC
    2. NADP binding Source: InterPro

    GO - Biological processi

    1. pantothenate biosynthetic process Source: UniProtKB-UniPathway

    Keywords - Molecular functioni

    Oxidoreductase

    Keywords - Biological processi

    Pantothenate biosynthesis

    Keywords - Ligandi

    NADP

    Enzyme and pathway databases

    UniPathwayiUPA00028; UER00004.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Probable 2-dehydropantoate 2-reductase (EC:1.1.1.169)
    Alternative name(s):
    Ketopantoate reductase
    Short name:
    KPA reductase
    Short name:
    KPR
    Gene namesi
    Name:panE
    Ordered Locus Names:PA4397
    OrganismiPseudomonas aeruginosa (strain ATCC 15692 / PAO1 / 1C / PRS 101 / LMG 12228)
    Taxonomic identifieri208964 [NCBI]
    Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaPseudomonadalesPseudomonadaceaePseudomonas
    ProteomesiUP000002438: Chromosome

    Organism-specific databases

    PseudoCAPiPA4397.

    Subcellular locationi

    Cytoplasm Curated

    GO - Cellular componenti

    1. cytoplasm Source: UniProtKB-SubCell

    Keywords - Cellular componenti

    Cytoplasm

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 303303Probable 2-dehydropantoate 2-reductasePRO_0000157308Add
    BLAST

    Interactioni

    Protein-protein interaction databases

    STRINGi208964.PA4397.

    Structurei

    3D structure databases

    ProteinModelPortaliQ9HW09.
    SMRiQ9HW09. Positions 1-293.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Sequence similaritiesi

    Belongs to the ketopantoate reductase family.Curated

    Phylogenomic databases

    eggNOGiCOG1893.
    HOGENOMiHOG000050223.
    KOiK00077.
    OMAiSQCHILL.
    OrthoDBiEOG68SVW3.
    PhylomeDBiQ9HW09.

    Family and domain databases

    Gene3Di1.10.1040.10. 1 hit.
    3.40.50.720. 1 hit.
    InterProiIPR008927. 6-PGluconate_DH_C-like.
    IPR003710. ApbA.
    IPR013328. DH_multihelical.
    IPR013752. KPA_reductase.
    IPR013332. KPR_N.
    IPR016040. NAD(P)-bd_dom.
    [Graphical view]
    PfamiPF02558. ApbA. 1 hit.
    PF08546. ApbA_C. 1 hit.
    [Graphical view]
    SUPFAMiSSF48179. SSF48179. 1 hit.
    TIGRFAMsiTIGR00745. apbA_panE. 1 hit.

    Sequencei

    Sequence statusi: Complete.

    Q9HW09-1 [UniParc]FASTAAdd to Basket

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    MTWHILGAGS LGSLWAARLG RAGLPVRLIL RDRQRLRRYQ QAGGLSLVED    50
    GQASLYPIAA ETPDGGQPIQ RLLLACKAYD AEEAASSVAH RLAGNAELLL 100
    LQNGLGSQQA VAARLPRSRC LFASSTEGAF RDGDFRVVFA GRGHTWLGDP 150
    RDTNAPAWLT QLSQAGIPHS WSDDILERLW RKLALNCAIN PLTVLHDCRN 200
    GGLRQHPEEI AALCDELGQL LHASGYDAAA RSLLEDVRAV IDATAANYSS 250
    MHQDVTRGRR TEIGYLLGYA CQHGQRLGLP LPRLGTLLAR LQAHLRQRGL 300
    PDR 303
    Length:303
    Mass (Da):33,062
    Last modified:March 1, 2001 - v1
    Checksum:i664A30DF3028E1D8
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AE004091 Genomic DNA. Translation: AAG07785.1.
    PIRiE83096.
    RefSeqiNP_253087.1. NC_002516.2.

    Genome annotation databases

    EnsemblBacteriaiAAG07785; AAG07785; PA4397.
    GeneIDi881354.
    KEGGipae:PA4397.
    PATRICi19843517. VBIPseAer58763_4605.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AE004091 Genomic DNA. Translation: AAG07785.1 .
    PIRi E83096.
    RefSeqi NP_253087.1. NC_002516.2.

    3D structure databases

    ProteinModelPortali Q9HW09.
    SMRi Q9HW09. Positions 1-293.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 208964.PA4397.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    EnsemblBacteriai AAG07785 ; AAG07785 ; PA4397 .
    GeneIDi 881354.
    KEGGi pae:PA4397.
    PATRICi 19843517. VBIPseAer58763_4605.

    Organism-specific databases

    PseudoCAPi PA4397.

    Phylogenomic databases

    eggNOGi COG1893.
    HOGENOMi HOG000050223.
    KOi K00077.
    OMAi SQCHILL.
    OrthoDBi EOG68SVW3.
    PhylomeDBi Q9HW09.

    Enzyme and pathway databases

    UniPathwayi UPA00028 ; UER00004 .

    Family and domain databases

    Gene3Di 1.10.1040.10. 1 hit.
    3.40.50.720. 1 hit.
    InterProi IPR008927. 6-PGluconate_DH_C-like.
    IPR003710. ApbA.
    IPR013328. DH_multihelical.
    IPR013752. KPA_reductase.
    IPR013332. KPR_N.
    IPR016040. NAD(P)-bd_dom.
    [Graphical view ]
    Pfami PF02558. ApbA. 1 hit.
    PF08546. ApbA_C. 1 hit.
    [Graphical view ]
    SUPFAMi SSF48179. SSF48179. 1 hit.
    TIGRFAMsi TIGR00745. apbA_panE. 1 hit.
    ProtoNeti Search...

    Publicationsi

    1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: ATCC 15692 / PAO1 / 1C / PRS 101 / LMG 12228.

    Entry informationi

    Entry nameiPANE_PSEAE
    AccessioniPrimary (citable) accession number: Q9HW09
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: February 21, 2002
    Last sequence update: March 1, 2001
    Last modified: October 1, 2014
    This is version 92 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programProkaryotic Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. PATHWAY comments
      Index of metabolic and biosynthesis pathways
    2. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3