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Q9HW09 (PANE_PSEAE) Reviewed, UniProtKB/Swiss-Prot

Last modified July 9, 2014. Version 90. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Probable 2-dehydropantoate 2-reductase

EC=1.1.1.169
Alternative name(s):
Ketopantoate reductase
Short name=KPA reductase
Short name=KPR
Gene names
Name:panE
Ordered Locus Names:PA4397
OrganismPseudomonas aeruginosa (strain ATCC 15692 / PAO1 / 1C / PRS 101 / LMG 12228) [Reference proteome] [HAMAP]
Taxonomic identifier208964 [NCBI]
Taxonomic lineageBacteriaProteobacteriaGammaproteobacteriaPseudomonadalesPseudomonadaceaePseudomonas

Protein attributes

Sequence length303 AA.
Sequence statusComplete.
Protein existenceInferred from homology

General annotation (Comments)

Function

Catalyzes the NADPH-dependent reduction of ketopantoate into pantoic acid.

Catalytic activity

(R)-pantoate + NADP+ = 2-dehydropantoate + NADPH.

Pathway

Cofactor biosynthesis; (R)-pantothenate biosynthesis; (R)-pantoate from 3-methyl-2-oxobutanoate: step 2/2.

Subcellular location

Cytoplasm Potential.

Sequence similarities

Belongs to the ketopantoate reductase family.

Ontologies

Keywords
   Biological processPantothenate biosynthesis
   Cellular componentCytoplasm
   LigandNADP
   Molecular functionOxidoreductase
   Technical termComplete proteome
Reference proteome
Gene Ontology (GO)
   Biological_processpantothenate biosynthetic process

Inferred from electronic annotation. Source: UniProtKB-UniPathway

   Cellular_componentcytoplasm

Inferred from electronic annotation. Source: UniProtKB-SubCell

   Molecular_function2-dehydropantoate 2-reductase activity

Inferred from electronic annotation. Source: UniProtKB-EC

NADP binding

Inferred from electronic annotation. Source: InterPro

Complete GO annotation...

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 303303Probable 2-dehydropantoate 2-reductase
PRO_0000157308

Regions

Nucleotide binding7 – 126NADP By similarity

Sites

Active site1821Proton donor By similarity
Binding site311NADP; via amide nitrogen By similarity
Binding site1031NADP; via amide nitrogen By similarity
Binding site1031Substrate By similarity
Binding site1291NADP; via amide nitrogen and carbonyl oxygen By similarity
Binding site1861Substrate By similarity
Binding site1901Substrate By similarity
Binding site2001Substrate By similarity
Binding site2471Substrate By similarity
Binding site2501Substrate By similarity
Binding site2621NADP By similarity

Sequences

Sequence LengthMass (Da)Tools
Q9HW09 [UniParc].

Last modified March 1, 2001. Version 1.
Checksum: 664A30DF3028E1D8

FASTA30333,062
        10         20         30         40         50         60 
MTWHILGAGS LGSLWAARLG RAGLPVRLIL RDRQRLRRYQ QAGGLSLVED GQASLYPIAA 

        70         80         90        100        110        120 
ETPDGGQPIQ RLLLACKAYD AEEAASSVAH RLAGNAELLL LQNGLGSQQA VAARLPRSRC 

       130        140        150        160        170        180 
LFASSTEGAF RDGDFRVVFA GRGHTWLGDP RDTNAPAWLT QLSQAGIPHS WSDDILERLW 

       190        200        210        220        230        240 
RKLALNCAIN PLTVLHDCRN GGLRQHPEEI AALCDELGQL LHASGYDAAA RSLLEDVRAV 

       250        260        270        280        290        300 
IDATAANYSS MHQDVTRGRR TEIGYLLGYA CQHGQRLGLP LPRLGTLLAR LQAHLRQRGL 


PDR 

« Hide

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
AE004091 Genomic DNA. Translation: AAG07785.1.
PIRE83096.
RefSeqNP_253087.1. NC_002516.2.

3D structure databases

ProteinModelPortalQ9HW09.
SMRQ9HW09. Positions 1-293.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

STRING208964.PA4397.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaAAG07785; AAG07785; PA4397.
GeneID881354.
KEGGpae:PA4397.
PATRIC19843517. VBIPseAer58763_4605.

Organism-specific databases

PseudoCAPPA4397.

Phylogenomic databases

eggNOGCOG1893.
HOGENOMHOG000050223.
KOK00077.
OMASQCHILL.
OrthoDBEOG68SVW3.
PhylomeDBQ9HW09.

Enzyme and pathway databases

UniPathwayUPA00028; UER00004.

Family and domain databases

Gene3D1.10.1040.10. 1 hit.
3.40.50.720. 1 hit.
InterProIPR008927. 6-PGluconate_DH_C-like.
IPR003710. ApbA.
IPR013752. ApbA_C.
IPR013332. ApbA_N.
IPR013328. DH_multihelical.
IPR016040. NAD(P)-bd_dom.
[Graphical view]
PfamPF02558. ApbA. 1 hit.
PF08546. ApbA_C. 1 hit.
[Graphical view]
SUPFAMSSF48179. SSF48179. 1 hit.
TIGRFAMsTIGR00745. apbA_panE. 1 hit.
ProtoNetSearch...

Entry information

Entry namePANE_PSEAE
AccessionPrimary (citable) accession number: Q9HW09
Entry history
Integrated into UniProtKB/Swiss-Prot: February 21, 2002
Last sequence update: March 1, 2001
Last modified: July 9, 2014
This is version 90 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families

PATHWAY comments

Index of metabolic and biosynthesis pathways