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Protein

Probable 2-dehydropantoate 2-reductase

Gene

panE

Organism
Pseudomonas aeruginosa (strain ATCC 15692 / PAO1 / 1C / PRS 101 / LMG 12228)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Protein inferred from homologyi

Functioni

Catalyzes the NADPH-dependent reduction of ketopantoate into pantoic acid.

Catalytic activityi

(R)-pantoate + NADP+ = 2-dehydropantoate + NADPH.

Pathwayi

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Binding sitei31 – 311NADP; via amide nitrogenBy similarity
Binding sitei103 – 1031NADP; via amide nitrogenBy similarity
Binding sitei103 – 1031SubstrateBy similarity
Binding sitei129 – 1291NADP; via amide nitrogen and carbonyl oxygenBy similarity
Active sitei182 – 1821Proton donorBy similarity
Binding sitei186 – 1861SubstrateBy similarity
Binding sitei190 – 1901SubstrateBy similarity
Binding sitei200 – 2001SubstrateBy similarity
Binding sitei247 – 2471SubstrateBy similarity
Binding sitei250 – 2501SubstrateBy similarity
Binding sitei262 – 2621NADPBy similarity

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Nucleotide bindingi7 – 126NADPBy similarity

GO - Molecular functioni

  1. 2-dehydropantoate 2-reductase activity Source: UniProtKB-EC
  2. NADP binding Source: InterPro

GO - Biological processi

  1. pantothenate biosynthetic process Source: UniProtKB-UniPathway
Complete GO annotation...

Keywords - Molecular functioni

Oxidoreductase

Keywords - Biological processi

Pantothenate biosynthesis

Keywords - Ligandi

NADP

Enzyme and pathway databases

UniPathwayiUPA00028; UER00004.

Names & Taxonomyi

Protein namesi
Recommended name:
Probable 2-dehydropantoate 2-reductase (EC:1.1.1.169)
Alternative name(s):
Ketopantoate reductase
Short name:
KPA reductase
Short name:
KPR
Gene namesi
Name:panE
Ordered Locus Names:PA4397
OrganismiPseudomonas aeruginosa (strain ATCC 15692 / PAO1 / 1C / PRS 101 / LMG 12228)
Taxonomic identifieri208964 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaPseudomonadalesPseudomonadaceaePseudomonas
ProteomesiUP000002438: Chromosome

Organism-specific databases

PseudoCAPiPA4397.

Subcellular locationi

Cytoplasm Curated

GO - Cellular componenti

  1. cytoplasm Source: UniProtKB-SubCell
Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 303303Probable 2-dehydropantoate 2-reductasePRO_0000157308Add
BLAST

Interactioni

Protein-protein interaction databases

STRINGi208964.PA4397.

Structurei

3D structure databases

ProteinModelPortaliQ9HW09.
SMRiQ9HW09. Positions 1-293.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the ketopantoate reductase family.Curated

Phylogenomic databases

eggNOGiCOG1893.
HOGENOMiHOG000050223.
InParanoidiQ9HW09.
KOiK00077.
OMAiMTWHILG.
OrthoDBiEOG68SVW3.
PhylomeDBiQ9HW09.

Family and domain databases

Gene3Di1.10.1040.10. 1 hit.
3.40.50.720. 1 hit.
InterProiIPR008927. 6-PGluconate_DH_C-like.
IPR003710. ApbA.
IPR013328. DH_multihelical.
IPR013752. KPA_reductase.
IPR013332. KPR_N.
IPR016040. NAD(P)-bd_dom.
[Graphical view]
PfamiPF02558. ApbA. 1 hit.
PF08546. ApbA_C. 1 hit.
[Graphical view]
SUPFAMiSSF48179. SSF48179. 1 hit.
TIGRFAMsiTIGR00745. apbA_panE. 1 hit.

Sequencei

Sequence statusi: Complete.

Q9HW09-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MTWHILGAGS LGSLWAARLG RAGLPVRLIL RDRQRLRRYQ QAGGLSLVED
60 70 80 90 100
GQASLYPIAA ETPDGGQPIQ RLLLACKAYD AEEAASSVAH RLAGNAELLL
110 120 130 140 150
LQNGLGSQQA VAARLPRSRC LFASSTEGAF RDGDFRVVFA GRGHTWLGDP
160 170 180 190 200
RDTNAPAWLT QLSQAGIPHS WSDDILERLW RKLALNCAIN PLTVLHDCRN
210 220 230 240 250
GGLRQHPEEI AALCDELGQL LHASGYDAAA RSLLEDVRAV IDATAANYSS
260 270 280 290 300
MHQDVTRGRR TEIGYLLGYA CQHGQRLGLP LPRLGTLLAR LQAHLRQRGL

PDR
Length:303
Mass (Da):33,062
Last modified:March 1, 2001 - v1
Checksum:i664A30DF3028E1D8
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AE004091 Genomic DNA. Translation: AAG07785.1.
PIRiE83096.
RefSeqiNP_253087.1. NC_002516.2.

Genome annotation databases

EnsemblBacteriaiAAG07785; AAG07785; PA4397.
GeneIDi881354.
KEGGipae:PA4397.
PATRICi19843517. VBIPseAer58763_4605.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AE004091 Genomic DNA. Translation: AAG07785.1.
PIRiE83096.
RefSeqiNP_253087.1. NC_002516.2.

3D structure databases

ProteinModelPortaliQ9HW09.
SMRiQ9HW09. Positions 1-293.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi208964.PA4397.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaiAAG07785; AAG07785; PA4397.
GeneIDi881354.
KEGGipae:PA4397.
PATRICi19843517. VBIPseAer58763_4605.

Organism-specific databases

PseudoCAPiPA4397.

Phylogenomic databases

eggNOGiCOG1893.
HOGENOMiHOG000050223.
InParanoidiQ9HW09.
KOiK00077.
OMAiMTWHILG.
OrthoDBiEOG68SVW3.
PhylomeDBiQ9HW09.

Enzyme and pathway databases

UniPathwayiUPA00028; UER00004.

Family and domain databases

Gene3Di1.10.1040.10. 1 hit.
3.40.50.720. 1 hit.
InterProiIPR008927. 6-PGluconate_DH_C-like.
IPR003710. ApbA.
IPR013328. DH_multihelical.
IPR013752. KPA_reductase.
IPR013332. KPR_N.
IPR016040. NAD(P)-bd_dom.
[Graphical view]
PfamiPF02558. ApbA. 1 hit.
PF08546. ApbA_C. 1 hit.
[Graphical view]
SUPFAMiSSF48179. SSF48179. 1 hit.
TIGRFAMsiTIGR00745. apbA_panE. 1 hit.
ProtoNetiSearch...

Publicationsi

  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: ATCC 15692 / PAO1 / 1C / PRS 101 / LMG 12228.

Entry informationi

Entry nameiPANE_PSEAE
AccessioniPrimary (citable) accession number: Q9HW09
Entry historyi
Integrated into UniProtKB/Swiss-Prot: February 21, 2002
Last sequence update: March 1, 2001
Last modified: January 7, 2015
This is version 94 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.