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Q9HVX6 (SYW_PSEAE) Reviewed, UniProtKB/Swiss-Prot

Last modified July 9, 2014. Version 74. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Tryptophan--tRNA ligase

EC=6.1.1.2
Alternative name(s):
Tryptophanyl-tRNA synthetase
Short name=TrpRS
Gene names
Name:trpS
Ordered Locus Names:PA4439
OrganismPseudomonas aeruginosa (strain ATCC 15692 / PAO1 / 1C / PRS 101 / LMG 12228) [Reference proteome] [HAMAP]
Taxonomic identifier208964 [NCBI]
Taxonomic lineageBacteriaProteobacteriaGammaproteobacteriaPseudomonadalesPseudomonadaceaePseudomonas

Protein attributes

Sequence length448 AA.
Sequence statusComplete.
Protein existenceInferred from homology

General annotation (Comments)

Catalytic activity

ATP + L-tryptophan + tRNA(Trp) = AMP + diphosphate + L-tryptophyl-tRNA(Trp). HAMAP-Rule MF_00140

Subunit structure

Homodimer By similarity. HAMAP-Rule MF_00140

Subcellular location

Cytoplasm By similarity HAMAP-Rule MF_00140.

Sequence similarities

Belongs to the class-I aminoacyl-tRNA synthetase family.

Ontologies

Keywords
   Biological processProtein biosynthesis
   Cellular componentCytoplasm
   LigandATP-binding
Nucleotide-binding
   Molecular functionAminoacyl-tRNA synthetase
Ligase
   Technical termComplete proteome
Reference proteome
Gene Ontology (GO)
   Biological_processtryptophanyl-tRNA aminoacylation

Inferred from electronic annotation. Source: UniProtKB-HAMAP

   Cellular_componentcytoplasm

Inferred from electronic annotation. Source: UniProtKB-SubCell

   Molecular_functionATP binding

Inferred from electronic annotation. Source: UniProtKB-HAMAP

tryptophan-tRNA ligase activity

Inferred from electronic annotation. Source: UniProtKB-HAMAP

Complete GO annotation...

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 448448Tryptophan--tRNA ligase HAMAP-Rule MF_00140
PRO_0000136662

Regions

Motif11 – 199"HIGH" region HAMAP-Rule MF_00140
Motif204 – 2085"KMSKS" region HAMAP-Rule MF_00140

Sites

Binding site2071ATP By similarity

Sequences

Sequence LengthMass (Da)Tools
Q9HVX6 [UniParc].

Last modified March 1, 2001. Version 1.
Checksum: FA82ECA10A049A84

FASTA44848,962
        10         20         30         40         50         60 
MTTRILTGIT PTGTPHLGNY AGAIRPAILA SRRSDVDSFY FLADYHALIK CDDPARIQRS 

        70         80         90        100        110        120 
RLEIAATWLA GGLDVERATF YRQSDIPEIP ELTWLLTCVS AKGLLNRAHA YKAAVDRNVE 

       130        140        150        160        170        180 
AGEDPDAGVT MGLYSYPVLM AADILMFNAH KIPVGRDQVQ HVEMARDIGQ RFNHLFGNGR 

       190        200        210        220        230        240 
EFFVLPEAVI EENVATLPGL DGRKMSKSYD NTIPLFSPSR QLKDAIARIV TDSRAPGEPK 

       250        260        270        280        290        300 
DPDSSHLFLL YSAFASAEQV AAFRQELLEG LAWGEAKQRL FQLLDNELGE ARERYQALIA 

       310        320        330        340        350        360 
KPDDIEDILL AGAAKARRIA TPFIAELREA VGLRSLREPL KSAESGKKKA AKAARLVSFR 

       370        380        390        400        410        420 
DDDGSFRFRL LDAAGEQLLL SRAFADGKAA GAVSKRLLAG ETADLRAEGN AFGLWLDGEA 

       430        440 
VAQSPAFADA AARDAAIERT REALAPQE 

« Hide

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
AE004091 Genomic DNA. Translation: AAG07827.1.
PIRA83091.
RefSeqNP_253129.1. NC_002516.2.

3D structure databases

ProteinModelPortalQ9HVX6.
SMRQ9HVX6. Positions 4-333.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

STRING208964.PA4439.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaAAG07827; AAG07827; PA4439.
GeneID880958.
KEGGpae:PA4439.
PATRIC19843603. VBIPseAer58763_4648.

Organism-specific databases

PseudoCAPPA4439.

Phylogenomic databases

eggNOGCOG0180.
HOGENOMHOG000059939.
KOK01867.
OMALELYWIL.
OrthoDBEOG686NJQ.
PhylomeDBQ9HVX6.

Family and domain databases

Gene3D3.40.50.620. 1 hit.
HAMAPMF_00140_B. Trp_tRNA_synth_B.
InterProIPR001412. aa-tRNA-synth_I_CS.
IPR002305. aa-tRNA-synth_Ic.
IPR014729. Rossmann-like_a/b/a_fold.
IPR002306. Trp-tRNA-ligase.
IPR024109. Trp-tRNA-ligase_bac-type.
[Graphical view]
PANTHERPTHR10055. PTHR10055. 1 hit.
PfamPF00579. tRNA-synt_1b. 1 hit.
[Graphical view]
PRINTSPR01039. TRNASYNTHTRP.
TIGRFAMsTIGR00233. trpS. 1 hit.
PROSITEPS00178. AA_TRNA_LIGASE_I. 1 hit.
[Graphical view]
ProtoNetSearch...

Entry information

Entry nameSYW_PSEAE
AccessionPrimary (citable) accession number: Q9HVX6
Entry history
Integrated into UniProtKB/Swiss-Prot: November 8, 2002
Last sequence update: March 1, 2001
Last modified: July 9, 2014
This is version 74 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families

Aminoacyl-tRNA synthetases

List of aminoacyl-tRNA synthetase entries