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Protein

Histidinol dehydrogenase

Gene

hisD

Organism
Pseudomonas aeruginosa (strain ATCC 15692 / PAO1 / 1C / PRS 101 / LMG 12228)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Protein inferred from homologyi

Functioni

Catalyzes the sequential NAD-dependent oxidations of L-histidinol to L-histidinaldehyde and then to L-histidine.UniRule annotation

Catalytic activityi

L-histidinol + H2O + 2 NAD+ = L-histidine + 2 NADH.UniRule annotation

Cofactori

Zn2+UniRule annotationNote: Binds 1 zinc ion per subunit.UniRule annotation

Pathwayi

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Binding sitei136 – 1361NADUniRule annotation
Binding sitei197 – 1971NADUniRule annotation
Binding sitei220 – 2201NADUniRule annotation
Binding sitei243 – 2431SubstrateUniRule annotation
Metal bindingi265 – 2651ZincUniRule annotation
Binding sitei265 – 2651SubstrateUniRule annotation
Metal bindingi268 – 2681ZincUniRule annotation
Binding sitei268 – 2681SubstrateUniRule annotation
Active sitei333 – 3331Proton acceptorUniRule annotation
Active sitei334 – 3341Proton acceptorUniRule annotation
Binding sitei334 – 3341SubstrateUniRule annotation
Metal bindingi367 – 3671ZincUniRule annotation
Binding sitei367 – 3671SubstrateUniRule annotation
Binding sitei421 – 4211SubstrateUniRule annotation
Metal bindingi426 – 4261ZincUniRule annotation
Binding sitei426 – 4261SubstrateUniRule annotation

GO - Molecular functioni

  1. histidinol dehydrogenase activity Source: UniProtKB-HAMAP
  2. NAD binding Source: InterPro
  3. zinc ion binding Source: UniProtKB-HAMAP

GO - Biological processi

  1. histidine biosynthetic process Source: UniProtKB-HAMAP
Complete GO annotation...

Keywords - Molecular functioni

Oxidoreductase

Keywords - Biological processi

Amino-acid biosynthesis, Histidine biosynthesis

Keywords - Ligandi

Metal-binding, NAD, Zinc

Enzyme and pathway databases

UniPathwayiUPA00031; UER00014.

Names & Taxonomyi

Protein namesi
Recommended name:
Histidinol dehydrogenaseUniRule annotation (EC:1.1.1.23UniRule annotation)
Short name:
HDHUniRule annotation
Gene namesi
Name:hisDUniRule annotation
Ordered Locus Names:PA4448
OrganismiPseudomonas aeruginosa (strain ATCC 15692 / PAO1 / 1C / PRS 101 / LMG 12228)
Taxonomic identifieri208964 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaPseudomonadalesPseudomonadaceaePseudomonas
ProteomesiUP000002438: Chromosome

Organism-specific databases

PseudoCAPiPA4448.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 440440Histidinol dehydrogenasePRO_0000135819Add
BLAST

Interactioni

Protein-protein interaction databases

STRINGi208964.PA4448.

Structurei

3D structure databases

ProteinModelPortaliQ9HVW9.
SMRiQ9HVW9. Positions 7-403.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the histidinol dehydrogenase family.UniRule annotation

Phylogenomic databases

eggNOGiCOG0141.
HOGENOMiHOG000243914.
InParanoidiQ9HVW9.
KOiK00013.
OMAiLSVQSFL.
OrthoDBiEOG6CVVCR.
PhylomeDBiQ9HVW9.

Family and domain databases

HAMAPiMF_01024. HisD.
InterProiIPR016161. Ald_DH/histidinol_DH.
IPR001692. Histidinol_DH_CS.
IPR022695. Histidinol_DH_monofunct.
IPR012131. Hstdl_DH.
[Graphical view]
PfamiPF00815. Histidinol_dh. 1 hit.
[Graphical view]
PIRSFiPIRSF000099. Histidinol_dh. 1 hit.
PRINTSiPR00083. HOLDHDRGNASE.
SUPFAMiSSF53720. SSF53720. 1 hit.
TIGRFAMsiTIGR00069. hisD. 1 hit.
PROSITEiPS00611. HISOL_DEHYDROGENASE. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q9HVW9-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MTAPFAIRRL NAADPDFGRH LDHLLSWESV SDDSVNQRVL DIIAAVRSRG
60 70 80 90 100
DAAVVEFTQR FDGLQAASMA DLILPRERLE LALTRITVAQ REALEVAAER
110 120 130 140 150
VRSYHEKQKQ GSWRYTEADG TVLGQQVTPL DRAGLYVPGG KASYPSSVLM
160 170 180 190 200
NAIPAKVAGV SEVVMVVPTP RGEINEIVLA AACIAGVDRV FTIGGAQAVA
210 220 230 240 250
ALAYGTESVP RVDKIVGPGN IYVATAKRHV FGQVGIDMIA GPSEILVVCD
260 270 280 290 300
GQTDPDWIAM DLFSQAEHDE DAQSILVSPD AAFLDRVADS IARLLPTMER
310 320 330 340 350
AEIIRTSLEG RGALIQVADQ AQACAVANRI APEHLELSVA DPESWLPEIR
360 370 380 390 400
HAGAIFMGRY TAEALGDYCA GPNHVLPTSG TARFSSPLGV YDFQKRSSII
410 420 430 440
NCSAEGASVL GRTASVLARG ESLTAHARSA EYRILDEKEA
Length:440
Mass (Da):47,179
Last modified:March 1, 2001 - v1
Checksum:i4620B34F7177C98C
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AE004091 Genomic DNA. Translation: AAG07836.1.
PIRiD83089.
RefSeqiNP_253138.1. NC_002516.2.

Genome annotation databases

EnsemblBacteriaiAAG07836; AAG07836; PA4448.
GeneIDi880992.
KEGGipae:PA4448.
PATRICi19843621. VBIPseAer58763_4657.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AE004091 Genomic DNA. Translation: AAG07836.1.
PIRiD83089.
RefSeqiNP_253138.1. NC_002516.2.

3D structure databases

ProteinModelPortaliQ9HVW9.
SMRiQ9HVW9. Positions 7-403.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi208964.PA4448.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaiAAG07836; AAG07836; PA4448.
GeneIDi880992.
KEGGipae:PA4448.
PATRICi19843621. VBIPseAer58763_4657.

Organism-specific databases

PseudoCAPiPA4448.

Phylogenomic databases

eggNOGiCOG0141.
HOGENOMiHOG000243914.
InParanoidiQ9HVW9.
KOiK00013.
OMAiLSVQSFL.
OrthoDBiEOG6CVVCR.
PhylomeDBiQ9HVW9.

Enzyme and pathway databases

UniPathwayiUPA00031; UER00014.

Family and domain databases

HAMAPiMF_01024. HisD.
InterProiIPR016161. Ald_DH/histidinol_DH.
IPR001692. Histidinol_DH_CS.
IPR022695. Histidinol_DH_monofunct.
IPR012131. Hstdl_DH.
[Graphical view]
PfamiPF00815. Histidinol_dh. 1 hit.
[Graphical view]
PIRSFiPIRSF000099. Histidinol_dh. 1 hit.
PRINTSiPR00083. HOLDHDRGNASE.
SUPFAMiSSF53720. SSF53720. 1 hit.
TIGRFAMsiTIGR00069. hisD. 1 hit.
PROSITEiPS00611. HISOL_DEHYDROGENASE. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: ATCC 15692 / PAO1 / 1C / PRS 101 / LMG 12228.

Entry informationi

Entry nameiHISX_PSEAE
AccessioniPrimary (citable) accession number: Q9HVW9
Entry historyi
Integrated into UniProtKB/Swiss-Prot: March 25, 2003
Last sequence update: March 1, 2001
Last modified: January 7, 2015
This is version 92 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.