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Protein

Probable malate:quinone oxidoreductase 2

Gene

mqo2

Organism
Pseudomonas aeruginosa (strain ATCC 15692 / DSM 22644 / CIP 104116 / JCM 14847 / LMG 12228 / 1C / PRS 101 / PAO1)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Protein inferred from homologyi

Functioni

Catalytic activityi

(S)-malate + a quinone = oxaloacetate + reduced quinone.UniRule annotation

Cofactori

FADUniRule annotation

Pathwayi: tricarboxylic acid cycle

This protein is involved in step 1 of the subpathway that synthesizes oxaloacetate from (S)-malate (quinone route).UniRule annotation
Proteins known to be involved in this subpathway in this organism are:
  1. Probable malate:quinone oxidoreductase 1 (mqo1), Probable malate:quinone oxidoreductase 2 (mqo2)
This subpathway is part of the pathway tricarboxylic acid cycle, which is itself part of Carbohydrate metabolism.
View all proteins of this organism that are known to be involved in the subpathway that synthesizes oxaloacetate from (S)-malate (quinone route), the pathway tricarboxylic acid cycle and in Carbohydrate metabolism.

GO - Molecular functioni

GO - Biological processi

  • ethanol oxidation Source: PseudoCAP
  • tricarboxylic acid cycle Source: UniProtKB-HAMAP
Complete GO annotation...

Keywords - Molecular functioni

Oxidoreductase

Keywords - Biological processi

Tricarboxylic acid cycle

Keywords - Ligandi

FAD, Flavoprotein

Enzyme and pathway databases

BRENDAi1.1.5.4. 5087.
UniPathwayiUPA00223; UER01008.

Names & Taxonomyi

Protein namesi
Recommended name:
Probable malate:quinone oxidoreductase 2UniRule annotation (EC:1.1.5.4UniRule annotation)
Alternative name(s):
MQO 2UniRule annotation
Malate dehydrogenase [quinone] 2UniRule annotation
Gene namesi
Name:mqo2UniRule annotation
Synonyms:mqoB
Ordered Locus Names:PA4640
OrganismiPseudomonas aeruginosa (strain ATCC 15692 / DSM 22644 / CIP 104116 / JCM 14847 / LMG 12228 / 1C / PRS 101 / PAO1)
Taxonomic identifieri208964 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaPseudomonadalesPseudomonadaceaePseudomonas
Proteomesi
  • UP000002438 Componenti: Chromosome

Organism-specific databases

PseudoCAPiPA4640.

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001287301 – 507Probable malate:quinone oxidoreductase 2Add BLAST507

Proteomic databases

PaxDbiQ9HVF1.
PRIDEiQ9HVF1.

Interactioni

Protein-protein interaction databases

STRINGi208964.PA4640.

Structurei

3D structure databases

ProteinModelPortaliQ9HVF1.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the MQO family.UniRule annotation

Phylogenomic databases

eggNOGiENOG4105DWT. Bacteria.
COG0579. LUCA.
HOGENOMiHOG000109379.
InParanoidiQ9HVF1.
KOiK00116.
OMAiEAKAEDW.
PhylomeDBiQ9HVF1.

Family and domain databases

Gene3Di3.50.50.60. 2 hits.
HAMAPiMF_00212. MQO. 1 hit.
InterProiIPR023753. FAD/NAD-binding_dom.
IPR006231. MQO.
[Graphical view]
PfamiPF06039. Mqo. 1 hit.
[Graphical view]
SUPFAMiSSF51905. SSF51905. 1 hit.
TIGRFAMsiTIGR01320. mal_quin_oxido. 1 hit.

Sequencei

Sequence statusi: Complete.

Q9HVF1-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MAQNDHETVD MLLVGAGIMS ATLAVLLKEL DPNLKMEVVE LQESGAIESS
60 70 80 90 100
NPWNNAGTGH AGLCELNYTP QSADGSIDIK KAVGINTMFE VSKQFWSHLV
110 120 130 140 150
AKGTFGSPKT FINPVPHLSF VRGSEGIAYL KKRFESLTKH HAFETMVYSE
160 170 180 190 200
DKATLAEWMP LMMPGRPADE AIAATRVEGG TDVNFGALTN QLLQHLAQQP
210 220 230 240 250
GAQIRYNQKV THLRRADNGW RVTVKDTRNG GDREIQARFV FLGAGGGALP
260 270 280 290 300
LLQLSGIPEG KGFGGFPVSG QWLRCDNPEI VKQHQAKVYS QAEVGSPPMS
310 320 330 340 350
VPHLDTRVVD GKKSLLFGPY AGFSTKFLRH GSFLDLPLSV RPGNILPMLS
360 370 380 390 400
VARDNMDLTR YLIGQVMQSP EQRLEALRKF YPEARAEDWR LEVAGQRVQI
410 420 430 440 450
IKKDPKKGGI LQFGTELVAA HDGSIAALLG ASPGASVTVS IMLGLIERCF
460 470 480 490 500
PEQARSPEWS AKLKEIFPAR EKELESDAEL YRSVSSRCSE VLELTAKNDV

QAPVNAE
Length:507
Mass (Da):55,498
Last modified:March 1, 2001 - v1
Checksum:i0A7F91E4172CAA8D
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AY129296 Genomic DNA. Translation: AAN01356.1.
AE004091 Genomic DNA. Translation: AAG08028.1.
PIRiG83065.
RefSeqiNP_253330.1. NC_002516.2.
WP_003099345.1. NZ_ASJY01000743.1.

Genome annotation databases

EnsemblBacteriaiAAG08028; AAG08028; PA4640.
GeneIDi881249.
KEGGipae:PA4640.
PATRICi19844039. VBIPseAer58763_4861.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AY129296 Genomic DNA. Translation: AAN01356.1.
AE004091 Genomic DNA. Translation: AAG08028.1.
PIRiG83065.
RefSeqiNP_253330.1. NC_002516.2.
WP_003099345.1. NZ_ASJY01000743.1.

3D structure databases

ProteinModelPortaliQ9HVF1.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi208964.PA4640.

Proteomic databases

PaxDbiQ9HVF1.
PRIDEiQ9HVF1.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaiAAG08028; AAG08028; PA4640.
GeneIDi881249.
KEGGipae:PA4640.
PATRICi19844039. VBIPseAer58763_4861.

Organism-specific databases

PseudoCAPiPA4640.

Phylogenomic databases

eggNOGiENOG4105DWT. Bacteria.
COG0579. LUCA.
HOGENOMiHOG000109379.
InParanoidiQ9HVF1.
KOiK00116.
OMAiEAKAEDW.
PhylomeDBiQ9HVF1.

Enzyme and pathway databases

UniPathwayiUPA00223; UER01008.
BRENDAi1.1.5.4. 5087.

Family and domain databases

Gene3Di3.50.50.60. 2 hits.
HAMAPiMF_00212. MQO. 1 hit.
InterProiIPR023753. FAD/NAD-binding_dom.
IPR006231. MQO.
[Graphical view]
PfamiPF06039. Mqo. 1 hit.
[Graphical view]
SUPFAMiSSF51905. SSF51905. 1 hit.
TIGRFAMsiTIGR01320. mal_quin_oxido. 1 hit.
ProtoNetiSearch...

Entry informationi

Entry nameiMQO2_PSEAE
AccessioniPrimary (citable) accession number: Q9HVF1
Entry historyi
Integrated into UniProtKB/Swiss-Prot: November 1, 2002
Last sequence update: March 1, 2001
Last modified: November 2, 2016
This is version 90 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.