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Q9HVC3 (PTH_PSEAE) Reviewed, UniProtKB/Swiss-Prot

Last modified May 1, 2013. Version 74. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data text xml rdf/xml gff fasta
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Names and origin

Protein namesRecommended name:
Peptidyl-tRNA hydrolase
Short name=PTH
EC=3.1.1.29
Gene names
Name:pth
Ordered Locus Names:PA4672
OrganismPseudomonas aeruginosa (strain ATCC 15692 / PAO1 / 1C / PRS 101 / LMG 12228) [Reference proteome] [HAMAP]
Taxonomic identifier208964 [NCBI]
Taxonomic lineageBacteria › Proteobacteria › Gammaproteobacteria › Pseudomonadales › Pseudomonadaceae › Pseudomonas ›

Protein attributes

Sequence length194 AA.
Sequence statusComplete.
Protein existenceEvidence at protein level

General annotation (Comments)

Function

The natural substrate for this enzyme may be peptidyl-tRNAs which drop off the ribosome during protein synthesis By similarity. HAMAP-Rule MF_00083

Catalytic activity

N-substituted aminoacyl-tRNA + H2O = N-substituted amino acid + tRNA. HAMAP-Rule MF_00083

Subunit structure

Monomer By similarity.

Subcellular location

Cytoplasm By similarity.

Sequence similarities

Belongs to the PTH family.

Ontologies

Keywords
   Cellular componentCytoplasm
   Molecular functionHydrolase
   Technical term3D-structure
Complete proteome
Reference proteome
Gene Ontology (GO)
   Biological_processtranslation

Inferred from electronic annotation. Source: HAMAP

   Cellular_componentcytoplasm

Inferred from electronic annotation. Source: UniProtKB-SubCell

   Molecular_functionaminoacyl-tRNA hydrolase activity

Inferred from electronic annotation. Source: HAMAP

Complete GO annotation...

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 194194Peptidyl-tRNA hydrolase HAMAP-Rule MF_00083
PRO_0000187796

Secondary structure

1 ...................................... 194
Helix Strand Turn

Details...

Sequences

Sequence LengthMass (Da)Tools
Q9HVC3 [UniParc].

Last modified March 1, 2001. Version 1.
Checksum: A6E14ECBF84B61AA

FASTA19420,804
        10         20         30         40         50         60 
MTAVQLIVGL GNPGPEYDQT RHNAGALFVE RLAHAQGVSL VADRKYFGLV GKFSHQGKDV 

        70         80         90        100        110        120 
RLLIPTTYMN RSGQSVAALA GFFRIAPDAI LVAHDELDMP PGVAKLKTGG GHGGHNGLRD 

       130        140        150        160        170        180 
IIAQLGNQNS FHRLRLGIGH PGHSSLVSGY VLGRAPRSEQ ELLDTSIDFA LGVLPEMLAG 

       190 
DWTRAMQKLH SQKA

« Hide

Cross-references

Sequence databases

EMBL
GenBank
DDBJ		AE004091 Genomic DNA. Translation: AAG08059.1.
PIRH83060.
RefSeqNP_253361.1. NC_002516.2.

3D structure databases

PDBe
RCSB PDB
PDBj
EntryMethodResolution (Å)ChainPositionsPDBsum
4DHWX-ray2.43A/B1-194[»]
4DJJX-ray2.94A/B1-194[»]
4ERXX-ray2.50A/B1-194[»]
4FNOX-ray2.25A/B1-194[»]
4FYJX-ray1.77A2-193[»]
ProteinModelPortalQ9HVC3.
SMRQ9HVC3. Positions 1-194.
ModBaseSearch...

Protein-protein interaction databases

STRING208964.PA4672.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

GeneID881396.
KEGGpae:PA4672.
PATRIC19844107. VBIPseAer58763_4894.

Organism-specific databases

PseudoCAPPA4672.

Phylogenomic databases

eggNOGCOG0193.
HOGENOMHOG000004796.
KOK01056.
OMAIKFKTGG.
ProtClustDBPRK05426.

Family and domain databases

Gene3D3.40.50.1470. 1 hit.
HAMAPMF_00083. Pept_tRNA_hydro_bact.
InterProIPR001328. Pept_tRNA_hydro.
IPR018171. Pept_tRNA_hydro_CS.
[Graphical view]
PANTHERPTHR17224. PTHR17224. 1 hit.
PfamPF01195. Pept_tRNA_hydro. 1 hit.
[Graphical view]
SUPFAMSSF53178. Pept_tRNA_hydro. 1 hit.
TIGRFAMsTIGR00447. pth. 1 hit.
PROSITEPS01195. PEPT_TRNA_HYDROL_1. 1 hit.
PS01196. PEPT_TRNA_HYDROL_2. 1 hit.
[Graphical view]
ProtoNetSearch...

Entry information

Entry namePTH_PSEAE
AccessionPrimary (citable) accession number: Q9HVC3
Entry history
Integrated into UniProtKB/Swiss-Prot: June 1, 2001
Last sequence update: March 1, 2001
Last modified: May 1, 2013
This is version 74 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Relevant documents

PDB cross-references

Index of Protein Data Bank (PDB) cross-references

SIMILARITY comments

Index of protein domains and families

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