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Protein

Peptidyl-tRNA hydrolase

Gene

pth

Organism
Pseudomonas aeruginosa (strain ATCC 15692 / DSM 22644 / CIP 104116 / JCM 14847 / LMG 12228 / 1C / PRS 101 / PAO1)
Status
Reviewed-Annotation score: Annotation score: 2 out of 5-Experimental evidence at protein leveli

Functioni

The natural substrate for this enzyme may be peptidyl-tRNAs which drop off the ribosome during protein synthesis.UniRule annotation

Catalytic activityi

N-substituted aminoacyl-tRNA + H2O = N-substituted amino acid + tRNA.UniRule annotation

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Hydrolase

Names & Taxonomyi

Protein namesi
Recommended name:
Peptidyl-tRNA hydrolaseUniRule annotation (EC:3.1.1.29UniRule annotation)
Short name:
PTHUniRule annotation
Gene namesi
Name:pthUniRule annotation
Ordered Locus Names:PA4672
OrganismiPseudomonas aeruginosa (strain ATCC 15692 / DSM 22644 / CIP 104116 / JCM 14847 / LMG 12228 / 1C / PRS 101 / PAO1)
Taxonomic identifieri208964 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaPseudomonadalesPseudomonadaceaePseudomonas
Proteomesi
  • UP000002438 Componenti: Chromosome

Organism-specific databases

PseudoCAPiPA4672.

Subcellular locationi

  • Cytoplasm UniRule annotation

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001877961 – 194Peptidyl-tRNA hydrolaseAdd BLAST194

Proteomic databases

PaxDbiQ9HVC3.

Interactioni

Subunit structurei

Monomer.UniRule annotation

Protein-protein interaction databases

STRINGi208964.PA4672.

Structurei

Secondary structure

1194
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details
Feature keyPosition(s)DescriptionActionsGraphical viewLength
Beta strandi6 – 9Combined sources4
Helixi15 – 17Combined sources3
Helixi21 – 23Combined sources3
Helixi24 – 35Combined sources12
Beta strandi41 – 43Combined sources3
Helixi44 – 46Combined sources3
Beta strandi48 – 55Combined sources8
Beta strandi58 – 65Combined sources8
Helixi69 – 71Combined sources3
Helixi72 – 83Combined sources12
Helixi87 – 89Combined sources3
Beta strandi90 – 96Combined sources7
Beta strandi104 – 109Combined sources6
Helixi116 – 124Combined sources9
Beta strandi127 – 129Combined sources3
Beta strandi131 – 137Combined sources7
Helixi144 – 146Combined sources3
Helixi147 – 151Combined sources5
Helixi157 – 172Combined sources16
Helixi174 – 179Combined sources6
Helixi182 – 190Combined sources9

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
4DHWX-ray2.43A/B1-194[»]
4DJJX-ray2.94A/B1-194[»]
4ERXX-ray2.50A/B1-194[»]
4FNOX-ray2.25A/B1-194[»]
4FYJX-ray1.77A2-193[»]
4JC4X-ray2.25A1-194[»]
4QAJX-ray1.50A1-194[»]
4QBKX-ray1.77A1-194[»]
4QD3X-ray1.89A1-194[»]
ProteinModelPortaliQ9HVC3.
SMRiQ9HVC3.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the PTH family.UniRule annotation

Phylogenomic databases

eggNOGiENOG4108ZPD. Bacteria.
COG0193. LUCA.
HOGENOMiHOG000004796.
InParanoidiQ9HVC3.
KOiK01056.
OMAiRFYKILP.
PhylomeDBiQ9HVC3.

Family and domain databases

CDDicd00462. PTH. 1 hit.
Gene3Di3.40.50.1470. 1 hit.
HAMAPiMF_00083. Pept_tRNA_hydro_bact. 1 hit.
InterProiIPR001328. Pept_tRNA_hydro.
IPR018171. Pept_tRNA_hydro_CS.
[Graphical view]
PANTHERiPTHR17224. PTHR17224. 1 hit.
PfamiPF01195. Pept_tRNA_hydro. 1 hit.
[Graphical view]
SUPFAMiSSF53178. SSF53178. 1 hit.
TIGRFAMsiTIGR00447. pth. 1 hit.
PROSITEiPS01195. PEPT_TRNA_HYDROL_1. 1 hit.
PS01196. PEPT_TRNA_HYDROL_2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q9HVC3-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MTAVQLIVGL GNPGPEYDQT RHNAGALFVE RLAHAQGVSL VADRKYFGLV
60 70 80 90 100
GKFSHQGKDV RLLIPTTYMN RSGQSVAALA GFFRIAPDAI LVAHDELDMP
110 120 130 140 150
PGVAKLKTGG GHGGHNGLRD IIAQLGNQNS FHRLRLGIGH PGHSSLVSGY
160 170 180 190
VLGRAPRSEQ ELLDTSIDFA LGVLPEMLAG DWTRAMQKLH SQKA
Length:194
Mass (Da):20,804
Last modified:March 1, 2001 - v1
Checksum:iA6E14ECBF84B61AA
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AE004091 Genomic DNA. Translation: AAG08059.1.
PIRiH83060.
RefSeqiNP_253361.1. NC_002516.2.
WP_003099278.1. NZ_ASJY01000743.1.

Genome annotation databases

EnsemblBacteriaiAAG08059; AAG08059; PA4672.
GeneIDi881396.
KEGGipae:PA4672.
PATRICi19844107. VBIPseAer58763_4894.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AE004091 Genomic DNA. Translation: AAG08059.1.
PIRiH83060.
RefSeqiNP_253361.1. NC_002516.2.
WP_003099278.1. NZ_ASJY01000743.1.

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
4DHWX-ray2.43A/B1-194[»]
4DJJX-ray2.94A/B1-194[»]
4ERXX-ray2.50A/B1-194[»]
4FNOX-ray2.25A/B1-194[»]
4FYJX-ray1.77A2-193[»]
4JC4X-ray2.25A1-194[»]
4QAJX-ray1.50A1-194[»]
4QBKX-ray1.77A1-194[»]
4QD3X-ray1.89A1-194[»]
ProteinModelPortaliQ9HVC3.
SMRiQ9HVC3.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi208964.PA4672.

Proteomic databases

PaxDbiQ9HVC3.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaiAAG08059; AAG08059; PA4672.
GeneIDi881396.
KEGGipae:PA4672.
PATRICi19844107. VBIPseAer58763_4894.

Organism-specific databases

PseudoCAPiPA4672.

Phylogenomic databases

eggNOGiENOG4108ZPD. Bacteria.
COG0193. LUCA.
HOGENOMiHOG000004796.
InParanoidiQ9HVC3.
KOiK01056.
OMAiRFYKILP.
PhylomeDBiQ9HVC3.

Family and domain databases

CDDicd00462. PTH. 1 hit.
Gene3Di3.40.50.1470. 1 hit.
HAMAPiMF_00083. Pept_tRNA_hydro_bact. 1 hit.
InterProiIPR001328. Pept_tRNA_hydro.
IPR018171. Pept_tRNA_hydro_CS.
[Graphical view]
PANTHERiPTHR17224. PTHR17224. 1 hit.
PfamiPF01195. Pept_tRNA_hydro. 1 hit.
[Graphical view]
SUPFAMiSSF53178. SSF53178. 1 hit.
TIGRFAMsiTIGR00447. pth. 1 hit.
PROSITEiPS01195. PEPT_TRNA_HYDROL_1. 1 hit.
PS01196. PEPT_TRNA_HYDROL_2. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiPTH_PSEAE
AccessioniPrimary (citable) accession number: Q9HVC3
Entry historyi
Integrated into UniProtKB/Swiss-Prot: June 1, 2001
Last sequence update: March 1, 2001
Last modified: November 2, 2016
This is version 98 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.