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Protein

Peptidyl-tRNA hydrolase

Gene

pth

Organism
Pseudomonas aeruginosa (strain ATCC 15692 / PAO1 / 1C / PRS 101 / LMG 12228)
Status
Reviewed-Annotation score: Annotation score: 2 out of 5-Experimental evidence at protein leveli

Functioni

The natural substrate for this enzyme may be peptidyl-tRNAs which drop off the ribosome during protein synthesis.UniRule annotation

Catalytic activityi

N-substituted aminoacyl-tRNA + H2O = N-substituted amino acid + tRNA.UniRule annotation

GO - Molecular functioni

  1. aminoacyl-tRNA hydrolase activity Source: UniProtKB-HAMAP

GO - Biological processi

  1. translation Source: UniProtKB-HAMAP
Complete GO annotation...

Keywords - Molecular functioni

Hydrolase

Names & Taxonomyi

Protein namesi
Recommended name:
Peptidyl-tRNA hydrolaseUniRule annotation (EC:3.1.1.29UniRule annotation)
Short name:
PTHUniRule annotation
Gene namesi
Name:pthUniRule annotation
Ordered Locus Names:PA4672
OrganismiPseudomonas aeruginosa (strain ATCC 15692 / PAO1 / 1C / PRS 101 / LMG 12228)
Taxonomic identifieri208964 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaPseudomonadalesPseudomonadaceaePseudomonas
ProteomesiUP000002438: Chromosome

Organism-specific databases

PseudoCAPiPA4672.

Subcellular locationi

Cytoplasm UniRule annotation

GO - Cellular componenti

  1. cytoplasm Source: UniProtKB-SubCell
Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 194194Peptidyl-tRNA hydrolasePRO_0000187796Add
BLAST

Interactioni

Subunit structurei

Monomer.UniRule annotation

Protein-protein interaction databases

STRINGi208964.PA4672.

Structurei

Secondary structure

1
194
Legend: HelixTurnBeta strand
Show more details
Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Beta strandi6 – 94Combined sources
Helixi15 – 173Combined sources
Helixi21 – 233Combined sources
Helixi24 – 3512Combined sources
Beta strandi41 – 433Combined sources
Helixi44 – 463Combined sources
Beta strandi48 – 558Combined sources
Beta strandi58 – 658Combined sources
Helixi69 – 713Combined sources
Helixi72 – 8312Combined sources
Helixi87 – 893Combined sources
Beta strandi90 – 967Combined sources
Beta strandi104 – 1096Combined sources
Helixi116 – 1249Combined sources
Beta strandi127 – 1293Combined sources
Beta strandi131 – 1377Combined sources
Helixi144 – 1463Combined sources
Helixi147 – 1515Combined sources
Helixi157 – 17216Combined sources
Helixi174 – 1796Combined sources
Helixi182 – 1909Combined sources

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
EntryMethodResolution (Å)ChainPositionsPDBsum
4DHWX-ray2.43A/B1-194[»]
4DJJX-ray2.94A/B1-194[»]
4ERXX-ray2.50A/B1-194[»]
4FNOX-ray2.25A/B1-194[»]
4FYJX-ray1.77A2-193[»]
4JC4X-ray2.25A1-194[»]
4QAJX-ray1.50A1-194[»]
4QBKX-ray1.77A1-194[»]
4QD3X-ray1.89A1-194[»]
ProteinModelPortaliQ9HVC3.
SMRiQ9HVC3. Positions 1-194.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the PTH family.UniRule annotation

Phylogenomic databases

eggNOGiCOG0193.
HOGENOMiHOG000004796.
InParanoidiQ9HVC3.
KOiK01056.
OMAiSLDAHCG.
OrthoDBiEOG6C5RTR.
PhylomeDBiQ9HVC3.

Family and domain databases

Gene3Di3.40.50.1470. 1 hit.
HAMAPiMF_00083. Pept_tRNA_hydro_bact.
InterProiIPR001328. Pept_tRNA_hydro.
IPR018171. Pept_tRNA_hydro_CS.
[Graphical view]
PANTHERiPTHR17224. PTHR17224. 1 hit.
PfamiPF01195. Pept_tRNA_hydro. 1 hit.
[Graphical view]
SUPFAMiSSF53178. SSF53178. 1 hit.
TIGRFAMsiTIGR00447. pth. 1 hit.
PROSITEiPS01195. PEPT_TRNA_HYDROL_1. 1 hit.
PS01196. PEPT_TRNA_HYDROL_2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q9HVC3-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MTAVQLIVGL GNPGPEYDQT RHNAGALFVE RLAHAQGVSL VADRKYFGLV
60 70 80 90 100
GKFSHQGKDV RLLIPTTYMN RSGQSVAALA GFFRIAPDAI LVAHDELDMP
110 120 130 140 150
PGVAKLKTGG GHGGHNGLRD IIAQLGNQNS FHRLRLGIGH PGHSSLVSGY
160 170 180 190
VLGRAPRSEQ ELLDTSIDFA LGVLPEMLAG DWTRAMQKLH SQKA
Length:194
Mass (Da):20,804
Last modified:March 1, 2001 - v1
Checksum:iA6E14ECBF84B61AA
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AE004091 Genomic DNA. Translation: AAG08059.1.
PIRiH83060.
RefSeqiNP_253361.1. NC_002516.2.

Genome annotation databases

EnsemblBacteriaiAAG08059; AAG08059; PA4672.
GeneIDi881396.
KEGGipae:PA4672.
PATRICi19844107. VBIPseAer58763_4894.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AE004091 Genomic DNA. Translation: AAG08059.1.
PIRiH83060.
RefSeqiNP_253361.1. NC_002516.2.

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
EntryMethodResolution (Å)ChainPositionsPDBsum
4DHWX-ray2.43A/B1-194[»]
4DJJX-ray2.94A/B1-194[»]
4ERXX-ray2.50A/B1-194[»]
4FNOX-ray2.25A/B1-194[»]
4FYJX-ray1.77A2-193[»]
4JC4X-ray2.25A1-194[»]
4QAJX-ray1.50A1-194[»]
4QBKX-ray1.77A1-194[»]
4QD3X-ray1.89A1-194[»]
ProteinModelPortaliQ9HVC3.
SMRiQ9HVC3. Positions 1-194.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi208964.PA4672.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaiAAG08059; AAG08059; PA4672.
GeneIDi881396.
KEGGipae:PA4672.
PATRICi19844107. VBIPseAer58763_4894.

Organism-specific databases

PseudoCAPiPA4672.

Phylogenomic databases

eggNOGiCOG0193.
HOGENOMiHOG000004796.
InParanoidiQ9HVC3.
KOiK01056.
OMAiSLDAHCG.
OrthoDBiEOG6C5RTR.
PhylomeDBiQ9HVC3.

Family and domain databases

Gene3Di3.40.50.1470. 1 hit.
HAMAPiMF_00083. Pept_tRNA_hydro_bact.
InterProiIPR001328. Pept_tRNA_hydro.
IPR018171. Pept_tRNA_hydro_CS.
[Graphical view]
PANTHERiPTHR17224. PTHR17224. 1 hit.
PfamiPF01195. Pept_tRNA_hydro. 1 hit.
[Graphical view]
SUPFAMiSSF53178. SSF53178. 1 hit.
TIGRFAMsiTIGR00447. pth. 1 hit.
PROSITEiPS01195. PEPT_TRNA_HYDROL_1. 1 hit.
PS01196. PEPT_TRNA_HYDROL_2. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: ATCC 15692 / PAO1 / 1C / PRS 101 / LMG 12228.

Entry informationi

Entry nameiPTH_PSEAE
AccessioniPrimary (citable) accession number: Q9HVC3
Entry historyi
Integrated into UniProtKB/Swiss-Prot: June 1, 2001
Last sequence update: March 1, 2001
Last modified: February 4, 2015
This is version 90 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.