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Protein

Glucose-6-phosphate isomerase

Gene

pgi

Organism
Pseudomonas aeruginosa (strain ATCC 15692 / PAO1 / 1C / PRS 101 / LMG 12228)
Status
Reviewed-Annotation score: Annotation score: 2 out of 5-Protein inferred from homologyi

Functioni

Catalytic activityi

D-glucose 6-phosphate = D-fructose 6-phosphate.

Pathwayi

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Active sitei359 – 3591Proton donorBy similarity
Active sitei390 – 3901By similarity
Active sitei518 – 5181By similarity

GO - Molecular functioni

  1. glucose-6-phosphate isomerase activity Source: UniProtKB-HAMAP

GO - Biological processi

  1. gluconeogenesis Source: UniProtKB-HAMAP
  2. glycolytic process Source: UniProtKB-HAMAP
Complete GO annotation...

Keywords - Molecular functioni

Isomerase

Keywords - Biological processi

Gluconeogenesis, Glycolysis

Enzyme and pathway databases

UniPathwayiUPA00109; UER00181.

Names & Taxonomyi

Protein namesi
Recommended name:
Glucose-6-phosphate isomerase (EC:5.3.1.9)
Short name:
GPI
Alternative name(s):
Phosphoglucose isomerase
Short name:
PGI
Phosphohexose isomerase
Short name:
PHI
Gene namesi
Name:pgi
Ordered Locus Names:PA4732
OrganismiPseudomonas aeruginosa (strain ATCC 15692 / PAO1 / 1C / PRS 101 / LMG 12228)
Taxonomic identifieri208964 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaPseudomonadalesPseudomonadaceaePseudomonas
ProteomesiUP000002438: Chromosome

Organism-specific databases

PseudoCAPiPA4732.

Subcellular locationi

Cytoplasm By similarity

GO - Cellular componenti

  1. cytoplasm Source: UniProtKB-SubCell
Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 554554Glucose-6-phosphate isomerasePRO_0000180708Add
BLAST

Interactioni

Protein-protein interaction databases

STRINGi208964.PA4732.

Structurei

3D structure databases

ProteinModelPortaliQ9HV67.
SMRiQ9HV67. Positions 5-550.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the GPI family.Curated

Phylogenomic databases

eggNOGiCOG0166.
HOGENOMiHOG000261370.
InParanoidiQ9HV67.
KOiK01810.
OMAiCETQAML.
OrthoDBiEOG64R61J.
PhylomeDBiQ9HV67.

Family and domain databases

Gene3Di1.10.1390.10. 1 hit.
HAMAPiMF_00473. G6P_isomerase.
InterProiIPR001672. G6P_Isomerase.
IPR023096. G6P_Isomerase_C.
IPR018189. Phosphoglucose_isomerase_CS.
[Graphical view]
PANTHERiPTHR11469. PTHR11469. 1 hit.
PfamiPF00342. PGI. 1 hit.
[Graphical view]
PRINTSiPR00662. G6PISOMERASE.
PROSITEiPS00765. P_GLUCOSE_ISOMERASE_1. 1 hit.
PS00174. P_GLUCOSE_ISOMERASE_2. 1 hit.
PS51463. P_GLUCOSE_ISOMERASE_3. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q9HV67-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MKHHLTPLDA TQLDSWRALA AHRQELQDFR MRQAFIDDPE RFKRFSFSAC
60 70 80 90 100
GLFLDFSKNL IRQDTIDLLV KLAEEARLSD AIRAMFDGEA INASERRPVL
110 120 130 140 150
HTALRRPIGD KVLVDGVDVM PEVHRVLHQM TELVGYVHNG LWRGYTEKPI
160 170 180 190 200
TDVVNIGIGG SFLGPQLVSE ALLPFAQKGV RCHYLANIDG SEFHELASRL
210 220 230 240 250
NAETTLFIVS SKSFGTLETL KNAQAARAWY LAQGGTEEEL YRHFIAVSSN
260 270 280 290 300
KEAAIAFGIR EENIFPMWDW VGGRYSLWSA IGLPIAMSIG ISNFKELLSG
310 320 330 340 350
AYNMDQHFQT APFERNIPVL LGLLGVWYGD FWGANSHAIL PYDYYLRNIT
360 370 380 390 400
DHLQQLDMES NGKSVRQDGT PVTSGTGPVI WGGVGCNGQH AYHQLLHQGT
410 420 430 440 450
QLIPADFIVP VSSYNPVADH HQWLYANCLS QSQALMLGKS REEAEAELRA
460 470 480 490 500
KGLPEAEVQR LAPHKVIPGN RPSNTLVVER ISARRLGALI AMYEHKVYVQ
510 520 530 540 550
SILWGINAFD QWGVELGKEL GKGVYSRLVG SEETPAEDAS TQGLIDFFRG

RHRG
Length:554
Mass (Da):61,944
Last modified:March 1, 2001 - v1
Checksum:i883AB9EB7B22A307
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AE004091 Genomic DNA. Translation: AAG08118.1.
PIRiH83053.
RefSeqiNP_253420.1. NC_002516.2.

Genome annotation databases

EnsemblBacteriaiAAG08118; AAG08118; PA4732.
GeneIDi881638.
KEGGipae:PA4732.
PATRICi19844245. VBIPseAer58763_4957.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AE004091 Genomic DNA. Translation: AAG08118.1.
PIRiH83053.
RefSeqiNP_253420.1. NC_002516.2.

3D structure databases

ProteinModelPortaliQ9HV67.
SMRiQ9HV67. Positions 5-550.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi208964.PA4732.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaiAAG08118; AAG08118; PA4732.
GeneIDi881638.
KEGGipae:PA4732.
PATRICi19844245. VBIPseAer58763_4957.

Organism-specific databases

PseudoCAPiPA4732.

Phylogenomic databases

eggNOGiCOG0166.
HOGENOMiHOG000261370.
InParanoidiQ9HV67.
KOiK01810.
OMAiCETQAML.
OrthoDBiEOG64R61J.
PhylomeDBiQ9HV67.

Enzyme and pathway databases

UniPathwayiUPA00109; UER00181.

Family and domain databases

Gene3Di1.10.1390.10. 1 hit.
HAMAPiMF_00473. G6P_isomerase.
InterProiIPR001672. G6P_Isomerase.
IPR023096. G6P_Isomerase_C.
IPR018189. Phosphoglucose_isomerase_CS.
[Graphical view]
PANTHERiPTHR11469. PTHR11469. 1 hit.
PfamiPF00342. PGI. 1 hit.
[Graphical view]
PRINTSiPR00662. G6PISOMERASE.
PROSITEiPS00765. P_GLUCOSE_ISOMERASE_1. 1 hit.
PS00174. P_GLUCOSE_ISOMERASE_2. 1 hit.
PS51463. P_GLUCOSE_ISOMERASE_3. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: ATCC 15692 / PAO1 / 1C / PRS 101 / LMG 12228.

Entry informationi

Entry nameiG6PI_PSEAE
AccessioniPrimary (citable) accession number: Q9HV67
Entry historyi
Integrated into UniProtKB/Swiss-Prot: November 2, 2001
Last sequence update: March 1, 2001
Last modified: January 7, 2015
This is version 81 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.