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Protein

Glucose-6-phosphate isomerase

Gene

pgi

Organism
Pseudomonas aeruginosa (strain ATCC 15692 / DSM 22644 / CIP 104116 / JCM 14847 / LMG 12228 / 1C / PRS 101 / PAO1)
Status
Reviewed-Annotation score: -Protein inferred from homologyi

Functioni

Catalytic activityi

D-glucose 6-phosphate = D-fructose 6-phosphate.

Pathwayi: glycolysis

This protein is involved in step 2 of the subpathway that synthesizes D-glyceraldehyde 3-phosphate and glycerone phosphate from D-glucose.
Proteins known to be involved in the 4 steps of the subpathway in this organism are:
  1. no protein annotated in this organism
  2. Glucose-6-phosphate isomerase (pgi)
  3. no protein annotated in this organism
  4. Fructose-bisphosphate aldolase (fba)
This subpathway is part of the pathway glycolysis, which is itself part of Carbohydrate degradation.
View all proteins of this organism that are known to be involved in the subpathway that synthesizes D-glyceraldehyde 3-phosphate and glycerone phosphate from D-glucose, the pathway glycolysis and in Carbohydrate degradation.

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Active sitei359Proton donorBy similarity1
Active sitei390By similarity1
Active sitei518By similarity1

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionIsomerase
Biological processGluconeogenesis, Glycolysis

Enzyme and pathway databases

BioCyciPAER208964:G1FZ6-4842-MONOMER
UniPathwayiUPA00109; UER00181

Names & Taxonomyi

Protein namesi
Recommended name:
Glucose-6-phosphate isomerase (EC:5.3.1.9)
Short name:
GPI
Alternative name(s):
Phosphoglucose isomerase
Short name:
PGI
Phosphohexose isomerase
Short name:
PHI
Gene namesi
Name:pgi
Ordered Locus Names:PA4732
OrganismiPseudomonas aeruginosa (strain ATCC 15692 / DSM 22644 / CIP 104116 / JCM 14847 / LMG 12228 / 1C / PRS 101 / PAO1)
Taxonomic identifieri208964 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaPseudomonadalesPseudomonadaceaePseudomonas
Proteomesi
  • UP000002438 Componenti: Chromosome

Organism-specific databases

PseudoCAPiPA4732

Subcellular locationi

GO - Cellular componenti

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001807081 – 554Glucose-6-phosphate isomeraseAdd BLAST554

Proteomic databases

PaxDbiQ9HV67

Interactioni

Protein-protein interaction databases

STRINGi208964.PA4732

Structurei

3D structure databases

ProteinModelPortaliQ9HV67
SMRiQ9HV67
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the GPI family.Curated

Phylogenomic databases

eggNOGiENOG4107QP8 Bacteria
COG0166 LUCA
HOGENOMiHOG000261370
InParanoidiQ9HV67
KOiK01810
OMAiTNSQHAF
PhylomeDBiQ9HV67

Family and domain databases

CDDicd05015 SIS_PGI_1, 1 hit
cd05016 SIS_PGI_2, 1 hit
Gene3Di1.10.1390.101 hit
HAMAPiMF_00473 G6P_isomerase, 1 hit
InterProiView protein in InterPro
IPR001672 G6P_Isomerase
IPR023096 G6P_Isomerase_C
IPR018189 Phosphoglucose_isomerase_CS
IPR035476 SIS_PGI_1
IPR035482 SIS_PGI_2
PANTHERiPTHR11469 PTHR11469, 1 hit
PfamiView protein in Pfam
PF00342 PGI, 1 hit
PRINTSiPR00662 G6PISOMERASE
PROSITEiView protein in PROSITE
PS00765 P_GLUCOSE_ISOMERASE_1, 1 hit
PS00174 P_GLUCOSE_ISOMERASE_2, 1 hit
PS51463 P_GLUCOSE_ISOMERASE_3, 1 hit

Sequencei

Sequence statusi: Complete.

Q9HV67-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MKHHLTPLDA TQLDSWRALA AHRQELQDFR MRQAFIDDPE RFKRFSFSAC
60 70 80 90 100
GLFLDFSKNL IRQDTIDLLV KLAEEARLSD AIRAMFDGEA INASERRPVL
110 120 130 140 150
HTALRRPIGD KVLVDGVDVM PEVHRVLHQM TELVGYVHNG LWRGYTEKPI
160 170 180 190 200
TDVVNIGIGG SFLGPQLVSE ALLPFAQKGV RCHYLANIDG SEFHELASRL
210 220 230 240 250
NAETTLFIVS SKSFGTLETL KNAQAARAWY LAQGGTEEEL YRHFIAVSSN
260 270 280 290 300
KEAAIAFGIR EENIFPMWDW VGGRYSLWSA IGLPIAMSIG ISNFKELLSG
310 320 330 340 350
AYNMDQHFQT APFERNIPVL LGLLGVWYGD FWGANSHAIL PYDYYLRNIT
360 370 380 390 400
DHLQQLDMES NGKSVRQDGT PVTSGTGPVI WGGVGCNGQH AYHQLLHQGT
410 420 430 440 450
QLIPADFIVP VSSYNPVADH HQWLYANCLS QSQALMLGKS REEAEAELRA
460 470 480 490 500
KGLPEAEVQR LAPHKVIPGN RPSNTLVVER ISARRLGALI AMYEHKVYVQ
510 520 530 540 550
SILWGINAFD QWGVELGKEL GKGVYSRLVG SEETPAEDAS TQGLIDFFRG

RHRG
Length:554
Mass (Da):61,944
Last modified:March 1, 2001 - v1
Checksum:i883AB9EB7B22A307
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AE004091 Genomic DNA Translation: AAG08118.1
PIRiH83053
RefSeqiNP_253420.1, NC_002516.2
WP_003100194.1, NC_002516.2

Genome annotation databases

EnsemblBacteriaiAAG08118; AAG08118; PA4732
GeneIDi881638
KEGGipae:PA4732
PATRICifig|208964.12.peg.4957

Similar proteinsi

Entry informationi

Entry nameiG6PI_PSEAE
AccessioniPrimary (citable) accession number: Q9HV67
Entry historyiIntegrated into UniProtKB/Swiss-Prot: November 2, 2001
Last sequence update: March 1, 2001
Last modified: February 28, 2018
This is version 91 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome