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Q9HV66 (ACSA2_PSEAE) Reviewed, UniProtKB/Swiss-Prot

Last modified January 25, 2012. Version 59. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (1) | Third-party data text xml rdf/xml gff fasta
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Names and origin

Protein namesRecommended name:
Acetyl-coenzyme A synthetase 2
EC=6.2.1.1
Alternative name(s):
Acetate--CoA ligase 2
Acyl-activating enzyme 2
Gene names
Name:acsA2
Synonyms:acsB
Ordered Locus Names:PA4733
OrganismPseudomonas aeruginosa (strain ATCC 15692 / PAO1 / 1C / PRS 101 / LMG 12228)
Taxonomic identifier208964 [NCBI]
Taxonomic lineageBacteria › Proteobacteria › Gammaproteobacteria › Pseudomonadales › Pseudomonadaceae › Pseudomonas

Protein attributes

Sequence length645 AA.
Sequence statusComplete.
Protein existenceInferred from homology

General annotation (Comments)

Catalytic activity

ATP + acetate + CoA = AMP + diphosphate + acetyl-CoA. HAMAP MF_01123

Post-translational modification

Acetylated. Deacetylation by the SIR2-homolog deacetylase activates the enzyme By similarity. HAMAP MF_01123

Sequence similarities

Belongs to the ATP-dependent AMP-binding enzyme family.

Ontologies

Keywords
   LigandATP-binding
Nucleotide-binding
   Molecular functionLigase
   PTMAcetylation
   Technical termComplete proteome
Reference proteome
Gene Ontology (GO)
   Molecular functionAMP binding

Inferred from electronic annotation. Source: InterPro

ATP binding

Inferred from electronic annotation. Source: UniProtKB-KW

acetate-CoA ligase activity

Inferred from electronic annotation. Source: EC

Complete GO annotation...

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 645645Acetyl-coenzyme A synthetase 2 HAMAP MF_01123
PRO_0000208375

Sites

Active site5141 By similarity

Amino acid modifications

Modified residue6061N6-acetyllysine By similarity

Sequences

Sequence LengthMass (Da)Tools
Q9HV66 [UniParc].

Last modified March 1, 2001. Version 1.
Checksum: 03033C03913995D6

FASTA64571,624
        10         20         30         40         50         60 
MFEISVHPVP DAVRQRAYLN DDDYQRLYRQ SVENPDEFWG EQAKAFLDWF KPWHSVHHGD 

        70         80         90        100        110        120 
LRKGQATWFK GGQLNVAYNC IDRHLERRGE QIAIVWEGDN PSESAHITYR KLHHNVCRLA 

       130        140        150        160        170        180 
NVLKSRGVEK GDRVCIYMPM IPEAAYAMLA CARIGAVHSV VFGGFSPDSL RDRILDADCR 

       190        200        210        220        230        240 
TVITADEGVR GGKYIPLKQN VEKALKDCPD VSTVVVVERT QGDIPWVEGR DIWYHEALHA 

       250        260        270        280        290        300 
ASADCPAEAM DAEDPLFILY TSGSTGKPKG VLHTTGGYLL GAAMTHKYVF DYHDGDVYWC 

       310        320        330        340        350        360 
TADVGWVTGH SYIVYGPLAN GATTLMFEGV PNYPDASRFW QVIDKHQVNI FYTAPTAIRA 

       370        380        390        400        410        420 
LMREGDAPVR QTSRSSLRLL GSVGEPINPE AWEWYYQVVG EKRCPILDTW WQTETGSILI 

       430        440        450        460        470        480 
TPLPGATALK PGSATRPFFG VQPVLLDEKG KEIDGAGSGV LAIKASWPSQ IRSVYGDHQR 

       490        500        510        520        530        540 
MIDTYFKPYP GYYFSGDGAR RDEDGYYWIT GRVDDVINVS GHRIGTAEVE SALVLHDAVA 

       550        560        570        580        590        600 
EAAVVGCPHD VKGQAIYAFV TLMAGSQPSE ALQQELLALV GKEIGSFAKP DHLQWAPSLP 

       610        620        630        640 
KTRSGKIMRR ILRKIACNEL DSLGDTSTLA DPGVVQGLID NRLNR

« Hide

Cross-references

Sequence databases

EMBL
GenBank
DDBJ		AE004091 Genomic DNA. Translation: AAG08119.1.
PIRA83054.
RefSeqNP_253421.1. NC_002516.2.

3D structure databases

ProteinModelPortalQ9HV66.
SMRQ9HV66. Positions 7-642.
ModBaseSearch...

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

GeneID881650.
GenomeReviewsGene locus PA4733 in contig AE004091_GR.
KEGGpae:PA4733.
NMPDRfig|208964.1.peg.4731.
PATRIC19844247. VBIPseAer58763_4958.

Organism-specific databases

PseudoCAPPA4733.

Phylogenomic databases

HOGENOMHBG547964.
OMAHQRMVDT.
ProtClustDBPRK00174.

Enzyme and pathway databases

BioCycPAER208964:PA4733-MONOMER.

Family and domain databases

HAMAPMF_01123. Ac_CoA_synth.
[Tree]
InterProIPR011904. Ac_CoA_lig.
IPR024597. Acyl-CoA_synth_DUF3448.
IPR020845. AMP-binding_CS.
IPR000873. AMP-dep_Synth/Lig.
[Graphical view]
KOK01895.
PANTHERPTHR24095:SF42. PTHR24095:SF42. 1 hit.
PfamPF00501. AMP-binding. 1 hit.
PF11930. DUF3448. 1 hit.
[Graphical view]
TIGRFAMsTIGR02188. Ac_CoA_lig_AcsA. 1 hit.
PROSITEPS00455. AMP_BINDING. 1 hit.
[Graphical view]
ProtoNetSearch...

Entry information

Entry nameACSA2_PSEAE
AccessionPrimary (citable) accession number: Q9HV66
Entry history
Integrated into UniProtKB/Swiss-Prot: September 26, 2003
Last sequence update: March 1, 2001
Last modified: January 25, 2012
This is version 59 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families

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