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Q9HV14

- Q9HV14_PSEAE

UniProt

Q9HV14 - Q9HV14_PSEAE

Protein
Submitted name:

Uncharacterized protein

Gene

PA4794

Organism
Pseudomonas aeruginosa (strain ATCC 15692 / PAO1 / 1C / PRS 101 / LMG 12228)
Status
Unreviewed - Annotation score: 1 out of 5- Experimental evidence at protein leveli
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    • History
      Entry version 77 (01 Oct 2014)
      Sequence version 1 (01 Mar 2001)
      Previous versions | rss
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    Functioni

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Binding sitei20 – 201Chloramphenicol 2
    Binding sitei29 – 291CoenzymeAImported
    Binding sitei86 – 861Chloramphenicol 1; via carbonyl oxygen
    Binding sitei88 – 881Chloramphenicol 2
    Binding sitei94 – 941Chloride 3; via amide nitrogen
    Binding sitei121 – 1211Chloramphenicol 2
    Binding sitei121 – 1211CoenzymeAImported
    Binding sitei141 – 1411Sulfate 2
    Binding sitei142 – 1421Sulfate 3
    Binding sitei153 – 1531Sulfate 2

    GO - Molecular functioni

    1. N-acetyltransferase activity Source: InterPro

    Names & Taxonomyi

    Protein namesi
    Submitted name:
    Uncharacterized proteinImported
    Gene namesi
    Ordered Locus Names:PA4794Imported
    OrganismiPseudomonas aeruginosa (strain ATCC 15692 / PAO1 / 1C / PRS 101 / LMG 12228)Imported
    Taxonomic identifieri208964 [NCBI]
    Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaPseudomonadalesPseudomonadaceaePseudomonas
    ProteomesiUP000002438: Chromosome

    Organism-specific databases

    PseudoCAPiPA4794.

    Interactioni

    Protein-protein interaction databases

    STRINGi208964.PA4794.

    Structurei

    3D structure databases

    Select the link destinations:
    PDBe
    RCSB PDB
    PDBj
    Links Updated
    EntryMethodResolution (Å)ChainPositionsPDBsum
    3KKWX-ray1.41A1-160[»]
    3PGPX-ray1.42A1-160[»]
    4KLVX-ray1.30A1-160[»]
    4KLWX-ray1.30A1-160[»]
    4KORX-ray1.25A1-160[»]
    4KOSX-ray1.55A1-160[»]
    4KOTX-ray1.55A1-160[»]
    4KOUX-ray1.60A1-160[»]
    4KOVX-ray1.60A1-160[»]
    4KOWX-ray1.45A1-160[»]
    4KOXX-ray1.80A1-160[»]
    4KOYX-ray1.40A1-160[»]
    4KUAX-ray1.50A1-160[»]
    4KUBX-ray1.57A1-160[»]
    4L89X-ray1.60A1-160[»]
    4L8AX-ray1.20A1-160[»]
    4M3SX-ray1.30A1-160[»]
    4OADX-ray1.45A1-160[»]
    4OAEX-ray1.25A1-160[»]
    ProteinModelPortaliQ9HV14.
    SMRiQ9HV14. Positions 1-159.
    ModBaseiSearch...
    MobiDBiSearch...

    Miscellaneous databases

    EvolutionaryTraceiQ9HV14.

    Family & Domainsi

    Region

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Regioni81 – 833CoenzymeA bindingImported
    Regioni89 – 946CoenzymeA bindingImported
    Regioni90 – 945Sulfate 8 binding
    Regioni126 – 1305CoenzymeA bindingImported

    Phylogenomic databases

    HOGENOMiHOG000133531.
    OMAiELFYMFP.
    OrthoDBiEOG6DC6JX.
    PhylomeDBiQ9HV14.

    Family and domain databases

    Gene3Di3.40.630.30. 1 hit.
    InterProiIPR016181. Acyl_CoA_acyltransferase.
    IPR000182. GNAT_dom.
    [Graphical view]
    PfamiPF00583. Acetyltransf_1. 1 hit.
    [Graphical view]
    SUPFAMiSSF55729. SSF55729. 1 hit.
    PROSITEiPS51186. GNAT. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Q9HV14-1 [UniParc]FASTAAdd to Basket

    « Hide

    MQLSHRPAET GDLETVAGFP QDRDELFYCY PKAIWPFSVA QLAAAIAERR    50
    GSTVAVHDGQ VLGFANFYQW QHGDFCALGN MMVAPAARGL GVARYLIGVM 100
    ENLAREQYKA RLMKISCFNA NAAGLLLYTQ LGYQPRAIAE RHDPDGRRVA 150
    LIQMDKPLEP 160
    Length:160
    Mass (Da):17,785
    Last modified:March 1, 2001 - v1
    Checksum:i6DE397F9A25DF686
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AE004091 Genomic DNA. Translation: AAG08180.1.
    PIRiH83047.
    RefSeqiNP_253482.1. NC_002516.2.

    Genome annotation databases

    EnsemblBacteriaiAAG08180; AAG08180; PA4794.
    GeneIDi880440.
    KEGGipae:PA4794.
    PATRICi19844379. VBIPseAer58763_5022.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AE004091 Genomic DNA. Translation: AAG08180.1 .
    PIRi H83047.
    RefSeqi NP_253482.1. NC_002516.2.

    3D structure databases

    Select the link destinations:
    PDBe
    RCSB PDB
    PDBj
    Links Updated
    Entry Method Resolution (Å) Chain Positions PDBsum
    3KKW X-ray 1.41 A 1-160 [» ]
    3PGP X-ray 1.42 A 1-160 [» ]
    4KLV X-ray 1.30 A 1-160 [» ]
    4KLW X-ray 1.30 A 1-160 [» ]
    4KOR X-ray 1.25 A 1-160 [» ]
    4KOS X-ray 1.55 A 1-160 [» ]
    4KOT X-ray 1.55 A 1-160 [» ]
    4KOU X-ray 1.60 A 1-160 [» ]
    4KOV X-ray 1.60 A 1-160 [» ]
    4KOW X-ray 1.45 A 1-160 [» ]
    4KOX X-ray 1.80 A 1-160 [» ]
    4KOY X-ray 1.40 A 1-160 [» ]
    4KUA X-ray 1.50 A 1-160 [» ]
    4KUB X-ray 1.57 A 1-160 [» ]
    4L89 X-ray 1.60 A 1-160 [» ]
    4L8A X-ray 1.20 A 1-160 [» ]
    4M3S X-ray 1.30 A 1-160 [» ]
    4OAD X-ray 1.45 A 1-160 [» ]
    4OAE X-ray 1.25 A 1-160 [» ]
    ProteinModelPortali Q9HV14.
    SMRi Q9HV14. Positions 1-159.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 208964.PA4794.

    Protocols and materials databases

    DNASUi 880440.
    Structural Biology Knowledgebase Search...

    Genome annotation databases

    EnsemblBacteriai AAG08180 ; AAG08180 ; PA4794 .
    GeneIDi 880440.
    KEGGi pae:PA4794.
    PATRICi 19844379. VBIPseAer58763_5022.

    Organism-specific databases

    PseudoCAPi PA4794.

    Phylogenomic databases

    HOGENOMi HOG000133531.
    OMAi ELFYMFP.
    OrthoDBi EOG6DC6JX.
    PhylomeDBi Q9HV14.

    Miscellaneous databases

    EvolutionaryTracei Q9HV14.

    Family and domain databases

    Gene3Di 3.40.630.30. 1 hit.
    InterProi IPR016181. Acyl_CoA_acyltransferase.
    IPR000182. GNAT_dom.
    [Graphical view ]
    Pfami PF00583. Acetyltransf_1. 1 hit.
    [Graphical view ]
    SUPFAMi SSF55729. SSF55729. 1 hit.
    PROSITEi PS51186. GNAT. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: ATCC 15692 / PAO1 / 1C / PRS 101 / LMG 12228Imported.
    2. "Crystal structure of His-tagged form of PA4794 protein."
      Majorek K.A., Chruszcz M., Joachimiak A., Minor W.
      Submitted (NOV-2009) to the PDB data bank
      Cited for: X-RAY CRYSTALLOGRAPHY (1.41 ANGSTROMS).
    3. "Structural, functional, and inhibition studies of a Gcn5-related N-acetyltransferase (GNAT) superfamily protein PA4794: a new C-terminal lysine protein acetyltransferase from pseudomonas aeruginosa."
      Majorek K.A., Kuhn M.L., Chruszcz M., Anderson W.F., Minor W.
      J. Biol. Chem. 288:30223-30235(2013) [PubMed] [Europe PMC] [Abstract]
      Cited for: X-RAY CRYSTALLOGRAPHY (1.20 ANGSTROMS) IN COMPLEX WITH COENZYMEA.
    4. "Crystal structure of a GNAT superfamily acetyltransferase PA4794 in complex with HEPES."
      Majorek K.A., Kuhn M.L., Chruszcz M., Anderson W.F., Minor W.
      Submitted (AUG-2013) to the PDB data bank
      Cited for: X-RAY CRYSTALLOGRAPHY (1.30 ANGSTROMS).
    5. "Crystal structure of a GNAT superfamily acetyltransferase PA4794 C29A/C117A/Y128A mutant in complex with chloramphenicol."
      Majorek K.A., Chruszcz M., Joachimiak A., Minor W.
      Submitted (JAN-2014) to the PDB data bank
      Cited for: X-RAY CRYSTALLOGRAPHY (1.25 ANGSTROMS).
    6. "Crystal structure of a GNAT superfamily acetyltransferase PA4794 in complex with chloramphenicol."
      Majorek K.A., Niedzialkowska E., Chruszcz M., Joachimiak A., Minor W.
      Submitted (JAN-2014) to the PDB data bank
      Cited for: X-RAY CRYSTALLOGRAPHY (1.45 ANGSTROMS).

    Entry informationi

    Entry nameiQ9HV14_PSEAE
    AccessioniPrimary (citable) accession number: Q9HV14
    Entry historyi
    Integrated into UniProtKB/TrEMBL: March 1, 2001
    Last sequence update: March 1, 2001
    Last modified: October 1, 2014
    This is version 77 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiUnreviewed (UniProtKB/TrEMBL)

    Miscellaneousi

    Keywords - Technical termi

    3D-structureImported, Complete proteome, Reference proteomeImported

    External Data

    Dasty 3