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Q9HV14

- Q9HV14_PSEAE

UniProt

Q9HV14 - Q9HV14_PSEAE

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Protein
Submitted name:

Uncharacterized protein

Gene

PA4794

Organism
Pseudomonas aeruginosa (strain ATCC 15692 / PAO1 / 1C / PRS 101 / LMG 12228)
Status
Unreviewed - Annotation score: 1 out of 5- Experimental evidence at protein leveli

Functioni

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Binding sitei20 – 201Chloramphenicol 2
Binding sitei29 – 291CoenzymeAImported
Binding sitei86 – 861Chloramphenicol 1; via carbonyl oxygen
Binding sitei88 – 881Chloramphenicol 2
Binding sitei94 – 941Chloride 3; via amide nitrogen
Binding sitei121 – 1211Chloramphenicol 2
Binding sitei121 – 1211CoenzymeAImported
Binding sitei141 – 1411Sulfate 2
Binding sitei142 – 1421Sulfate 3
Binding sitei153 – 1531Sulfate 2

GO - Molecular functioni

  1. N-acetyltransferase activity Source: InterPro
Complete GO annotation...

Names & Taxonomyi

Protein namesi
Submitted name:
Uncharacterized proteinImported
Gene namesi
Ordered Locus Names:PA4794Imported
OrganismiPseudomonas aeruginosa (strain ATCC 15692 / PAO1 / 1C / PRS 101 / LMG 12228)Imported
Taxonomic identifieri208964 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaPseudomonadalesPseudomonadaceaePseudomonas
ProteomesiUP000002438: Chromosome

Organism-specific databases

PseudoCAPiPA4794.

Interactioni

Protein-protein interaction databases

STRINGi208964.PA4794.

Structurei

3D structure databases

Select the link destinations:
PDBe
RCSB PDB
PDBj
Links Updated
EntryMethodResolution (Å)ChainPositionsPDBsum
3KKWX-ray1.41A1-160[»]
3PGPX-ray1.42A1-160[»]
4KLVX-ray1.30A1-160[»]
4KLWX-ray1.30A1-160[»]
4KORX-ray1.25A1-160[»]
4KOSX-ray1.55A1-160[»]
4KOTX-ray1.55A1-160[»]
4KOUX-ray1.60A1-160[»]
4KOVX-ray1.60A1-160[»]
4KOWX-ray1.45A1-160[»]
4KOXX-ray1.80A1-160[»]
4KOYX-ray1.40A1-160[»]
4KUAX-ray1.50A1-160[»]
4KUBX-ray1.57A1-160[»]
4L89X-ray1.60A1-160[»]
4L8AX-ray1.20A1-160[»]
4M3SX-ray1.30A1-160[»]
4OADX-ray1.45A1-160[»]
4OAEX-ray1.25A1-160[»]
ProteinModelPortaliQ9HV14.
SMRiQ9HV14. Positions 1-159.
ModBaseiSearch...
MobiDBiSearch...

Miscellaneous databases

EvolutionaryTraceiQ9HV14.

Family & Domainsi

Region

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Regioni81 – 833CoenzymeA bindingImported
Regioni89 – 946CoenzymeA bindingImported
Regioni90 – 945Sulfate 8 binding
Regioni126 – 1305CoenzymeA bindingImported

Phylogenomic databases

HOGENOMiHOG000133531.
OMAiELFYMFP.
OrthoDBiEOG6DC6JX.
PhylomeDBiQ9HV14.

Family and domain databases

Gene3Di3.40.630.30. 1 hit.
InterProiIPR016181. Acyl_CoA_acyltransferase.
IPR000182. GNAT_dom.
[Graphical view]
PfamiPF00583. Acetyltransf_1. 1 hit.
[Graphical view]
SUPFAMiSSF55729. SSF55729. 1 hit.
PROSITEiPS51186. GNAT. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q9HV14 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MQLSHRPAET GDLETVAGFP QDRDELFYCY PKAIWPFSVA QLAAAIAERR
60 70 80 90 100
GSTVAVHDGQ VLGFANFYQW QHGDFCALGN MMVAPAARGL GVARYLIGVM
110 120 130 140 150
ENLAREQYKA RLMKISCFNA NAAGLLLYTQ LGYQPRAIAE RHDPDGRRVA
160
LIQMDKPLEP
Length:160
Mass (Da):17,785
Last modified:March 1, 2001 - v1
Checksum:i6DE397F9A25DF686
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AE004091 Genomic DNA. Translation: AAG08180.1.
PIRiH83047.
RefSeqiNP_253482.1. NC_002516.2.

Genome annotation databases

EnsemblBacteriaiAAG08180; AAG08180; PA4794.
GeneIDi880440.
KEGGipae:PA4794.
PATRICi19844379. VBIPseAer58763_5022.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AE004091 Genomic DNA. Translation: AAG08180.1 .
PIRi H83047.
RefSeqi NP_253482.1. NC_002516.2.

3D structure databases

Select the link destinations:
PDBe
RCSB PDB
PDBj
Links Updated
Entry Method Resolution (Å) Chain Positions PDBsum
3KKW X-ray 1.41 A 1-160 [» ]
3PGP X-ray 1.42 A 1-160 [» ]
4KLV X-ray 1.30 A 1-160 [» ]
4KLW X-ray 1.30 A 1-160 [» ]
4KOR X-ray 1.25 A 1-160 [» ]
4KOS X-ray 1.55 A 1-160 [» ]
4KOT X-ray 1.55 A 1-160 [» ]
4KOU X-ray 1.60 A 1-160 [» ]
4KOV X-ray 1.60 A 1-160 [» ]
4KOW X-ray 1.45 A 1-160 [» ]
4KOX X-ray 1.80 A 1-160 [» ]
4KOY X-ray 1.40 A 1-160 [» ]
4KUA X-ray 1.50 A 1-160 [» ]
4KUB X-ray 1.57 A 1-160 [» ]
4L89 X-ray 1.60 A 1-160 [» ]
4L8A X-ray 1.20 A 1-160 [» ]
4M3S X-ray 1.30 A 1-160 [» ]
4OAD X-ray 1.45 A 1-160 [» ]
4OAE X-ray 1.25 A 1-160 [» ]
ProteinModelPortali Q9HV14.
SMRi Q9HV14. Positions 1-159.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 208964.PA4794.

Protocols and materials databases

DNASUi 880440.
Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai AAG08180 ; AAG08180 ; PA4794 .
GeneIDi 880440.
KEGGi pae:PA4794.
PATRICi 19844379. VBIPseAer58763_5022.

Organism-specific databases

PseudoCAPi PA4794.

Phylogenomic databases

HOGENOMi HOG000133531.
OMAi ELFYMFP.
OrthoDBi EOG6DC6JX.
PhylomeDBi Q9HV14.

Miscellaneous databases

EvolutionaryTracei Q9HV14.

Family and domain databases

Gene3Di 3.40.630.30. 1 hit.
InterProi IPR016181. Acyl_CoA_acyltransferase.
IPR000182. GNAT_dom.
[Graphical view ]
Pfami PF00583. Acetyltransf_1. 1 hit.
[Graphical view ]
SUPFAMi SSF55729. SSF55729. 1 hit.
PROSITEi PS51186. GNAT. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: ATCC 15692 / PAO1 / 1C / PRS 101 / LMG 12228Imported.
  2. "Crystal structure of His-tagged form of PA4794 protein."
    Majorek K.A., Chruszcz M., Joachimiak A., Minor W.
    Submitted (NOV-2009) to the PDB data bank
    Cited for: X-RAY CRYSTALLOGRAPHY (1.41 ANGSTROMS).
  3. "Structural, functional, and inhibition studies of a Gcn5-related N-acetyltransferase (GNAT) superfamily protein PA4794: a new C-terminal lysine protein acetyltransferase from pseudomonas aeruginosa."
    Majorek K.A., Kuhn M.L., Chruszcz M., Anderson W.F., Minor W.
    J. Biol. Chem. 288:30223-30235(2013) [PubMed] [Europe PMC] [Abstract]
    Cited for: X-RAY CRYSTALLOGRAPHY (1.20 ANGSTROMS) IN COMPLEX WITH COENZYMEA.
  4. "Crystal structure of a GNAT superfamily acetyltransferase PA4794 in complex with HEPES."
    Majorek K.A., Kuhn M.L., Chruszcz M., Anderson W.F., Minor W.
    Submitted (AUG-2013) to the PDB data bank
    Cited for: X-RAY CRYSTALLOGRAPHY (1.30 ANGSTROMS).
  5. "Crystal structure of a GNAT superfamily acetyltransferase PA4794 C29A/C117A/Y128A mutant in complex with chloramphenicol."
    Majorek K.A., Chruszcz M., Joachimiak A., Minor W.
    Submitted (JAN-2014) to the PDB data bank
    Cited for: X-RAY CRYSTALLOGRAPHY (1.25 ANGSTROMS).
  6. "Crystal structure of a GNAT superfamily acetyltransferase PA4794 in complex with chloramphenicol."
    Majorek K.A., Niedzialkowska E., Chruszcz M., Joachimiak A., Minor W.
    Submitted (JAN-2014) to the PDB data bank
    Cited for: X-RAY CRYSTALLOGRAPHY (1.45 ANGSTROMS).

Entry informationi

Entry nameiQ9HV14_PSEAE
AccessioniPrimary (citable) accession number: Q9HV14
Entry historyi
Integrated into UniProtKB/TrEMBL: March 1, 2001
Last sequence update: March 1, 2001
Last modified: October 29, 2014
This is version 78 of the entry and version 1 of the sequence. [Complete history]
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Keywords - Technical termi

3D-structureImported, Complete proteome, Reference proteomeImported

External Data

Dasty 3