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Q9HV14

- Q9HV14_PSEAE

UniProt

Q9HV14 - Q9HV14_PSEAE

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Protein
Submitted name: Uncharacterized protein
Gene
PA4794
Organism
Pseudomonas aeruginosa (strain ATCC 15692 / PAO1 / 1C / PRS 101 / LMG 12228)
Status
Unreviewed - Annotation score: 2 out of 5 - Experimental evidence at protein leveli

Functioni

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Binding sitei20 – 201Chloramphenicol 2
Binding sitei29 – 291Coenzyme AImported
Binding sitei49 – 491CefoxitinImported
Binding sitei68 – 681CefoxitinImported
Binding sitei86 – 861Chloramphenicol 1; via carbonyl oxygen
Binding sitei88 – 881Chloramphenicol 2
Binding sitei94 – 941Chloride 3; via amide nitrogen
Binding sitei116 – 1161Cefoxitin; via carbonyl oxygenImported
Binding sitei121 – 1211Chloramphenicol 2
Binding sitei121 – 1211Coenzyme AImported
Binding sitei141 – 1411CefoxitinImported
Binding sitei141 – 1411Sulfate 2
Binding sitei142 – 1421Sulfate 3
Binding sitei153 – 1531Sulfate 2

GO - Molecular functioni

  1. N-acetyltransferase activity Source: InterPro
Complete GO annotation...

Names & Taxonomyi

Protein namesi
Submitted name:
Uncharacterized proteinImported
Gene namesi
Ordered Locus Names:PA4794Imported
OrganismiPseudomonas aeruginosa (strain ATCC 15692 / PAO1 / 1C / PRS 101 / LMG 12228)Imported
Taxonomic identifieri208964 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaPseudomonadalesPseudomonadaceaePseudomonas
ProteomesiUP000002438: Chromosome

Organism-specific databases

PseudoCAPiPA4794.

Interactioni

Protein-protein interaction databases

STRINGi208964.PA4794.

Structurei

3D structure databases

Select the link destinations:
PDBe
RCSB PDB
PDBj
Links Updated
EntryMethodResolution (Å)ChainPositionsPDBsum
3KKWX-ray1.41A1-160[»]
3PGPX-ray1.42A1-160[»]
4KLVX-ray1.30A1-160[»]
4KLWX-ray1.30A1-160[»]
4KORX-ray1.25A1-160[»]
4KOSX-ray1.55A1-160[»]
4KOTX-ray1.55A1-160[»]
4KOUX-ray1.60A1-160[»]
4KOVX-ray1.60A1-160[»]
4KOWX-ray1.45A1-160[»]
4KOXX-ray1.80A1-160[»]
4KOYX-ray1.40A1-160[»]
4KUAX-ray1.50A1-160[»]
4KUBX-ray1.57A1-160[»]
4L89X-ray1.60A1-160[»]
4L8AX-ray1.20A1-160[»]
4M3SX-ray1.30A1-160[»]
4OADX-ray1.45A1-160[»]
4OAEX-ray1.25A1-160[»]
ProteinModelPortaliQ9HV14.
SMRiQ9HV14. Positions 1-159.

Miscellaneous databases

EvolutionaryTraceiQ9HV14.

Family & Domainsi

Region

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Regioni80 – 812Cefoxitin bindingImported
Regioni81 – 833Coenzyme A bindingImported
Regioni89 – 946Coenzyme A bindingImported
Regioni90 – 945Sulfate 8 binding
Regioni126 – 1305Coenzyme A bindingImported

Phylogenomic databases

HOGENOMiHOG000133531.
OMAiELFYMFP.
OrthoDBiEOG6DC6JX.
PhylomeDBiQ9HV14.

Family and domain databases

Gene3Di3.40.630.30. 1 hit.
InterProiIPR016181. Acyl_CoA_acyltransferase.
IPR000182. GNAT_dom.
[Graphical view]
PfamiPF00583. Acetyltransf_1. 1 hit.
[Graphical view]
SUPFAMiSSF55729. SSF55729. 1 hit.
PROSITEiPS51186. GNAT. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q9HV14-1 [UniParc]FASTAAdd to Basket

« Hide

MQLSHRPAET GDLETVAGFP QDRDELFYCY PKAIWPFSVA QLAAAIAERR    50
GSTVAVHDGQ VLGFANFYQW QHGDFCALGN MMVAPAARGL GVARYLIGVM 100
ENLAREQYKA RLMKISCFNA NAAGLLLYTQ LGYQPRAIAE RHDPDGRRVA 150
LIQMDKPLEP 160
Length:160
Mass (Da):17,785
Last modified:March 1, 2001 - v1
Checksum:i6DE397F9A25DF686
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AE004091 Genomic DNA. Translation: AAG08180.1.
PIRiH83047.
RefSeqiNP_253482.1. NC_002516.2.

Genome annotation databases

EnsemblBacteriaiAAG08180; AAG08180; PA4794.
GeneIDi880440.
KEGGipae:PA4794.
PATRICi19844379. VBIPseAer58763_5022.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AE004091 Genomic DNA. Translation: AAG08180.1 .
PIRi H83047.
RefSeqi NP_253482.1. NC_002516.2.

3D structure databases

Select the link destinations:
PDBe
RCSB PDB
PDBj
Links Updated
Entry Method Resolution (Å) Chain Positions PDBsum
3KKW X-ray 1.41 A 1-160 [» ]
3PGP X-ray 1.42 A 1-160 [» ]
4KLV X-ray 1.30 A 1-160 [» ]
4KLW X-ray 1.30 A 1-160 [» ]
4KOR X-ray 1.25 A 1-160 [» ]
4KOS X-ray 1.55 A 1-160 [» ]
4KOT X-ray 1.55 A 1-160 [» ]
4KOU X-ray 1.60 A 1-160 [» ]
4KOV X-ray 1.60 A 1-160 [» ]
4KOW X-ray 1.45 A 1-160 [» ]
4KOX X-ray 1.80 A 1-160 [» ]
4KOY X-ray 1.40 A 1-160 [» ]
4KUA X-ray 1.50 A 1-160 [» ]
4KUB X-ray 1.57 A 1-160 [» ]
4L89 X-ray 1.60 A 1-160 [» ]
4L8A X-ray 1.20 A 1-160 [» ]
4M3S X-ray 1.30 A 1-160 [» ]
4OAD X-ray 1.45 A 1-160 [» ]
4OAE X-ray 1.25 A 1-160 [» ]
ProteinModelPortali Q9HV14.
SMRi Q9HV14. Positions 1-159.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 208964.PA4794.

Protocols and materials databases

DNASUi 880440.
Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai AAG08180 ; AAG08180 ; PA4794 .
GeneIDi 880440.
KEGGi pae:PA4794.
PATRICi 19844379. VBIPseAer58763_5022.

Organism-specific databases

PseudoCAPi PA4794.

Phylogenomic databases

HOGENOMi HOG000133531.
OMAi ELFYMFP.
OrthoDBi EOG6DC6JX.
PhylomeDBi Q9HV14.

Miscellaneous databases

EvolutionaryTracei Q9HV14.

Family and domain databases

Gene3Di 3.40.630.30. 1 hit.
InterProi IPR016181. Acyl_CoA_acyltransferase.
IPR000182. GNAT_dom.
[Graphical view ]
Pfami PF00583. Acetyltransf_1. 1 hit.
[Graphical view ]
SUPFAMi SSF55729. SSF55729. 1 hit.
PROSITEi PS51186. GNAT. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: ATCC 15692 / PAO1 / 1C / PRS 101 / LMG 12228.
  2. "Crystal structure of His-tagged form of PA4794 protein."
    Majorek K.A., Chruszcz M., Joachimiak A., Minor W.
    Submitted (NOV-2009) to the PDB data bank
    Cited for: X-RAY CRYSTALLOGRAPHY (1.41 ANGSTROMS).
  3. "Structural, functional, and inhibition studies of a Gcn5-related N-acetyltransferase (GNAT) superfamily protein PA4794: a new C-terminal lysine protein acetyltransferase from pseudomonas aeruginosa."
    Majorek K.A., Kuhn M.L., Chruszcz M., Anderson W.F., Minor W.
    J. Biol. Chem. 288:30223-30235(2013) [PubMed] [Europe PMC] [Abstract]
    Cited for: X-RAY CRYSTALLOGRAPHY (1.20 ANGSTROMS) IN COMPLEX WITH CEFOXITIN AND COENZYME A.
  4. "Crystal structure of a GNAT superfamily acetyltransferase PA4794 in complex with HEPES."
    Majorek K.A., Kuhn M.L., Chruszcz M., Anderson W.F., Minor W.
    Submitted (AUG-2013) to the PDB data bank
    Cited for: X-RAY CRYSTALLOGRAPHY (1.30 ANGSTROMS).
  5. "Crystal structure of a GNAT superfamily acetyltransferase PA4794 C29A/C117A/Y128A mutant in complex with chloramphenicol."
    Majorek K.A., Chruszcz M., Joachimiak A., Minor W.
    Submitted (JAN-2014) to the PDB data bank
    Cited for: X-RAY CRYSTALLOGRAPHY (1.25 ANGSTROMS) IN COMPLEX WITH CHLORAMPHENICOL.
  6. "Crystal structure of a GNAT superfamily acetyltransferase PA4794 in complex with chloramphenicol."
    Majorek K.A., Niedzialkowska E., Chruszcz M., Joachimiak A., Minor W.
    Submitted (JAN-2014) to the PDB data bank
    Cited for: X-RAY CRYSTALLOGRAPHY (1.45 ANGSTROMS) IN COMPLEX WITH CHLORAMPHENICOL.

Entry informationi

Entry nameiQ9HV14_PSEAE
AccessioniPrimary (citable) accession number: Q9HV14
Entry historyi
Integrated into UniProtKB/TrEMBL: March 1, 2001
Last sequence update: March 1, 2001
Last modified: September 3, 2014
This is version 76 of the entry and version 1 of the sequence. [Complete history]
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Keywords - Technical termi

3D-structureImported, Complete proteome, Reference proteome

External Data

Dasty 3

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