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Q9HUX1

- SPEA_PSEAE

UniProt

Q9HUX1 - SPEA_PSEAE

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Protein
Biosynthetic arginine decarboxylase
Gene
speA, PA4839
Organism
Pseudomonas aeruginosa (strain ATCC 15692 / PAO1 / 1C / PRS 101 / LMG 12228)
Status
Reviewed - Annotation score: 3 out of 5 - Protein inferred from homologyi

Functioni

Catalyzes the biosynthesis of agmatine from arginine By similarity.UniRule annotation

Catalytic activityi

L-arginine = agmatine + CO2.UniRule annotation

Cofactori

Magnesium By similarity.UniRule annotation
Pyridoxal phosphate By similarity.UniRule annotation

GO - Molecular functioni

  1. arginine decarboxylase activity Source: CACAO
  2. metal ion binding Source: UniProtKB-KW

GO - Biological processi

  1. arginine catabolic process Source: InterPro
  2. putrescine biosynthetic process from arginine Source: PseudoCAP
  3. spermidine biosynthetic process Source: UniProtKB-HAMAP
Complete GO annotation...

Keywords - Molecular functioni

Decarboxylase, Lyase

Keywords - Biological processi

Polyamine biosynthesis, Spermidine biosynthesis

Keywords - Ligandi

Magnesium, Metal-binding, Pyridoxal phosphate

Enzyme and pathway databases

BioCyciMetaCyc:MONOMER-12.

Names & Taxonomyi

Protein namesi
Recommended name:
Biosynthetic arginine decarboxylase (EC:4.1.1.19)
Short name:
ADC
Gene namesi
Name:speA
Ordered Locus Names:PA4839
OrganismiPseudomonas aeruginosa (strain ATCC 15692 / PAO1 / 1C / PRS 101 / LMG 12228)
Taxonomic identifieri208964 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaPseudomonadalesPseudomonadaceaePseudomonas
ProteomesiUP000002438: Chromosome

Organism-specific databases

PseudoCAPiPA4839.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 636636Biosynthetic arginine decarboxylaseUniRule annotation
PRO_0000149971Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei110 – 1101N6-(pyridoxal phosphate)lysine By similarity

Interactioni

Protein-protein interaction databases

STRINGi208964.PA4839.

Structurei

3D structure databases

ProteinModelPortaliQ9HUX1.
SMRiQ9HUX1. Positions 20-635.

Family & Domainsi

Region

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Regioni290 – 30011Substrate-binding Reviewed prediction
Add
BLAST

Sequence similaritiesi

Phylogenomic databases

eggNOGiCOG1166.
HOGENOMiHOG000029191.
KOiK01585.
OMAiIDHYVDG.
OrthoDBiEOG676Z0R.
PhylomeDBiQ9HUX1.

Family and domain databases

Gene3Di2.40.37.10. 2 hits.
3.20.20.10. 1 hit.
HAMAPiMF_01417. SpeA.
InterProiIPR009006. Ala_racemase/Decarboxylase_C.
IPR002985. Arg_decrbxlase.
IPR022643. De-COase2_C.
IPR022657. De-COase2_CS.
IPR022644. De-COase2_N.
IPR022653. De-COase2_pyr-phos_BS.
IPR000183. Orn/DAP/Arg_de-COase.
IPR029066. PLP-binding_barrel.
[Graphical view]
PfamiPF02784. Orn_Arg_deC_N. 1 hit.
PF00278. Orn_DAP_Arg_deC. 1 hit.
[Graphical view]
PIRSFiPIRSF001336. Arg_decrbxlase. 1 hit.
PRINTSiPR01180. ARGDCRBXLASE.
PR01179. ODADCRBXLASE.
SUPFAMiSSF50621. SSF50621. 1 hit.
SSF51419. SSF51419. 1 hit.
TIGRFAMsiTIGR01273. speA. 1 hit.
PROSITEiPS00878. ODR_DC_2_1. 1 hit.
PS00879. ODR_DC_2_2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q9HUX1-1 [UniParc]FASTAAdd to Basket

« Hide

MAARRTRKDD GSNWTVADSR GVYGIRHWGA GYFAINDGGN VEVRPQGADS    50
TPIDLYELVG QLREAGLSLP LLVRFPDILQ DRVRKLTGAF DANIERLEYQ 100
SRYTALYPIK VNQQEAVVEN IIATENVSIG LEAGSKPELM AVLALAPKGG 150
TIVCNGYKDR EFIKLALMGQ KLGHNVFIVI EKESEVQLVI EEAANVGVQP 200
QVGLRVRLSS LASSKWADTG GEKAKFGLSA AQLLSVVERF RQAGLDQGVR 250
LLHFHMGSQI ANLADYQHGF KEAIRYYGEL RALGLPVDHI DVGGGLGVDY 300
DGTHSRNASS INYDIDDYAG VVVGMLKEFC DAQGLPHPHI FSESGRALTA 350
HHAVLITQVT DVERHNDDVP KIVDLDEQPE IVRWLAELLG PTDAEMVTET 400
YWRATHYIGD AAAQYADGKI SLAQKALAEQ CYFAICRRLH NQLKARQRSH 450
RQVLDELNDK LADKYICNFS VFQSLPDTWA IGQVLPILPL HRLGEEPDRR 500
AVLQDLTCDS DGKITQYVDE QSIETSLPVH EVKEGEDYLI GVFLVGAYQE 550
ILGDMHNLFG DTDSVNVYQR ADGGIYHAGI ETHDTIEDML RYVHLSPEEL 600
MTLYRDKVAG AKLTARERNQ YLDALRLGLT RSAYLS 636
Length:636
Mass (Da):70,668
Last modified:March 1, 2001 - v1
Checksum:iE7274FD432E0D187
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AE004091 Genomic DNA. Translation: AAG08224.1.
PIRiH83040.
RefSeqiNP_253526.1. NC_002516.2.

Genome annotation databases

EnsemblBacteriaiAAG08224; AAG08224; PA4839.
GeneIDi879594.
KEGGipae:PA4839.
PATRICi19844477. VBIPseAer58763_5070.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AE004091 Genomic DNA. Translation: AAG08224.1 .
PIRi H83040.
RefSeqi NP_253526.1. NC_002516.2.

3D structure databases

ProteinModelPortali Q9HUX1.
SMRi Q9HUX1. Positions 20-635.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 208964.PA4839.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai AAG08224 ; AAG08224 ; PA4839 .
GeneIDi 879594.
KEGGi pae:PA4839.
PATRICi 19844477. VBIPseAer58763_5070.

Organism-specific databases

PseudoCAPi PA4839.

Phylogenomic databases

eggNOGi COG1166.
HOGENOMi HOG000029191.
KOi K01585.
OMAi IDHYVDG.
OrthoDBi EOG676Z0R.
PhylomeDBi Q9HUX1.

Enzyme and pathway databases

BioCyci MetaCyc:MONOMER-12.

Family and domain databases

Gene3Di 2.40.37.10. 2 hits.
3.20.20.10. 1 hit.
HAMAPi MF_01417. SpeA.
InterProi IPR009006. Ala_racemase/Decarboxylase_C.
IPR002985. Arg_decrbxlase.
IPR022643. De-COase2_C.
IPR022657. De-COase2_CS.
IPR022644. De-COase2_N.
IPR022653. De-COase2_pyr-phos_BS.
IPR000183. Orn/DAP/Arg_de-COase.
IPR029066. PLP-binding_barrel.
[Graphical view ]
Pfami PF02784. Orn_Arg_deC_N. 1 hit.
PF00278. Orn_DAP_Arg_deC. 1 hit.
[Graphical view ]
PIRSFi PIRSF001336. Arg_decrbxlase. 1 hit.
PRINTSi PR01180. ARGDCRBXLASE.
PR01179. ODADCRBXLASE.
SUPFAMi SSF50621. SSF50621. 1 hit.
SSF51419. SSF51419. 1 hit.
TIGRFAMsi TIGR01273. speA. 1 hit.
PROSITEi PS00878. ODR_DC_2_1. 1 hit.
PS00879. ODR_DC_2_2. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: ATCC 15692 / PAO1 / 1C / PRS 101 / LMG 12228.

Entry informationi

Entry nameiSPEA_PSEAE
AccessioniPrimary (citable) accession number: Q9HUX1
Entry historyi
Integrated into UniProtKB/Swiss-Prot: March 29, 2004
Last sequence update: March 1, 2001
Last modified: July 9, 2014
This is version 78 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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