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Q9HUX1

- SPEA_PSEAE

UniProt

Q9HUX1 - SPEA_PSEAE

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Protein

Biosynthetic arginine decarboxylase

Gene

speA

Organism
Pseudomonas aeruginosa (strain ATCC 15692 / PAO1 / 1C / PRS 101 / LMG 12228)
Status
Reviewed - Annotation score: 3 out of 5- Protein inferred from homologyi

Functioni

Catalyzes the biosynthesis of agmatine from arginine.UniRule annotation

Catalytic activityi

L-arginine = agmatine + CO2.UniRule annotation

Cofactori

Magnesium.UniRule annotation
Pyridoxal phosphate.UniRule annotation

GO - Molecular functioni

  1. arginine decarboxylase activity Source: CACAO
  2. metal ion binding Source: UniProtKB-KW

GO - Biological processi

  1. arginine catabolic process Source: InterPro
  2. putrescine biosynthetic process from arginine Source: PseudoCAP
  3. spermidine biosynthetic process Source: UniProtKB-HAMAP
Complete GO annotation...

Keywords - Molecular functioni

Decarboxylase, Lyase

Keywords - Biological processi

Polyamine biosynthesis, Spermidine biosynthesis

Keywords - Ligandi

Magnesium, Metal-binding, Pyridoxal phosphate

Enzyme and pathway databases

BioCyciMetaCyc:MONOMER-12.

Names & Taxonomyi

Protein namesi
Recommended name:
Biosynthetic arginine decarboxylaseUniRule annotation (EC:4.1.1.19UniRule annotation)
Short name:
ADCUniRule annotation
Gene namesi
Name:speAUniRule annotation
Ordered Locus Names:PA4839
OrganismiPseudomonas aeruginosa (strain ATCC 15692 / PAO1 / 1C / PRS 101 / LMG 12228)
Taxonomic identifieri208964 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaPseudomonadalesPseudomonadaceaePseudomonas
ProteomesiUP000002438: Chromosome

Organism-specific databases

PseudoCAPiPA4839.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 636636Biosynthetic arginine decarboxylasePRO_0000149971Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei110 – 1101N6-(pyridoxal phosphate)lysineUniRule annotation

Interactioni

Protein-protein interaction databases

STRINGi208964.PA4839.

Structurei

3D structure databases

ProteinModelPortaliQ9HUX1.
SMRiQ9HUX1. Positions 20-635.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Region

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Regioni290 – 30011Substrate-bindingUniRule annotationAdd
BLAST

Sequence similaritiesi

Belongs to the Orn/Lys/Arg decarboxylase class-II family. SpeA subfamily.UniRule annotation

Phylogenomic databases

eggNOGiCOG1166.
HOGENOMiHOG000029191.
InParanoidiQ9HUX1.
KOiK01585.
OMAiIDHYVDG.
OrthoDBiEOG676Z0R.
PhylomeDBiQ9HUX1.

Family and domain databases

Gene3Di2.40.37.10. 2 hits.
3.20.20.10. 1 hit.
HAMAPiMF_01417. SpeA.
InterProiIPR009006. Ala_racemase/Decarboxylase_C.
IPR002985. Arg_decrbxlase.
IPR022643. De-COase2_C.
IPR022657. De-COase2_CS.
IPR022644. De-COase2_N.
IPR022653. De-COase2_pyr-phos_BS.
IPR000183. Orn/DAP/Arg_de-COase.
IPR029066. PLP-binding_barrel.
[Graphical view]
PfamiPF02784. Orn_Arg_deC_N. 1 hit.
PF00278. Orn_DAP_Arg_deC. 1 hit.
[Graphical view]
PIRSFiPIRSF001336. Arg_decrbxlase. 1 hit.
PRINTSiPR01180. ARGDCRBXLASE.
PR01179. ODADCRBXLASE.
SUPFAMiSSF50621. SSF50621. 1 hit.
SSF51419. SSF51419. 1 hit.
TIGRFAMsiTIGR01273. speA. 1 hit.
PROSITEiPS00878. ODR_DC_2_1. 1 hit.
PS00879. ODR_DC_2_2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q9HUX1-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MAARRTRKDD GSNWTVADSR GVYGIRHWGA GYFAINDGGN VEVRPQGADS
60 70 80 90 100
TPIDLYELVG QLREAGLSLP LLVRFPDILQ DRVRKLTGAF DANIERLEYQ
110 120 130 140 150
SRYTALYPIK VNQQEAVVEN IIATENVSIG LEAGSKPELM AVLALAPKGG
160 170 180 190 200
TIVCNGYKDR EFIKLALMGQ KLGHNVFIVI EKESEVQLVI EEAANVGVQP
210 220 230 240 250
QVGLRVRLSS LASSKWADTG GEKAKFGLSA AQLLSVVERF RQAGLDQGVR
260 270 280 290 300
LLHFHMGSQI ANLADYQHGF KEAIRYYGEL RALGLPVDHI DVGGGLGVDY
310 320 330 340 350
DGTHSRNASS INYDIDDYAG VVVGMLKEFC DAQGLPHPHI FSESGRALTA
360 370 380 390 400
HHAVLITQVT DVERHNDDVP KIVDLDEQPE IVRWLAELLG PTDAEMVTET
410 420 430 440 450
YWRATHYIGD AAAQYADGKI SLAQKALAEQ CYFAICRRLH NQLKARQRSH
460 470 480 490 500
RQVLDELNDK LADKYICNFS VFQSLPDTWA IGQVLPILPL HRLGEEPDRR
510 520 530 540 550
AVLQDLTCDS DGKITQYVDE QSIETSLPVH EVKEGEDYLI GVFLVGAYQE
560 570 580 590 600
ILGDMHNLFG DTDSVNVYQR ADGGIYHAGI ETHDTIEDML RYVHLSPEEL
610 620 630
MTLYRDKVAG AKLTARERNQ YLDALRLGLT RSAYLS
Length:636
Mass (Da):70,668
Last modified:March 1, 2001 - v1
Checksum:iE7274FD432E0D187
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AE004091 Genomic DNA. Translation: AAG08224.1.
PIRiH83040.
RefSeqiNP_253526.1. NC_002516.2.

Genome annotation databases

EnsemblBacteriaiAAG08224; AAG08224; PA4839.
GeneIDi879594.
KEGGipae:PA4839.
PATRICi19844477. VBIPseAer58763_5070.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AE004091 Genomic DNA. Translation: AAG08224.1 .
PIRi H83040.
RefSeqi NP_253526.1. NC_002516.2.

3D structure databases

ProteinModelPortali Q9HUX1.
SMRi Q9HUX1. Positions 20-635.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 208964.PA4839.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai AAG08224 ; AAG08224 ; PA4839 .
GeneIDi 879594.
KEGGi pae:PA4839.
PATRICi 19844477. VBIPseAer58763_5070.

Organism-specific databases

PseudoCAPi PA4839.

Phylogenomic databases

eggNOGi COG1166.
HOGENOMi HOG000029191.
InParanoidi Q9HUX1.
KOi K01585.
OMAi IDHYVDG.
OrthoDBi EOG676Z0R.
PhylomeDBi Q9HUX1.

Enzyme and pathway databases

BioCyci MetaCyc:MONOMER-12.

Family and domain databases

Gene3Di 2.40.37.10. 2 hits.
3.20.20.10. 1 hit.
HAMAPi MF_01417. SpeA.
InterProi IPR009006. Ala_racemase/Decarboxylase_C.
IPR002985. Arg_decrbxlase.
IPR022643. De-COase2_C.
IPR022657. De-COase2_CS.
IPR022644. De-COase2_N.
IPR022653. De-COase2_pyr-phos_BS.
IPR000183. Orn/DAP/Arg_de-COase.
IPR029066. PLP-binding_barrel.
[Graphical view ]
Pfami PF02784. Orn_Arg_deC_N. 1 hit.
PF00278. Orn_DAP_Arg_deC. 1 hit.
[Graphical view ]
PIRSFi PIRSF001336. Arg_decrbxlase. 1 hit.
PRINTSi PR01180. ARGDCRBXLASE.
PR01179. ODADCRBXLASE.
SUPFAMi SSF50621. SSF50621. 1 hit.
SSF51419. SSF51419. 1 hit.
TIGRFAMsi TIGR01273. speA. 1 hit.
PROSITEi PS00878. ODR_DC_2_1. 1 hit.
PS00879. ODR_DC_2_2. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: ATCC 15692 / PAO1 / 1C / PRS 101 / LMG 12228.

Entry informationi

Entry nameiSPEA_PSEAE
AccessioniPrimary (citable) accession number: Q9HUX1
Entry historyi
Integrated into UniProtKB/Swiss-Prot: March 29, 2004
Last sequence update: March 1, 2001
Last modified: October 29, 2014
This is version 80 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3