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Q9HUV9

- PUR9_PSEAE

UniProt

Q9HUV9 - PUR9_PSEAE

Protein

Bifunctional purine biosynthesis protein PurH

Gene

purH

Organism
Pseudomonas aeruginosa (strain ATCC 15692 / PAO1 / 1C / PRS 101 / LMG 12228)
Status
Reviewed - Annotation score: 2 out of 5- Protein inferred from homologyi
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    • History
      Entry version 80 (01 Oct 2014)
      Sequence version 1 (01 Mar 2001)
      Previous versions | rss
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    Functioni

    Catalytic activityi

    10-formyltetrahydrofolate + 5-amino-1-(5-phospho-D-ribosyl)imidazole-4-carboxamide = tetrahydrofolate + 5-formamido-1-(5-phospho-D-ribosyl)imidazole-4-carboxamide.UniRule annotation
    IMP + H2O = 5-formamido-1-(5-phospho-D-ribosyl)imidazole-4-carboxamide.UniRule annotation

    Pathwayi

    GO - Molecular functioni

    1. IMP cyclohydrolase activity Source: UniProtKB-HAMAP
    2. phosphoribosylaminoimidazolecarboxamide formyltransferase activity Source: UniProtKB-HAMAP

    GO - Biological processi

    1. 'de novo' IMP biosynthetic process Source: UniProtKB-UniPathway

    Keywords - Molecular functioni

    Hydrolase, Transferase

    Keywords - Biological processi

    Purine biosynthesis

    Enzyme and pathway databases

    UniPathwayiUPA00074; UER00133.
    UPA00074; UER00135.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Bifunctional purine biosynthesis protein PurHUniRule annotation
    Including the following 2 domains:
    Phosphoribosylaminoimidazolecarboxamide formyltransferaseUniRule annotation (EC:2.1.2.3UniRule annotation)
    Alternative name(s):
    AICAR transformylaseUniRule annotation
    IMP cyclohydrolaseUniRule annotation (EC:3.5.4.10UniRule annotation)
    Alternative name(s):
    ATICUniRule annotation
    IMP synthaseUniRule annotation
    InosinicaseUniRule annotation
    Gene namesi
    Name:purHUniRule annotation
    Ordered Locus Names:PA4854
    OrganismiPseudomonas aeruginosa (strain ATCC 15692 / PAO1 / 1C / PRS 101 / LMG 12228)
    Taxonomic identifieri208964 [NCBI]
    Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaPseudomonadalesPseudomonadaceaePseudomonas
    ProteomesiUP000002438: Chromosome

    Organism-specific databases

    PseudoCAPiPA4854.

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 535535Bifunctional purine biosynthesis protein PurHPRO_0000192112Add
    BLAST

    Interactioni

    Protein-protein interaction databases

    STRINGi208964.PA4854.

    Structurei

    3D structure databases

    ProteinModelPortaliQ9HUV9.
    SMRiQ9HUV9. Positions 7-535.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Domaini

    The IMP cyclohydrolase activity resides in the N-terminal region.UniRule annotation

    Sequence similaritiesi

    Belongs to the PurH family.UniRule annotation

    Phylogenomic databases

    eggNOGiCOG0138.
    HOGENOMiHOG000230373.
    KOiK00602.
    OMAiRAFKTDP.
    OrthoDBiEOG6QCDFF.
    PhylomeDBiQ9HUV9.

    Family and domain databases

    Gene3Di3.40.140.20. 2 hits.
    3.40.50.1380. 1 hit.
    HAMAPiMF_00139. PurH.
    InterProiIPR024051. AICAR_Tfase_dom.
    IPR002695. AICARFT_IMPCHas.
    IPR016193. Cytidine_deaminase-like.
    IPR011607. MGS-like_dom.
    [Graphical view]
    PANTHERiPTHR11692. PTHR11692. 1 hit.
    PfamiPF01808. AICARFT_IMPCHas. 1 hit.
    PF02142. MGS. 1 hit.
    [Graphical view]
    PIRSFiPIRSF000414. AICARFT_IMPCHas. 1 hit.
    SMARTiSM00798. AICARFT_IMPCHas. 1 hit.
    SM00851. MGS. 1 hit.
    [Graphical view]
    SUPFAMiSSF52335. SSF52335. 1 hit.
    SSF53927. SSF53927. 1 hit.
    TIGRFAMsiTIGR00355. purH. 1 hit.

    Sequencei

    Sequence statusi: Complete.

    Q9HUV9-1 [UniParc]FASTAAdd to Basket

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    MTDQTTRLPI RRALISVSDK TGVVDFAREL VALGVEILST GGTYKLLRDN    50
    GISAVEVADY TGFPEMMDGR VKTLHPKVHG GILGRRDLDG AVMEQHGIKP 100
    IDLVAVNLYP FEATVARPDC DLPTAIENID IGGPTMVRSA AKNHKDVAIV 150
    VNAGDYAAVI ESLKAGGLTY AQRFDLALKA FEHTSAYDGM IANYLGTIDQ 200
    TRDTLGTADR GAFPRTFNSQ FVKAQEMRYG ENPHQSAAFY VEAKKGEASV 250
    STAIQLQGKE LSFNNVADTD AALECVKSFL KPACVIVKHA NPCGVAVVPE 300
    DEGGIRKAYD LAYATDSESA FGGIIAFNRE LDGETAKAIV ERQFVEVIIA 350
    PKISAAAREV VAAKANVRLL ECGEWPAERA PGWDFKRVNG GLLVQSRDIG 400
    MIKAEDLKIV TRRAPTEQEI HDLIFAWKVA KFVKSNAIVY ARNRQTVGVG 450
    AGQMSRVNSA RIAAIKAEHA GLEVKGAVMA SDAFFPFRDG IDNAAKAGIT 500
    AVIQPGGSMR DNEVIAAADE ADIAMVFTGM RHFRH 535
    Length:535
    Mass (Da):57,666
    Last modified:March 1, 2001 - v1
    Checksum:i38B912B9570E23BD
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AE004091 Genomic DNA. Translation: AAG08239.1.
    PIRiF83040.
    RefSeqiNP_253541.1. NC_002516.2.

    Genome annotation databases

    EnsemblBacteriaiAAG08239; AAG08239; PA4854.
    GeneIDi880046.
    KEGGipae:PA4854.
    PATRICi19844509. VBIPseAer58763_5086.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AE004091 Genomic DNA. Translation: AAG08239.1 .
    PIRi F83040.
    RefSeqi NP_253541.1. NC_002516.2.

    3D structure databases

    ProteinModelPortali Q9HUV9.
    SMRi Q9HUV9. Positions 7-535.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 208964.PA4854.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    EnsemblBacteriai AAG08239 ; AAG08239 ; PA4854 .
    GeneIDi 880046.
    KEGGi pae:PA4854.
    PATRICi 19844509. VBIPseAer58763_5086.

    Organism-specific databases

    PseudoCAPi PA4854.

    Phylogenomic databases

    eggNOGi COG0138.
    HOGENOMi HOG000230373.
    KOi K00602.
    OMAi RAFKTDP.
    OrthoDBi EOG6QCDFF.
    PhylomeDBi Q9HUV9.

    Enzyme and pathway databases

    UniPathwayi UPA00074 ; UER00133 .
    UPA00074 ; UER00135 .

    Family and domain databases

    Gene3Di 3.40.140.20. 2 hits.
    3.40.50.1380. 1 hit.
    HAMAPi MF_00139. PurH.
    InterProi IPR024051. AICAR_Tfase_dom.
    IPR002695. AICARFT_IMPCHas.
    IPR016193. Cytidine_deaminase-like.
    IPR011607. MGS-like_dom.
    [Graphical view ]
    PANTHERi PTHR11692. PTHR11692. 1 hit.
    Pfami PF01808. AICARFT_IMPCHas. 1 hit.
    PF02142. MGS. 1 hit.
    [Graphical view ]
    PIRSFi PIRSF000414. AICARFT_IMPCHas. 1 hit.
    SMARTi SM00798. AICARFT_IMPCHas. 1 hit.
    SM00851. MGS. 1 hit.
    [Graphical view ]
    SUPFAMi SSF52335. SSF52335. 1 hit.
    SSF53927. SSF53927. 1 hit.
    TIGRFAMsi TIGR00355. purH. 1 hit.
    ProtoNeti Search...

    Publicationsi

    1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: ATCC 15692 / PAO1 / 1C / PRS 101 / LMG 12228.

    Entry informationi

    Entry nameiPUR9_PSEAE
    AccessioniPrimary (citable) accession number: Q9HUV9
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: June 20, 2003
    Last sequence update: March 1, 2001
    Last modified: October 1, 2014
    This is version 80 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programProkaryotic Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Multifunctional enzyme, Reference proteome

    Documents

    1. PATHWAY comments
      Index of metabolic and biosynthesis pathways
    2. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3