Reviewed, UniProtKB/Swiss-Prot Q9HUP4 (PNCB1_PSEAE)

Names and origin

Protein names

Recommended name:
    Nicotinate phosphoribosyltransferase 1
      Short name=NAPRTase 1
    EC=2.4.2.11

Gene names

Name:	pncB1
Ordered Locus Names:	PA4919

Organism

Pseudomonas aeruginosa [Complete proteome] [HAMAP]

Taxonomic identifier

287 [NCBI]

Taxonomic lineage

Bacteria › Proteobacteria › Gammaproteobacteria › Pseudomonadales › Pseudomonadaceae › Pseudomonas

Protein attributes

Sequence length	399 AA.
Sequence status	Complete.
Protein existence	Inferred from homology.

General annotation (Comments)

Catalytic activity	Nicotinate D-ribonucleotide + diphosphate = nicotinate + 5-phospho-alpha-D-ribose 1-diphosphate. HAMAP MF_00570
Pathway	Cofactor biosynthesis; NAD(+) biosynthesis; nicotinate D-ribonucleotide from nicotinate: step 1/1. HAMAP MF_00570
Subcellular location	Cytoplasm By similarity HAMAP MF_00570.
Sequence similarities	Belongs to the NAPRTase family.

Ontologies

Keywords
Biological process	Pyridine nucleotide biosynthesis
Cellular component	Cytoplasm
Molecular function	Glycosyltransferase Transferase
Technical term	Complete proteome
Gene Ontology (GO)
Biological process	NAD biosynthetic process Inferred from electronic annotation. Source: HAMAP nicotinate nucleotide biosynthetic process Inferred from electronic annotation. Source: InterPro
Cellular component	cytoplasm Inferred from electronic annotation. Source: UniProtKB-SubCell
Molecular function	nicotinate phosphoribosyltransferase activity Inferred from electronic annotation. Source: HAMAP
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 399	399	Nicotinate phosphoribosyltransferase 1 HAMAP MF_00570		PRO_0000205837

Sequences

	Sequence		Length	Mass (Da)
	Q9HUP4-1 [UniParc]. Last modified March 1, 2001. Version 1. Checksum: 49B2266CF47346DE	FASTA	399	46,095
	10 20 30 40 50 60 MAESVFAERI VQNLLDTDFY KLTMMQAVLH NYPNAEVEWE FRCRNAEDLR PYLAEIRYQI 70 80 90 100 110 120 ERLAEVEVTA DQLAFLERIP FMKPDFIRFL SLFRFNLRYV HTGIEDGQLA IRLRGPWLHV 130 140 150 160 170 180 ILFEVPLLAI VSEVRNRYRY REVVLEQVGE QLYRKLDWLS AQASSEELAE FQVADFGTRR 190 200 210 220 230 240 RFSYRTQEEV VHILKRDFPG RFVGTSNVHL AREYDLKPIG TMAHEWLMAH QQLGPRLVDS 250 260 270 280 290 300 QQAALDCWVR EYRGQLGIAL TDCITMDAFL DDFDLYFAKL FDGLRHDSGD PLAWAEKAIA 310 320 330 340 350 360 HYRRLGIDPL SKTLVFSDGL DMPKALQLFR ALRGKINVSF GIGTNLTCDI PGVEPMNIVL 370 380 390 KMTACNGHPV AKISDAPGKT QCRDENFVAY LRHVFNVPA

References

[1]

"Complete genome sequence of Pseudomonas aeruginosa PAO1, an opportunistic pathogen." Stover C.K., Pham X.-Q.T., Erwin A.L., Mizoguchi S.D., Warrener P., Hickey M.J., Brinkman F.S.L., Hufnagle W.O., Kowalik D.J., Lagrou M., Garber R.L., Goltry L., Tolentino E., Westbrock-Wadman S., Yuan Y., Brody L.L., Coulter S.N., Folger K.R. , Kas A., Larbig K., Lim R.M., Smith K.A., Spencer D.H., Wong G.K.-S., Wu Z., Paulsen I.T., Reizer J., Saier M.H. Jr., Hancock R.E.W., Lory S., Olson M.V. Nature 406:959-964(2000) [PubMed: 10984043] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: ATCC 15692 / PAO1 / 1C / PRS 101 / LMG 12228.

Cross-references

Sequence databases
EMBL GenBank DDBJ	AE004091 Genomic DNA. Translation: AAG08304.1.
PIR	E83030.
RefSeq	NP_253606.1.
3D structure databases
SMR	Q9HUP4. Positions 1-397.
ModBase	Search...
Genome annotation databases
GeneID	882212.
GenomeReviews	Gene locus PA4919 in contig AE004091_GR.
KEGG	pae:PA4919.
Organism-specific databases
PseudoCAP	PA4919.
CMR	Search...
Phylogenomic databases
HOGENOM	HBG325503.
OMA	GNTFYGK.
Enzyme and pathway databases
BioCyc	PAER208964:PA4919-MONOMER.
BRENDA	2.4.2.11. 354.
Family and domain databases
HAMAP	MF_00570. NAPRTase. [Tree]
InterPro	IPR006406. Nic_PRibTrfase. IPR015977. Nic_PRibTrfase-like. IPR007229. Nic_PRibTrfase-rel. [Graphical view]
PANTHER	PTHR11098:SF1. NAPRTase. 1 hit.
Pfam	PF04095. NAPRTase. 1 hit. [Graphical view]
PIRSF	PIRSF000484. NAPRT. 1 hit.
TIGRFAMs	TIGR01514. NAPRTase. 1 hit.
ProtoNet	Search...

Entry information

Entry name

PNCB1_PSEAE

Accession

Primary (citable) accession number: Q9HUP4

Entry history

Integrated into UniProtKB/Swiss-Prot:	July 11, 2002
Last sequence update:	March 1, 2001
Last modified:	February 9, 2010
This is version 56 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation project

HAMAP (High-quality Automated and Manual Annotation of microbial Proteomes)