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Protein

Nicotinate phosphoribosyltransferase 1

Gene

pncB1

Organism
Pseudomonas aeruginosa (strain ATCC 15692 / PAO1 / 1C / PRS 101 / LMG 12228)
Status
Reviewed-Annotation score: Annotation score: 2 out of 5-Protein inferred from homologyi

Functioni

Catalyzes the synthesis of beta-nicotinate D-ribonucleotide from nicotinate and 5-phospho-D-ribose 1-phosphate at the expense of ATP.UniRule annotation

Catalytic activityi

Nicotinate + 5-phospho-alpha-D-ribose 1-diphosphate + ATP + H2O = beta-nicotinate D-ribonucleotide + diphosphate + ADP + phosphate.UniRule annotation

Pathwayi

GO - Molecular functioni

  1. ligase activity Source: UniProtKB-KW
  2. nicotinate-nucleotide diphosphorylase (carboxylating) activity Source: InterPro
  3. nicotinate phosphoribosyltransferase activity Source: UniProtKB-HAMAP

GO - Biological processi

  1. NAD biosynthetic process Source: UniProtKB-HAMAP
  2. nicotinate nucleotide biosynthetic process Source: InterPro
Complete GO annotation...

Keywords - Molecular functioni

Ligase, Transferase

Keywords - Biological processi

Pyridine nucleotide biosynthesis

Enzyme and pathway databases

UniPathwayiUPA00253; UER00457.

Names & Taxonomyi

Protein namesi
Recommended name:
Nicotinate phosphoribosyltransferase 1UniRule annotation (EC:6.3.4.21UniRule annotation)
Short name:
NAPRTase 1UniRule annotation
Gene namesi
Name:pncB1UniRule annotation
Ordered Locus Names:PA4919
OrganismiPseudomonas aeruginosa (strain ATCC 15692 / PAO1 / 1C / PRS 101 / LMG 12228)
Taxonomic identifieri208964 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaPseudomonadalesPseudomonadaceaePseudomonas
ProteomesiUP000002438: Chromosome

Organism-specific databases

PseudoCAPiPA4919.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 399399Nicotinate phosphoribosyltransferase 1PRO_0000205837Add
BLAST

Interactioni

Protein-protein interaction databases

STRINGi208964.PA4919.

Structurei

3D structure databases

ProteinModelPortaliQ9HUP4.
SMRiQ9HUP4. Positions 1-397.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the NAPRTase family.UniRule annotation

Phylogenomic databases

eggNOGiCOG1488.
HOGENOMiHOG000284928.
InParanoidiQ9HUP4.
KOiK00763.
OMAiLYKFTMW.
OrthoDBiEOG6X10XB.
PhylomeDBiQ9HUP4.

Family and domain databases

HAMAPiMF_00570. NAPRTase.
InterProiIPR006406. Nic_PRibTrfase.
IPR007229. Nic_PRibTrfase-Fam.
IPR002638. Quinolinate_PRibosylTrfase_C.
[Graphical view]
PANTHERiPTHR11098. PTHR11098. 1 hit.
PfamiPF04095. NAPRTase. 1 hit.
[Graphical view]
PIRSFiPIRSF000484. NAPRT. 1 hit.
SUPFAMiSSF51690. SSF51690. 1 hit.
TIGRFAMsiTIGR01514. NAPRTase. 1 hit.

Sequencei

Sequence statusi: Complete.

Q9HUP4-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MAESVFAERI VQNLLDTDFY KLTMMQAVLH NYPNAEVEWE FRCRNAEDLR
60 70 80 90 100
PYLAEIRYQI ERLAEVEVTA DQLAFLERIP FMKPDFIRFL SLFRFNLRYV
110 120 130 140 150
HTGIEDGQLA IRLRGPWLHV ILFEVPLLAI VSEVRNRYRY REVVLEQVGE
160 170 180 190 200
QLYRKLDWLS AQASSEELAE FQVADFGTRR RFSYRTQEEV VHILKRDFPG
210 220 230 240 250
RFVGTSNVHL AREYDLKPIG TMAHEWLMAH QQLGPRLVDS QQAALDCWVR
260 270 280 290 300
EYRGQLGIAL TDCITMDAFL DDFDLYFAKL FDGLRHDSGD PLAWAEKAIA
310 320 330 340 350
HYRRLGIDPL SKTLVFSDGL DMPKALQLFR ALRGKINVSF GIGTNLTCDI
360 370 380 390
PGVEPMNIVL KMTACNGHPV AKISDAPGKT QCRDENFVAY LRHVFNVPA
Length:399
Mass (Da):46,095
Last modified:March 1, 2001 - v1
Checksum:i49B2266CF47346DE
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AE004091 Genomic DNA. Translation: AAG08304.1.
PIRiE83030.
RefSeqiNP_253606.1. NC_002516.2.

Genome annotation databases

EnsemblBacteriaiAAG08304; AAG08304; PA4919.
GeneIDi882212.
KEGGipae:PA4919.
PATRICi19844642. VBIPseAer58763_5152.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AE004091 Genomic DNA. Translation: AAG08304.1.
PIRiE83030.
RefSeqiNP_253606.1. NC_002516.2.

3D structure databases

ProteinModelPortaliQ9HUP4.
SMRiQ9HUP4. Positions 1-397.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi208964.PA4919.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaiAAG08304; AAG08304; PA4919.
GeneIDi882212.
KEGGipae:PA4919.
PATRICi19844642. VBIPseAer58763_5152.

Organism-specific databases

PseudoCAPiPA4919.

Phylogenomic databases

eggNOGiCOG1488.
HOGENOMiHOG000284928.
InParanoidiQ9HUP4.
KOiK00763.
OMAiLYKFTMW.
OrthoDBiEOG6X10XB.
PhylomeDBiQ9HUP4.

Enzyme and pathway databases

UniPathwayiUPA00253; UER00457.

Family and domain databases

HAMAPiMF_00570. NAPRTase.
InterProiIPR006406. Nic_PRibTrfase.
IPR007229. Nic_PRibTrfase-Fam.
IPR002638. Quinolinate_PRibosylTrfase_C.
[Graphical view]
PANTHERiPTHR11098. PTHR11098. 1 hit.
PfamiPF04095. NAPRTase. 1 hit.
[Graphical view]
PIRSFiPIRSF000484. NAPRT. 1 hit.
SUPFAMiSSF51690. SSF51690. 1 hit.
TIGRFAMsiTIGR01514. NAPRTase. 1 hit.
ProtoNetiSearch...

Publicationsi

  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: ATCC 15692 / PAO1 / 1C / PRS 101 / LMG 12228.

Entry informationi

Entry nameiPNCB1_PSEAE
AccessioniPrimary (citable) accession number: Q9HUP4
Entry historyi
Integrated into UniProtKB/Swiss-Prot: July 11, 2002
Last sequence update: March 1, 2001
Last modified: February 4, 2015
This is version 94 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.