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Q9HUP4

- PNCB1_PSEAE

UniProt

Q9HUP4 - PNCB1_PSEAE

Protein

Nicotinate phosphoribosyltransferase 1

Gene

pncB1

Organism
Pseudomonas aeruginosa (strain ATCC 15692 / PAO1 / 1C / PRS 101 / LMG 12228)
Status
Reviewed - Annotation score: 2 out of 5- Protein inferred from homologyi
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    • History
      Entry version 91 (01 Oct 2014)
      Sequence version 1 (01 Mar 2001)
      Previous versions | rss
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    Functioni

    Catalyzes the synthesis of beta-nicotinate D-ribonucleotide from nicotinate and 5-phospho-D-ribose 1-phosphate at the expense of ATP.UniRule annotation

    Catalytic activityi

    Nicotinate + 5-phospho-alpha-D-ribose 1-diphosphate + ATP + H2O = beta-nicotinate D-ribonucleotide + diphosphate + ADP + phosphate.UniRule annotation

    Pathwayi

    GO - Molecular functioni

    1. ligase activity Source: UniProtKB-KW
    2. nicotinate-nucleotide diphosphorylase (carboxylating) activity Source: InterPro
    3. nicotinate phosphoribosyltransferase activity Source: InterPro

    GO - Biological processi

    1. NAD biosynthetic process Source: UniProtKB-UniPathway
    2. nicotinate nucleotide biosynthetic process Source: InterPro

    Keywords - Molecular functioni

    Ligase, Transferase

    Keywords - Biological processi

    Pyridine nucleotide biosynthesis

    Enzyme and pathway databases

    UniPathwayiUPA00253; UER00457.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Nicotinate phosphoribosyltransferase 1UniRule annotation (EC:6.3.4.21UniRule annotation)
    Short name:
    NAPRTase 1UniRule annotation
    Gene namesi
    Name:pncB1UniRule annotation
    Ordered Locus Names:PA4919
    OrganismiPseudomonas aeruginosa (strain ATCC 15692 / PAO1 / 1C / PRS 101 / LMG 12228)
    Taxonomic identifieri208964 [NCBI]
    Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaPseudomonadalesPseudomonadaceaePseudomonas
    ProteomesiUP000002438: Chromosome

    Organism-specific databases

    PseudoCAPiPA4919.

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 399399Nicotinate phosphoribosyltransferase 1PRO_0000205837Add
    BLAST

    Interactioni

    Protein-protein interaction databases

    STRINGi208964.PA4919.

    Structurei

    3D structure databases

    ProteinModelPortaliQ9HUP4.
    SMRiQ9HUP4. Positions 1-397.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Sequence similaritiesi

    Belongs to the NAPRTase family.UniRule annotation

    Phylogenomic databases

    eggNOGiCOG1488.
    HOGENOMiHOG000284928.
    KOiK00763.
    OMAiECWVREY.
    OrthoDBiEOG6X10XB.
    PhylomeDBiQ9HUP4.

    Family and domain databases

    HAMAPiMF_00570. NAPRTase.
    InterProiIPR006406. Nic_PRibTrfase.
    IPR007229. Nic_PRibTrfase-Fam.
    IPR002638. Quinolinate_PRibosylTrfase_C.
    [Graphical view]
    PANTHERiPTHR11098. PTHR11098. 1 hit.
    PfamiPF04095. NAPRTase. 1 hit.
    [Graphical view]
    PIRSFiPIRSF000484. NAPRT. 1 hit.
    SUPFAMiSSF51690. SSF51690. 1 hit.
    TIGRFAMsiTIGR01514. NAPRTase. 1 hit.

    Sequencei

    Sequence statusi: Complete.

    Q9HUP4-1 [UniParc]FASTAAdd to Basket

    « Hide

    MAESVFAERI VQNLLDTDFY KLTMMQAVLH NYPNAEVEWE FRCRNAEDLR    50
    PYLAEIRYQI ERLAEVEVTA DQLAFLERIP FMKPDFIRFL SLFRFNLRYV 100
    HTGIEDGQLA IRLRGPWLHV ILFEVPLLAI VSEVRNRYRY REVVLEQVGE 150
    QLYRKLDWLS AQASSEELAE FQVADFGTRR RFSYRTQEEV VHILKRDFPG 200
    RFVGTSNVHL AREYDLKPIG TMAHEWLMAH QQLGPRLVDS QQAALDCWVR 250
    EYRGQLGIAL TDCITMDAFL DDFDLYFAKL FDGLRHDSGD PLAWAEKAIA 300
    HYRRLGIDPL SKTLVFSDGL DMPKALQLFR ALRGKINVSF GIGTNLTCDI 350
    PGVEPMNIVL KMTACNGHPV AKISDAPGKT QCRDENFVAY LRHVFNVPA 399
    Length:399
    Mass (Da):46,095
    Last modified:March 1, 2001 - v1
    Checksum:i49B2266CF47346DE
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AE004091 Genomic DNA. Translation: AAG08304.1.
    PIRiE83030.
    RefSeqiNP_253606.1. NC_002516.2.

    Genome annotation databases

    EnsemblBacteriaiAAG08304; AAG08304; PA4919.
    GeneIDi882212.
    KEGGipae:PA4919.
    PATRICi19844642. VBIPseAer58763_5152.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AE004091 Genomic DNA. Translation: AAG08304.1 .
    PIRi E83030.
    RefSeqi NP_253606.1. NC_002516.2.

    3D structure databases

    ProteinModelPortali Q9HUP4.
    SMRi Q9HUP4. Positions 1-397.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 208964.PA4919.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    EnsemblBacteriai AAG08304 ; AAG08304 ; PA4919 .
    GeneIDi 882212.
    KEGGi pae:PA4919.
    PATRICi 19844642. VBIPseAer58763_5152.

    Organism-specific databases

    PseudoCAPi PA4919.

    Phylogenomic databases

    eggNOGi COG1488.
    HOGENOMi HOG000284928.
    KOi K00763.
    OMAi ECWVREY.
    OrthoDBi EOG6X10XB.
    PhylomeDBi Q9HUP4.

    Enzyme and pathway databases

    UniPathwayi UPA00253 ; UER00457 .

    Family and domain databases

    HAMAPi MF_00570. NAPRTase.
    InterProi IPR006406. Nic_PRibTrfase.
    IPR007229. Nic_PRibTrfase-Fam.
    IPR002638. Quinolinate_PRibosylTrfase_C.
    [Graphical view ]
    PANTHERi PTHR11098. PTHR11098. 1 hit.
    Pfami PF04095. NAPRTase. 1 hit.
    [Graphical view ]
    PIRSFi PIRSF000484. NAPRT. 1 hit.
    SUPFAMi SSF51690. SSF51690. 1 hit.
    TIGRFAMsi TIGR01514. NAPRTase. 1 hit.
    ProtoNeti Search...

    Publicationsi

    1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: ATCC 15692 / PAO1 / 1C / PRS 101 / LMG 12228.

    Entry informationi

    Entry nameiPNCB1_PSEAE
    AccessioniPrimary (citable) accession number: Q9HUP4
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: July 11, 2002
    Last sequence update: March 1, 2001
    Last modified: October 1, 2014
    This is version 91 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programProkaryotic Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. PATHWAY comments
      Index of metabolic and biosynthesis pathways
    2. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3