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Protein

RNA-binding protein Hfq

Gene

hfq

Organism
Pseudomonas aeruginosa (strain ATCC 15692 / PAO1 / 1C / PRS 101 / LMG 12228)
Status
Reviewed-Annotation score: Annotation score: 2 out of 5-Experimental evidence at protein leveli

Functioni

RNA chaperone that binds small regulatory RNA (sRNAs) and mRNAs to facilitate mRNA translational regulation in response to envelope stress, environmental stress and changes in metabolite concentrations. Also binds with high specificity to tRNAs.UniRule annotation

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Biological processi

Stress response

Keywords - Ligandi

RNA-binding

Names & Taxonomyi

Protein namesi
Recommended name:
RNA-binding protein HfqUniRule annotation
Gene namesi
Name:hfqUniRule annotation
Ordered Locus Names:PA4944
OrganismiPseudomonas aeruginosa (strain ATCC 15692 / PAO1 / 1C / PRS 101 / LMG 12228)
Taxonomic identifieri208964 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaPseudomonadalesPseudomonadaceaePseudomonas
Proteomesi
  • UP000002438 Componenti: Chromosome

Organism-specific databases

PseudoCAPiPA4944.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 8282RNA-binding protein HfqPRO_0000095656Add
BLAST

Proteomic databases

PaxDbiQ9HUM0.

Interactioni

Subunit structurei

Homohexamer.UniRule annotation

Protein-protein interaction databases

STRINGi208964.PA4944.

Structurei

Secondary structure

1
82
Legend: HelixTurnBeta strand
Show more details
Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Turni4 – 74Combined sources
Helixi8 – 1710Combined sources
Beta strandi22 – 265Combined sources
Beta strandi31 – 399Combined sources
Beta strandi41 – 5010Combined sources
Beta strandi52 – 554Combined sources
Helixi56 – 583Combined sources
Beta strandi59 – 668Combined sources

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
EntryMethodResolution (Å)ChainPositionsPDBsum
1U1SX-ray1.60A/B/C/D/E/F1-82[»]
1U1TX-ray1.90A/B/C/D/E/F1-82[»]
3INZX-ray1.70A/B/C/D/E/F1-82[»]
3M4GX-ray2.05A/B/C/D/E/F/G/H/I/J/K/L1-82[»]
3QUIX-ray1.93A/B/C/D/E/F1-82[»]
4J5YX-ray2.10A/B/C/D/E/F1-82[»]
4J6WX-ray1.80A/B/C/D/E/F1-82[»]
4J6XX-ray2.22A/B/C/D/E/F1-82[»]
4J6YX-ray2.14A/B/C/D/E/F1-82[»]
4MMKX-ray2.16A/B/C/D/E/F/G/H/I/J/K/L1-82[»]
4MMLX-ray1.80A1-82[»]
ProteinModelPortaliQ9HUM0.
SMRiQ9HUM0. Positions 4-69.
ModBaseiSearch...
MobiDBiSearch...

Miscellaneous databases

EvolutionaryTraceiQ9HUM0.

Family & Domainsi

Sequence similaritiesi

Belongs to the Hfq family.UniRule annotation

Phylogenomic databases

eggNOGiENOG4105KW8. Bacteria.
COG1923. LUCA.
HOGENOMiHOG000004931.
InParanoidiQ9HUM0.
KOiK03666.
OMAiQDPYLNV.
OrthoDBiEOG68SW3W.
PhylomeDBiQ9HUM0.

Family and domain databases

HAMAPiMF_00436. Hfq.
InterProiIPR005001. Hfq.
IPR010920. LSM_dom.
[Graphical view]
SUPFAMiSSF50182. SSF50182. 1 hit.
TIGRFAMsiTIGR02383. Hfq. 1 hit.

Sequencei

Sequence statusi: Complete.

Q9HUM0-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MSKGHSLQDP YLNTLRKERV PVSIYLVNGI KLQGQIESFD QFVILLKNTV
60 70 80
SQMVYKHAIS TVVPSRPVRL PSGDQPAEPG NA
Length:82
Mass (Da):9,104
Last modified:March 1, 2001 - v1
Checksum:i1153661DC4C5AE2F
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AE004091 Genomic DNA. Translation: AAG08329.1.
PIRiD83028.
RefSeqiNP_253631.1. NC_002516.2.
WP_003095657.1. NZ_ASJY01000789.1.

Genome annotation databases

EnsemblBacteriaiAAG08329; AAG08329; PA4944.
GeneIDi878015.
KEGGipae:PA4944.
PATRICi19844696. VBIPseAer58763_5177.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AE004091 Genomic DNA. Translation: AAG08329.1.
PIRiD83028.
RefSeqiNP_253631.1. NC_002516.2.
WP_003095657.1. NZ_ASJY01000789.1.

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
EntryMethodResolution (Å)ChainPositionsPDBsum
1U1SX-ray1.60A/B/C/D/E/F1-82[»]
1U1TX-ray1.90A/B/C/D/E/F1-82[»]
3INZX-ray1.70A/B/C/D/E/F1-82[»]
3M4GX-ray2.05A/B/C/D/E/F/G/H/I/J/K/L1-82[»]
3QUIX-ray1.93A/B/C/D/E/F1-82[»]
4J5YX-ray2.10A/B/C/D/E/F1-82[»]
4J6WX-ray1.80A/B/C/D/E/F1-82[»]
4J6XX-ray2.22A/B/C/D/E/F1-82[»]
4J6YX-ray2.14A/B/C/D/E/F1-82[»]
4MMKX-ray2.16A/B/C/D/E/F/G/H/I/J/K/L1-82[»]
4MMLX-ray1.80A1-82[»]
ProteinModelPortaliQ9HUM0.
SMRiQ9HUM0. Positions 4-69.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi208964.PA4944.

Proteomic databases

PaxDbiQ9HUM0.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaiAAG08329; AAG08329; PA4944.
GeneIDi878015.
KEGGipae:PA4944.
PATRICi19844696. VBIPseAer58763_5177.

Organism-specific databases

PseudoCAPiPA4944.

Phylogenomic databases

eggNOGiENOG4105KW8. Bacteria.
COG1923. LUCA.
HOGENOMiHOG000004931.
InParanoidiQ9HUM0.
KOiK03666.
OMAiQDPYLNV.
OrthoDBiEOG68SW3W.
PhylomeDBiQ9HUM0.

Miscellaneous databases

EvolutionaryTraceiQ9HUM0.

Family and domain databases

HAMAPiMF_00436. Hfq.
InterProiIPR005001. Hfq.
IPR010920. LSM_dom.
[Graphical view]
SUPFAMiSSF50182. SSF50182. 1 hit.
TIGRFAMsiTIGR02383. Hfq. 1 hit.
ProtoNetiSearch...

Publicationsi

  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: ATCC 15692 / PAO1 / 1C / PRS 101 / LMG 12228.

Entry informationi

Entry nameiHFQ_PSEAE
AccessioniPrimary (citable) accession number: Q9HUM0
Entry historyi
Integrated into UniProtKB/Swiss-Prot: August 29, 2001
Last sequence update: March 1, 2001
Last modified: November 11, 2015
This is version 93 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.