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Q9HUK6

- Q9HUK6_PSEAE

UniProt

Q9HUK6 - Q9HUK6_PSEAE

Protein
Submitted name:

FimX

Gene

fimX

Organism
Pseudomonas aeruginosa (strain ATCC 15692 / PAO1 / 1C / PRS 101 / LMG 12228)
Status
Unreviewed - Annotation score: 1 out of 5- Experimental evidence at protein leveli
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    • History
      Entry version 93 (01 Oct 2014)
      Sequence version 1 (01 Mar 2001)
      Previous versions | rss
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    Functioni

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Binding sitei461 – 4611Cyclicdiguanosine monophosphateImported
    Binding sitei507 – 5071Cyclicdiguanosine monophosphateImported
    Binding sitei533 – 5331Cyclicdiguanosine monophosphateImported
    Binding sitei673 – 6731Cyclicdiguanosine monophosphateImported

    Regions

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Nucleotide bindingi478 – 4792Cyclicdiguanosine monophosphateImported
    Nucleotide bindingi652 – 6543Cyclicdiguanosine monophosphateImported

    GO - Molecular functioni

    1. nucleotide binding Source: UniProtKB-KW
    2. phosphorelay response regulator activity Source: InterPro
    3. phosphorus-oxygen lyase activity Source: InterPro

    GO - Biological processi

    1. cyclic nucleotide biosynthetic process Source: InterPro
    2. regulation of transcription, DNA-templated Source: InterPro

    Keywords - Ligandi

    Nucleotide-bindingImported

    Names & Taxonomyi

    Protein namesi
    Submitted name:
    FimXImported
    Gene namesi
    Name:fimXImported
    Ordered Locus Names:PA4959Imported
    OrganismiPseudomonas aeruginosa (strain ATCC 15692 / PAO1 / 1C / PRS 101 / LMG 12228)Imported
    Taxonomic identifieri208964 [NCBI]
    Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaPseudomonadalesPseudomonadaceaePseudomonas
    ProteomesiUP000002438: Chromosome

    Organism-specific databases

    PseudoCAPiPA4959.

    Interactioni

    Protein-protein interaction databases

    DIPiDIP-48302N.
    STRINGi208964.PA4959.

    Structurei

    3D structure databases

    Select the link destinations:
    PDBe
    RCSB PDB
    PDBj
    Links Updated
    EntryMethodResolution (Å)ChainPositionsPDBsum
    3HV8X-ray1.44A429-691[»]
    3HV9X-ray2.30A429-691[»]
    3HVAX-ray2.04A/B260-431[»]
    4AFYX-ray2.01A/B439-691[»]
    4AG0X-ray2.30A/B439-691[»]
    4J40X-ray2.99A/B260-691[»]
    ProteinModelPortaliQ9HUK6.
    SMRiQ9HUK6. Positions 255-686.
    ModBaseiSearch...
    MobiDBiSearch...

    Miscellaneous databases

    EvolutionaryTraceiQ9HUK6.

    Family & Domainsi

    Phylogenomic databases

    HOGENOMiHOG000225944.
    OMAiACKRINE.
    OrthoDBiEOG69GZGV.
    PhylomeDBiQ9HUK6.

    Family and domain databases

    Gene3Di3.20.20.450. 1 hit.
    InterProiIPR001054. A/G_cyclase.
    IPR011006. CheY-like_superfamily.
    IPR001633. Diguanylate_PEstase_EAL_dom.
    IPR000160. GGDEF_dom.
    IPR000014. PAS.
    IPR013767. PAS_fold.
    IPR001789. Sig_transdc_resp-reg_receiver.
    [Graphical view]
    PfamiPF00563. EAL. 1 hit.
    PF00990. GGDEF. 1 hit.
    PF00989. PAS. 1 hit.
    [Graphical view]
    SMARTiSM00052. EAL. 1 hit.
    SM00267. GGDEF. 1 hit.
    SM00091. PAS. 1 hit.
    [Graphical view]
    SUPFAMiSSF141868. SSF141868. 1 hit.
    SSF52172. SSF52172. 1 hit.
    SSF55073. SSF55073. 1 hit.
    SSF55785. SSF55785. 1 hit.
    TIGRFAMsiTIGR00254. GGDEF. 1 hit.
    TIGR00229. sensory_box. 1 hit.
    PROSITEiPS50883. EAL. 1 hit.
    PS50887. GGDEF. 1 hit.
    PS50110. RESPONSE_REGULATORY. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Q9HUK6-1 [UniParc]FASTAAdd to Basket

    « Hide

    MAIEKKTIRL LILEDSQNEA ERLVSLFRNA GHATRVHRLT SPEDLAETLQ    50
    QSWDLLIAAP TSECLEPGEA LATLRRQSRD IPFIQLVADN SSDAITDALM 100
    LGAQDALPQG EDERLVLVAN RELAGLAERR ARRAAELALR EAEKRCQLLL 150
    DSSVDAITYV HDGMHIYANR SYMALFGYED AEELEGLPVI DLIASCDQGA 200
    FKDFLKGYQN DQRQTELVCT GVKLDGQEFK ARISLSAATY DGEPCIQVVI 250
    RGEVDNAELE EKLREVSSQD PVTGLYNRSH FLDLMDAAVQ QAVTARKPST 300
    LAYIHLNGYP SLQADHGLSG IDLLLGQLAG LMREQFGEEA DLARFGDSIF 350
    AALFKGKTPE QAQAALQRLL KKVENHLFEL NGRSAQATLS IGVAGLDEKT 400
    AKAQDVMNRA HRCADDAARK GGSQIKQYNP AEELAAAAQR GDVIAILQQA 450
    LETNSFRLLF QPVISLRGDS HENYEVLLRL LNPQGQEVPP AEFLHAAKEA 500
    GLAEKIDRWV ILNSIKLLAE HRAKGHQTKL FVHLSSASLQ DPGLLPWLGV 550
    ALKAARLPPE SLVFQISEAD ATSYLKQAKQ LTQGLATLHC QAAISQFGCS 600
    LNPFNALKHL TVQFIKIDGS FVQDLNQVEN QEILKGLIAE LHEQQKLSIV 650
    PFVESASVLA TLWQAGATYI QGYYLQGPSQ AMDYDFSSGD E 691
    Length:691
    Mass (Da):75,993
    Last modified:March 1, 2001 - v1
    Checksum:i518BAFE4C8977B43
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AE004091 Genomic DNA. Translation: AAG08344.1.
    PIRiE83027.
    RefSeqiNP_253646.1. NC_002516.2.

    Genome annotation databases

    EnsemblBacteriaiAAG08344; AAG08344; PA4959.
    GeneIDi878416.
    KEGGipae:PA4959.
    PATRICi19844728. VBIPseAer58763_5193.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AE004091 Genomic DNA. Translation: AAG08344.1 .
    PIRi E83027.
    RefSeqi NP_253646.1. NC_002516.2.

    3D structure databases

    Select the link destinations:
    PDBe
    RCSB PDB
    PDBj
    Links Updated
    Entry Method Resolution (Å) Chain Positions PDBsum
    3HV8 X-ray 1.44 A 429-691 [» ]
    3HV9 X-ray 2.30 A 429-691 [» ]
    3HVA X-ray 2.04 A/B 260-431 [» ]
    4AFY X-ray 2.01 A/B 439-691 [» ]
    4AG0 X-ray 2.30 A/B 439-691 [» ]
    4J40 X-ray 2.99 A/B 260-691 [» ]
    ProteinModelPortali Q9HUK6.
    SMRi Q9HUK6. Positions 255-686.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    DIPi DIP-48302N.
    STRINGi 208964.PA4959.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    EnsemblBacteriai AAG08344 ; AAG08344 ; PA4959 .
    GeneIDi 878416.
    KEGGi pae:PA4959.
    PATRICi 19844728. VBIPseAer58763_5193.

    Organism-specific databases

    PseudoCAPi PA4959.

    Phylogenomic databases

    HOGENOMi HOG000225944.
    OMAi ACKRINE.
    OrthoDBi EOG69GZGV.
    PhylomeDBi Q9HUK6.

    Miscellaneous databases

    EvolutionaryTracei Q9HUK6.

    Family and domain databases

    Gene3Di 3.20.20.450. 1 hit.
    InterProi IPR001054. A/G_cyclase.
    IPR011006. CheY-like_superfamily.
    IPR001633. Diguanylate_PEstase_EAL_dom.
    IPR000160. GGDEF_dom.
    IPR000014. PAS.
    IPR013767. PAS_fold.
    IPR001789. Sig_transdc_resp-reg_receiver.
    [Graphical view ]
    Pfami PF00563. EAL. 1 hit.
    PF00990. GGDEF. 1 hit.
    PF00989. PAS. 1 hit.
    [Graphical view ]
    SMARTi SM00052. EAL. 1 hit.
    SM00267. GGDEF. 1 hit.
    SM00091. PAS. 1 hit.
    [Graphical view ]
    SUPFAMi SSF141868. SSF141868. 1 hit.
    SSF52172. SSF52172. 1 hit.
    SSF55073. SSF55073. 1 hit.
    SSF55785. SSF55785. 1 hit.
    TIGRFAMsi TIGR00254. GGDEF. 1 hit.
    TIGR00229. sensory_box. 1 hit.
    PROSITEi PS50883. EAL. 1 hit.
    PS50887. GGDEF. 1 hit.
    PS50110. RESPONSE_REGULATORY. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: ATCC 15692 / PAO1 / 1C / PRS 101 / LMG 12228Imported.
    2. "Structural analysis of the GGDEF-EAL domain-containing c-di-GMP receptor FimX."
      Navarro M.V., De N., Bae N., Wang Q., Sondermann H.
      Structure 17:1104-1116(2009) [PubMed] [Europe PMC] [Abstract]
      Cited for: X-RAY CRYSTALLOGRAPHY (1.44 ANGSTROMS) OF 429-691 IN COMPLEX WITH CYCLICDIGUANOSINE MONOPHOSPHATE.
    3. "Crystal structure of an EAL domain in complex with reaction product 5'-pGpG."
      Robert-Paganin J., Nonin-Lecomte S., Rety S.
      PLoS ONE 7:e52424-e52424(2012) [PubMed] [Europe PMC] [Abstract]
      Cited for: X-RAY CRYSTALLOGRAPHY (2.01 ANGSTROMS) OF 439-691.

    Entry informationi

    Entry nameiQ9HUK6_PSEAE
    AccessioniPrimary (citable) accession number: Q9HUK6
    Entry historyi
    Integrated into UniProtKB/TrEMBL: March 1, 2001
    Last sequence update: March 1, 2001
    Last modified: October 1, 2014
    This is version 93 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiUnreviewed (UniProtKB/TrEMBL)

    Miscellaneousi

    Keywords - Technical termi

    3D-structureImported, Complete proteome, Reference proteomeImported

    External Data

    Dasty 3