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Protein
Submitted name:

FimX

Gene

fimX

Organism
Pseudomonas aeruginosa (strain ATCC 15692 / PAO1 / 1C / PRS 101 / LMG 12228)
Status
Unreviewed-Annotation score: Annotation score: 1 out of 5-Experimental evidence at protein leveli

Functioni

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Binding sitei461 – 4611Cyclicdiguanosine monophosphateCombined sources
Binding sitei507 – 5071Cyclicdiguanosine monophosphateCombined sources
Binding sitei533 – 5331Cyclicdiguanosine monophosphateCombined sources
Binding sitei673 – 6731Cyclicdiguanosine monophosphateCombined sources

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Nucleotide bindingi478 – 4792Cyclicdiguanosine monophosphateCombined sources
Nucleotide bindingi652 – 6543Cyclicdiguanosine monophosphateCombined sources

GO - Molecular functioni

  1. nucleotide binding Source: UniProtKB-KW
  2. signal transducer activity Source: InterPro

GO - Biological processi

  1. phosphorelay signal transduction system Source: InterPro
  2. regulation of transcription, DNA-templated Source: InterPro
Complete GO annotation...

Keywords - Ligandi

Nucleotide-bindingCombined sources

Names & Taxonomyi

Protein namesi
Submitted name:
FimXImported
Gene namesi
Name:fimXImported
Ordered Locus Names:PA4959Imported
OrganismiPseudomonas aeruginosa (strain ATCC 15692 / PAO1 / 1C / PRS 101 / LMG 12228)Imported
Taxonomic identifieri208964 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaPseudomonadalesPseudomonadaceaePseudomonas
ProteomesiUP000002438: Chromosome

Organism-specific databases

PseudoCAPiPA4959.

Interactioni

Protein-protein interaction databases

DIPiDIP-48302N.
STRINGi208964.PA4959.

Structurei

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
EntryMethodResolution (Å)ChainPositionsPDBsum
3HV8X-ray1.44A429-691[»]
3HV9X-ray2.30A429-691[»]
3HVAX-ray2.04A/B260-431[»]
4AFYX-ray2.01A/B439-691[»]
4AG0X-ray2.30A/B439-691[»]
4J40X-ray2.99A/B260-691[»]
ProteinModelPortaliQ9HUK6.
SMRiQ9HUK6. Positions 255-686.
ModBaseiSearch...
MobiDBiSearch...

Miscellaneous databases

EvolutionaryTraceiQ9HUK6.

Family & Domainsi

Phylogenomic databases

HOGENOMiHOG000225944.
InParanoidiQ9HUK6.
OMAiACKRINE.
OrthoDBiEOG69GZGV.
PhylomeDBiQ9HUK6.

Family and domain databases

Gene3Di3.20.20.450. 1 hit.
InterProiIPR011006. CheY-like_superfamily.
IPR001633. EAL_dom.
IPR000160. GGDEF_dom.
IPR029787. Nucleotide_cyclase.
IPR000014. PAS.
IPR013767. PAS_fold.
IPR001789. Sig_transdc_resp-reg_receiver.
[Graphical view]
PfamiPF00563. EAL. 1 hit.
PF00990. GGDEF. 1 hit.
PF00989. PAS. 1 hit.
[Graphical view]
SMARTiSM00052. EAL. 1 hit.
SM00267. GGDEF. 1 hit.
SM00091. PAS. 1 hit.
[Graphical view]
SUPFAMiSSF141868. SSF141868. 1 hit.
SSF52172. SSF52172. 1 hit.
SSF55073. SSF55073. 1 hit.
SSF55785. SSF55785. 1 hit.
TIGRFAMsiTIGR00254. GGDEF. 1 hit.
TIGR00229. sensory_box. 1 hit.
PROSITEiPS50883. EAL. 1 hit.
PS50887. GGDEF. 1 hit.
PS50110. RESPONSE_REGULATORY. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q9HUK6-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MAIEKKTIRL LILEDSQNEA ERLVSLFRNA GHATRVHRLT SPEDLAETLQ
60 70 80 90 100
QSWDLLIAAP TSECLEPGEA LATLRRQSRD IPFIQLVADN SSDAITDALM
110 120 130 140 150
LGAQDALPQG EDERLVLVAN RELAGLAERR ARRAAELALR EAEKRCQLLL
160 170 180 190 200
DSSVDAITYV HDGMHIYANR SYMALFGYED AEELEGLPVI DLIASCDQGA
210 220 230 240 250
FKDFLKGYQN DQRQTELVCT GVKLDGQEFK ARISLSAATY DGEPCIQVVI
260 270 280 290 300
RGEVDNAELE EKLREVSSQD PVTGLYNRSH FLDLMDAAVQ QAVTARKPST
310 320 330 340 350
LAYIHLNGYP SLQADHGLSG IDLLLGQLAG LMREQFGEEA DLARFGDSIF
360 370 380 390 400
AALFKGKTPE QAQAALQRLL KKVENHLFEL NGRSAQATLS IGVAGLDEKT
410 420 430 440 450
AKAQDVMNRA HRCADDAARK GGSQIKQYNP AEELAAAAQR GDVIAILQQA
460 470 480 490 500
LETNSFRLLF QPVISLRGDS HENYEVLLRL LNPQGQEVPP AEFLHAAKEA
510 520 530 540 550
GLAEKIDRWV ILNSIKLLAE HRAKGHQTKL FVHLSSASLQ DPGLLPWLGV
560 570 580 590 600
ALKAARLPPE SLVFQISEAD ATSYLKQAKQ LTQGLATLHC QAAISQFGCS
610 620 630 640 650
LNPFNALKHL TVQFIKIDGS FVQDLNQVEN QEILKGLIAE LHEQQKLSIV
660 670 680 690
PFVESASVLA TLWQAGATYI QGYYLQGPSQ AMDYDFSSGD E
Length:691
Mass (Da):75,993
Last modified:March 1, 2001 - v1
Checksum:i518BAFE4C8977B43
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AE004091 Genomic DNA. Translation: AAG08344.1.
PIRiE83027.
RefSeqiNP_253646.1. NC_002516.2.

Genome annotation databases

EnsemblBacteriaiAAG08344; AAG08344; PA4959.
GeneIDi878416.
KEGGipae:PA4959.
PATRICi19844728. VBIPseAer58763_5193.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AE004091 Genomic DNA. Translation: AAG08344.1.
PIRiE83027.
RefSeqiNP_253646.1. NC_002516.2.

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
EntryMethodResolution (Å)ChainPositionsPDBsum
3HV8X-ray1.44A429-691[»]
3HV9X-ray2.30A429-691[»]
3HVAX-ray2.04A/B260-431[»]
4AFYX-ray2.01A/B439-691[»]
4AG0X-ray2.30A/B439-691[»]
4J40X-ray2.99A/B260-691[»]
ProteinModelPortaliQ9HUK6.
SMRiQ9HUK6. Positions 255-686.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

DIPiDIP-48302N.
STRINGi208964.PA4959.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaiAAG08344; AAG08344; PA4959.
GeneIDi878416.
KEGGipae:PA4959.
PATRICi19844728. VBIPseAer58763_5193.

Organism-specific databases

PseudoCAPiPA4959.

Phylogenomic databases

HOGENOMiHOG000225944.
InParanoidiQ9HUK6.
OMAiACKRINE.
OrthoDBiEOG69GZGV.
PhylomeDBiQ9HUK6.

Miscellaneous databases

EvolutionaryTraceiQ9HUK6.

Family and domain databases

Gene3Di3.20.20.450. 1 hit.
InterProiIPR011006. CheY-like_superfamily.
IPR001633. EAL_dom.
IPR000160. GGDEF_dom.
IPR029787. Nucleotide_cyclase.
IPR000014. PAS.
IPR013767. PAS_fold.
IPR001789. Sig_transdc_resp-reg_receiver.
[Graphical view]
PfamiPF00563. EAL. 1 hit.
PF00990. GGDEF. 1 hit.
PF00989. PAS. 1 hit.
[Graphical view]
SMARTiSM00052. EAL. 1 hit.
SM00267. GGDEF. 1 hit.
SM00091. PAS. 1 hit.
[Graphical view]
SUPFAMiSSF141868. SSF141868. 1 hit.
SSF52172. SSF52172. 1 hit.
SSF55073. SSF55073. 1 hit.
SSF55785. SSF55785. 1 hit.
TIGRFAMsiTIGR00254. GGDEF. 1 hit.
TIGR00229. sensory_box. 1 hit.
PROSITEiPS50883. EAL. 1 hit.
PS50887. GGDEF. 1 hit.
PS50110. RESPONSE_REGULATORY. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: ATCC 15692 / PAO1 / 1C / PRS 101 / LMG 12228Imported.
  2. "Structural analysis of the GGDEF-EAL domain-containing c-di-GMP receptor FimX."
    Navarro M.V., De N., Bae N., Wang Q., Sondermann H.
    Structure 17:1104-1116(2009) [PubMed] [Europe PMC] [Abstract]
    Cited for: X-RAY CRYSTALLOGRAPHY (1.44 ANGSTROMS) OF 429-691 IN COMPLEX WITH CYCLICDIGUANOSINE MONOPHOSPHATE.
  3. "Crystal structure of an EAL domain in complex with reaction product 5'-pGpG."
    Robert-Paganin J., Nonin-Lecomte S., Rety S.
    PLoS ONE 7:e52424-e52424(2012) [PubMed] [Europe PMC] [Abstract]
    Cited for: X-RAY CRYSTALLOGRAPHY (2.01 ANGSTROMS) OF 439-691.

Entry informationi

Entry nameiQ9HUK6_PSEAE
AccessioniPrimary (citable) accession number: Q9HUK6
Entry historyi
Integrated into UniProtKB/TrEMBL: March 1, 2001
Last sequence update: March 1, 2001
Last modified: January 7, 2015
This is version 95 of the entry and version 1 of the sequence. [Complete history]
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Keywords - Technical termi

3D-structureCombined sources, Complete proteome, Reference proteomeImported

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.