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Q9HUK6

- Q9HUK6_PSEAE

UniProt

Q9HUK6 - Q9HUK6_PSEAE

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Protein
Submitted name: FimX
Gene
fimX, PA4959
Organism
Pseudomonas aeruginosa (strain ATCC 15692 / PAO1 / 1C / PRS 101 / LMG 12228)
Status
Unreviewed - Annotation score: 2 out of 5 - Experimental evidence at protein leveli

Functioni

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Binding sitei461 – 4611Cyclic diguanosine monophosphateImported
Binding sitei461 – 4611Phosphate 1Imported
Binding sitei507 – 5071Cyclic diguanosine monophosphateImported
Binding sitei533 – 5331Cyclic diguanosine monophosphateImported
Binding sitei534 – 5341Phosphate 2; via amide nitrogen and carbonyl oxygenImported
Binding sitei595 – 5951Phosphate 2Imported
Binding sitei652 – 6521Phosphate 1Imported
Binding sitei671 – 6711Phosphate 1Imported
Binding sitei673 – 6731Cyclic diguanosine monophosphateImported

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Nucleotide bindingi478 – 4792Cyclic diguanosine monophosphateImported
Nucleotide bindingi652 – 6543Cyclic diguanosine monophosphateImported

GO - Molecular functioni

  1. nucleotide binding Source: UniProtKB-KW
  2. phosphorelay response regulator activity Source: InterPro
  3. phosphorus-oxygen lyase activity Source: InterPro

GO - Biological processi

  1. cyclic nucleotide biosynthetic process Source: InterPro
  2. regulation of transcription, DNA-templated Source: InterPro
Complete GO annotation...

Keywords - Ligandi

Nucleotide-bindingImported

Names & Taxonomyi

Protein namesi
Submitted name:
FimXImported
Gene namesi
Name:fimXImported
Ordered Locus Names:PA4959Imported
OrganismiPseudomonas aeruginosa (strain ATCC 15692 / PAO1 / 1C / PRS 101 / LMG 12228)Imported
Taxonomic identifieri208964 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaPseudomonadalesPseudomonadaceaePseudomonas
ProteomesiUP000002438: Chromosome

Organism-specific databases

PseudoCAPiPA4959.

Interactioni

Protein-protein interaction databases

DIPiDIP-48302N.
STRINGi208964.PA4959.

Structurei

3D structure databases

Select the link destinations:
PDBe
RCSB PDB
PDBj
Links Updated
EntryMethodResolution (Å)ChainPositionsPDBsum
3HV8X-ray1.44A429-691[»]
3HV9X-ray2.30A429-691[»]
3HVAX-ray2.04A/B260-431[»]
4AFYX-ray2.01A/B439-691[»]
4AG0X-ray2.30A/B439-691[»]
4J40X-ray2.99A/B260-691[»]
ProteinModelPortaliQ9HUK6.
SMRiQ9HUK6. Positions 7-123, 255-686.

Miscellaneous databases

EvolutionaryTraceiQ9HUK6.

Family & Domainsi

Region

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Regioni565 – 5673Phosphate 2 bindingImported

Phylogenomic databases

HOGENOMiHOG000225944.
OMAiACKRINE.
OrthoDBiEOG69GZGV.
PhylomeDBiQ9HUK6.

Family and domain databases

Gene3Di3.20.20.450. 1 hit.
InterProiIPR001054. A/G_cyclase.
IPR011006. CheY-like_superfamily.
IPR001633. Diguanylate_PEstase_EAL_dom.
IPR000160. GGDEF_dom.
IPR000014. PAS.
IPR013767. PAS_fold.
IPR001789. Sig_transdc_resp-reg_receiver.
[Graphical view]
PfamiPF00563. EAL. 1 hit.
PF00990. GGDEF. 1 hit.
PF00989. PAS. 1 hit.
[Graphical view]
SMARTiSM00052. EAL. 1 hit.
SM00267. GGDEF. 1 hit.
SM00091. PAS. 1 hit.
[Graphical view]
SUPFAMiSSF141868. SSF141868. 1 hit.
SSF52172. SSF52172. 1 hit.
SSF55073. SSF55073. 1 hit.
SSF55785. SSF55785. 1 hit.
TIGRFAMsiTIGR00254. GGDEF. 1 hit.
TIGR00229. sensory_box. 1 hit.
PROSITEiPS50883. EAL. 1 hit.
PS50887. GGDEF. 1 hit.
PS50110. RESPONSE_REGULATORY. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q9HUK6-1 [UniParc]FASTAAdd to Basket

« Hide

MAIEKKTIRL LILEDSQNEA ERLVSLFRNA GHATRVHRLT SPEDLAETLQ    50
QSWDLLIAAP TSECLEPGEA LATLRRQSRD IPFIQLVADN SSDAITDALM 100
LGAQDALPQG EDERLVLVAN RELAGLAERR ARRAAELALR EAEKRCQLLL 150
DSSVDAITYV HDGMHIYANR SYMALFGYED AEELEGLPVI DLIASCDQGA 200
FKDFLKGYQN DQRQTELVCT GVKLDGQEFK ARISLSAATY DGEPCIQVVI 250
RGEVDNAELE EKLREVSSQD PVTGLYNRSH FLDLMDAAVQ QAVTARKPST 300
LAYIHLNGYP SLQADHGLSG IDLLLGQLAG LMREQFGEEA DLARFGDSIF 350
AALFKGKTPE QAQAALQRLL KKVENHLFEL NGRSAQATLS IGVAGLDEKT 400
AKAQDVMNRA HRCADDAARK GGSQIKQYNP AEELAAAAQR GDVIAILQQA 450
LETNSFRLLF QPVISLRGDS HENYEVLLRL LNPQGQEVPP AEFLHAAKEA 500
GLAEKIDRWV ILNSIKLLAE HRAKGHQTKL FVHLSSASLQ DPGLLPWLGV 550
ALKAARLPPE SLVFQISEAD ATSYLKQAKQ LTQGLATLHC QAAISQFGCS 600
LNPFNALKHL TVQFIKIDGS FVQDLNQVEN QEILKGLIAE LHEQQKLSIV 650
PFVESASVLA TLWQAGATYI QGYYLQGPSQ AMDYDFSSGD E 691
Length:691
Mass (Da):75,993
Last modified:March 1, 2001 - v1
Checksum:i518BAFE4C8977B43
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AE004091 Genomic DNA. Translation: AAG08344.1.
PIRiE83027.
RefSeqiNP_253646.1. NC_002516.2.

Genome annotation databases

EnsemblBacteriaiAAG08344; AAG08344; PA4959.
GeneIDi878416.
KEGGipae:PA4959.
PATRICi19844728. VBIPseAer58763_5193.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AE004091 Genomic DNA. Translation: AAG08344.1 .
PIRi E83027.
RefSeqi NP_253646.1. NC_002516.2.

3D structure databases

Select the link destinations:
PDBe
RCSB PDB
PDBj
Links Updated
Entry Method Resolution (Å) Chain Positions PDBsum
3HV8 X-ray 1.44 A 429-691 [» ]
3HV9 X-ray 2.30 A 429-691 [» ]
3HVA X-ray 2.04 A/B 260-431 [» ]
4AFY X-ray 2.01 A/B 439-691 [» ]
4AG0 X-ray 2.30 A/B 439-691 [» ]
4J40 X-ray 2.99 A/B 260-691 [» ]
ProteinModelPortali Q9HUK6.
SMRi Q9HUK6. Positions 7-123, 255-686.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

DIPi DIP-48302N.
STRINGi 208964.PA4959.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai AAG08344 ; AAG08344 ; PA4959 .
GeneIDi 878416.
KEGGi pae:PA4959.
PATRICi 19844728. VBIPseAer58763_5193.

Organism-specific databases

PseudoCAPi PA4959.

Phylogenomic databases

HOGENOMi HOG000225944.
OMAi ACKRINE.
OrthoDBi EOG69GZGV.
PhylomeDBi Q9HUK6.

Miscellaneous databases

EvolutionaryTracei Q9HUK6.

Family and domain databases

Gene3Di 3.20.20.450. 1 hit.
InterProi IPR001054. A/G_cyclase.
IPR011006. CheY-like_superfamily.
IPR001633. Diguanylate_PEstase_EAL_dom.
IPR000160. GGDEF_dom.
IPR000014. PAS.
IPR013767. PAS_fold.
IPR001789. Sig_transdc_resp-reg_receiver.
[Graphical view ]
Pfami PF00563. EAL. 1 hit.
PF00990. GGDEF. 1 hit.
PF00989. PAS. 1 hit.
[Graphical view ]
SMARTi SM00052. EAL. 1 hit.
SM00267. GGDEF. 1 hit.
SM00091. PAS. 1 hit.
[Graphical view ]
SUPFAMi SSF141868. SSF141868. 1 hit.
SSF52172. SSF52172. 1 hit.
SSF55073. SSF55073. 1 hit.
SSF55785. SSF55785. 1 hit.
TIGRFAMsi TIGR00254. GGDEF. 1 hit.
TIGR00229. sensory_box. 1 hit.
PROSITEi PS50883. EAL. 1 hit.
PS50887. GGDEF. 1 hit.
PS50110. RESPONSE_REGULATORY. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: ATCC 15692 / PAO1 / 1C / PRS 101 / LMG 12228.
  2. "Structural analysis of the GGDEF-EAL domain-containing c-di-GMP receptor FimX."
    Navarro M.V., De N., Bae N., Wang Q., Sondermann H.
    Structure 17:1104-1116(2009) [PubMed] [Europe PMC] [Abstract]
    Cited for: X-RAY CRYSTALLOGRAPHY (1.44 ANGSTROMS) OF 429-691.
  3. "Crystal structure of an EAL domain in complex with reaction product 5'-pGpG."
    Robert-Paganin J., Nonin-Lecomte S., Rety S.
    PLoS ONE 7:e52424-e52424(2012) [PubMed] [Europe PMC] [Abstract]
    Cited for: X-RAY CRYSTALLOGRAPHY (2.01 ANGSTROMS) OF 439-691 IN COMPLEX WITH PHOSPHATE.

Entry informationi

Entry nameiQ9HUK6_PSEAE
AccessioniPrimary (citable) accession number: Q9HUK6
Entry historyi
Integrated into UniProtKB/TrEMBL: March 1, 2001
Last sequence update: March 1, 2001
Last modified: July 9, 2014
This is version 92 of the entry and version 1 of the sequence. [Complete history]
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Keywords - Technical termi

3D-structureImported, Complete proteome, Reference proteome

External Data

Dasty 3

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