Q9HUF1 (MSRA_PSEAE) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Peptide methionine sulfoxide reductase MsrA
Short name=Protein-methionine-S-oxide reductase
EC=1.8.4.11

Alternative name(s):
Peptide-methionine (S)-S-oxide reductase
Short name=Peptide Met(O) reductase

Gene names

Name:	msrA
Ordered Locus Names:	PA5018

Organism

Pseudomonas aeruginosa (strain ATCC 15692 / PAO1 / 1C / PRS 101 / LMG 12228)

Taxonomic identifier

208964 [NCBI]

Taxonomic lineage

Bacteria › Proteobacteria › Gammaproteobacteria › Pseudomonadales › Pseudomonadaceae › Pseudomonas

Protein attributes

Sequence length	215 AA.
Sequence status	Complete.
Protein existence	Inferred from homology

General annotation (Comments)

Function	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine By similarity. HAMAP MF_01401
Catalytic activity	Peptide-L-methionine + thioredoxin disulfide + H2O = peptide-L-methionine (S)-S-oxide + thioredoxin. HAMAP MF_01401 L-methionine + thioredoxin disulfide + H2O = L-methionine (S)-S-oxide + thioredoxin. HAMAP MF_01401
Sequence similarities	Belongs to the MsrA Met sulfoxide reductase family.

Ontologies

Keywords
Molecular function	Oxidoreductase
Technical term	Complete proteome Reference proteome
Gene Ontology (GO)
Biological process	protein metabolic process Inferred from electronic annotation. Source: InterPro
Molecular function	peptide-methionine-(S)-S-oxide reductase activity Inferred from electronic annotation. Source: EC
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 215	215	Peptide methionine sulfoxide reductase MsrA HAMAP MF_01401		PRO_0000138566
Sites
	Active site	58	1	By similarity

Sequences

	Sequence		Length	Mass (Da)
	Q9HUF1 [UniParc]. Last modified January 11, 2001. Version 1. Checksum: 6B5BC8E8D63FDA6D	FASTA	215	23,518
	10 20 30 40 50 60 MVLRSEILTK KSELPTPDQA LPGRESAMPV PEAHFVNGRP LTAPFPAGLQ QVLFGMGCFW 70 80 90 100 110 120 GAERRLWQQP GVWVTAVGYA GGYTPNPTYD EVCSGLTGHS EVVLVVYNPQ ETSFEQLLKV 130 140 150 160 170 180 FWEAHDPTQG MRQGGDIGTQ YRSVIYTFDA AQKAAAMASR ESFQAELAKA GYDRITTEIA 190 200 210 DVPPFYYAEA YHQQYLAKNP NGYCGLGGTG VCLPA

References

[1]

"Complete genome sequence of Pseudomonas aeruginosa PAO1, an opportunistic pathogen." Stover C.K., Pham X.-Q.T., Erwin A.L., Mizoguchi S.D., Warrener P., Hickey M.J., Brinkman F.S.L., Hufnagle W.O., Kowalik D.J., Lagrou M., Garber R.L., Goltry L., Tolentino E., Westbrock-Wadman S., Yuan Y., Brody L.L., Coulter S.N., Folger K.R. , Kas A., Larbig K., Lim R.M., Smith K.A., Spencer D.H., Wong G.K.-S., Wu Z., Paulsen I.T., Reizer J., Saier M.H. Jr., Hancock R.E.W., Lory S., Olson M.V. Nature 406:959-964(2000) [PubMed: 10984043] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: ATCC 15692 / PAO1 / 1C / PRS 101 / LMG 12228.

+

Additional computationally mapped references.

Cross-references

Sequence databases
EMBL GenBank DDBJ	AE004091 Genomic DNA. Translation: AAG08403.1.
PIR	B83019.
RefSeq	NP_253705.1. NC_002516.2.
3D structure databases
ProteinModelPortal	Q9HUF1.
SMR	Q9HUF1. Positions 16-214.
ModBase	Search...
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
GeneID	881240.
GenomeReviews	Gene locus PA5018 in contig AE004091_GR.
KEGG	pae:PA5018.
NMPDR	fig|208964.1.peg.5015.
PATRIC	19844863. VBIPseAer58763_5260.
Organism-specific databases
PseudoCAP	PA5018.
Phylogenomic databases
HOGENOM	HBG748152.
OMA	QETSFEQ.
ProtClustDB	CLSK869064.
Enzyme and pathway databases
BioCyc	PAER208964:PA5018-MONOMER.
Family and domain databases
HAMAP	MF_01401. MsrA. [Tree]
InterPro	IPR002569. Peptide_Met_Sox_Rdtase_MsrA. [Graphical view]
Gene3D	G3DSA:3.30.1060.10. MsrA. 1 hit.
KO	K07304.
Pfam	PF01625. PMSR. 1 hit. [Graphical view]
SUPFAM	SSF55068. MsrA. 1 hit.
TIGRFAMs	TIGR00401. MsrA. 1 hit.
ProtoNet	Search...

Entry information

Entry name

MSRA_PSEAE

Accession

Primary (citable) accession number: Q9HUF1

Entry history

Integrated into UniProtKB/Swiss-Prot:	January 11, 2001
Last sequence update:	January 11, 2001
Last modified:	January 25, 2012
This is version 67 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Prokaryotic Protein Annotation Program