Unreviewed, UniProtKB/TrEMBL Q9HU22 (Q9HU22_PSEAE)

Names and origin

Protein names

Recommended name:
    Glucose-1-phosphate thymidylyltransferase RuleBase RU003706V0
    EC=2.7.7.24

Gene names

Name:	rmlA EMBL AAG08548.1
Ordered Locus Names:	PA5163

Organism

Pseudomonas aeruginosa [Complete proteome] [HAMAP]

Taxonomic identifier

287 [NCBI]

Taxonomic lineage

Bacteria › Proteobacteria › Gammaproteobacteria › Pseudomonadales › Pseudomonadaceae › Pseudomonas

Protein attributes

Sequence length	293 AA.
Sequence status	Complete.
Sequence processing	The displayed sequence is not processed.
Protein existence	Evidence at protein level.

General annotation (Comments)

Function	Catalyzes the formation of dTDP-glucose, from dTTP and glucose 1-phosphate, as well as its pyrophosphorolysis By similarity. RuleBase RU003706V0
Catalytic activity	dTTP + alpha-D-glucose 1-phosphate = diphosphate + dTDP-glucose. RuleBase RU003706V0
Sequence similarities	Belongs to the glucose-1-phosphate thymidylyltransferase family. RuleBase RU003706V0

Ontologies

Keywords
Ligand	Magnesium RuleBase RU003706V0 Metal-binding RuleBase RU003706V0
Molecular function	Nucleotidyltransferase RuleBase RU003706V0 Transferase
Technical term	Complete proteome
Gene Ontology (GO)
Biological process	extracellular polysaccharide biosynthetic process Inferred from electronic annotation. Source: InterPro
Molecular function	glucose-1-phosphate thymidylyltransferase activity Inferred from electronic annotation. Source: EC magnesium ion binding Inferred from electronic annotation. Source: UniProtKB-KW
Complete GO annotation...

Sequences

	Sequence		Length	Mass (Da)
	Q9HU22-1 [UniParc]. Last modified March 1, 2001. Version 1. Checksum: 1E249F4359DC0553	FASTA	293	32,457
	10 20 30 40 50 60 MKRKGIILAG GSGTRLHPAT LAISKQLLPV YDKPMIYYPL STLMLAGIRE ILIISTPQDT 70 80 90 100 110 120 PRFQQLLGDG SNWGLDLQYA VQPSPDGLAQ AFLIGESFIG NDLSALVLGD NLYYGHDFHE 130 140 150 160 170 180 LLGSASQRQT GASVFAYHVL DPERYGVVEF DQGGKAISLE EKPLEPKSNY AVTGLYFYDQ 190 200 210 220 230 240 QVVDIARDLK PSPRGELEIT DVNRAYLERG QLSVEIMGRG YAWLDTGTHD SLLEAGQFIA 250 260 270 280 290 TLENRQGLKV ACPEEIAYRQ KWIDAAQLEK LAAPLAKNGY GQYLKRLLTE TVY

References

	« Hide 'large scale' referencesShow 'large scale' references »
[1]	"Complete genome sequence of Pseudomonas aeruginosa PAO1, an opportunistic pathogen." Stover C.K., Pham X.-Q.T., Erwin A.L., Mizoguchi S.D., Warrener P., Hickey M.J., Brinkman F.S.L., Hufnagle W.O., Kowalik D.J., Lagrou M., Garber R.L., Goltry L., Tolentino E., Westbrock-Wadman S., Yuan Y., Brody L.L., Coulter S.N., Folger K.R. , Kas A., Larbig K., Lim R.M., Smith K.A., Spencer D.H., Wong G.K.-S., Wu Z., Paulsen I.T., Reizer J., Saier M.H. Jr., Hancock R.E.W., Lory S., Olson M.V. Nature 406:959-964(2000) [PubMed: 10984043] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: ATCC 15692 / PAO1 / 1C / PRS 101 / LMG 12228.
[2]	"Cloning and characterization of the rmlA gene of Pseudomonas aeruginosa." Maeki M. Submitted (AUG-2000) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE. Strain: PA01 EMBL CAC82197.1.
+	Additional computationally mapped references.

Cross-references

Sequence databases

EMBLGenBankDDBJ

AE004091 Genomic DNA. Translation: AAG08548.1.
AJ298592 Genomic DNA. Translation: CAC82197.1.

PIR

D83000.

RefSeq

NP_253850.1.

3D structure databases

PDBPDBe

Entry	Method	Resolution (Å)	Chain	Positions	PDBsum
1FXO	X-ray	1.66	A/B/C/D/E/F/G/H	1-293	[»]
1FZW	X-ray	1.90	A/B/C/D/E/F/G/H	1-293	[»]
1G0R	X-ray	1.87	A/B/C/D/E/F/G/H	1-293	[»]
1G1L	X-ray	1.77	A/B/C/D/E/F/G/H	1-293	[»]
1G23	X-ray	2.80	A/B/C/D/E/F/G/H	1-293	[»]
1G2V	X-ray	2.60	A/B/C/D/E/F/G/H	1-293	[»]
1G3L	X-ray	2.70	A/B/C/D	1-293	[»]

ModBase

Search...

Genome annotation databases

GeneID

879990.

GenomeReviews

Gene locus PA5163 in contig AE004091_GR.

KEGG

pae:PA5163.

NMPDR

fig|208964.1.peg.5160.

Organism-specific databases

PseudoCAP

PA5163.

CMR

Search...

Phylogenomic databases

HOGENOM

Q9HU22.

OMA

FAYHVLD

Enzyme and pathway databases

BioCyc

PAER208964:PA5163-MON.

Family and domain databases

InterPro

IPR005907. G1P_thy_trans_l.
IPR005835. NTP_transferase.
[Graphical view]

Pfam

PF00483. NTP_transferase. 1 hit.
[Graphical view]

TIGRFAMs

TIGR01207. rmlA. 1 hit.

ProtoNet

Search...

Entry information

Entry name

Q9HU22_PSEAE

Accession

Primary (citable) accession number: Q9HU22
Secondary accession number(s): Q7AYQ9

Entry history

Integrated into UniProtKB/TrEMBL:	March 1, 2001
Last sequence update:	March 1, 2001
Last modified:	November 3, 2009
This is version 53 of the entry and version 1 of the sequence. [Complete history]

Entry status

Unreviewed (UniProtKB/TrEMBL)