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Q9HTX7

- GCSP2_PSEAE

UniProt

Q9HTX7 - GCSP2_PSEAE

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Protein

Glycine dehydrogenase (decarboxylating) 2

Gene

gcvP2

Organism
Pseudomonas aeruginosa (strain ATCC 15692 / PAO1 / 1C / PRS 101 / LMG 12228)
Status
Reviewed - Annotation score: 3 out of 5- Protein inferred from homologyi

Functioni

The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor; CO2 is released and the remaining methylamine moiety is then transferred to the lipoamide cofactor of the H protein (By similarity).By similarity

Catalytic activityi

Glycine + [glycine-cleavage complex H protein]-N(6)-lipoyl-L-lysine = [glycine-cleavage complex H protein]-S-aminomethyl-N(6)-dihydrolipoyl-L-lysine + CO2.

Cofactori

GO - Molecular functioni

  1. glycine dehydrogenase (decarboxylating) activity Source: UniProtKB-EC
  2. pyridoxal phosphate binding Source: InterPro

GO - Biological processi

  1. glycine decarboxylation via glycine cleavage system Source: UniProtKB-HAMAP
Complete GO annotation...

Keywords - Molecular functioni

Oxidoreductase

Keywords - Ligandi

Pyridoxal phosphate

Names & Taxonomyi

Protein namesi
Recommended name:
Glycine dehydrogenase (decarboxylating) 2 (EC:1.4.4.2)
Alternative name(s):
Glycine cleavage system P-protein 2
Glycine decarboxylase 2
Glycine dehydrogenase (aminomethyl-transferring) 2
Gene namesi
Name:gcvP2
Ordered Locus Names:PA5213
OrganismiPseudomonas aeruginosa (strain ATCC 15692 / PAO1 / 1C / PRS 101 / LMG 12228)
Taxonomic identifieri208964 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaPseudomonadalesPseudomonadaceaePseudomonas
ProteomesiUP000002438: Chromosome

Organism-specific databases

PseudoCAPiPA5213.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 958958Glycine dehydrogenase (decarboxylating) 2PRO_0000166926Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei707 – 7071N6-(pyridoxal phosphate)lysineBy similarity

Proteomic databases

PRIDEiQ9HTX7.

Interactioni

Subunit structurei

The glycine cleavage system is composed of four proteins: P, T, L and H.By similarity

Protein-protein interaction databases

STRINGi208964.PA5213.

Structurei

3D structure databases

ProteinModelPortaliQ9HTX7.
SMRiQ9HTX7. Positions 9-950.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the GcvP family.Curated

Phylogenomic databases

eggNOGiCOG1003.
HOGENOMiHOG000239369.
InParanoidiQ9HTX7.
KOiK00281.
OMAiIRVQVII.
OrthoDBiEOG6HMXDX.
PhylomeDBiQ9HTX7.

Family and domain databases

Gene3Di3.40.640.10. 2 hits.
HAMAPiMF_00711. GcvP.
InterProiIPR020580. GDC-P_N.
IPR020581. GDC_P.
IPR003437. GDC_P_homo.
IPR015424. PyrdxlP-dep_Trfase.
IPR015421. PyrdxlP-dep_Trfase_major_sub1.
[Graphical view]
PANTHERiPTHR11773. PTHR11773. 1 hit.
PfamiPF02347. GDC-P. 2 hits.
[Graphical view]
SUPFAMiSSF53383. SSF53383. 3 hits.
TIGRFAMsiTIGR00461. gcvP. 1 hit.

Sequencei

Sequence statusi: Complete.

Q9HTX7-1 [UniParc]FASTAAdd to Basket

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        10         20         30         40         50
MSQTPSLAQL QPADAFLRRH LGPDPAEQQA MLAFLGVSTR AELIVQTVPP
60 70 80 90 100
AIRLNRPLEL PAALDEQAAL ARLRGYAGLN QRWTSLIGMG YYGTVTPSVI
110 120 130 140 150
LRNVLENPGW YTAYTPYQPE IAQGRLEALL NFQQLTIDLT GLDLASASLL
160 170 180 190 200
DEATAAAEAM ALARRVAKAR SNRFFVDAHC HPQTVSVLRT RAEAFGFELV
210 220 230 240 250
VDEPDNLAAH AVFGALLQYP DSRGEIRDLR PLIEALHGQQ ALACVASDLL
260 270 280 290 300
ALLLLTPPGE LGADVVLGSA QRFGVPMGYG GPHAAFFATR EGYKRAMPGR
310 320 330 340 350
IIGVSRDARG NPALRMALQT REQHIRREKA NSNICTAQVL LANIASLYAV
360 370 380 390 400
YHGPQELKRI AQRVQRLTAL LAAGLKSKGL RRLNRHFFDT LTYEVGERQA
410 420 430 440 450
AILERARAAR VNLRVVDDRR LALSLDETCD AATLATLFEI FLGAGHGLDV
460 470 480 490 500
AHLDGGAVAD GIPAVLQRTS AYLQHPVFNA HHSETEMLRY LRQLEGKDLA
510 520 530 540 550
LNQAMIPLGS CTMKLNASSE MIPITWPEFA ELHPFVPREQ AEGYRRMIDE
560 570 580 590 600
LEAWLRAITG FDAICMQPNS GAQGEYAGLL AIRRYHQSRG DSQRDICLIP
610 620 630 640 650
ASAHGTNPAS AIMASMRVVI VECDPRGNVD LDDLRLKAAE AGDRLSCLMI
660 670 680 690 700
TYPSTHGVYE EGIGEICEVV HRHGGQVYMD GANLNAQVGL ARPADIGADV
710 720 730 740 750
SHMNLHKTFC IPHGGGGPGM GPIGVKRHLA PFVANHPVIR VEGPNPLNDA
760 770 780 790 800
VSATPWGSAS ILPISWMYIA MMGPQLADAS EVAILSANYL ANRLDGAFPV
810 820 830 840 850
LYRGRNERVA HECILDLRPL KAQTGITEED VAKRLMDYGF HAPTMSFPVP
860 870 880 890 900
GTLMVEPTES ESKAELDRFV EAMLSIRAEI GKVESGAWPA EDNPLKRAPH
910 920 930 940 950
TLADVTGIWQ RPYEIAEAVT PSEHARAFKY WPAVNRVDNV YGDRNLFCAC

VPLDDYRE
Length:958
Mass (Da):104,711
Last modified:March 1, 2001 - v1
Checksum:i5A2FC2B07691C8DC
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AE004091 Genomic DNA. Translation: AAG08598.1.
PIRiE82994.
RefSeqiNP_253900.1. NC_002516.2.

Genome annotation databases

EnsemblBacteriaiAAG08598; AAG08598; PA5213.
GeneIDi880606.
KEGGipae:PA5213.
PATRICi19845273. VBIPseAer58763_5463.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AE004091 Genomic DNA. Translation: AAG08598.1 .
PIRi E82994.
RefSeqi NP_253900.1. NC_002516.2.

3D structure databases

ProteinModelPortali Q9HTX7.
SMRi Q9HTX7. Positions 9-950.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 208964.PA5213.

Proteomic databases

PRIDEi Q9HTX7.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai AAG08598 ; AAG08598 ; PA5213 .
GeneIDi 880606.
KEGGi pae:PA5213.
PATRICi 19845273. VBIPseAer58763_5463.

Organism-specific databases

PseudoCAPi PA5213.

Phylogenomic databases

eggNOGi COG1003.
HOGENOMi HOG000239369.
InParanoidi Q9HTX7.
KOi K00281.
OMAi IRVQVII.
OrthoDBi EOG6HMXDX.
PhylomeDBi Q9HTX7.

Family and domain databases

Gene3Di 3.40.640.10. 2 hits.
HAMAPi MF_00711. GcvP.
InterProi IPR020580. GDC-P_N.
IPR020581. GDC_P.
IPR003437. GDC_P_homo.
IPR015424. PyrdxlP-dep_Trfase.
IPR015421. PyrdxlP-dep_Trfase_major_sub1.
[Graphical view ]
PANTHERi PTHR11773. PTHR11773. 1 hit.
Pfami PF02347. GDC-P. 2 hits.
[Graphical view ]
SUPFAMi SSF53383. SSF53383. 3 hits.
TIGRFAMsi TIGR00461. gcvP. 1 hit.
ProtoNeti Search...

Publicationsi

  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: ATCC 15692 / PAO1 / 1C / PRS 101 / LMG 12228.

Entry informationi

Entry nameiGCSP2_PSEAE
AccessioniPrimary (citable) accession number: Q9HTX7
Entry historyi
Integrated into UniProtKB/Swiss-Prot: September 19, 2003
Last sequence update: March 1, 2001
Last modified: November 26, 2014
This is version 86 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3