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Q9HTX7 (GCSP2_PSEAE) Reviewed, UniProtKB/Swiss-Prot

Last modified July 9, 2014. Version 83. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (1) | Third-party data text xml rdf/xml gff fasta
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Names and origin

Protein namesRecommended name:
Glycine dehydrogenase (decarboxylating) 2

EC=1.4.4.2
Alternative name(s):
Glycine cleavage system P-protein 2
Glycine decarboxylase 2
Glycine dehydrogenase (aminomethyl-transferring) 2
Gene names
Name:gcvP2
Ordered Locus Names:PA5213
OrganismPseudomonas aeruginosa (strain ATCC 15692 / PAO1 / 1C / PRS 101 / LMG 12228) [Reference proteome] [HAMAP]
Taxonomic identifier208964 [NCBI]
Taxonomic lineageBacteriaProteobacteriaGammaproteobacteriaPseudomonadalesPseudomonadaceaePseudomonas

Protein attributes

Sequence length958 AA.
Sequence statusComplete.
Protein existenceInferred from homology

General annotation (Comments)

Function

The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor; CO2 is released and the remaining methylamine moiety is then transferred to the lipoamide cofactor of the H protein By similarity. HAMAP-Rule MF_00711

Catalytic activity

Glycine + [glycine-cleavage complex H protein]-N(6)-lipoyl-L-lysine = [glycine-cleavage complex H protein]-S-aminomethyl-N(6)-dihydrolipoyl-L-lysine + CO2. HAMAP-Rule MF_00711

Cofactor

Pyridoxal phosphate By similarity. HAMAP-Rule MF_00711

Subunit structure

The glycine cleavage system is composed of four proteins: P, T, L and H By similarity.

Sequence similarities

Belongs to the GcvP family.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 958958Glycine dehydrogenase (decarboxylating) 2 HAMAP-Rule MF_00711
PRO_0000166926

Amino acid modifications

Modified residue7071N6-(pyridoxal phosphate)lysine By similarity

Sequences

Sequence LengthMass (Da)Tools
Q9HTX7 [UniParc].

Last modified March 1, 2001. Version 1.
Checksum: 5A2FC2B07691C8DC

FASTA958104,711
        10         20         30         40         50         60 
MSQTPSLAQL QPADAFLRRH LGPDPAEQQA MLAFLGVSTR AELIVQTVPP AIRLNRPLEL 

        70         80         90        100        110        120 
PAALDEQAAL ARLRGYAGLN QRWTSLIGMG YYGTVTPSVI LRNVLENPGW YTAYTPYQPE 

       130        140        150        160        170        180 
IAQGRLEALL NFQQLTIDLT GLDLASASLL DEATAAAEAM ALARRVAKAR SNRFFVDAHC 

       190        200        210        220        230        240 
HPQTVSVLRT RAEAFGFELV VDEPDNLAAH AVFGALLQYP DSRGEIRDLR PLIEALHGQQ 

       250        260        270        280        290        300 
ALACVASDLL ALLLLTPPGE LGADVVLGSA QRFGVPMGYG GPHAAFFATR EGYKRAMPGR 

       310        320        330        340        350        360 
IIGVSRDARG NPALRMALQT REQHIRREKA NSNICTAQVL LANIASLYAV YHGPQELKRI 

       370        380        390        400        410        420 
AQRVQRLTAL LAAGLKSKGL RRLNRHFFDT LTYEVGERQA AILERARAAR VNLRVVDDRR 

       430        440        450        460        470        480 
LALSLDETCD AATLATLFEI FLGAGHGLDV AHLDGGAVAD GIPAVLQRTS AYLQHPVFNA 

       490        500        510        520        530        540 
HHSETEMLRY LRQLEGKDLA LNQAMIPLGS CTMKLNASSE MIPITWPEFA ELHPFVPREQ 

       550        560        570        580        590        600 
AEGYRRMIDE LEAWLRAITG FDAICMQPNS GAQGEYAGLL AIRRYHQSRG DSQRDICLIP 

       610        620        630        640        650        660 
ASAHGTNPAS AIMASMRVVI VECDPRGNVD LDDLRLKAAE AGDRLSCLMI TYPSTHGVYE 

       670        680        690        700        710        720 
EGIGEICEVV HRHGGQVYMD GANLNAQVGL ARPADIGADV SHMNLHKTFC IPHGGGGPGM 

       730        740        750        760        770        780 
GPIGVKRHLA PFVANHPVIR VEGPNPLNDA VSATPWGSAS ILPISWMYIA MMGPQLADAS 

       790        800        810        820        830        840 
EVAILSANYL ANRLDGAFPV LYRGRNERVA HECILDLRPL KAQTGITEED VAKRLMDYGF 

       850        860        870        880        890        900 
HAPTMSFPVP GTLMVEPTES ESKAELDRFV EAMLSIRAEI GKVESGAWPA EDNPLKRAPH 

       910        920        930        940        950 
TLADVTGIWQ RPYEIAEAVT PSEHARAFKY WPAVNRVDNV YGDRNLFCAC VPLDDYRE 

« Hide

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
AE004091 Genomic DNA. Translation: AAG08598.1.
PIRE82994.
RefSeqNP_253900.1. NC_002516.2.

3D structure databases

ProteinModelPortalQ9HTX7.
SMRQ9HTX7. Positions 9-950.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

STRING208964.PA5213.

Proteomic databases

PRIDEQ9HTX7.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaAAG08598; AAG08598; PA5213.
GeneID880606.
KEGGpae:PA5213.
PATRIC19845273. VBIPseAer58763_5463.

Organism-specific databases

PseudoCAPPA5213.

Phylogenomic databases

eggNOGCOG1003.
HOGENOMHOG000239369.
KOK00281.
OMAIRVQVII.
OrthoDBEOG6HMXDX.
PhylomeDBQ9HTX7.

Family and domain databases

Gene3D3.40.640.10. 2 hits.
HAMAPMF_00711. GcvP.
InterProIPR020580. GDC-P_N.
IPR020581. GDC_P.
IPR003437. GDC_P_homo.
IPR015424. PyrdxlP-dep_Trfase.
IPR015421. PyrdxlP-dep_Trfase_major_sub1.
[Graphical view]
PANTHERPTHR11773. PTHR11773. 1 hit.
PfamPF02347. GDC-P. 2 hits.
[Graphical view]
SUPFAMSSF53383. SSF53383. 3 hits.
TIGRFAMsTIGR00461. gcvP. 1 hit.
ProtoNetSearch...

Entry information

Entry nameGCSP2_PSEAE
AccessionPrimary (citable) accession number: Q9HTX7
Entry history
Integrated into UniProtKB/Swiss-Prot: September 19, 2003
Last sequence update: March 1, 2001
Last modified: July 9, 2014
This is version 83 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families