SubmitCancel

Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.

Q9HTX7

- GCSP2_PSEAE

UniProt

Q9HTX7 - GCSP2_PSEAE

(max 400 entries)x

Your basket is currently empty.

Select item(s) and click on "Add to basket" to create your own collection here
(400 entries max)

Protein

Glycine dehydrogenase (decarboxylating) 2

Gene
gcvP2, PA5213
Organism
Pseudomonas aeruginosa (strain ATCC 15692 / PAO1 / 1C / PRS 101 / LMG 12228)
Status
Reviewed - Annotation score: 3 out of 5 - Protein inferred from homologyi

Functioni

The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor; CO2 is released and the remaining methylamine moiety is then transferred to the lipoamide cofactor of the H protein By similarity.UniRule annotation

Catalytic activityi

Glycine + [glycine-cleavage complex H protein]-N(6)-lipoyl-L-lysine = [glycine-cleavage complex H protein]-S-aminomethyl-N(6)-dihydrolipoyl-L-lysine + CO2.UniRule annotation

Cofactori

Pyridoxal phosphate By similarity.UniRule annotation

GO - Molecular functioni

  1. glycine dehydrogenase (decarboxylating) activity Source: UniProtKB-EC
  2. pyridoxal phosphate binding Source: InterPro

GO - Biological processi

  1. glycine decarboxylation via glycine cleavage system Source: UniProtKB-HAMAP
Complete GO annotation...

Keywords - Molecular functioni

Oxidoreductase

Keywords - Ligandi

Pyridoxal phosphate

Names & Taxonomyi

Protein namesi
Recommended name:
Glycine dehydrogenase (decarboxylating) 2 (EC:1.4.4.2)
Alternative name(s):
Glycine cleavage system P-protein 2
Glycine decarboxylase 2
Glycine dehydrogenase (aminomethyl-transferring) 2
Gene namesi
Name:gcvP2
Ordered Locus Names:PA5213
OrganismiPseudomonas aeruginosa (strain ATCC 15692 / PAO1 / 1C / PRS 101 / LMG 12228)
Taxonomic identifieri208964 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaPseudomonadalesPseudomonadaceaePseudomonas
ProteomesiUP000002438: Chromosome

Organism-specific databases

PseudoCAPiPA5213.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 958958Glycine dehydrogenase (decarboxylating) 2UniRule annotationPRO_0000166926Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei707 – 7071N6-(pyridoxal phosphate)lysine By similarity

Proteomic databases

PRIDEiQ9HTX7.

Interactioni

Subunit structurei

The glycine cleavage system is composed of four proteins: P, T, L and H By similarity.

Protein-protein interaction databases

STRINGi208964.PA5213.

Structurei

3D structure databases

ProteinModelPortaliQ9HTX7.
SMRiQ9HTX7. Positions 9-950.

Family & Domainsi

Sequence similaritiesi

Belongs to the GcvP family.

Phylogenomic databases

eggNOGiCOG1003.
HOGENOMiHOG000239369.
KOiK00281.
OMAiIRVQVII.
OrthoDBiEOG6HMXDX.
PhylomeDBiQ9HTX7.

Family and domain databases

Gene3Di3.40.640.10. 2 hits.
HAMAPiMF_00711. GcvP.
InterProiIPR020580. GDC-P_N.
IPR020581. GDC_P.
IPR003437. GDC_P_homo.
IPR015424. PyrdxlP-dep_Trfase.
IPR015421. PyrdxlP-dep_Trfase_major_sub1.
[Graphical view]
PANTHERiPTHR11773. PTHR11773. 1 hit.
PfamiPF02347. GDC-P. 2 hits.
[Graphical view]
SUPFAMiSSF53383. SSF53383. 3 hits.
TIGRFAMsiTIGR00461. gcvP. 1 hit.

Sequencei

Sequence statusi: Complete.

Q9HTX7-1 [UniParc]FASTAAdd to Basket

« Hide

MSQTPSLAQL QPADAFLRRH LGPDPAEQQA MLAFLGVSTR AELIVQTVPP    50
AIRLNRPLEL PAALDEQAAL ARLRGYAGLN QRWTSLIGMG YYGTVTPSVI 100
LRNVLENPGW YTAYTPYQPE IAQGRLEALL NFQQLTIDLT GLDLASASLL 150
DEATAAAEAM ALARRVAKAR SNRFFVDAHC HPQTVSVLRT RAEAFGFELV 200
VDEPDNLAAH AVFGALLQYP DSRGEIRDLR PLIEALHGQQ ALACVASDLL 250
ALLLLTPPGE LGADVVLGSA QRFGVPMGYG GPHAAFFATR EGYKRAMPGR 300
IIGVSRDARG NPALRMALQT REQHIRREKA NSNICTAQVL LANIASLYAV 350
YHGPQELKRI AQRVQRLTAL LAAGLKSKGL RRLNRHFFDT LTYEVGERQA 400
AILERARAAR VNLRVVDDRR LALSLDETCD AATLATLFEI FLGAGHGLDV 450
AHLDGGAVAD GIPAVLQRTS AYLQHPVFNA HHSETEMLRY LRQLEGKDLA 500
LNQAMIPLGS CTMKLNASSE MIPITWPEFA ELHPFVPREQ AEGYRRMIDE 550
LEAWLRAITG FDAICMQPNS GAQGEYAGLL AIRRYHQSRG DSQRDICLIP 600
ASAHGTNPAS AIMASMRVVI VECDPRGNVD LDDLRLKAAE AGDRLSCLMI 650
TYPSTHGVYE EGIGEICEVV HRHGGQVYMD GANLNAQVGL ARPADIGADV 700
SHMNLHKTFC IPHGGGGPGM GPIGVKRHLA PFVANHPVIR VEGPNPLNDA 750
VSATPWGSAS ILPISWMYIA MMGPQLADAS EVAILSANYL ANRLDGAFPV 800
LYRGRNERVA HECILDLRPL KAQTGITEED VAKRLMDYGF HAPTMSFPVP 850
GTLMVEPTES ESKAELDRFV EAMLSIRAEI GKVESGAWPA EDNPLKRAPH 900
TLADVTGIWQ RPYEIAEAVT PSEHARAFKY WPAVNRVDNV YGDRNLFCAC 950
VPLDDYRE 958
Length:958
Mass (Da):104,711
Last modified:March 1, 2001 - v1
Checksum:i5A2FC2B07691C8DC
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AE004091 Genomic DNA. Translation: AAG08598.1.
PIRiE82994.
RefSeqiNP_253900.1. NC_002516.2.

Genome annotation databases

EnsemblBacteriaiAAG08598; AAG08598; PA5213.
GeneIDi880606.
KEGGipae:PA5213.
PATRICi19845273. VBIPseAer58763_5463.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AE004091 Genomic DNA. Translation: AAG08598.1 .
PIRi E82994.
RefSeqi NP_253900.1. NC_002516.2.

3D structure databases

ProteinModelPortali Q9HTX7.
SMRi Q9HTX7. Positions 9-950.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 208964.PA5213.

Proteomic databases

PRIDEi Q9HTX7.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai AAG08598 ; AAG08598 ; PA5213 .
GeneIDi 880606.
KEGGi pae:PA5213.
PATRICi 19845273. VBIPseAer58763_5463.

Organism-specific databases

PseudoCAPi PA5213.

Phylogenomic databases

eggNOGi COG1003.
HOGENOMi HOG000239369.
KOi K00281.
OMAi IRVQVII.
OrthoDBi EOG6HMXDX.
PhylomeDBi Q9HTX7.

Family and domain databases

Gene3Di 3.40.640.10. 2 hits.
HAMAPi MF_00711. GcvP.
InterProi IPR020580. GDC-P_N.
IPR020581. GDC_P.
IPR003437. GDC_P_homo.
IPR015424. PyrdxlP-dep_Trfase.
IPR015421. PyrdxlP-dep_Trfase_major_sub1.
[Graphical view ]
PANTHERi PTHR11773. PTHR11773. 1 hit.
Pfami PF02347. GDC-P. 2 hits.
[Graphical view ]
SUPFAMi SSF53383. SSF53383. 3 hits.
TIGRFAMsi TIGR00461. gcvP. 1 hit.
ProtoNeti Search...

Publicationsi

  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: ATCC 15692 / PAO1 / 1C / PRS 101 / LMG 12228.

Entry informationi

Entry nameiGCSP2_PSEAE
AccessioniPrimary (citable) accession number: Q9HTX7
Entry historyi
Integrated into UniProtKB/Swiss-Prot: September 19, 2003
Last sequence update: March 1, 2001
Last modified: July 9, 2014
This is version 83 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi