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Protein

3-octaprenyl-4-hydroxybenzoate carboxy-lyase

Gene

ubiD

Organism
Pseudomonas aeruginosa (strain ATCC 15692 / DSM 22644 / CIP 104116 / JCM 14847 / LMG 12228 / 1C / PRS 101 / PAO1)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Protein inferred from homologyi

Functioni

Catalyzes the decarboxylation of 3-octaprenyl-4-hydroxy benzoate to 2-octaprenylphenol, an intermediate step in ubiquinone biosynthesis.UniRule annotation

Catalytic activityi

A 4-hydroxy-3-polyprenylbenzoate = a 2-polyprenylphenol + CO2.UniRule annotation

Cofactori

Mn2+UniRule annotation, prenyl-FMNUniRule annotationNote: Binds 1 prenylated FMN (prenyl-FMN) per subunit.UniRule annotation

Pathwayi: ubiquinone biosynthesis

This protein is involved in the pathway ubiquinone biosynthesis, which is part of Cofactor biosynthesis.UniRule annotation
View all proteins of this organism that are known to be involved in the pathway ubiquinone biosynthesis and in Cofactor biosynthesis.

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Metal bindingi172ManganeseUniRule annotation1
Metal bindingi238ManganeseUniRule annotation1
Active sitei287Proton donorUniRule annotation1

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Decarboxylase, Lyase

Keywords - Biological processi

Ubiquinone biosynthesis

Keywords - Ligandi

Manganese, Metal-binding

Enzyme and pathway databases

UniPathwayiUPA00232.

Names & Taxonomyi

Protein namesi
Recommended name:
3-octaprenyl-4-hydroxybenzoate carboxy-lyaseUniRule annotation (EC:4.1.1.98UniRule annotation)
Alternative name(s):
Polyprenyl p-hydroxybenzoate decarboxylaseUniRule annotation
Gene namesi
Name:ubiDUniRule annotation
Ordered Locus Names:PA5237
OrganismiPseudomonas aeruginosa (strain ATCC 15692 / DSM 22644 / CIP 104116 / JCM 14847 / LMG 12228 / 1C / PRS 101 / PAO1)
Taxonomic identifieri208964 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaPseudomonadalesPseudomonadaceaePseudomonas
Proteomesi
  • UP000002438 Componenti: Chromosome

Organism-specific databases

PseudoCAPiPA5237.

Subcellular locationi

  • Cell membrane UniRule annotation; Peripheral membrane protein UniRule annotation

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Cell membrane, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001573641 – 4883-octaprenyl-4-hydroxybenzoate carboxy-lyaseAdd BLAST488

Proteomic databases

PaxDbiQ9HTV3.

Interactioni

Subunit structurei

Homohexamer.UniRule annotation

Protein-protein interaction databases

STRINGi208964.PA5237.

Structurei

3D structure databases

ProteinModelPortaliQ9HTV3.
SMRiQ9HTV3.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Regioni172 – 177prenyl-FMN bindingUniRule annotation6
Regioni194 – 195prenyl-FMN bindingUniRule annotation2

Sequence similaritiesi

Belongs to the UbiD family.UniRule annotation

Phylogenomic databases

eggNOGiENOG4105D3H. Bacteria.
COG0043. LUCA.
HOGENOMiHOG000227663.
InParanoidiQ9HTV3.
KOiK03182.
OMAiDFQEWCQ.
PhylomeDBiQ9HTV3.

Family and domain databases

HAMAPiMF_01636. UbiD. 1 hit.
InterProiIPR012349. Split_barrel_FMN-bd.
IPR002830. UbiD.
IPR023677. UbiD_bacteria.
[Graphical view]
PfamiPF01977. UbiD. 1 hit.
[Graphical view]
SUPFAMiSSF50475. SSF50475. 1 hit.
TIGRFAMsiTIGR00148. TIGR00148. 1 hit.

Sequencei

Sequence statusi: Complete.

Q9HTV3-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MTFKDLRDFI AQLEQRGALK RIQVPISPVL EMTEVCDRTL RAKGPALLFE
60 70 80 90 100
KPTGFDMPVL GNLFGTPERV ALGMGAEDVG ALREIGKLLA QLKEPEPPKG
110 120 130 140 150
LKDAWAKLPM YRKVLSMAPK VLKDAPCQEV VEEGEDVDLG RLPVQTCWPG
160 170 180 190 200
DVGPLITWGL TVTRGPNKER QNLGIYRQQV IGRNKVIMRW LSHRGGALDY
210 220 230 240 250
REWCQKHPGQ PYPVAVALGA DPATILGAVT PVPDTLSEYA FAGLLRGHRT
260 270 280 290 300
ELVKCRGSDL QVPASAEIVL EGVIHPGEMA DEGPYGDHTG YYNEVDRFPV
310 320 330 340 350
FTVERVTRRQ KPIYHSTYTG RPPDEPAILG VALNEVFVPI LQKQFPEIVD
360 370 380 390 400
FYLPPEGCSY RMAVVTMKKQ YPGHAKRVML GVWSFLRQFM YTKFVIVTDD
410 420 430 440 450
DIDARDWNDV IWAITTRMDP KRDTVMIDNT PIDYLDFASP VSGLGSKMGL
460 470 480
DATHKWPGET SREWGRAIVK DEAVTRRIDA LWSSLGID
Length:488
Mass (Da):54,621
Last modified:March 1, 2001 - v1
Checksum:iF22CF188CAD42326
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AE004091 Genomic DNA. Translation: AAG08622.1.
PIRiD82991.
RefSeqiNP_253924.1. NC_002516.2.
WP_003096332.1. NZ_ASJY01000816.1.

Genome annotation databases

EnsemblBacteriaiAAG08622; AAG08622; PA5237.
GeneIDi880853.
KEGGipae:PA5237.
PATRICi19845323. VBIPseAer58763_5488.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AE004091 Genomic DNA. Translation: AAG08622.1.
PIRiD82991.
RefSeqiNP_253924.1. NC_002516.2.
WP_003096332.1. NZ_ASJY01000816.1.

3D structure databases

ProteinModelPortaliQ9HTV3.
SMRiQ9HTV3.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi208964.PA5237.

Proteomic databases

PaxDbiQ9HTV3.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaiAAG08622; AAG08622; PA5237.
GeneIDi880853.
KEGGipae:PA5237.
PATRICi19845323. VBIPseAer58763_5488.

Organism-specific databases

PseudoCAPiPA5237.

Phylogenomic databases

eggNOGiENOG4105D3H. Bacteria.
COG0043. LUCA.
HOGENOMiHOG000227663.
InParanoidiQ9HTV3.
KOiK03182.
OMAiDFQEWCQ.
PhylomeDBiQ9HTV3.

Enzyme and pathway databases

UniPathwayiUPA00232.

Family and domain databases

HAMAPiMF_01636. UbiD. 1 hit.
InterProiIPR012349. Split_barrel_FMN-bd.
IPR002830. UbiD.
IPR023677. UbiD_bacteria.
[Graphical view]
PfamiPF01977. UbiD. 1 hit.
[Graphical view]
SUPFAMiSSF50475. SSF50475. 1 hit.
TIGRFAMsiTIGR00148. TIGR00148. 1 hit.
ProtoNetiSearch...

Entry informationi

Entry nameiUBID_PSEAE
AccessioniPrimary (citable) accession number: Q9HTV3
Entry historyi
Integrated into UniProtKB/Swiss-Prot: June 20, 2001
Last sequence update: March 1, 2001
Last modified: November 30, 2016
This is version 95 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.