ID   Q9HTS8_PSEAE            Unreviewed;       950 AA.
AC   Q9HTS8;
DT   01-MAR-2001, integrated into UniProtKB/TrEMBL.
DT   01-MAR-2001, sequence version 1.
DT   27-MAR-2024, entry version 102.
DE   SubName: Full=Adenylate cyclase {ECO:0000313|EMBL:AAG08657.1};
GN   Name=cyaA {ECO:0000313|EMBL:AAG08657.1};
GN   OrderedLocusNames=PA5272 {ECO:0000313|EMBL:AAG08657.1};
OS   Pseudomonas aeruginosa (strain ATCC 15692 / DSM 22644 / CIP 104116 / JCM
OS   14847 / LMG 12228 / 1C / PRS 101 / PAO1).
OC   Bacteria; Pseudomonadota; Gammaproteobacteria; Pseudomonadales;
OC   Pseudomonadaceae; Pseudomonas.
OX   NCBI_TaxID=208964 {ECO:0000313|EMBL:AAG08657.1, ECO:0000313|Proteomes:UP000002438};
RN   [1] {ECO:0000313|EMBL:AAG08657.1, ECO:0000313|Proteomes:UP000002438}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=ATCC 15692 / DSM 22644 / CIP 104116 / JCM 14847 / LMG 12228 /
RC   1C / PRS 101 / PAO1 {ECO:0000313|Proteomes:UP000002438};
RX   PubMed=10984043; DOI=10.1038/35023079;
RA   Stover C.K., Pham X.Q., Erwin A.L., Mizoguchi S.D., Warrener P.,
RA   Hickey M.J., Brinkman F.S., Hufnagle W.O., Kowalik D.J., Lagrou M.,
RA   Garber R.L., Goltry L., Tolentino E., Westbrock-Wadman S., Yuan Y.,
RA   Brody L.L., Coulter S.N., Folger K.R., Kas A., Larbig K., Lim R., Smith K.,
RA   Spencer D., Wong G.K., Wu Z., Paulsen I.T., Reizer J., Saier M.H.,
RA   Hancock R.E., Lory S., Olson M.V.;
RT   "Complete genome sequence of Pseudomonas aeruginosa PAO1, an opportunistic
RT   pathogen.";
RL   Nature 406:959-964(2000).
CC   ---------------------------------------------------------------------------
CC   Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC   Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC   ---------------------------------------------------------------------------
DR   EMBL; AE004091; AAG08657.1; -; Genomic_DNA.
DR   PIR; A82986; A82986.
DR   RefSeq; NP_253959.1; NC_002516.2.
DR   RefSeq; WP_003114341.1; NZ_QZGE01000020.1.
DR   AlphaFoldDB; Q9HTS8; -.
DR   STRING; 208964.PA5272; -.
DR   PaxDb; 208964-PA5272; -.
DR   GeneID; 877744; -.
DR   KEGG; pae:PA5272; -.
DR   PATRIC; fig|208964.12.peg.5525; -.
DR   PseudoCAP; PA5272; -.
DR   HOGENOM; CLU_013280_0_0_6; -.
DR   InParanoid; Q9HTS8; -.
DR   OrthoDB; 5571448at2; -.
DR   PhylomeDB; Q9HTS8; -.
DR   BioCyc; PAER208964:G1FZ6-5393-MONOMER; -.
DR   Proteomes; UP000002438; Chromosome.
DR   GO; GO:0004016; F:adenylate cyclase activity; IMP:PseudoCAP.
DR   GO; GO:0006171; P:cAMP biosynthetic process; IMP:PseudoCAP.
DR   InterPro; IPR000274; Adenylate_cyclase_1.
DR   InterPro; IPR024685; Adenylate_cyclase_1_N.
DR   PANTHER; PTHR38760; ADENYLATE CYCLASE; 1.
DR   PANTHER; PTHR38760:SF1; ADENYLATE CYCLASE; 1.
DR   Pfam; PF12633; Adenyl_cycl_N; 1.
DR   Pfam; PF01295; Adenylate_cycl; 1.
DR   PIRSF; PIRSF001444; Adenylate_cycl; 1.
PE   4: Predicted;
KW   Reference proteome {ECO:0000313|Proteomes:UP000002438}.
FT   DOMAIN          21..217
FT                   /note="Adenylate cyclase class-I N-terminal"
FT                   /evidence="ECO:0000259|Pfam:PF12633"
SQ   SEQUENCE   950 AA;  108714 MW;  B1601A7AF82720C5 CRC64;
     MNRHPALSLD LDDGIDRKVL GQLRQRFLAV NAGRLQRARQ ALSSRQERVL RLLPLLFHIN
     HPLLPGYLSA STPAGLSGFE ADDEVLAEAQ RLARSFVYKP RRQEPAQQPI HGLFLMGSLG
     SLAQEEQSDL DLWVCHAPEL EPGARQELRR KCALIEDWAR SQGSEVHCFL IDVARFGQDE
     REDRKEPGGD GNTQHFLLLD EFYRSAIWLG GRTPLWWLVP PAHERRYDEY CRTLLGKRFI
     RAEEVLDLGH LAHIPAREFI GAGLWQLSKA IDSPYKSLLK LLLTEAYASE HPRVRCVALR
     FKEQVFAGQL DLDELDPYVL VYRHLERYLR EQQAPERLEL VRRCLYLKVG RKLGGRQRQA
     QKGWQHLSME RLVAEWQWEP RRLALLDSRS QWKMRQVMEE RRTVVNELTY SYRLLFQIAR
     QQGADSGIDS RDLGLLGRRL YAAFERKAGK VENINPGIAP DLGEDVLTLV QLPADDGREQ
     AQWAIFPGAL GAHQWPDYAP LKRSLRLVEL LAWCHRNGVI DSATRLSLHP GQSDLGDAEL
     DNLLGSLRQF LPVPLATVDD ADLLQPRRLK SVLLLVNVGV DPLRHHSQMN LHMATGRTDV
     LGYAGVRDNL VLTLDQLSLN SWNELTVRHY AGPQALPECL AEFLDAVREK PGSPPQPPEL
     MVRCFCRNRA AAIAVRVEEL FRETYGQLLG GQPSRYLLQI RQQYHLLEMS PEAVSHESLP
     DLPSLLQHLG RERDGYSALK LDRHALEGED LGLILSMGRP DCIQVFYRRD FDSAEISLLD
     ERNALWRQRQ ALRDERSLLA PLQRFLQSLL YRRNALSLAE QVPAALDIRY YELLSNDGRV
     HVEPREAPEA LAGPALYELQ ALLERGERKR VQVTLYCDHQ EFSELEYGAG LFKAVARHIL
     AHRAESEPYP CYLTDLDLSR LFADEQPQTL HYLRYKSVLE TALNQALLEQ
//