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Q9HTM2

- KGUA_PSEAE

UniProt

Q9HTM2 - KGUA_PSEAE

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Protein

Guanylate kinase

Gene

gmk

Organism
Pseudomonas aeruginosa (strain ATCC 15692 / PAO1 / 1C / PRS 101 / LMG 12228)
Status
Reviewed - Annotation score: 2 out of 5- Protein inferred from homologyi

Functioni

Essential for recycling GMP and indirectly, cGMP.By similarity

Catalytic activityi

ATP + GMP = ADP + GDP.

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Nucleotide bindingi10 – 178ATPBy similarity

GO - Molecular functioni

  1. ATP binding Source: UniProtKB-HAMAP
  2. guanylate kinase activity Source: UniProtKB-HAMAP

GO - Biological processi

  1. purine nucleotide metabolic process Source: UniProtKB-HAMAP
Complete GO annotation...

Keywords - Molecular functioni

Kinase, Transferase

Keywords - Ligandi

ATP-binding, Nucleotide-binding

Names & Taxonomyi

Protein namesi
Recommended name:
Guanylate kinase (EC:2.7.4.8)
Alternative name(s):
GMP kinase
Gene namesi
Name:gmk
Ordered Locus Names:PA5336
OrganismiPseudomonas aeruginosa (strain ATCC 15692 / PAO1 / 1C / PRS 101 / LMG 12228)
Taxonomic identifieri208964 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaPseudomonadalesPseudomonadaceaePseudomonas
ProteomesiUP000002438: Chromosome

Organism-specific databases

PseudoCAPiPA5336.

Subcellular locationi

Cytoplasm By similarity

GO - Cellular componenti

  1. cytoplasm Source: UniProtKB-HAMAP
Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 203203Guanylate kinasePRO_0000170587Add
BLAST

Interactioni

Protein-protein interaction databases

STRINGi208964.PA5336.

Structurei

3D structure databases

ProteinModelPortaliQ9HTM2.
SMRiQ9HTM2. Positions 3-203.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini3 – 181179Guanylate kinase-likeAdd
BLAST

Sequence similaritiesi

Belongs to the guanylate kinase family.Curated
Contains 1 guanylate kinase-like domain.Curated

Phylogenomic databases

eggNOGiCOG0194.
HOGENOMiHOG000037638.
InParanoidiQ9HTM2.
KOiK00942.
OMAiNFLEWEE.
OrthoDBiEOG6CP410.
PhylomeDBiQ9HTM2.

Family and domain databases

Gene3Di3.40.50.300. 2 hits.
HAMAPiMF_00328. Guanylate_kinase.
InterProiIPR008145. GK/Ca_channel_bsu.
IPR008144. Guanylate_kin-like.
IPR017665. Guanylate_kinase.
IPR020590. Guanylate_kinase_CS.
IPR027417. P-loop_NTPase.
[Graphical view]
PfamiPF00625. Guanylate_kin. 1 hit.
[Graphical view]
SMARTiSM00072. GuKc. 1 hit.
[Graphical view]
SUPFAMiSSF52540. SSF52540. 1 hit.
TIGRFAMsiTIGR03263. guanyl_kin. 1 hit.
PROSITEiPS00856. GUANYLATE_KINASE_1. 1 hit.
PS50052. GUANYLATE_KINASE_2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q9HTM2-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MSGTLYIVSA PSGAGKTSLV KALLDAAPEV RVSVSHTTRG MRPGEVDGVN
60 70 80 90 100
YHFTSREEFL AMLERNEFLE HAEVFGNLYG TSQRWVEKTL AEGLDLILEI
110 120 130 140 150
DWQGAQQVRR LMPEAQSIFI LPPSQEALRQ RLTNRGQDSD EVIERRMREA
160 170 180 190 200
VSEMSHYVEY DHLVINDDFA HALDDLKAIF RARQLRQDAQ QQRHAELLGR

LLA
Length:203
Mass (Da):23,102
Last modified:March 1, 2001 - v1
Checksum:iDE35644BBE88623A
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AE004091 Genomic DNA. Translation: AAG08721.1.
PIRiF82978.
RefSeqiNP_254023.1. NC_002516.2.

Genome annotation databases

EnsemblBacteriaiAAG08721; AAG08721; PA5336.
GeneIDi878047.
KEGGipae:PA5336.
PATRICi19845529. VBIPseAer58763_5591.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AE004091 Genomic DNA. Translation: AAG08721.1 .
PIRi F82978.
RefSeqi NP_254023.1. NC_002516.2.

3D structure databases

ProteinModelPortali Q9HTM2.
SMRi Q9HTM2. Positions 3-203.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 208964.PA5336.

Protocols and materials databases

DNASUi 878047.
Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai AAG08721 ; AAG08721 ; PA5336 .
GeneIDi 878047.
KEGGi pae:PA5336.
PATRICi 19845529. VBIPseAer58763_5591.

Organism-specific databases

PseudoCAPi PA5336.

Phylogenomic databases

eggNOGi COG0194.
HOGENOMi HOG000037638.
InParanoidi Q9HTM2.
KOi K00942.
OMAi NFLEWEE.
OrthoDBi EOG6CP410.
PhylomeDBi Q9HTM2.

Family and domain databases

Gene3Di 3.40.50.300. 2 hits.
HAMAPi MF_00328. Guanylate_kinase.
InterProi IPR008145. GK/Ca_channel_bsu.
IPR008144. Guanylate_kin-like.
IPR017665. Guanylate_kinase.
IPR020590. Guanylate_kinase_CS.
IPR027417. P-loop_NTPase.
[Graphical view ]
Pfami PF00625. Guanylate_kin. 1 hit.
[Graphical view ]
SMARTi SM00072. GuKc. 1 hit.
[Graphical view ]
SUPFAMi SSF52540. SSF52540. 1 hit.
TIGRFAMsi TIGR03263. guanyl_kin. 1 hit.
PROSITEi PS00856. GUANYLATE_KINASE_1. 1 hit.
PS50052. GUANYLATE_KINASE_2. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: ATCC 15692 / PAO1 / 1C / PRS 101 / LMG 12228.

Entry informationi

Entry nameiKGUA_PSEAE
AccessioniPrimary (citable) accession number: Q9HTM2
Entry historyi
Integrated into UniProtKB/Swiss-Prot: April 27, 2001
Last sequence update: March 1, 2001
Last modified: October 29, 2014
This is version 81 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3