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Protein

Guanylate kinase

Gene

gmk

Organism
Pseudomonas aeruginosa (strain ATCC 15692 / DSM 22644 / CIP 104116 / JCM 14847 / LMG 12228 / 1C / PRS 101 / PAO1)
Status
Reviewed-Annotation score: -Protein inferred from homologyi

Functioni

Essential for recycling GMP and indirectly, cGMP.By similarity

Catalytic activityi

ATP + GMP = ADP + GDP.

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Nucleotide bindingi10 – 17ATPBy similarity8

GO - Molecular functioni

Keywordsi

Molecular functionKinase, Transferase
LigandATP-binding, Nucleotide-binding

Enzyme and pathway databases

BioCyciPAER208964:G1FZ6-5458-MONOMER

Names & Taxonomyi

Protein namesi
Recommended name:
Guanylate kinase (EC:2.7.4.8)
Alternative name(s):
GMP kinase
Gene namesi
Name:gmk
Ordered Locus Names:PA5336
OrganismiPseudomonas aeruginosa (strain ATCC 15692 / DSM 22644 / CIP 104116 / JCM 14847 / LMG 12228 / 1C / PRS 101 / PAO1)
Taxonomic identifieri208964 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaPseudomonadalesPseudomonadaceaePseudomonas
Proteomesi
  • UP000002438 Componenti: Chromosome

Organism-specific databases

PseudoCAPiPA5336

Subcellular locationi

GO - Cellular componenti

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001705871 – 203Guanylate kinaseAdd BLAST203

Proteomic databases

PaxDbiQ9HTM2

Interactioni

Protein-protein interaction databases

STRINGi208964.PA5336

Structurei

3D structure databases

ProteinModelPortaliQ9HTM2
SMRiQ9HTM2
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini3 – 181Guanylate kinase-likeAdd BLAST179

Sequence similaritiesi

Belongs to the guanylate kinase family.Curated

Phylogenomic databases

eggNOGiENOG4108UHA Bacteria
COG0194 LUCA
HOGENOMiHOG000037638
InParanoidiQ9HTM2
KOiK00942
OMAiAGNYYGT
PhylomeDBiQ9HTM2

Family and domain databases

HAMAPiMF_00328 Guanylate_kinase, 1 hit
InterProiView protein in InterPro
IPR008145 GK/Ca_channel_bsu
IPR008144 Guanylate_kin-like_dom
IPR017665 Guanylate_kinase
IPR020590 Guanylate_kinase_CS
IPR027417 P-loop_NTPase
PfamiView protein in Pfam
PF00625 Guanylate_kin, 1 hit
SMARTiView protein in SMART
SM00072 GuKc, 1 hit
SUPFAMiSSF52540 SSF52540, 1 hit
TIGRFAMsiTIGR03263 guanyl_kin, 1 hit
PROSITEiView protein in PROSITE
PS00856 GUANYLATE_KINASE_1, 1 hit
PS50052 GUANYLATE_KINASE_2, 1 hit

Sequencei

Sequence statusi: Complete.

Q9HTM2-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MSGTLYIVSA PSGAGKTSLV KALLDAAPEV RVSVSHTTRG MRPGEVDGVN
60 70 80 90 100
YHFTSREEFL AMLERNEFLE HAEVFGNLYG TSQRWVEKTL AEGLDLILEI
110 120 130 140 150
DWQGAQQVRR LMPEAQSIFI LPPSQEALRQ RLTNRGQDSD EVIERRMREA
160 170 180 190 200
VSEMSHYVEY DHLVINDDFA HALDDLKAIF RARQLRQDAQ QQRHAELLGR

LLA
Length:203
Mass (Da):23,102
Last modified:March 1, 2001 - v1
Checksum:iDE35644BBE88623A
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AE004091 Genomic DNA Translation: AAG08721.1
PIRiF82978
RefSeqiNP_254023.1, NC_002516.2
WP_003098317.1, NC_002516.2

Genome annotation databases

EnsemblBacteriaiAAG08721; AAG08721; PA5336
GeneIDi878047
KEGGipae:PA5336
PATRICifig|208964.12.peg.5591

Similar proteinsi

Entry informationi

Entry nameiKGUA_PSEAE
AccessioniPrimary (citable) accession number: Q9HTM2
Entry historyiIntegrated into UniProtKB/Swiss-Prot: April 27, 2001
Last sequence update: March 1, 2001
Last modified: March 28, 2018
This is version 96 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

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