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Reviewed, UniProtKB/Swiss-Prot Q9HTJ1 (BETB_PSEAE)

Last modified June 16, 2009. Version 48. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (3) | Third-party data | Customize display text xml rdf/xml gff fasta
Names and origin · Protein attributes · General annotation (Comments) · Ontologies · Sequence annotation (Features) · Sequences · References · Cross-references · Entry information · Relevant documents

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Names and origin

Protein namesRecommended name:
    Betaine aldehyde dehydrogenase
      Short name=BADH
    EC=1.2.1.8
Gene names
Name: betB
Ordered Locus Names: PA5373
OrganismPseudomonas aeruginosa [Complete proteome] [HAMAP]
Taxonomic identifier287 [NCBI]
Taxonomic lineageBacteria › Proteobacteria › Gammaproteobacteria › Pseudomonadales › Pseudomonadaceae › Pseudomonas

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Protein attributes

Sequence length490 AA.
Sequence statusComplete.
Sequence processingThe displayed sequence is not processed.
Protein existenceEvidence at protein level.

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General annotation (Comments)

Catalytic activity

Betaine aldehyde + NAD+ + H2O = betaine + NADH. HAMAP MF_00804

Pathway

Amine and polyamine biosynthesis; betaine biosynthesis via choline pathway; betaine from betaine aldehyde: step 1/1. HAMAP MF_00804

Sequence similarities

Belongs to the aldehyde dehydrogenase family.

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Ontologies

Keywords
   LigandNAD
   Molecular functionOxidoreductase
   Technical term3D-structure
Complete proteome
Gene Ontology (GO)
   Biological processglycine betaine biosynthetic process from choline

Inferred from electronic annotation. Source: HAMAP

oxidation reduction

Inferred from electronic annotation. Source: UniProtKB-KW

   Molecular functionbetaine-aldehyde dehydrogenase activity

Inferred from electronic annotation. Source: HAMAP

Complete GO annotation...

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Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 490490Betaine aldehyde dehydrogenase HAMAP MF_00804
PRO_0000056546

Regions

Nucleotide binding229 – 2346NAD By similarity

Sites

Active site2521 By similarity
Active site2861 By similarity

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Sequences

Sequence LengthMass (Da)Tools
Q9HTJ1-1 [UniParc].

Last modified March 1, 2001. Version 1.
Checksum: F48249A085E3A970

FASTA49053,332
        10         20         30         40         50         60 
MARFEEQKLY IGGRYVEASS GATFETINPA NGEVLAKVQR ASREDVERAV QSAVEGQKVW 

        70         80         90        100        110        120 
AAMTAMQRSR ILRRAVDILR ERNDELAALE TLDTGKPLAE TRSVDIVTGA DVLEYYAGLV 

       130        140        150        160        170        180 
PAIEGEQIPL RETSFVYTRR EPLGVVAGIG AWNYPVQIAL WKSAPALAAG NAMIFKPSEV 

       190        200        210        220        230        240 
TPLTALKLAE IYTEAGVPDG VFNVLTGSGR EVGQWLTEHP LIEKISFTGG TSTGKKVMAS 

       250        260        270        280        290        300 
ASSSSLKEVT MELGGKSPLI IFPDADLDRA ADIAVMANFF SSGQVCTNGT RVFIHRSQQA 

       310        320        330        340        350        360 
RFEAKVLERV QRIRLGDPQD ENTNFGPLVS FPHMESVLGY IESGKAQKAR LLCGGERVTD 

       370        380        390        400        410        420 
GAFGKGAYVA PTVFTDCRDD MTIVREEIFG PVMSILVYDD EDEAIRRAND TEYGLAAGVV 

       430        440        450        460        470        480 
TQDLARAHRA IHRLEAGICW INTWGESPAE MPVGGYKQSG VGRENGLTTL AHYTRIKSVQ 

       490 
VELGDYASVF

« Hide

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Cross-references

Sequence databases

AE004091 Genomic DNA. Translation: AAG08758.1.
PIRF82973.
RefSeqNP_254060.1.

3D structure databases

EntryMethodResolution (Å)ChainPositionsPDBsum
2VE5X-ray2.10A/B/D/F/G/H1-490[»]
C/E1-490[»]
ModBaseSearch...

Genome annotation databases

GeneID881619.
GenomeReviewsGene locus PA5373 in contig AE004091_GR.
KEGGpae:PA5373.
NMPDRfig|208964.1.peg.5370.

Organism-specific databases

PseudoCAPPA5373.
CMRSearch...

Phylogenomic databases

HOGENOMQ9HTJ1.
OMAQ9HTJ1. TLKEVTM.

Enzyme and pathway databases

BioCycPAER208964:PA5373-MON.
BRENDA1.2.1.8. 354.

Family and domain databases

HAMAPMF_00804.
[Tree]
InterProIPR016160. Ald_DH_CS.
IPR016162. Ald_DH_N.
IPR015590. Aldehyde_DH.
IPR011264. Betaine_Ald_DH.
[Graphical view]
Gene3DG3DSA:3.40.605.10. Aldehyde_dehydrogenase_N. 1 hit.
PANTHERPTHR11699. Aldehyde_dehyd. 1 hit.
PfamPF00171. Aldedh. 1 hit.
[Graphical view]
TIGRFAMsTIGR01804. BADH. 1 hit.
PROSITEPS00070. ALDEHYDE_DEHYDR_CYS. 1 hit.
PS00687. ALDEHYDE_DEHYDR_GLU. 1 hit.
[Graphical view]
ProtoNetSearch...

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Entry information

Entry nameBETB_PSEAE
AccessionPrimary (citable) accession number: Q9HTJ1
Entry history
Integrated into UniProtKB/Swiss-Prot: February 1, 2005
Last sequence update: March 1, 2001
Last modified: June 16, 2009
This is version 48 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation projectHAMAP (High-quality Automated and Manual Annotation of microbial Proteomes)

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Relevant documents

PATHWAY comments

Index of metabolic and biosynthesis pathways

PDB cross-references

Index of Protein Data Bank (PDB) cross-references

SIMILARITY comments

Index of protein domains and families

Names and origin · Protein attributes · General annotation (Comments) · Ontologies · Sequence annotation (Features) · Sequences · References · Cross-references · Entry information · Relevant documents