Q9HTF1 (LTAE_PSEAE) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Low specificity L-threonine aldolase
Short name=Low specificity L-TA
EC=4.1.2.48

Gene names

Name:	ltaE
Ordered Locus Names:	PA5413

Organism

Pseudomonas aeruginosa (strain ATCC 15692 / PAO1 / 1C / PRS 101 / LMG 12228)

Taxonomic identifier

208964 [NCBI]

Taxonomic lineage

Bacteria › Proteobacteria › Gammaproteobacteria › Pseudomonadales › Pseudomonadaceae › Pseudomonas

Protein attributes

Sequence length	346 AA.
Sequence status	Complete.
Protein existence	Inferred from homology

General annotation (Comments)

Function	Catalyzes the cleavage of L-allo-threonine and L-threonine to glycine and acetaldehyde By similarity.
Catalytic activity	L-threonine = glycine + acetaldehyde. L-allo-threonine = glycine + acetaldehyde.
Cofactor	Pyridoxal phosphate By similarity.
Subunit structure	Homotetramer By similarity.
Sequence similarities	Belongs to the threonine aldolase family.

Ontologies

Keywords
Ligand	Pyridoxal phosphate
Molecular function	Lyase
Technical term	Complete proteome Reference proteome
Gene Ontology (GO)
Biological process	cellular amino acid metabolic process Inferred from electronic annotation. Source: InterPro
Molecular function	pyridoxal phosphate binding Inferred from electronic annotation. Source: InterPro threonine aldolase activity Inferred from electronic annotation. Source: EC
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 346	346	Low specificity L-threonine aldolase		PRO_0000121577
Amino acid modifications
	Modified residue	207	1	N6-(pyridoxal phosphate)lysine By similarity

Sequences

	Sequence		Length	Mass (Da)
	Q9HTF1 [UniParc]. Last modified March 1, 2001. Version 1. Checksum: 52129E3422DAC845	FASTA	346	38,213
	10 20 30 40 50 60 MTDHTQQFAS DNYSGICPEA WAAMAEANRG HERAYGDDQW TARASDYFRQ LFETDCEVFF 70 80 90 100 110 120 AFNGTAANSL ALAALCQSYH SVICSETAHV ETDECGAPEF FSNGSKLLLA QTEVGKLTPA 130 140 150 160 170 180 SIRDIALKRQ DIHYPKPRVV TLTQATEVGT VYRPDELKAI SATCKELGLH LHMDGARFSN 190 200 210 220 230 240 ACAFLGCSPA ELSWKAGVDV LCFGGTKNGM AVGEAILFFN RDLAEDFDYR CKQAGQLASK 250 260 270 280 290 300 MRFLAAPWVG VLQDDAWLRY ADHANRCARL LAELVADVPG VSLMFPVEAN GVFLQLSEPA 310 320 330 340 IEALRARGWR FYTFIGEGGA RFMCSWDTDI ERVRELARDI RLVMGA

References

[1]

"Complete genome sequence of Pseudomonas aeruginosa PAO1, an opportunistic pathogen." Stover C.K., Pham X.-Q.T., Erwin A.L., Mizoguchi S.D., Warrener P., Hickey M.J., Brinkman F.S.L., Hufnagle W.O., Kowalik D.J., Lagrou M., Garber R.L., Goltry L., Tolentino E., Westbrock-Wadman S., Yuan Y., Brody L.L., Coulter S.N., Folger K.R. , Kas A., Larbig K., Lim R.M., Smith K.A., Spencer D.H., Wong G.K.-S., Wu Z., Paulsen I.T., Reizer J., Saier M.H. Jr., Hancock R.E.W., Lory S., Olson M.V. Nature 406:959-964(2000) [PubMed: 10984043] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: ATCC 15692 / PAO1 / 1C / PRS 101 / LMG 12228.

Cross-references

Sequence databases
EMBL GenBank DDBJ	AE004091 Genomic DNA. Translation: AAG08798.1.
PIR	A82971.
RefSeq	NP_254100.1. NC_002516.2.
3D structure databases
ProteinModelPortal	Q9HTF1.
ModBase	Search...
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
GeneID	880064.
GenomeReviews	Gene locus PA5413 in contig AE004091_GR.
KEGG	pae:PA5413.
NMPDR	fig|208964.1.peg.5410.
PATRIC	19845703. VBIPseAer58763_5673.
Organism-specific databases
PseudoCAP	PA5413.
Phylogenomic databases
HOGENOM	HBG301980.
OMA	GQLASKM.
ProtClustDB	CLSK869332.
Enzyme and pathway databases
BioCyc	PAER208964:PA5413-MONOMER.
Family and domain databases
InterPro	IPR001597. ArAA_b-elim_lyase/Thr_aldolase. IPR015424. PyrdxlP-dep_Trfase_major_dom. IPR015421. PyrdxlP-dep_Trfase_major_sub1. IPR015422. PyrdxlP-dep_Trfase_major_sub2. [Graphical view]
Gene3D	G3DSA:3.40.640.10. PyrdxlP-dep_Trfase_major_sub1. 1 hit. G3DSA:3.90.1150.10. PyrdxlP-dep_Trfase_major_sub2. 1 hit.
KO	K01620.
Pfam	PF01212. Beta_elim_lyase. 1 hit. [Graphical view]
SUPFAM	SSF53383. PyrdxlP-dep_Trfase_major. 1 hit.
ProtoNet	Search...

Entry information

Entry name

LTAE_PSEAE

Accession

Primary (citable) accession number: Q9HTF1

Entry history

Integrated into UniProtKB/Swiss-Prot:	October 18, 2001
Last sequence update:	March 1, 2001
Last modified:	January 25, 2012
This is version 54 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Prokaryotic Protein Annotation Program