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Reviewed, UniProtKB/Swiss-Prot Q9HTE3 (FADH_PSEAE)

Last modified June 16, 2009. Version 51. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (1) | Third-party data | Customize display text xml rdf/xml gff fasta
Names and origin · Protein attributes · General annotation (Comments) · Ontologies · Sequence annotation (Features) · Sequences · References · Cross-references · Entry information · Relevant documents

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Names and origin

Protein namesRecommended name:
    Glutathione-independent formaldehyde dehydrogenase
      Short name=FALDH
      Short name=FDH
    EC=1.2.1.46
Gene names
Name: fdhA
Ordered Locus Names: PA5421
OrganismPseudomonas aeruginosa [Complete proteome] [HAMAP]
Taxonomic identifier287 [NCBI]
Taxonomic lineageBacteria › Proteobacteria › Gammaproteobacteria › Pseudomonadales › Pseudomonadaceae › Pseudomonas

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Protein attributes

Sequence length399 AA.
Sequence statusComplete.
Sequence processingThe displayed sequence is further processed into a mature form.
Protein existenceInferred from homology.

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General annotation (Comments)

Function

Catalyzes the oxidation of long-chain alcohols but is inactive against ethanol By similarity.

Catalytic activity

Formaldehyde + NAD+ + H2O = formate + NADH.

An alcohol + NAD+ = an aldehyde or ketone + NADH.

Cofactor

Binds 2 zinc ions per subunit By similarity.

Subunit structure

Homotetramer By similarity.

Sequence similarities

Belongs to the zinc-containing alcohol dehydrogenase family.

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Ontologies

Keywords
   LigandMetal-binding
NAD
Zinc
   Molecular functionOxidoreductase
   Technical termComplete proteome
Gene Ontology (GO)
   Biological processoxidation reduction

Inferred from electronic annotation. Source: UniProtKB-KW

   Molecular functionformaldehyde dehydrogenase activity

Inferred from electronic annotation. Source: EC

zinc ion binding

Inferred from electronic annotation. Source: UniProtKB-KW

Complete GO annotation...

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Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Initiator methionine11Removed By similarity
Chain2 – 399398Glutathione-independent formaldehyde dehydrogenase
PRO_0000287742

Regions

Region172 – 338167Cofactor-binding

Sites

Metal binding471Zinc 1; catalytic By similarity
Metal binding681Zinc 1; catalytic By similarity
Metal binding981Zinc 2 By similarity
Metal binding1011Zinc 2 By similarity
Metal binding1041Zinc 2 By similarity
Metal binding1121Zinc 2 By similarity
Metal binding1771Zinc 1; catalytic By similarity

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Sequences

Sequence LengthMass (Da)Tools
Q9HTE3-1 [UniParc].

Last modified March 1, 2001. Version 1.
Checksum: FE1FBAE68A90C9FC

FASTA39942,008
        10         20         30         40         50         60 
MSGNRGVVYL GPGKVEVQNI PYPKMQDPQG RQIDHGVILR VVSTNICGSD QHMVRGRTTA 

        70         80         90        100        110        120 
PEGLVLGHEI TGEVVEIGRG VETMKIGDLV SVPFNVACGH CRTCKEQHTG VCLTVNPARA 

       130        140        150        160        170        180 
GGAYGYVDMG GWVGGQAEYV LVPYADFNLL KLPNREAAME KIRDLTCLSD ILPTGYHGAV 

       190        200        210        220        230        240 
TAGVGPGSTV YIAGAGPVGL AAAASARLLG AAVVIVGDVN PTRLAHAKKQ GFEIADLSKD 

       250        260        270        280        290        300 
TPLHEQIAAL LGEPEVDCAV DAVGFEARGH GHSGSQQEAP ATVLNSLMGI TRVAGKIGIP 

       310        320        330        340        350        360 
GLYVTEDPGA VDAAAKHGAL SIRFGLGWAK SHSFHTGQTP VMKYNRQLMQ AIMWDRIKIA 

       370        380        390 
DIVGVEVITL DDAPKGYGEF DAGVPKKFVI DPHNLFRAA

« Hide

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Cross-references

Sequence databases

AE004091 Genomic DNA. Translation: AAG08806.1.
PIRE82969.
RefSeqNP_254108.1.

3D structure databases

HSSPHSSP built from PDB template 1KOL based on UniProtKB P46154.
SMRQ9HTE3. Positions 3-398.
ModBaseSearch...

Genome annotation databases

GeneID880053.
GenomeReviewsGene locus PA5421 in contig AE004091_GR.
KEGGpae:PA5421.

Organism-specific databases

PseudoCAPPA5421.
CMRSearch...

Phylogenomic databases

HOGENOMQ9HTE3.
OMAQ9HTE3. VACGRCR.

Enzyme and pathway databases

BioCycPAER208964:PA5421-MON.
BRENDA1.2.1.46. 354.

Family and domain databases

InterProIPR013154. ADH_GroES-like.
IPR002085. ADH_SF_Zn.
IPR013149. ADH_Zn-bd.
IPR002328. ADH_Zn_CS.
IPR014184. HCHO_DH_non_GSH.
[Graphical view]
PANTHERPTHR11695. ADH_Sf_Zn. 1 hit.
PfamPF08240. ADH_N. 1 hit.
PF00107. ADH_zinc_N. 1 hit.
[Graphical view]
TIGRFAMsTIGR02819. fdhA_non_GSH. 1 hit.
PROSITEPS00059. ADH_ZINC. 1 hit.
[Graphical view]
ProtoNetSearch...

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Entry information

Entry nameFADH_PSEAE
AccessionPrimary (citable) accession number: Q9HTE3
Entry history
Integrated into UniProtKB/Swiss-Prot: May 15, 2007
Last sequence update: March 1, 2001
Last modified: June 16, 2009
This is version 51 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation projectHAMAP (High-quality Automated and Manual Annotation of microbial Proteomes)

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Relevant documents

SIMILARITY comments

Index of protein domains and families

Names and origin · Protein attributes · General annotation (Comments) · Ontologies · Sequence annotation (Features) · Sequences · References · Cross-references · Entry information · Relevant documents