Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Protein
Submitted name:

Alcohol dehydrogenase

Gene

adhA

Organism
Pseudomonas aeruginosa (strain ATCC 15692 / PAO1 / 1C / PRS 101 / LMG 12228)
Status
Unreviewed-Annotation score: Annotation score: 2 out of 5-Experimental evidence at protein leveli

Functioni

Cofactori

Zn2+UniRule annotation

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Metal bindingi44 – 441Zinc 1Combined sources
Metal bindingi67 – 671Zinc 1; via tele nitrogenCombined sources
Metal bindingi98 – 981Zinc 2Combined sources
Metal bindingi101 – 1011Zinc 2Combined sources
Metal bindingi104 – 1041Zinc 2Combined sources
Metal bindingi112 – 1121Zinc 2Combined sources
Metal bindingi154 – 1541Zinc 1Combined sources
Binding sitei201 – 2011NADCombined sources
Binding sitei206 – 2061NADCombined sources

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Nucleotide bindingi45 – 495NADCombined sources
Nucleotide bindingi181 – 1822NADCombined sources
Nucleotide bindingi266 – 2683NADCombined sources
Nucleotide bindingi290 – 2923NADCombined sources

GO - Molecular functioni

Complete GO annotation...

Keywords - Ligandi

Metal-bindingUniRule annotationCombined sources, NADCombined sources, Nucleotide-bindingCombined sources, ZincUniRule annotationCombined sources

Names & Taxonomyi

Protein namesi
Submitted name:
Alcohol dehydrogenaseImported
Gene namesi
Name:adhAImported
Ordered Locus Names:PA5427Imported
OrganismiPseudomonas aeruginosa (strain ATCC 15692 / PAO1 / 1C / PRS 101 / LMG 12228)Imported
Taxonomic identifieri208964 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaPseudomonadalesPseudomonadaceaePseudomonas
Proteomesi
  • UP000002438 Componenti: Chromosome

Organism-specific databases

PseudoCAPiPA5427.

PTM / Processingi

Proteomic databases

PaxDbiQ9HTD9.

Interactioni

Protein-protein interaction databases

STRINGi208964.PA5427.

Structurei

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
EntryMethodResolution (Å)ChainPositionsPDBsum
1LLUX-ray2.30A/B/C/D/E/F/G/H1-342[»]
ProteinModelPortaliQ9HTD9.
SMRiQ9HTD9. Positions 2-342.
ModBaseiSearch...
MobiDBiSearch...

Miscellaneous databases

EvolutionaryTraceiQ9HTD9.

Family & Domainsi

Sequence similaritiesi

Belongs to the zinc-containing alcohol dehydrogenase family.UniRule annotation

Phylogenomic databases

eggNOGiENOG4105DQ4. Bacteria.
COG1064. LUCA.
HOGENOMiHOG000294685.
InParanoidiQ9HTD9.
KOiK13953.
OMAiNCEYCTT.
OrthoDBiEOG6BPDJN.
PhylomeDBiQ9HTD9.

Family and domain databases

Gene3Di3.40.50.720. 1 hit.
3.90.180.10. 1 hit.
InterProiIPR013149. ADH_C.
IPR013154. ADH_N.
IPR002085. ADH_SF_Zn-type.
IPR002328. ADH_Zn_CS.
IPR011032. GroES-like.
IPR016040. NAD(P)-bd_dom.
IPR020843. PKS_ER.
[Graphical view]
PANTHERiPTHR11695. PTHR11695. 1 hit.
PfamiPF08240. ADH_N. 1 hit.
PF00107. ADH_zinc_N. 1 hit.
[Graphical view]
SMARTiSM00829. PKS_ER. 1 hit.
[Graphical view]
SUPFAMiSSF50129. SSF50129. 2 hits.
SSF51735. SSF51735. 1 hit.
PROSITEiPS00059. ADH_ZINC. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q9HTD9-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MTLPQTMKAA VVHAYGAPLR IEEVKVPLPG PGQVLVKIEA SGVCHTDLHA
60 70 80 90 100
AEGDWPVKPP LPFIPGHEGV GYVAAVGSGV TRVKEGDRVG IPWLYTACGC
110 120 130 140 150
CEHCLTGWET LCESQQNTGY SVNGGYAEYV LADPNYVGIL PKNVEFAEIA
160 170 180 190 200
PILCAGVTVY KGLKQTNARP GQWVAISGIG GLGHVAVQYA RAMGLHVAAI
210 220 230 240 250
DIDDAKLELA RKLGASLTVN ARQEDPVEVL QRDIGGAHGV LVTAVSNSAF
260 270 280 290 300
GQAIGMARRG GTIALVGLPP GDFPTPIFDV VLKGLHIAGS IVGTRADLQE
310 320 330 340
ALDFAGEGLV KATIHPGKLD DINQILDQMR AGQIEGRIVL EM
Length:342
Mass (Da):35,911
Last modified:March 1, 2001 - v1
Checksum:i88BDB4207436C124
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AE004091 Genomic DNA. Translation: AAG08812.1.
PIRiA82968.
RefSeqiNP_254114.1. NC_002516.2.
WP_003096816.1. NZ_ASJY01000833.1.

Genome annotation databases

EnsemblBacteriaiAAG08812; AAG08812; PA5427.
GeneIDi877625.
KEGGipae:PA5427.
PATRICi19845733. VBIPseAer58763_5688.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AE004091 Genomic DNA. Translation: AAG08812.1.
PIRiA82968.
RefSeqiNP_254114.1. NC_002516.2.
WP_003096816.1. NZ_ASJY01000833.1.

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
EntryMethodResolution (Å)ChainPositionsPDBsum
1LLUX-ray2.30A/B/C/D/E/F/G/H1-342[»]
ProteinModelPortaliQ9HTD9.
SMRiQ9HTD9. Positions 2-342.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi208964.PA5427.

Proteomic databases

PaxDbiQ9HTD9.

Protocols and materials databases

DNASUi877625.
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaiAAG08812; AAG08812; PA5427.
GeneIDi877625.
KEGGipae:PA5427.
PATRICi19845733. VBIPseAer58763_5688.

Organism-specific databases

PseudoCAPiPA5427.

Phylogenomic databases

eggNOGiENOG4105DQ4. Bacteria.
COG1064. LUCA.
HOGENOMiHOG000294685.
InParanoidiQ9HTD9.
KOiK13953.
OMAiNCEYCTT.
OrthoDBiEOG6BPDJN.
PhylomeDBiQ9HTD9.

Miscellaneous databases

EvolutionaryTraceiQ9HTD9.

Family and domain databases

Gene3Di3.40.50.720. 1 hit.
3.90.180.10. 1 hit.
InterProiIPR013149. ADH_C.
IPR013154. ADH_N.
IPR002085. ADH_SF_Zn-type.
IPR002328. ADH_Zn_CS.
IPR011032. GroES-like.
IPR016040. NAD(P)-bd_dom.
IPR020843. PKS_ER.
[Graphical view]
PANTHERiPTHR11695. PTHR11695. 1 hit.
PfamiPF08240. ADH_N. 1 hit.
PF00107. ADH_zinc_N. 1 hit.
[Graphical view]
SMARTiSM00829. PKS_ER. 1 hit.
[Graphical view]
SUPFAMiSSF50129. SSF50129. 2 hits.
SSF51735. SSF51735. 1 hit.
PROSITEiPS00059. ADH_ZINC. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: ATCC 15692 / PAO1 / 1C / PRS 101 / LMG 12228Imported.
  2. "The ternary complex of Pseudomonas aeruginosa alcohol dehydrogenase with NADH and ethylene glycol."
    Levin I., Meiri G., Peretz M., Burstein Y., Frolow F.
    Protein Sci. 13:1547-1556(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: X-RAY CRYSTALLOGRAPHY (2.30 ANGSTROMS) IN COMPLEX WITH NAD AND ZINC.

Entry informationi

Entry nameiQ9HTD9_PSEAE
AccessioniPrimary (citable) accession number: Q9HTD9
Entry historyi
Integrated into UniProtKB/TrEMBL: March 1, 2001
Last sequence update: March 1, 2001
Last modified: May 11, 2016
This is version 113 of the entry and version 1 of the sequence. [Complete history]
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Keywords - Technical termi

3D-structureCombined sources, Complete proteome, Reference proteomeImported

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.