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Protein

Aspartate ammonia-lyase

Gene

aspA

Organism
Pseudomonas aeruginosa (strain ATCC 15692 / DSM 22644 / CIP 104116 / JCM 14847 / LMG 12228 / 1C / PRS 101 / PAO1)
Status
Reviewed-Annotation score: Annotation score: 2 out of 5-Protein inferred from homologyi

Functioni

Catalytic activityi

L-aspartate = fumarate + NH3.

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Binding sitei105 – 1051SubstrateBy similarity

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Lyase

Names & Taxonomyi

Protein namesi
Recommended name:
Aspartate ammonia-lyase (EC:4.3.1.1)
Short name:
Aspartase
Gene namesi
Name:aspA
Ordered Locus Names:PA5429
OrganismiPseudomonas aeruginosa (strain ATCC 15692 / DSM 22644 / CIP 104116 / JCM 14847 / LMG 12228 / 1C / PRS 101 / PAO1)
Taxonomic identifieri208964 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaPseudomonadalesPseudomonadaceaePseudomonas
Proteomesi
  • UP000002438 Componenti: Chromosome

Organism-specific databases

PseudoCAPiPA5429.

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 474474Aspartate ammonia-lyasePRO_0000287771Add
BLAST

Proteomic databases

PaxDbiQ9HTD7.

Interactioni

Subunit structurei

Homotetramer.By similarity

Protein-protein interaction databases

STRINGi208964.PA5429.

Structurei

3D structure databases

ProteinModelPortaliQ9HTD7.
SMRiQ9HTD7. Positions 7-467.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Region

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Regioni144 – 1463Substrate bindingBy similarity

Sequence similaritiesi

Phylogenomic databases

eggNOGiENOG4108IJ0. Bacteria.
COG1027. LUCA.
HOGENOMiHOG000061737.
InParanoidiQ9HTD7.
KOiK01744.
OMAiEICENYV.
PhylomeDBiQ9HTD7.

Family and domain databases

Gene3Di1.10.275.10. 1 hit.
InterProiIPR004708. ApsA.
IPR024083. Fumarase/histidase_N.
IPR018951. Fumarase_C_C.
IPR020557. Fumarate_lyase_CS.
IPR000362. Fumarate_lyase_fam.
IPR022761. Fumarate_lyase_N.
IPR008948. L-Aspartase-like.
[Graphical view]
PANTHERiPTHR11444. PTHR11444. 1 hit.
PfamiPF10415. FumaraseC_C. 1 hit.
PF00206. Lyase_1. 1 hit.
[Graphical view]
PRINTSiPR00149. FUMRATELYASE.
SUPFAMiSSF48557. SSF48557. 1 hit.
TIGRFAMsiTIGR00839. aspA. 1 hit.
PROSITEiPS00163. FUMARATE_LYASES. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q9HTD7-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MSPVASSRIE KDLLGTLEVP ADAYYGIQTL RAVNNFRLSG VPLSHYPKLV
60 70 80 90 100
VALAMVKQAA ADANRQLGHL PEDKHAAISE ACARLIRGDF HEQFVVDMIQ
110 120 130 140 150
GGAGTSTNMN ANEVIANIAL EAMGHTKGEY KYLHPNNDVN MAQSTNDAYP
160 170 180 190 200
TAIRLGLLLG HDTLLASLDS LIQAFAAKGV EFAGVLKMGR TQLQDAVPMT
210 220 230 240 250
LGQEFHAFAT TLGEDLDRLR RLAPELLTEV NLGGTAIGTG INADPGYQKL
260 270 280 290 300
AVERLAAISG QPLKPAADLI EATSDMGAFV LFSGMLKRTA VKLSKICNDL
310 320 330 340 350
RLLSSGPRTG INEINLPPRQ PGSSIMPGKV NPVIPEAVNQ VAFEVIGNDL
360 370 380 390 400
ALTLAAEGGQ LQLNVMEPLI AYKIFDSIRL LQRAMDMLRE HCITGITANV
410 420 430 440 450
ERCHELVEHS IGLVTALNPY IGYENSTRIA KTALESGRGV LELVREEKLL
460 470
DEATLADILL PENMIAPRLI PLRA
Length:474
Mass (Da):51,070
Last modified:March 1, 2001 - v1
Checksum:iDE868A8CA8478429
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AE004091 Genomic DNA. Translation: AAG08814.1.
PIRiC82968.
RefSeqiNP_254116.1. NC_002516.2.
WP_003096822.1. NZ_ASJY01000833.1.

Genome annotation databases

EnsemblBacteriaiAAG08814; AAG08814; PA5429.
GeneIDi878603.
KEGGipae:PA5429.
PATRICi19845737. VBIPseAer58763_5690.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AE004091 Genomic DNA. Translation: AAG08814.1.
PIRiC82968.
RefSeqiNP_254116.1. NC_002516.2.
WP_003096822.1. NZ_ASJY01000833.1.

3D structure databases

ProteinModelPortaliQ9HTD7.
SMRiQ9HTD7. Positions 7-467.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi208964.PA5429.

Proteomic databases

PaxDbiQ9HTD7.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaiAAG08814; AAG08814; PA5429.
GeneIDi878603.
KEGGipae:PA5429.
PATRICi19845737. VBIPseAer58763_5690.

Organism-specific databases

PseudoCAPiPA5429.

Phylogenomic databases

eggNOGiENOG4108IJ0. Bacteria.
COG1027. LUCA.
HOGENOMiHOG000061737.
InParanoidiQ9HTD7.
KOiK01744.
OMAiEICENYV.
PhylomeDBiQ9HTD7.

Family and domain databases

Gene3Di1.10.275.10. 1 hit.
InterProiIPR004708. ApsA.
IPR024083. Fumarase/histidase_N.
IPR018951. Fumarase_C_C.
IPR020557. Fumarate_lyase_CS.
IPR000362. Fumarate_lyase_fam.
IPR022761. Fumarate_lyase_N.
IPR008948. L-Aspartase-like.
[Graphical view]
PANTHERiPTHR11444. PTHR11444. 1 hit.
PfamiPF10415. FumaraseC_C. 1 hit.
PF00206. Lyase_1. 1 hit.
[Graphical view]
PRINTSiPR00149. FUMRATELYASE.
SUPFAMiSSF48557. SSF48557. 1 hit.
TIGRFAMsiTIGR00839. aspA. 1 hit.
PROSITEiPS00163. FUMARATE_LYASES. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiASPA_PSEAE
AccessioniPrimary (citable) accession number: Q9HTD7
Entry historyi
Integrated into UniProtKB/Swiss-Prot: May 15, 2007
Last sequence update: March 1, 2001
Last modified: September 7, 2016
This is version 88 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.