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Q9HT86

- Q9HT86_PSEAE

UniProt

Q9HT86 - Q9HT86_PSEAE

Protein
Submitted name:

AmpDh2

Gene

ampDh2

Organism
Pseudomonas aeruginosa (strain ATCC 15692 / PAO1 / 1C / PRS 101 / LMG 12228)
Status
Unreviewed - Annotation score: 1 out of 5- Experimental evidence at protein leveli
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    • History
      Entry version 77 (01 Oct 2014)
      Sequence version 1 (01 Mar 2001)
      Previous versions | rss
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    Functioni

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Metal bindingi42 – 421Zinc; via pros nitrogenImported
    Metal bindingi153 – 1531Zinc; via pros nitrogenImported
    Metal bindingi163 – 1631ZincImported
    Binding sitei241 – 2411N-acetyl-D-glucosamine; via carbonyl oxygenImported

    GO - Molecular functioni

    1. metal ion binding Source: UniProtKB-KW
    2. N-acetylmuramoyl-L-alanine amidase activity Source: InterPro

    GO - Biological processi

    1. peptidoglycan catabolic process Source: InterPro

    Keywords - Ligandi

    Metal-bindingImported, ZincImported

    Names & Taxonomyi

    Protein namesi
    Submitted name:
    AmpDh2Imported
    Gene namesi
    Name:ampDh2Imported
    Ordered Locus Names:PA5485Imported
    OrganismiPseudomonas aeruginosa (strain ATCC 15692 / PAO1 / 1C / PRS 101 / LMG 12228)Imported
    Taxonomic identifieri208964 [NCBI]
    Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaPseudomonadalesPseudomonadaceaePseudomonas
    ProteomesiUP000002438: Chromosome

    Organism-specific databases

    PseudoCAPiPA5485.

    Interactioni

    Protein-protein interaction databases

    STRINGi208964.PA5485.

    Structurei

    3D structure databases

    Select the link destinations:
    PDBe
    RCSB PDB
    PDBj
    Links Updated
    EntryMethodResolution (Å)ChainPositionsPDBsum
    4BJ4X-ray1.72A/B18-259[»]
    4BOLX-ray1.70A/B1-259[»]
    4BPAX-ray2.70A/B1-259[»]
    ProteinModelPortaliQ9HT86.
    SMRiQ9HT86. Positions 18-259.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Region

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Regioni158 – 1603N-acetyl-D-glucosamine bindingImported
    Regioni227 – 2304N-acetyl-D-glucosamine bindingImported

    Phylogenomic databases

    HOGENOMiHOG000255964.
    KOiK11066.
    OMAiPPSIGWY.
    OrthoDBiEOG60GRR5.
    PhylomeDBiQ9HT86.

    Family and domain databases

    Gene3Di3.40.80.10. 1 hit.
    InterProiIPR002502. Amidase_domain.
    IPR002477. Peptidoglycan-bd-like.
    [Graphical view]
    PfamiPF01510. Amidase_2. 1 hit.
    PF01471. PG_binding_1. 1 hit.
    [Graphical view]
    SMARTiSM00644. Ami_2. 1 hit.
    [Graphical view]
    SUPFAMiSSF47090. SSF47090. 1 hit.
    SSF55846. SSF55846. 1 hit.

    Sequencei

    Sequence statusi: Complete.

    Q9HT86-1 [UniParc]FASTAAdd to Basket

    « Hide

    MRSFVLLAFT LSLLAGCSSG PRLNTDYTSA NQDSRVQFIV LHYTSTDLPH    50
    SLGILTHGGV SAHYLIGDDE PATVYRLVDE NRRAWHAGVS EWQGRTWLNA 100
    TSIGIEIVNQ GYRDTPQGRV WYPFSEAQIQ ALIPLLKDIA KRHGITPDRI 150
    IGHSDIAPGR KVDPGPLFPW KRLADAGLVP WPKPGELARR LAELNGQLPD 200
    VRWFQQQLAR HGYLVPQTGE LEKDTRDVIG AFQMKYRPAR FDGEPDLETA 250
    ALLLAVPTS 259
    Length:259
    Mass (Da):28,881
    Last modified:March 1, 2001 - v1
    Checksum:i4E299ECD2CFD91C3
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AE004091 Genomic DNA. Translation: AAG08870.1.
    PIRiD82960.
    RefSeqiNP_254172.1. NC_002516.2.

    Genome annotation databases

    EnsemblBacteriaiAAG08870; AAG08870; PA5485.
    GeneIDi880851.
    KEGGipae:PA5485.
    PATRICi19845857. VBIPseAer58763_5750.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AE004091 Genomic DNA. Translation: AAG08870.1 .
    PIRi D82960.
    RefSeqi NP_254172.1. NC_002516.2.

    3D structure databases

    Select the link destinations:
    PDBe
    RCSB PDB
    PDBj
    Links Updated
    Entry Method Resolution (Å) Chain Positions PDBsum
    4BJ4 X-ray 1.72 A/B 18-259 [» ]
    4BOL X-ray 1.70 A/B 1-259 [» ]
    4BPA X-ray 2.70 A/B 1-259 [» ]
    ProteinModelPortali Q9HT86.
    SMRi Q9HT86. Positions 18-259.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 208964.PA5485.

    Protocols and materials databases

    DNASUi 880851.
    Structural Biology Knowledgebase Search...

    Genome annotation databases

    EnsemblBacteriai AAG08870 ; AAG08870 ; PA5485 .
    GeneIDi 880851.
    KEGGi pae:PA5485.
    PATRICi 19845857. VBIPseAer58763_5750.

    Organism-specific databases

    PseudoCAPi PA5485.

    Phylogenomic databases

    HOGENOMi HOG000255964.
    KOi K11066.
    OMAi PPSIGWY.
    OrthoDBi EOG60GRR5.
    PhylomeDBi Q9HT86.

    Family and domain databases

    Gene3Di 3.40.80.10. 1 hit.
    InterProi IPR002502. Amidase_domain.
    IPR002477. Peptidoglycan-bd-like.
    [Graphical view ]
    Pfami PF01510. Amidase_2. 1 hit.
    PF01471. PG_binding_1. 1 hit.
    [Graphical view ]
    SMARTi SM00644. Ami_2. 1 hit.
    [Graphical view ]
    SUPFAMi SSF47090. SSF47090. 1 hit.
    SSF55846. SSF55846. 1 hit.
    ProtoNeti Search...

    Publicationsi

    1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: ATCC 15692 / PAO1 / 1C / PRS 101 / LMG 12228Imported.
    2. "Reaction products and the X-ray structure of AmpDh2, a virulence determinant of Pseudomonas aeruginosa."
      Martinez-Caballero S., Lee M., Artola-Recolons C., Carrasco-Lopez C., Hesek D., Spink E., Lastochkin E., Zhang W., Hellman L.M., Boggess B., Mobashery S., Hermoso J.A.
      J. Am. Chem. Soc. 135:10318-10321(2013) [PubMed] [Europe PMC] [Abstract]
      Cited for: X-RAY CRYSTALLOGRAPHY (1.70 ANGSTROMS) IN COMPLEX WITH N-ACETYL-D-GLUCOSAMINE AND ZINC.

    Entry informationi

    Entry nameiQ9HT86_PSEAE
    AccessioniPrimary (citable) accession number: Q9HT86
    Entry historyi
    Integrated into UniProtKB/TrEMBL: March 1, 2001
    Last sequence update: March 1, 2001
    Last modified: October 1, 2014
    This is version 77 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiUnreviewed (UniProtKB/TrEMBL)

    Miscellaneousi

    Keywords - Technical termi

    3D-structureImported, Complete proteome, Reference proteomeImported

    External Data

    Dasty 3