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Q9HT86

- Q9HT86_PSEAE

UniProt

Q9HT86 - Q9HT86_PSEAE

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Protein
Submitted name:

AmpDh2

Gene

ampDh2

Organism
Pseudomonas aeruginosa (strain ATCC 15692 / PAO1 / 1C / PRS 101 / LMG 12228)
Status
Unreviewed - Annotation score: 1 out of 5- Experimental evidence at protein leveli

Functioni

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Metal bindingi42 – 421Zinc; via pros nitrogenCombined sources
Metal bindingi153 – 1531Zinc; via pros nitrogenCombined sources
Metal bindingi163 – 1631ZincCombined sources
Binding sitei241 – 2411N-acetyl-D-glucosamine; via carbonyl oxygenCombined sources

GO - Molecular functioni

  1. metal ion binding Source: UniProtKB-KW
  2. N-acetylmuramoyl-L-alanine amidase activity Source: InterPro

GO - Biological processi

  1. peptidoglycan catabolic process Source: InterPro
Complete GO annotation...

Keywords - Ligandi

Metal-bindingCombined sources, ZincCombined sources

Names & Taxonomyi

Protein namesi
Submitted name:
AmpDh2Imported
Gene namesi
Name:ampDh2Imported
Ordered Locus Names:PA5485Imported
OrganismiPseudomonas aeruginosa (strain ATCC 15692 / PAO1 / 1C / PRS 101 / LMG 12228)Imported
Taxonomic identifieri208964 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaPseudomonadalesPseudomonadaceaePseudomonas
ProteomesiUP000002438: Chromosome

Organism-specific databases

PseudoCAPiPA5485.

Interactioni

Protein-protein interaction databases

STRINGi208964.PA5485.

Structurei

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
EntryMethodResolution (Å)ChainPositionsPDBsum
4BJ4X-ray1.72A/B18-259[»]
4BOLX-ray1.70A/B1-259[»]
4BPAX-ray2.70A/B1-259[»]
ProteinModelPortaliQ9HT86.
SMRiQ9HT86. Positions 18-259.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Region

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Regioni158 – 1603N-acetyl-D-glucosamine bindingCombined sources
Regioni227 – 2304N-acetyl-D-glucosamine bindingCombined sources

Phylogenomic databases

HOGENOMiHOG000255964.
InParanoidiQ9HT86.
KOiK11066.
OMAiGHDWGYP.
OrthoDBiEOG60GRR5.
PhylomeDBiQ9HT86.

Family and domain databases

Gene3Di3.40.80.10. 1 hit.
InterProiIPR002502. Amidase_domain.
IPR002477. Peptidoglycan-bd-like.
[Graphical view]
PfamiPF01510. Amidase_2. 1 hit.
PF01471. PG_binding_1. 1 hit.
[Graphical view]
SMARTiSM00644. Ami_2. 1 hit.
[Graphical view]
SUPFAMiSSF47090. SSF47090. 1 hit.
SSF55846. SSF55846. 1 hit.

Sequencei

Sequence statusi: Complete.

Q9HT86-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MRSFVLLAFT LSLLAGCSSG PRLNTDYTSA NQDSRVQFIV LHYTSTDLPH
60 70 80 90 100
SLGILTHGGV SAHYLIGDDE PATVYRLVDE NRRAWHAGVS EWQGRTWLNA
110 120 130 140 150
TSIGIEIVNQ GYRDTPQGRV WYPFSEAQIQ ALIPLLKDIA KRHGITPDRI
160 170 180 190 200
IGHSDIAPGR KVDPGPLFPW KRLADAGLVP WPKPGELARR LAELNGQLPD
210 220 230 240 250
VRWFQQQLAR HGYLVPQTGE LEKDTRDVIG AFQMKYRPAR FDGEPDLETA

ALLLAVPTS
Length:259
Mass (Da):28,881
Last modified:March 1, 2001 - v1
Checksum:i4E299ECD2CFD91C3
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AE004091 Genomic DNA. Translation: AAG08870.1.
PIRiD82960.
RefSeqiNP_254172.1. NC_002516.2.

Genome annotation databases

EnsemblBacteriaiAAG08870; AAG08870; PA5485.
GeneIDi880851.
KEGGipae:PA5485.
PATRICi19845857. VBIPseAer58763_5750.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AE004091 Genomic DNA. Translation: AAG08870.1 .
PIRi D82960.
RefSeqi NP_254172.1. NC_002516.2.

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
Entry Method Resolution (Å) Chain Positions PDBsum
4BJ4 X-ray 1.72 A/B 18-259 [» ]
4BOL X-ray 1.70 A/B 1-259 [» ]
4BPA X-ray 2.70 A/B 1-259 [» ]
ProteinModelPortali Q9HT86.
SMRi Q9HT86. Positions 18-259.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 208964.PA5485.

Protocols and materials databases

DNASUi 880851.
Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai AAG08870 ; AAG08870 ; PA5485 .
GeneIDi 880851.
KEGGi pae:PA5485.
PATRICi 19845857. VBIPseAer58763_5750.

Organism-specific databases

PseudoCAPi PA5485.

Phylogenomic databases

HOGENOMi HOG000255964.
InParanoidi Q9HT86.
KOi K11066.
OMAi GHDWGYP.
OrthoDBi EOG60GRR5.
PhylomeDBi Q9HT86.

Family and domain databases

Gene3Di 3.40.80.10. 1 hit.
InterProi IPR002502. Amidase_domain.
IPR002477. Peptidoglycan-bd-like.
[Graphical view ]
Pfami PF01510. Amidase_2. 1 hit.
PF01471. PG_binding_1. 1 hit.
[Graphical view ]
SMARTi SM00644. Ami_2. 1 hit.
[Graphical view ]
SUPFAMi SSF47090. SSF47090. 1 hit.
SSF55846. SSF55846. 1 hit.
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: ATCC 15692 / PAO1 / 1C / PRS 101 / LMG 12228Imported.
  2. "Reaction products and the X-ray structure of AmpDh2, a virulence determinant of Pseudomonas aeruginosa."
    Martinez-Caballero S., Lee M., Artola-Recolons C., Carrasco-Lopez C., Hesek D., Spink E., Lastochkin E., Zhang W., Hellman L.M., Boggess B., Mobashery S., Hermoso J.A.
    J. Am. Chem. Soc. 135:10318-10321(2013) [PubMed] [Europe PMC] [Abstract]
    Cited for: X-RAY CRYSTALLOGRAPHY (1.70 ANGSTROMS) IN COMPLEX WITH N-ACETYL-D-GLUCOSAMINE AND ZINC.

Entry informationi

Entry nameiQ9HT86_PSEAE
AccessioniPrimary (citable) accession number: Q9HT86
Entry historyi
Integrated into UniProtKB/TrEMBL: March 1, 2001
Last sequence update: March 1, 2001
Last modified: January 7, 2015
This is version 79 of the entry and version 1 of the sequence. [Complete history]
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Keywords - Technical termi

3D-structureCombined sources, Complete proteome, Reference proteomeImported

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.