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Q9HT35 (GCH4_PSEAE) Reviewed, UniProtKB/Swiss-Prot

Last modified July 9, 2014. Version 62. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
GTP cyclohydrolase FolE2

EC=3.5.4.16
Gene names
Name:folE2
Ordered Locus Names:PA5539
OrganismPseudomonas aeruginosa (strain ATCC 15692 / PAO1 / 1C / PRS 101 / LMG 12228) [Reference proteome] [HAMAP]
Taxonomic identifier208964 [NCBI]
Taxonomic lineageBacteriaProteobacteriaGammaproteobacteriaPseudomonadalesPseudomonadaceaePseudomonas

Protein attributes

Sequence length298 AA.
Sequence statusComplete.
Protein existenceInferred from homology

General annotation (Comments)

Function

Converts GTP to 7,8-dihydroneopterin triphosphate By similarity. HAMAP-Rule MF_01527

Catalytic activity

GTP + H2O = formate + 2-amino-4-hydroxy-6-(erythro-1,2,3-trihydroxypropyl)-dihydropteridine triphosphate. HAMAP-Rule MF_01527

Pathway

Cofactor biosynthesis; 7,8-dihydroneopterin triphosphate biosynthesis; 7,8-dihydroneopterin triphosphate from GTP: step 1/1. HAMAP-Rule MF_01527

Sequence similarities

Belongs to the GTP cyclohydrolase IV family.

Ontologies

Keywords
   Molecular functionHydrolase
   Technical termComplete proteome
Reference proteome
Gene Ontology (GO)
   Biological_process7,8-dihydroneopterin 3'-triphosphate biosynthetic process

Inferred from electronic annotation. Source: UniProtKB-UniPathway

   Molecular_functionGTP cyclohydrolase I activity

Inferred from electronic annotation. Source: UniProtKB-HAMAP

Complete GO annotation...

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 298298GTP cyclohydrolase FolE2 HAMAP-Rule MF_01527
PRO_0000147719

Sites

Site1491May be catalytically important By similarity

Sequences

Sequence LengthMass (Da)Tools
Q9HT35 [UniParc].

Last modified March 1, 2001. Version 1.
Checksum: 56C9CF2B60280239

FASTA29832,416
        10         20         30         40         50         60 
MNALTLPDIA RQTTTADLPL DWVGMQGIAL PVQIGGQRVA AEADAGVSLD DPQARGIHMS 

        70         80         90        100        110        120 
RLYLALAELE QGELDLSCLR AVLQRFLDSH AGLSRRAYLR LRLAPLLRRP ALVSPLSGWK 

       130        140        150        160        170        180 
RYPLVLDTRL EGDDFQAEVH LELTYSSTCP CSAALARQLI QERFDQDFAG QPLDHASVLA 

       190        200        210        220        230        240 
WLGSSAGIVA TPHSQRSSAH LRIGLAEDCI GLPLEELADL GESALGTAVQ TAVKRADEQA 

       250        260        270        280        290 
FALANGQNLM FCEDAVRRLH RALQGYPQAS RFSIRVVHAE SLHAHDAVAE SHWQRGAA 

« Hide

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
AE004091 Genomic DNA. Translation: AAG08924.1.
PIRH82953.
RefSeqNP_254226.1. NC_002516.2.

3D structure databases

ProteinModelPortalQ9HT35.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

STRING208964.PA5539.

Protocols and materials databases

DNASU877616.
StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaAAG08924; AAG08924; PA5539.
GeneID877616.
KEGGpae:PA5539.
PATRIC19845967. VBIPseAer58763_5805.

Organism-specific databases

PseudoCAPPA5539.

Phylogenomic databases

eggNOGCOG1469.
HOGENOMHOG000247517.
KOK09007.
OMAAGRTTIQ.
OrthoDBEOG6X6RBH.
PhylomeDBQ9HT35.

Enzyme and pathway databases

UniPathwayUPA00848; UER00151.

Family and domain databases

HAMAPMF_01527_B. GTP_cyclohydrol_B.
InterProIPR022838. GTP_cyclohydrolase_FolE2.
IPR003801. GTP_cyclohydrolase_FolE2/MptA.
[Graphical view]
PfamPF02649. GCHY-1. 1 hit.
[Graphical view]
ProtoNetSearch...

Entry information

Entry nameGCH4_PSEAE
AccessionPrimary (citable) accession number: Q9HT35
Entry history
Integrated into UniProtKB/Swiss-Prot: February 1, 2005
Last sequence update: March 1, 2001
Last modified: July 9, 2014
This is version 62 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families

PATHWAY comments

Index of metabolic and biosynthesis pathways