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Q9HT35

- GCH4_PSEAE

UniProt

Q9HT35 - GCH4_PSEAE

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Protein
GTP cyclohydrolase FolE2
Gene
folE2, PA5539
Organism
Pseudomonas aeruginosa (strain ATCC 15692 / PAO1 / 1C / PRS 101 / LMG 12228)
Status
Reviewed - Annotation score: 2 out of 5 - Protein inferred from homologyi

Functioni

Converts GTP to 7,8-dihydroneopterin triphosphate By similarity.UniRule annotation

Catalytic activityi

GTP + H2O = formate + 2-amino-4-hydroxy-6-(erythro-1,2,3-trihydroxypropyl)-dihydropteridine triphosphate.UniRule annotation

Pathwayi

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sitei149 – 1491May be catalytically important By similarity

GO - Molecular functioni

  1. GTP cyclohydrolase I activity Source: UniProtKB-HAMAP

GO - Biological processi

  1. 7,8-dihydroneopterin 3'-triphosphate biosynthetic process Source: UniProtKB-UniPathway
Complete GO annotation...

Keywords - Molecular functioni

Hydrolase

Enzyme and pathway databases

UniPathwayiUPA00848; UER00151.

Names & Taxonomyi

Protein namesi
Recommended name:
GTP cyclohydrolase FolE2 (EC:3.5.4.16)
Gene namesi
Name:folE2
Ordered Locus Names:PA5539
OrganismiPseudomonas aeruginosa (strain ATCC 15692 / PAO1 / 1C / PRS 101 / LMG 12228)
Taxonomic identifieri208964 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaPseudomonadalesPseudomonadaceaePseudomonas
ProteomesiUP000002438: Chromosome

Organism-specific databases

PseudoCAPiPA5539.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 298298GTP cyclohydrolase FolE2UniRule annotation
PRO_0000147719Add
BLAST

Interactioni

Protein-protein interaction databases

STRINGi208964.PA5539.

Structurei

3D structure databases

ProteinModelPortaliQ9HT35.

Family & Domainsi

Sequence similaritiesi

Phylogenomic databases

eggNOGiCOG1469.
HOGENOMiHOG000247517.
KOiK09007.
OMAiAGRTTIQ.
OrthoDBiEOG6X6RBH.
PhylomeDBiQ9HT35.

Family and domain databases

HAMAPiMF_01527_B. GTP_cyclohydrol_B.
InterProiIPR022838. GTP_cyclohydrolase_FolE2.
IPR003801. GTP_cyclohydrolase_FolE2/MptA.
[Graphical view]
PfamiPF02649. GCHY-1. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q9HT35-1 [UniParc]FASTAAdd to Basket

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MNALTLPDIA RQTTTADLPL DWVGMQGIAL PVQIGGQRVA AEADAGVSLD    50
DPQARGIHMS RLYLALAELE QGELDLSCLR AVLQRFLDSH AGLSRRAYLR 100
LRLAPLLRRP ALVSPLSGWK RYPLVLDTRL EGDDFQAEVH LELTYSSTCP 150
CSAALARQLI QERFDQDFAG QPLDHASVLA WLGSSAGIVA TPHSQRSSAH 200
LRIGLAEDCI GLPLEELADL GESALGTAVQ TAVKRADEQA FALANGQNLM 250
FCEDAVRRLH RALQGYPQAS RFSIRVVHAE SLHAHDAVAE SHWQRGAA 298
Length:298
Mass (Da):32,416
Last modified:March 1, 2001 - v1
Checksum:i56C9CF2B60280239
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AE004091 Genomic DNA. Translation: AAG08924.1.
PIRiH82953.
RefSeqiNP_254226.1. NC_002516.2.

Genome annotation databases

EnsemblBacteriaiAAG08924; AAG08924; PA5539.
GeneIDi877616.
KEGGipae:PA5539.
PATRICi19845967. VBIPseAer58763_5805.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AE004091 Genomic DNA. Translation: AAG08924.1 .
PIRi H82953.
RefSeqi NP_254226.1. NC_002516.2.

3D structure databases

ProteinModelPortali Q9HT35.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 208964.PA5539.

Protocols and materials databases

DNASUi 877616.
Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai AAG08924 ; AAG08924 ; PA5539 .
GeneIDi 877616.
KEGGi pae:PA5539.
PATRICi 19845967. VBIPseAer58763_5805.

Organism-specific databases

PseudoCAPi PA5539.

Phylogenomic databases

eggNOGi COG1469.
HOGENOMi HOG000247517.
KOi K09007.
OMAi AGRTTIQ.
OrthoDBi EOG6X6RBH.
PhylomeDBi Q9HT35.

Enzyme and pathway databases

UniPathwayi UPA00848 ; UER00151 .

Family and domain databases

HAMAPi MF_01527_B. GTP_cyclohydrol_B.
InterProi IPR022838. GTP_cyclohydrolase_FolE2.
IPR003801. GTP_cyclohydrolase_FolE2/MptA.
[Graphical view ]
Pfami PF02649. GCHY-1. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: ATCC 15692 / PAO1 / 1C / PRS 101 / LMG 12228.

Entry informationi

Entry nameiGCH4_PSEAE
AccessioniPrimary (citable) accession number: Q9HT35
Entry historyi
Integrated into UniProtKB/Swiss-Prot: February 1, 2005
Last sequence update: March 1, 2001
Last modified: July 9, 2014
This is version 62 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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