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Q9HT35

- GCH4_PSEAE

UniProt

Q9HT35 - GCH4_PSEAE

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Protein

GTP cyclohydrolase FolE2

Gene

folE2

Organism
Pseudomonas aeruginosa (strain ATCC 15692 / PAO1 / 1C / PRS 101 / LMG 12228)
Status
Reviewed - Annotation score: 2 out of 5- Protein inferred from homologyi

Functioni

Converts GTP to 7,8-dihydroneopterin triphosphate.UniRule annotation

Catalytic activityi

GTP + H2O = formate + 2-amino-4-hydroxy-6-(erythro-1,2,3-trihydroxypropyl)-dihydropteridine triphosphate.UniRule annotation

Pathwayi

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sitei149 – 1491May be catalytically importantUniRule annotation

GO - Molecular functioni

  1. GTP cyclohydrolase I activity Source: UniProtKB-HAMAP

GO - Biological processi

  1. 7,8-dihydroneopterin 3'-triphosphate biosynthetic process Source: UniProtKB-UniPathway
Complete GO annotation...

Keywords - Molecular functioni

Hydrolase

Enzyme and pathway databases

UniPathwayiUPA00848; UER00151.

Names & Taxonomyi

Protein namesi
Recommended name:
GTP cyclohydrolase FolE2UniRule annotation (EC:3.5.4.16UniRule annotation)
Gene namesi
Name:folE2UniRule annotation
Ordered Locus Names:PA5539
OrganismiPseudomonas aeruginosa (strain ATCC 15692 / PAO1 / 1C / PRS 101 / LMG 12228)
Taxonomic identifieri208964 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaPseudomonadalesPseudomonadaceaePseudomonas
ProteomesiUP000002438: Chromosome

Organism-specific databases

PseudoCAPiPA5539.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 298298GTP cyclohydrolase FolE2PRO_0000147719Add
BLAST

Interactioni

Protein-protein interaction databases

STRINGi208964.PA5539.

Structurei

3D structure databases

ProteinModelPortaliQ9HT35.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the GTP cyclohydrolase IV family.UniRule annotation

Phylogenomic databases

eggNOGiCOG1469.
HOGENOMiHOG000247517.
InParanoidiQ9HT35.
KOiK09007.
OMAiAGRTTIQ.
OrthoDBiEOG6X6RBH.
PhylomeDBiQ9HT35.

Family and domain databases

HAMAPiMF_01527_B. GTP_cyclohydrol_B.
InterProiIPR022838. GTP_cyclohydrolase_FolE2.
IPR003801. GTP_cyclohydrolase_FolE2/MptA.
[Graphical view]
PfamiPF02649. GCHY-1. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q9HT35-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MNALTLPDIA RQTTTADLPL DWVGMQGIAL PVQIGGQRVA AEADAGVSLD
60 70 80 90 100
DPQARGIHMS RLYLALAELE QGELDLSCLR AVLQRFLDSH AGLSRRAYLR
110 120 130 140 150
LRLAPLLRRP ALVSPLSGWK RYPLVLDTRL EGDDFQAEVH LELTYSSTCP
160 170 180 190 200
CSAALARQLI QERFDQDFAG QPLDHASVLA WLGSSAGIVA TPHSQRSSAH
210 220 230 240 250
LRIGLAEDCI GLPLEELADL GESALGTAVQ TAVKRADEQA FALANGQNLM
260 270 280 290
FCEDAVRRLH RALQGYPQAS RFSIRVVHAE SLHAHDAVAE SHWQRGAA
Length:298
Mass (Da):32,416
Last modified:March 1, 2001 - v1
Checksum:i56C9CF2B60280239
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AE004091 Genomic DNA. Translation: AAG08924.1.
PIRiH82953.
RefSeqiNP_254226.1. NC_002516.2.

Genome annotation databases

EnsemblBacteriaiAAG08924; AAG08924; PA5539.
GeneIDi877616.
KEGGipae:PA5539.
PATRICi19845967. VBIPseAer58763_5805.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AE004091 Genomic DNA. Translation: AAG08924.1 .
PIRi H82953.
RefSeqi NP_254226.1. NC_002516.2.

3D structure databases

ProteinModelPortali Q9HT35.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 208964.PA5539.

Protocols and materials databases

DNASUi 877616.
Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai AAG08924 ; AAG08924 ; PA5539 .
GeneIDi 877616.
KEGGi pae:PA5539.
PATRICi 19845967. VBIPseAer58763_5805.

Organism-specific databases

PseudoCAPi PA5539.

Phylogenomic databases

eggNOGi COG1469.
HOGENOMi HOG000247517.
InParanoidi Q9HT35.
KOi K09007.
OMAi AGRTTIQ.
OrthoDBi EOG6X6RBH.
PhylomeDBi Q9HT35.

Enzyme and pathway databases

UniPathwayi UPA00848 ; UER00151 .

Family and domain databases

HAMAPi MF_01527_B. GTP_cyclohydrol_B.
InterProi IPR022838. GTP_cyclohydrolase_FolE2.
IPR003801. GTP_cyclohydrolase_FolE2/MptA.
[Graphical view ]
Pfami PF02649. GCHY-1. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: ATCC 15692 / PAO1 / 1C / PRS 101 / LMG 12228.

Entry informationi

Entry nameiGCH4_PSEAE
AccessioniPrimary (citable) accession number: Q9HT35
Entry historyi
Integrated into UniProtKB/Swiss-Prot: February 1, 2005
Last sequence update: March 1, 2001
Last modified: October 29, 2014
This is version 64 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3