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Q9HT25

- GLMS_PSEAE

UniProt

Q9HT25 - GLMS_PSEAE

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Protein
Glutamine--fructose-6-phosphate aminotransferase [isomerizing]
Gene
glmS, PA5549
Organism
Pseudomonas aeruginosa (strain ATCC 15692 / PAO1 / 1C / PRS 101 / LMG 12228)
Status
Reviewed - Annotation score: 3 out of 5 - Protein inferred from homologyi

Functioni

Catalyzes the first step in hexosamine metabolism, converting fructose-6P into glucosamine-6P using glutamine as a nitrogen source By similarity.UniRule annotation

Catalytic activityi

L-glutamine + D-fructose 6-phosphate = L-glutamate + D-glucosamine 6-phosphate.UniRule annotation

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Active sitei2 – 21Nucleophile; for GATase activity By similarity
Active sitei606 – 6061For Fru-6P isomerization activity By similarity

GO - Molecular functioni

  1. carbohydrate binding Source: InterPro
  2. glutamine-fructose-6-phosphate transaminase (isomerizing) activity Source: UniProtKB-HAMAP

GO - Biological processi

  1. carbohydrate biosynthetic process Source: InterPro
  2. glutamine metabolic process Source: UniProtKB-HAMAP
Complete GO annotation...

Keywords - Molecular functioni

Aminotransferase, Transferase

Protein family/group databases

MEROPSiC44.971.

Names & Taxonomyi

Protein namesi
Recommended name:
Glutamine--fructose-6-phosphate aminotransferase [isomerizing] (EC:2.6.1.16)
Alternative name(s):
D-fructose-6-phosphate amidotransferase
GFAT
Glucosamine-6-phosphate synthase
Hexosephosphate aminotransferase
L-glutamine--D-fructose-6-phosphate amidotransferase
Gene namesi
Name:glmS
Ordered Locus Names:PA5549
OrganismiPseudomonas aeruginosa (strain ATCC 15692 / PAO1 / 1C / PRS 101 / LMG 12228)
Taxonomic identifieri208964 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaPseudomonadalesPseudomonadaceaePseudomonas
ProteomesiUP000002438: Chromosome

Organism-specific databases

PseudoCAPiPA5549.

Subcellular locationi

Cytoplasm By similarity UniRule annotation

GO - Cellular componenti

  1. cytoplasm Source: UniProtKB-SubCell
Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Initiator methioninei1 – 11Removed By similarity
Chaini2 – 611610Glutamine--fructose-6-phosphate aminotransferase [isomerizing]UniRule annotation
PRO_0000135367Add
BLAST

Interactioni

Subunit structurei

Homodimer By similarity.UniRule annotation

Protein-protein interaction databases

STRINGi208964.PA5549.

Structurei

3D structure databases

ProteinModelPortaliQ9HT25.
SMRiQ9HT25. Positions 2-611.

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini2 – 219218Glutamine amidotransferase type-2
Add
BLAST
Domaini287 – 427141SIS 1
Add
BLAST
Domaini460 – 601142SIS 2
Add
BLAST

Sequence similaritiesi

Contains 2 SIS domains.

Keywords - Domaini

Glutamine amidotransferase, Repeat

Phylogenomic databases

eggNOGiCOG0449.
HOGENOMiHOG000258898.
KOiK00820.
OMAiPVTRRFM.
OrthoDBiEOG6KT2Q1.
PhylomeDBiQ9HT25.

Family and domain databases

Gene3Di3.60.20.10. 1 hit.
HAMAPiMF_00164. GlmS.
InterProiIPR017932. GATase_2_dom.
IPR000583. GATase_dom.
IPR005855. GlmS_trans.
IPR029055. Ntn_hydrolases_N.
IPR001347. SIS.
[Graphical view]
PANTHERiPTHR10937:SF0. PTHR10937:SF0. 1 hit.
PfamiPF00310. GATase_2. 1 hit.
PF01380. SIS. 2 hits.
[Graphical view]
SUPFAMiSSF56235. SSF56235. 1 hit.
TIGRFAMsiTIGR01135. glmS. 1 hit.
PROSITEiPS51278. GATASE_TYPE_2. 1 hit.
PS51464. SIS. 2 hits.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q9HT25-1 [UniParc]FASTAAdd to Basket

« Hide

MCGIVGAIAE RNITPILIEG LKRLEYRGYD SAGVAVFDNE GRLQRCRRVG    50
KVASLEEGLA GTPLLGRLGI AHTRWATHGA PTEGNAHPHF SSDEVAVVHN 100
GIIENHEPLR ERLKGLGYVF TSQTDTEVIV HLLHHKLQSI GDLTLALKDA 150
VKELHGAYGL AVISAAQPDR IVAARSGSPL VIGLGLGENF LASDQLALRQ 200
VTDRFIYLEE GDIAEIRRDS VRLWDVQGND VQRETVQYHE GAEAADKGEY 250
RHFMLKEIHE QPSVVQRTLE GRLGQNQVLV ESFGPQAAEL FAKVRNVQIV 300
ACGTSYHAGM VARYWLESLT GIPCQVEVAS EFRYRKVAVQ PDCLFVTISQ 350
SGETADTLAA LRNAKELGFL SSVAICNVAT SSLVRESDLT LLTQAGPEIG 400
VASTKAFTTQ LVALLLLTLG IGQVQKRLAD GVEAELVDEL RRLPTRLGEA 450
LAMNRTVEKV SELFAEKHHT LFLGRGAQFP VALEGALKLK EISYIHAEAY 500
PAGELKHGPL ALVDSDMPVV TVAPNNELVE KLKSNLQEVR ARGGELVVFA 550
DEGAGIEAGE GTHVVGMPHI GDVLSPILYT IPLQLLSYHV AVLKGTDVDQ 600
PRNLAKSVTV E 611
Length:611
Mass (Da):66,295
Last modified:January 23, 2007 - v3
Checksum:iC566848D787BFAF1
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AE004091 Genomic DNA. Translation: AAG08934.1.
PIRiF82951.
RefSeqiNP_254236.1. NC_002516.2.

Genome annotation databases

EnsemblBacteriaiAAG08934; AAG08934; PA5549.
GeneIDi877797.
KEGGipae:PA5549.
PATRICi19845987. VBIPseAer58763_5815.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AE004091 Genomic DNA. Translation: AAG08934.1 .
PIRi F82951.
RefSeqi NP_254236.1. NC_002516.2.

3D structure databases

ProteinModelPortali Q9HT25.
SMRi Q9HT25. Positions 2-611.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 208964.PA5549.

Protein family/group databases

MEROPSi C44.971.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai AAG08934 ; AAG08934 ; PA5549 .
GeneIDi 877797.
KEGGi pae:PA5549.
PATRICi 19845987. VBIPseAer58763_5815.

Organism-specific databases

PseudoCAPi PA5549.

Phylogenomic databases

eggNOGi COG0449.
HOGENOMi HOG000258898.
KOi K00820.
OMAi PVTRRFM.
OrthoDBi EOG6KT2Q1.
PhylomeDBi Q9HT25.

Family and domain databases

Gene3Di 3.60.20.10. 1 hit.
HAMAPi MF_00164. GlmS.
InterProi IPR017932. GATase_2_dom.
IPR000583. GATase_dom.
IPR005855. GlmS_trans.
IPR029055. Ntn_hydrolases_N.
IPR001347. SIS.
[Graphical view ]
PANTHERi PTHR10937:SF0. PTHR10937:SF0. 1 hit.
Pfami PF00310. GATase_2. 1 hit.
PF01380. SIS. 2 hits.
[Graphical view ]
SUPFAMi SSF56235. SSF56235. 1 hit.
TIGRFAMsi TIGR01135. glmS. 1 hit.
PROSITEi PS51278. GATASE_TYPE_2. 1 hit.
PS51464. SIS. 2 hits.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: ATCC 15692 / PAO1 / 1C / PRS 101 / LMG 12228.

Entry informationi

Entry nameiGLMS_PSEAE
AccessioniPrimary (citable) accession number: Q9HT25
Entry historyi
Integrated into UniProtKB/Swiss-Prot: July 11, 2002
Last sequence update: January 23, 2007
Last modified: July 9, 2014
This is version 85 of the entry and version 3 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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