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Q9HT00

- GLMS_HALSA

UniProt

Q9HT00 - GLMS_HALSA

Protein

Glutamine--fructose-6-phosphate aminotransferase [isomerizing]

Gene

glmS

Organism
Halobacterium salinarum (strain ATCC 700922 / JCM 11081 / NRC-1) (Halobacterium halobium)
Status
Reviewed - Annotation score: 3 out of 5- Protein inferred from homologyi
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    • History
      Entry version 82 (01 Oct 2014)
      Sequence version 3 (23 Jan 2007)
      Previous versions | rss
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    Functioni

    Catalyzes the first step in hexosamine metabolism, converting fructose-6P into glucosamine-6P using glutamine as a nitrogen source.UniRule annotation

    Catalytic activityi

    L-glutamine + D-fructose 6-phosphate = L-glutamate + D-glucosamine 6-phosphate.UniRule annotation

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Active sitei2 – 21Nucleophile; for GATase activityUniRule annotation
    Active sitei596 – 5961For Fru-6P isomerization activityUniRule annotation

    GO - Molecular functioni

    1. carbohydrate binding Source: InterPro
    2. glutamine-fructose-6-phosphate transaminase (isomerizing) activity Source: UniProtKB-HAMAP

    GO - Biological processi

    1. carbohydrate biosynthetic process Source: InterPro
    2. glutamine metabolic process Source: UniProtKB-HAMAP

    Keywords - Molecular functioni

    Aminotransferase, Transferase

    Protein family/group databases

    MEROPSiC44.971.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Glutamine--fructose-6-phosphate aminotransferase [isomerizing]UniRule annotation (EC:2.6.1.16UniRule annotation)
    Alternative name(s):
    D-fructose-6-phosphate amidotransferaseUniRule annotation
    GFATUniRule annotation
    Glucosamine-6-phosphate synthaseUniRule annotation
    Hexosephosphate aminotransferaseUniRule annotation
    L-glutamine--D-fructose-6-phosphate amidotransferaseUniRule annotation
    Gene namesi
    Name:glmSUniRule annotation
    Ordered Locus Names:VNG_0006G
    OrganismiHalobacterium salinarum (strain ATCC 700922 / JCM 11081 / NRC-1) (Halobacterium halobium)
    Taxonomic identifieri64091 [NCBI]
    Taxonomic lineageiArchaeaEuryarchaeotaHalobacteriaHalobacterialesHalobacteriaceaeHalobacterium
    ProteomesiUP000000554: Chromosome

    Subcellular locationi

    Cytoplasm UniRule annotation

    GO - Cellular componenti

    1. cytoplasm Source: UniProtKB-SubCell

    Keywords - Cellular componenti

    Cytoplasm

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Initiator methioninei1 – 11RemovedUniRule annotation
    Chaini2 – 601600Glutamine--fructose-6-phosphate aminotransferase [isomerizing]PRO_0000135423Add
    BLAST

    Proteomic databases

    PaxDbiQ9HT00.

    Interactioni

    Subunit structurei

    Homodimer.UniRule annotation

    Protein-protein interaction databases

    STRINGi64091.VNG0006G.

    Structurei

    3D structure databases

    ProteinModelPortaliQ9HT00.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Domains and Repeats

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Domaini2 – 214213Glutamine amidotransferase type-2UniRule annotationAdd
    BLAST
    Domaini281 – 420140SIS 1UniRule annotationAdd
    BLAST
    Domaini453 – 591139SIS 2UniRule annotationAdd
    BLAST

    Sequence similaritiesi

    Contains 1 glutamine amidotransferase type-2 domain.UniRule annotation
    Contains 2 SIS domains.UniRule annotation

    Keywords - Domaini

    Glutamine amidotransferase, Repeat

    Phylogenomic databases

    eggNOGiCOG0449.
    KOiK00820.
    OMAiGYAHYML.
    PhylomeDBiQ9HT00.

    Family and domain databases

    Gene3Di3.60.20.10. 1 hit.
    HAMAPiMF_00164. GlmS.
    InterProiIPR017932. GATase_2_dom.
    IPR005855. GlmS_trans.
    IPR029055. Ntn_hydrolases_N.
    IPR001347. SIS.
    [Graphical view]
    PANTHERiPTHR10937:SF0. PTHR10937:SF0. 1 hit.
    PfamiPF01380. SIS. 2 hits.
    [Graphical view]
    SUPFAMiSSF56235. SSF56235. 1 hit.
    TIGRFAMsiTIGR01135. glmS. 1 hit.
    PROSITEiPS51278. GATASE_TYPE_2. 1 hit.
    PS51464. SIS. 2 hits.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Sequence processingi: The displayed sequence is further processed into a mature form.

    Q9HT00-1 [UniParc]FASTAAdd to Basket

    « Hide

    MCGITGYIGT DPTGRIVHEG LQNLEYRGYD SAGIALAGGG SLSVHKTGGE    50
    VGDLPVPSRE DGTRGIGHTR WSTHGEPTRE NAHPHTDCTG DVAVVHNGII 100
    ENYAALADEL RADHVFHSDT DTEVVPHLIE THLADGVSLL TAVQRTTERL 150
    TGSYALAITA AGHDGIVVAR SDSPLLLGHG DTGTFVASDA TAFIEHTNRV 200
    TYLRNGDIAH LTETEWTVYN DGARVSRDIE ALDWSADAAG KSGYDHYMLK 250
    EIHEQPRALR QAISGRISDL GTDVTLDMEL STETLQNVAE LQIVACGTSY 300
    HAGLYAKELL ETHADLPVTV HVASEYELRG GRSPEDTLVV AITQSGETAD 350
    TLAALRSAAQ KGAPTLALTN TLGSTVTREA DDALFIRAGP EIGVAATKTF 400
    VSQVATAALL TMHIGRARNA ISTGDAAALR DAIRDLPGAV QQVLDQAPEI 450
    ASIGREYADS DAFFYVGRRA GRPVALESAL KLKEISYDHA EGFSAGELKH 500
    GPLALVTDNT PVVAVLTEYA APERTANNVK EVQSRGADVI GLASDAGTAR 550
    HADVTITLPA CGPLEPVVAN VALQLFAYHI ANEKGRPIDK PRNLAKSVTV 600
    E 601
    Length:601
    Mass (Da):63,631
    Last modified:January 23, 2007 - v3
    Checksum:i946E75D2198428B6
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AE004437 Genomic DNA. Translation: AAG18649.1.
    PIRiE84160.
    RefSeqiNP_279169.1. NC_002607.1.

    Genome annotation databases

    EnsemblBacteriaiAAG18649; AAG18649; VNG_0006G.
    GeneIDi1446955.
    KEGGihal:VNG0006G.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AE004437 Genomic DNA. Translation: AAG18649.1 .
    PIRi E84160.
    RefSeqi NP_279169.1. NC_002607.1.

    3D structure databases

    ProteinModelPortali Q9HT00.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 64091.VNG0006G.

    Protein family/group databases

    MEROPSi C44.971.

    Proteomic databases

    PaxDbi Q9HT00.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    EnsemblBacteriai AAG18649 ; AAG18649 ; VNG_0006G .
    GeneIDi 1446955.
    KEGGi hal:VNG0006G.

    Phylogenomic databases

    eggNOGi COG0449.
    KOi K00820.
    OMAi GYAHYML.
    PhylomeDBi Q9HT00.

    Family and domain databases

    Gene3Di 3.60.20.10. 1 hit.
    HAMAPi MF_00164. GlmS.
    InterProi IPR017932. GATase_2_dom.
    IPR005855. GlmS_trans.
    IPR029055. Ntn_hydrolases_N.
    IPR001347. SIS.
    [Graphical view ]
    PANTHERi PTHR10937:SF0. PTHR10937:SF0. 1 hit.
    Pfami PF01380. SIS. 2 hits.
    [Graphical view ]
    SUPFAMi SSF56235. SSF56235. 1 hit.
    TIGRFAMsi TIGR01135. glmS. 1 hit.
    PROSITEi PS51278. GATASE_TYPE_2. 1 hit.
    PS51464. SIS. 2 hits.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: ATCC 700922 / JCM 11081 / NRC-1.

    Entry informationi

    Entry nameiGLMS_HALSA
    AccessioniPrimary (citable) accession number: Q9HT00
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: July 11, 2002
    Last sequence update: January 23, 2007
    Last modified: October 1, 2014
    This is version 82 of the entry and version 3 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programProkaryotic Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3