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Protein

dCTP deaminase, dUMP-forming

Gene

dcd

Organism
Halobacterium salinarum (strain ATCC 700922 / JCM 11081 / NRC-1) (Halobacterium halobium)
Status
Reviewed-Annotation score: -Protein inferred from homologyi

Functioni

Bifunctional enzyme that catalyzes both the deamination of dCTP to dUTP and the hydrolysis of dUTP to dUMP without releasing the toxic dUTP intermediate.UniRule annotation

Catalytic activityi

dCTP + 2 H2O = dUMP + diphosphate + NH3.UniRule annotation

Pathwayi: dUMP biosynthesis

This protein is involved in step 1 of the subpathway that synthesizes dUMP from dCTP.UniRule annotation
Proteins known to be involved in this subpathway in this organism are:
  1. dCTP deaminase, dUMP-forming (dcd)
This subpathway is part of the pathway dUMP biosynthesis, which is itself part of Pyrimidine metabolism.
View all proteins of this organism that are known to be involved in the subpathway that synthesizes dUMP from dCTP, the pathway dUMP biosynthesis and in Pyrimidine metabolism.

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sitei120 – 121Important for bifunctional activityUniRule annotation2
Binding sitei123dCTPUniRule annotation1
Active sitei133Proton donor/acceptorUniRule annotation1
Binding sitei152dCTPUniRule annotation1
Binding sitei166dCTPUniRule annotation1
Binding sitei173dCTPUniRule annotation1
Binding sitei177dCTPUniRule annotation1

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Nucleotide bindingi105 – 110dCTP bindingUniRule annotation6
Nucleotide bindingi131 – 133dCTP bindingUniRule annotation3

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionHydrolase
Biological processNucleotide metabolism
LigandNucleotide-binding

Enzyme and pathway databases

UniPathwayiUPA00610; UER00667

Names & Taxonomyi

Protein namesi
Recommended name:
dCTP deaminase, dUMP-formingUniRule annotation (EC:3.5.4.30UniRule annotation)
Alternative name(s):
Bifunctional dCTP deaminase:dUTPaseUniRule annotation
DCD-DUTUniRule annotation
Gene namesi
Name:dcdUniRule annotation
Synonyms:dtd
Ordered Locus Names:VNG_0245G
OrganismiHalobacterium salinarum (strain ATCC 700922 / JCM 11081 / NRC-1) (Halobacterium halobium)
Taxonomic identifieri64091 [NCBI]
Taxonomic lineageiArchaeaEuryarchaeotaHalobacteriaHalobacterialesHalobacteriaceaeHalobacterium
Proteomesi
  • UP000000554 Componenti: Chromosome

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001560281 – 195dCTP deaminase, dUMP-formingAdd BLAST195

Proteomic databases

PaxDbiQ9HSG3
PRIDEiQ9HSG3

Interactioni

Subunit structurei

Homotrimer.UniRule annotation

Protein-protein interaction databases

STRINGi64091.VNG0245G

Structurei

3D structure databases

ProteinModelPortaliQ9HSG3
SMRiQ9HSG3
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the dCTP deaminase family.UniRule annotation

Phylogenomic databases

eggNOGiarCOG04048 Archaea
COG0717 LUCA
InParanoidiQ9HSG3
KOiK01494
OMAiGQLCLFR
OrthoDBiPOG093Z0C6C
PhylomeDBiQ9HSG3

Family and domain databases

CDDicd07557 trimeric_dUTPase, 1 hit
Gene3Di2.70.40.10, 1 hit
HAMAPiMF_00146 dCTP_deaminase, 1 hit
InterProiView protein in InterPro
IPR010550 dCTP_deam_bac
IPR011962 dCTP_deaminase
IPR036157 dUTPase-like_sf
IPR033704 dUTPase_trimeric
PfamiView protein in Pfam
PF06559 DCD, 1 hit
SUPFAMiSSF51283 SSF51283, 1 hit
TIGRFAMsiTIGR02274 dCTP_deam, 1 hit

Sequencei

Sequence statusi: Complete.

Q9HSG3-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MILSDQDILA RLADGDLAIE PLEDVDLQVQ PASVDVRLGR RFLEFERANV
60 70 80 90 100
PCIHPNREDE VDEYVTETVV EDGDEFILHP GDFVLGTTKE RVEVPRDLVA
110 120 130 140 150
QVEGRSSLGR LAVVVHATAG FIDPGFNGRV TLELSNLGKV PVALTPEMRI
160 170 180 190
SQLVFTELTS PADRPYGDER GSKYQDQDGP QASRIRGDRE FGGTQ
Length:195
Mass (Da):21,542
Last modified:March 1, 2001 - v1
Checksum:i86CCDA4D48BC0C9D
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AE004437 Genomic DNA Translation: AAG18843.1
PIRiG84184
RefSeqiWP_010902137.1, NC_002607.1

Genome annotation databases

EnsemblBacteriaiAAG18843; AAG18843; VNG_0245G
GeneIDi5952441
KEGGihal:VNG_0245G
PATRICifig|64091.14.peg.178

Similar proteinsi

Entry informationi

Entry nameiDCDB_HALSA
AccessioniPrimary (citable) accession number: Q9HSG3
Entry historyiIntegrated into UniProtKB/Swiss-Prot: March 27, 2002
Last sequence update: March 1, 2001
Last modified: April 25, 2018
This is version 99 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome
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Main funding by: National Institutes of Health