Reviewed, UniProtKB/Swiss-Prot Q9HS66 (TRPE2_HALSA)

Names and origin

Protein names

Recommended name:
    Anthranilate synthase component 1 2
    EC=4.1.3.27
Alternative name(s):
    Anthranilate synthase component I 2

Gene names

Name:	trpE2
Ordered Locus Names:	VNG_0384G

Organism

Halobacterium salinarium (Halobacterium halobium) [Complete proteome] [HAMAP]

Taxonomic identifier

2242 [NCBI]

Taxonomic lineage

Archaea › Euryarchaeota › Halobacteria › Halobacteriales › Halobacteriaceae › Halobacterium

Protein attributes

Sequence length	488 AA.
Sequence status	Complete.
Sequence processing	The displayed sequence is not processed.
Protein existence	Inferred from homology.

General annotation (Comments)

Catalytic activity	Chorismate + L-glutamine = anthranilate + pyruvate + L-glutamate.
Pathway	Amino-acid biosynthesis; L-tryptophan biosynthesis; L-tryptophan from chorismate: step 1/5.
Subunit structure	Tetramer of two components I and two components II By similarity.
Miscellaneous	Component I catalyzes the formation of anthranilate using ammonia rather than glutamine, whereas component II provides glutamine amidotransferase activity.
Sequence similarities	Belongs to the anthranilate synthase component I family.

Ontologies

Keywords
Biological process	Amino-acid biosynthesis Aromatic amino acid biosynthesis Tryptophan biosynthesis
Molecular function	Lyase
Technical term	Complete proteome
Gene Ontology (GO)
Biological process	tryptophan biosynthetic process Inferred from electronic annotation. Source: UniProtKB-KW
Molecular function	anthranilate synthase activity Inferred from electronic annotation. Source: EC
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 488	488	Anthranilate synthase component 1 2		PRO_0000154126

Sequences

	Sequence		Length	Mass (Da)
	Q9HS66-1 [UniParc]. Last modified March 1, 2001. Version 1. Checksum: D42982AA9A28F75E	FASTA	488	51,350
	10 20 30 40 50 60 MPDSAALATD PAAFRDAAGD ATAPTRAVVE ARLPVTDPFA AYRRARGDAP SFHYETTGGS 70 80 90 100 110 120 DGWGYFGVDP ASMLRADGAG ALDTVQAAVG ARLARVGCDV PHPGGLFGWL SYDIARELEA 130 140 150 160 170 180 IPDTTTDARG LPRLQLGVYP TIAAWREPFT PGDDLRLIAA VPVDEYTPDG AFEAGRDRVQ 190 200 210 220 230 240 SLAAAIRDGD PAVGPPPADS PAPFESVAGR AAFESRVRRI QDAIRDGDTF QANVSHRLDA 250 260 270 280 290 300 PAAVHPVAVF EALRDTNPAP YSGIVEFPGV DLVSASPELL LARRGRELTT EPIAGTRPRG 310 320 330 340 350 360 ATPAEDDAAR AALRADDKER AEHAMLVDLE RNDLGKVSEY GSVAVPDYRR VDAYSEVLHL 370 380 390 400 410 420 VSEVTGRLRD SCSLRDAIAA VFPGGTITGA PKPRTMALID TVEATRRGPY TGSLAAIGFD 430 440 450 460 470 480 GDATLSITIR TLVRRAATYH LRVGAGIVHD STPAAEYDET LAKARALVTA LGDAGGIGRV ADTTPDNS

References

[1]

"Genome sequence of Halobacterium species NRC-1." Ng W.V., Kennedy S.P., Mahairas G.G., Berquist B., Pan M., Shukla H.D., Lasky S.R., Baliga N.S., Thorsson V., Sbrogna J., Swartzell S., Weir D., Hall J., Dahl T.A., Welti R., Goo Y.A., Leithauser B., Keller K. , Cruz R., Danson M.J., Hough D.W., Maddocks D.G., Jablonski P.E., Krebs M.P., Angevine C.M., Dale H., Isenbarger T.A., Peck R.F., Pohlschroder M., Spudich J.L., Jung K.-H., Alam M., Freitas T., Hou S., Daniels C.J., Dennis P.P., Omer A.D., Ebhardt H., Lowe T.M., Liang P., Riley M., Hood L., DasSarma S. Proc. Natl. Acad. Sci. U.S.A. 97:12176-12181(2000) [PubMed: 11016950] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: ATCC 700922 / JCM 11081 / NRC-1.

Cross-references

Sequence databases
EMBLGenBankDDBJ	AE004437 Genomic DNA. Translation: AAG18942.1.
PIR	B84197.
RefSeq	NP_279462.1.
3D structure databases
HSSP	HSSP built from PDB template 1K0E based on UniProtKB P05041.
ModBase	Search...
Genome annotation databases
GeneID	1447247.
GenomeReviews	Gene locus VNG_0384G in contig AE004437_GR.
KEGG	hal:VNG0384G.
NMPDR	fig|64091.1.peg.477.
Organism-specific databases
CMR	Search...
Phylogenomic databases
HOGENOM	Q9HS66.
OMA	QMDTSIT.
Enzyme and pathway databases
BioCyc	HSP64091:VNG0384G-MON.
BRENDA	4.1.3.27. 141893.
Family and domain databases
InterPro	IPR005801. ADC_synthase. IPR006805. Anth_synth_I_N. IPR019999. Anthranilate_synth_I_C. IPR015890. Chorismate-bd_C. IPR010118. Para-NH2Bz/anthranilate_synth. [Graphical view]
Gene3D	G3DSA:3.60.120.10. TRPE_1_chor_bd. 1 hit.
PANTHER	PTHR11236. TRPE_1_chor_bd. 1 hit.
Pfam	PF04715. Anth_synt_I_N. 1 hit. PF00425. Chorismate_bind. 1 hit. [Graphical view]
PRINTS	PR00095. ANTSNTHASEI.
ProDom	PD000779. Anth_synth_chor. 1 hit. [Graphical view] [Entries sharing at least one domain]
TIGRFAMs	TIGR01824. PabB-clade2. 1 hit.
ProtoNet	Search...

Entry information

Entry name

TRPE2_HALSA

Accession

Primary (citable) accession number: Q9HS66

Entry history

Integrated into UniProtKB/Swiss-Prot:	June 21, 2005
Last sequence update:	March 1, 2001
Last modified:	November 3, 2009
This is version 49 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation project

HAMAP (High-quality Automated and Manual Annotation of microbial Proteomes)