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Reviewed, UniProtKB/Swiss-Prot Q9HS66 (TRPE2_HALSA)

Last modified November 3, 2009. Version 49. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data | Customize display text xml rdf/xml gff fasta
Names and origin · Protein attributes · General annotation (Comments) · Ontologies · Sequence annotation (Features) · Sequences · References · Cross-references · Entry information · Relevant documents

Names and origin

Protein namesRecommended name:
    Anthranilate synthase component 1 2
    EC=4.1.3.27
Alternative name(s):
    Anthranilate synthase component I 2
Gene names
Name: trpE2
Ordered Locus Names: VNG_0384G
OrganismHalobacterium salinarium (Halobacterium halobium) [Complete proteome] [HAMAP]
Taxonomic identifier2242 [NCBI]
Taxonomic lineageArchaeaEuryarchaeotaHalobacteriaHalobacterialesHalobacteriaceaeHalobacterium

Protein attributes

Sequence length488 AA.
Sequence statusComplete.
Sequence processingThe displayed sequence is not processed.
Protein existenceInferred from homology.

General annotation (Comments)

Catalytic activity

Chorismate + L-glutamine = anthranilate + pyruvate + L-glutamate.

Pathway

Amino-acid biosynthesis; L-tryptophan biosynthesis; L-tryptophan from chorismate: step 1/5.

Subunit structure

Tetramer of two components I and two components II By similarity.

Miscellaneous

Component I catalyzes the formation of anthranilate using ammonia rather than glutamine, whereas component II provides glutamine amidotransferase activity.

Sequence similarities

Belongs to the anthranilate synthase component I family.

Ontologies

Keywords
   Biological processAmino-acid biosynthesis
Aromatic amino acid biosynthesis
Tryptophan biosynthesis
   Molecular functionLyase
   Technical termComplete proteome
Gene Ontology (GO)
   Biological processtryptophan biosynthetic process

Inferred from electronic annotation. Source: UniProtKB-KW

   Molecular functionanthranilate synthase activity

Inferred from electronic annotation. Source: EC

Complete GO annotation...

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 488488Anthranilate synthase component 1 2
PRO_0000154126

Sequences

Sequence LengthMass (Da)Tools
Q9HS66-1 [UniParc].

Last modified March 1, 2001. Version 1.
Checksum: D42982AA9A28F75E

FASTA48851,350
        10         20         30         40         50         60 
MPDSAALATD PAAFRDAAGD ATAPTRAVVE ARLPVTDPFA AYRRARGDAP SFHYETTGGS 

        70         80         90        100        110        120 
DGWGYFGVDP ASMLRADGAG ALDTVQAAVG ARLARVGCDV PHPGGLFGWL SYDIARELEA 

       130        140        150        160        170        180 
IPDTTTDARG LPRLQLGVYP TIAAWREPFT PGDDLRLIAA VPVDEYTPDG AFEAGRDRVQ 

       190        200        210        220        230        240 
SLAAAIRDGD PAVGPPPADS PAPFESVAGR AAFESRVRRI QDAIRDGDTF QANVSHRLDA 

       250        260        270        280        290        300 
PAAVHPVAVF EALRDTNPAP YSGIVEFPGV DLVSASPELL LARRGRELTT EPIAGTRPRG 

       310        320        330        340        350        360 
ATPAEDDAAR AALRADDKER AEHAMLVDLE RNDLGKVSEY GSVAVPDYRR VDAYSEVLHL 

       370        380        390        400        410        420 
VSEVTGRLRD SCSLRDAIAA VFPGGTITGA PKPRTMALID TVEATRRGPY TGSLAAIGFD 

       430        440        450        460        470        480 
GDATLSITIR TLVRRAATYH LRVGAGIVHD STPAAEYDET LAKARALVTA LGDAGGIGRV 


ADTTPDNS 

« Hide

Cross-references

Sequence databases

AE004437 Genomic DNA. Translation: AAG18942.1.
PIRB84197.
RefSeqNP_279462.1.

3D structure databases

HSSPHSSP built from PDB template 1K0E based on UniProtKB P05041.
ModBaseSearch...

Genome annotation databases

GeneID1447247.
GenomeReviewsGene locus VNG_0384G in contig AE004437_GR.
KEGGhal:VNG0384G.
NMPDRfig|64091.1.peg.477.

Organism-specific databases

CMRSearch...

Phylogenomic databases

HOGENOMQ9HS66.
OMAQMDTSIT.

Enzyme and pathway databases

BioCycHSP64091:VNG0384G-MON.
BRENDA4.1.3.27. 141893.

Family and domain databases

InterProIPR005801. ADC_synthase.
IPR006805. Anth_synth_I_N.
IPR019999. Anthranilate_synth_I_C.
IPR015890. Chorismate-bd_C.
IPR010118. Para-NH2Bz/anthranilate_synth.
[Graphical view]
Gene3DG3DSA:3.60.120.10. TRPE_1_chor_bd. 1 hit.
PANTHERPTHR11236. TRPE_1_chor_bd. 1 hit.
PfamPF04715. Anth_synt_I_N. 1 hit.
PF00425. Chorismate_bind. 1 hit.
[Graphical view]
PRINTSPR00095. ANTSNTHASEI.
ProDomPD000779. Anth_synth_chor. 1 hit.
[Graphical view] [Entries sharing at least one domain]
TIGRFAMsTIGR01824. PabB-clade2. 1 hit.
ProtoNetSearch...

Entry information

Entry nameTRPE2_HALSA
AccessionPrimary (citable) accession number: Q9HS66
Entry history
Integrated into UniProtKB/Swiss-Prot: June 21, 2005
Last sequence update: March 1, 2001
Last modified: November 3, 2009
This is version 49 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation projectHAMAP (High-quality Automated and Manual Annotation of microbial Proteomes)

Relevant documents

PATHWAY comments

Index of metabolic and biosynthesis pathways

SIMILARITY comments

Index of protein domains and families

Names and origin · Protein attributes · General annotation (Comments) · Ontologies · Sequence annotation (Features) · Sequences · References · Cross-references · Entry information · Relevant documents