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Protein

NADP-specific glutamate dehydrogenase A1

Gene

gdhA1

Organism
Halobacterium salinarum (strain ATCC 700922 / JCM 11081 / NRC-1) (Halobacterium halobium)
Status
Reviewed-Annotation score: Annotation score: 2 out of 5-Protein inferred from homologyi

Functioni

Catalytic activityi

L-glutamate + H2O + NADP+ = 2-oxoglutarate + NH3 + NADPH.

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Active sitei105 – 1051PROSITE-ProRule annotation

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Oxidoreductase

Keywords - Ligandi

NADP

Names & Taxonomyi

Protein namesi
Recommended name:
NADP-specific glutamate dehydrogenase A1 (EC:1.4.1.4)
Gene namesi
Name:gdhA1
Ordered Locus Names:VNG_0628G
OrganismiHalobacterium salinarum (strain ATCC 700922 / JCM 11081 / NRC-1) (Halobacterium halobium)
Taxonomic identifieri64091 [NCBI]
Taxonomic lineageiArchaeaEuryarchaeotaHalobacteriaHalobacterialesHalobacteriaceaeHalobacterium
Proteomesi
  • UP000000554 Componenti: Chromosome

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Initiator methionineiRemovedBy similarity
Chaini2 – 417416NADP-specific glutamate dehydrogenase A1PRO_0000428791Add
BLAST

Proteomic databases

PaxDbiQ9HRM7.
PRIDEiQ9HRM7.

Interactioni

Subunit structurei

Homohexamer.By similarity

Protein-protein interaction databases

STRINGi64091.VNG0628G.

Structurei

3D structure databases

ProteinModelPortaliQ9HRM7.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Phylogenomic databases

eggNOGiarCOG01352. Archaea.
COG0334. LUCA.
InParanoidiQ9HRM7.
KOiK00261.
PhylomeDBiQ9HRM7.

Family and domain databases

Gene3Di3.40.50.720. 1 hit.
InterProiIPR006095. Glu/Leu/Phe/Val_DH.
IPR033524. Glu/Leu/Phe/Val_DH_AS.
IPR006096. Glu/Leu/Phe/Val_DH_C.
IPR006097. Glu/Leu/Phe/Val_DH_dimer_dom.
IPR014362. Glu_DH.
IPR016040. NAD(P)-bd_dom.
[Graphical view]
PfamiPF00208. ELFV_dehydrog. 1 hit.
PF02812. ELFV_dehydrog_N. 1 hit.
[Graphical view]
PIRSFiPIRSF000185. Glu_DH. 1 hit.
PRINTSiPR00082. GLFDHDRGNASE.
SMARTiSM00839. ELFV_dehydrog. 1 hit.
[Graphical view]
SUPFAMiSSF51735. SSF51735. 1 hit.
PROSITEiPS00074. GLFV_DEHYDROGENASE. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q9HRM7-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MPEANPFESL QEQLDDAGEF LDVNADVLER LKHPERVLET TLSVEMDDGT
60 70 80 90 100
IETFKAFRSQ FNGDRGPYKG GIRYHPGVTR DEVKALSGWM VYKTAVADIP
110 120 130 140 150
YGGGKGGIIL DPEEYSDSEL ERITRAFATE LRPFIGEDKD VPAPDVNTGQ
160 170 180 190 200
REMNWIKDTY ETLEDTTAPG VITGKALENG GSEGRVNATG RSTMFAAREV
210 220 230 240 250
FDYLDRDLSD ATVAVQGYGN AGSVAAKLIA DQGADVVAVS DSSGAVHNPD
260 270 280 290 300
GLDTRAVKAF KTETGSVSGY EGATEELSNE ALLTMDVDLL VPAALENAID
310 320 330 340 350
EDLAHDVDAD VVVEAANGPL TPDADDVLTE RGVTVVPDIL ANAGGVTVSY
360 370 380 390 400
FEWVQNRQRF QWTEDRVNEE LEAIITDAFD AMTDAHEDAG TPNLRTAAYV
410
VAVQRVVDAY EGSGSWP
Length:417
Mass (Da):45,008
Last modified:April 16, 2014 - v2
Checksum:iC18FA67CA33E81A1
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AE004437 Genomic DNA. Translation: AAG19131.1.
PIRiG84220.
RefSeqiWP_012289198.1. NC_002607.1.

Genome annotation databases

EnsemblBacteriaiAAG19131; AAG19131; VNG_0628G.
GeneIDi5953644.
KEGGihal:VNG0628G.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AE004437 Genomic DNA. Translation: AAG19131.1.
PIRiG84220.
RefSeqiWP_012289198.1. NC_002607.1.

3D structure databases

ProteinModelPortaliQ9HRM7.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi64091.VNG0628G.

Proteomic databases

PaxDbiQ9HRM7.
PRIDEiQ9HRM7.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaiAAG19131; AAG19131; VNG_0628G.
GeneIDi5953644.
KEGGihal:VNG0628G.

Phylogenomic databases

eggNOGiarCOG01352. Archaea.
COG0334. LUCA.
InParanoidiQ9HRM7.
KOiK00261.
PhylomeDBiQ9HRM7.

Family and domain databases

Gene3Di3.40.50.720. 1 hit.
InterProiIPR006095. Glu/Leu/Phe/Val_DH.
IPR033524. Glu/Leu/Phe/Val_DH_AS.
IPR006096. Glu/Leu/Phe/Val_DH_C.
IPR006097. Glu/Leu/Phe/Val_DH_dimer_dom.
IPR014362. Glu_DH.
IPR016040. NAD(P)-bd_dom.
[Graphical view]
PfamiPF00208. ELFV_dehydrog. 1 hit.
PF02812. ELFV_dehydrog_N. 1 hit.
[Graphical view]
PIRSFiPIRSF000185. Glu_DH. 1 hit.
PRINTSiPR00082. GLFDHDRGNASE.
SMARTiSM00839. ELFV_dehydrog. 1 hit.
[Graphical view]
SUPFAMiSSF51735. SSF51735. 1 hit.
PROSITEiPS00074. GLFV_DEHYDROGENASE. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiDHE4_HALSA
AccessioniPrimary (citable) accession number: Q9HRM7
Entry historyi
Integrated into UniProtKB/Swiss-Prot: April 16, 2014
Last sequence update: April 16, 2014
Last modified: July 6, 2016
This is version 97 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Miscellaneous

Strain NRC-36014 contains 4 distinct glutamate dehydrogenases while strain NRC-1 contains only 3.1 Publication

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.