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Q9HRF0 (PANE_HALSA) Reviewed, UniProtKB/Swiss-Prot

Last modified April 16, 2014. Version 85. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Putative 2-dehydropantoate 2-reductase

EC=1.1.1.169
Alternative name(s):
Ketopantoate reductase
Short name=KPA reductase
Short name=KPR
Gene names
Ordered Locus Names:VNG_0730C
OrganismHalobacterium salinarum (strain ATCC 700922 / JCM 11081 / NRC-1) (Halobacterium halobium) [Reference proteome] [HAMAP]
Taxonomic identifier64091 [NCBI]
Taxonomic lineageArchaeaEuryarchaeotaHalobacteriaHalobacterialesHalobacteriaceaeHalobacterium

Protein attributes

Sequence length303 AA.
Sequence statusComplete.
Protein existenceInferred from homology

General annotation (Comments)

Function

Catalyzes the NADPH-dependent reduction of ketopantoate into pantoic acid By similarity.

Catalytic activity

(R)-pantoate + NADP+ = 2-dehydropantoate + NADPH.

Pathway

Cofactor biosynthesis; (R)-pantothenate biosynthesis; (R)-pantoate from 3-methyl-2-oxobutanoate: step 2/2.

Subcellular location

Cytoplasm Potential.

Sequence similarities

Belongs to the ketopantoate reductase family.

Ontologies

Keywords
   Biological processPantothenate biosynthesis
   Cellular componentCytoplasm
   LigandNADP
   Molecular functionOxidoreductase
   Technical termComplete proteome
Reference proteome
Gene Ontology (GO)
   Biological_processpantothenate biosynthetic process

Inferred from electronic annotation. Source: UniProtKB-UniPathway

   Cellular_componentcytoplasm

Inferred from electronic annotation. Source: UniProtKB-SubCell

   Molecular_function2-dehydropantoate 2-reductase activity

Inferred from electronic annotation. Source: UniProtKB-EC

NADP binding

Inferred from electronic annotation. Source: InterPro

Complete GO annotation...

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 303303Putative 2-dehydropantoate 2-reductase
PRO_0000157323

Regions

Nucleotide binding7 – 126NADP By similarity

Sites

Active site1851Proton donor By similarity
Binding site1031NADP; via amide nitrogen By similarity
Binding site1031Substrate By similarity
Binding site1891Substrate By similarity
Binding site1931Substrate By similarity
Binding site2551Substrate By similarity
Binding site2671NADP By similarity

Sequences

Sequence LengthMass (Da)Tools
Q9HRF0 [UniParc].

Last modified March 1, 2001. Version 1.
Checksum: B373143F2822DC94

FASTA30331,124
        10         20         30         40         50         60 
MRVVVQGPGS LGSLVGGVLA GGETAVTLLG HQSEHLTRVR EDGLRVVQPD GTTRVTRPSV 

        70         80         90        100        110        120 
ATDPSVVADA DLVVVCVKSY DTASAARALG RQCDGAMVLT LQNGLGNAAV LAEHVPADTV 

       130        140        150        160        170        180 
LVGTTTHGAA RTEPGVVRHA GGGETTIGRY RGANDARVAS VAAAFSTGGM ETTVTASPQR 

       190        200        210        220        230        240 
AVWEKVLVNV GINAATALAD VDNGALVECP PGERVLERAV TEGVRVAEAE GVSVSESVVE 

       250        260        270        280        290        300 
RARQVAARTA SNESSMRQDL AGGARTEVES LHGAVVERAR DHDIAVPVIR TLADLVRLAQ 


RDG 

« Hide

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
AE004437 Genomic DNA. Translation: AAG19208.1.
PIRD84230.
RefSeqNP_279728.1. NC_002607.1.

3D structure databases

ProteinModelPortalQ9HRF0.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

STRING64091.VNG0730C.

Proteomic databases

PaxDbQ9HRF0.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaAAG19208; AAG19208; VNG_0730C.
GeneID1447514.
KEGGhal:VNG0730C.

Phylogenomic databases

eggNOGCOG1893.
KOK00077.
OMAIDDDRGE.
PhylomeDBQ9HRF0.
ProtClustDBCLSK2300584.

Enzyme and pathway databases

UniPathwayUPA00028; UER00004.

Family and domain databases

Gene3D1.10.1040.10. 1 hit.
3.40.50.720. 1 hit.
InterProIPR008927. 6-PGluconate_DH_C-like.
IPR003710. ApbA.
IPR013752. ApbA_C.
IPR013332. ApbA_N.
IPR013328. DH_multihelical.
IPR016040. NAD(P)-bd_dom.
[Graphical view]
PfamPF02558. ApbA. 1 hit.
PF08546. ApbA_C. 1 hit.
[Graphical view]
SUPFAMSSF48179. SSF48179. 1 hit.
TIGRFAMsTIGR00745. apbA_panE. 1 hit.
ProtoNetSearch...

Entry information

Entry namePANE_HALSA
AccessionPrimary (citable) accession number: Q9HRF0
Entry history
Integrated into UniProtKB/Swiss-Prot: February 21, 2002
Last sequence update: March 1, 2001
Last modified: April 16, 2014
This is version 85 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families

PATHWAY comments

Index of metabolic and biosynthesis pathways