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Q9HRF0

- PANE_HALSA

UniProt

Q9HRF0 - PANE_HALSA

Protein

Putative 2-dehydropantoate 2-reductase

Gene

VNG_0730C

Organism
Halobacterium salinarum (strain ATCC 700922 / JCM 11081 / NRC-1) (Halobacterium halobium)
Status
Reviewed - Annotation score: 3 out of 5- Protein inferred from homologyi
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    • History
      Entry version 88 (01 Oct 2014)
      Sequence version 1 (01 Mar 2001)
      Previous versions | rss
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    Functioni

    Catalyzes the NADPH-dependent reduction of ketopantoate into pantoic acid.By similarity

    Catalytic activityi

    (R)-pantoate + NADP+ = 2-dehydropantoate + NADPH.

    Pathwayi

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Binding sitei103 – 1031NADP; via amide nitrogenBy similarity
    Binding sitei103 – 1031SubstrateBy similarity
    Active sitei185 – 1851Proton donorBy similarity
    Binding sitei189 – 1891SubstrateBy similarity
    Binding sitei193 – 1931SubstrateBy similarity
    Binding sitei255 – 2551SubstrateBy similarity
    Binding sitei267 – 2671NADPBy similarity

    Regions

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Nucleotide bindingi7 – 126NADPBy similarity

    GO - Molecular functioni

    1. 2-dehydropantoate 2-reductase activity Source: UniProtKB-EC
    2. NADP binding Source: InterPro

    GO - Biological processi

    1. pantothenate biosynthetic process Source: UniProtKB-UniPathway

    Keywords - Molecular functioni

    Oxidoreductase

    Keywords - Biological processi

    Pantothenate biosynthesis

    Keywords - Ligandi

    NADP

    Enzyme and pathway databases

    UniPathwayiUPA00028; UER00004.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Putative 2-dehydropantoate 2-reductase (EC:1.1.1.169)
    Alternative name(s):
    Ketopantoate reductase
    Short name:
    KPA reductase
    Short name:
    KPR
    Gene namesi
    Ordered Locus Names:VNG_0730C
    OrganismiHalobacterium salinarum (strain ATCC 700922 / JCM 11081 / NRC-1) (Halobacterium halobium)
    Taxonomic identifieri64091 [NCBI]
    Taxonomic lineageiArchaeaEuryarchaeotaHalobacteriaHalobacterialesHalobacteriaceaeHalobacterium
    ProteomesiUP000000554: Chromosome

    Subcellular locationi

    Cytoplasm Curated

    GO - Cellular componenti

    1. cytoplasm Source: UniProtKB-SubCell

    Keywords - Cellular componenti

    Cytoplasm

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 303303Putative 2-dehydropantoate 2-reductasePRO_0000157323Add
    BLAST

    Proteomic databases

    PaxDbiQ9HRF0.

    Interactioni

    Protein-protein interaction databases

    STRINGi64091.VNG0730C.

    Structurei

    3D structure databases

    ProteinModelPortaliQ9HRF0.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Sequence similaritiesi

    Belongs to the ketopantoate reductase family.Curated

    Phylogenomic databases

    eggNOGiCOG1893.
    KOiK00077.
    OMAiPGRVECT.
    PhylomeDBiQ9HRF0.

    Family and domain databases

    Gene3Di1.10.1040.10. 1 hit.
    3.40.50.720. 1 hit.
    InterProiIPR008927. 6-PGluconate_DH_C-like.
    IPR003710. ApbA.
    IPR013328. DH_multihelical.
    IPR013752. KPA_reductase.
    IPR013332. KPR_N.
    IPR016040. NAD(P)-bd_dom.
    [Graphical view]
    PfamiPF02558. ApbA. 1 hit.
    PF08546. ApbA_C. 1 hit.
    [Graphical view]
    SUPFAMiSSF48179. SSF48179. 1 hit.
    TIGRFAMsiTIGR00745. apbA_panE. 1 hit.

    Sequencei

    Sequence statusi: Complete.

    Q9HRF0-1 [UniParc]FASTAAdd to Basket

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    MRVVVQGPGS LGSLVGGVLA GGETAVTLLG HQSEHLTRVR EDGLRVVQPD    50
    GTTRVTRPSV ATDPSVVADA DLVVVCVKSY DTASAARALG RQCDGAMVLT 100
    LQNGLGNAAV LAEHVPADTV LVGTTTHGAA RTEPGVVRHA GGGETTIGRY 150
    RGANDARVAS VAAAFSTGGM ETTVTASPQR AVWEKVLVNV GINAATALAD 200
    VDNGALVECP PGERVLERAV TEGVRVAEAE GVSVSESVVE RARQVAARTA 250
    SNESSMRQDL AGGARTEVES LHGAVVERAR DHDIAVPVIR TLADLVRLAQ 300
    RDG 303
    Length:303
    Mass (Da):31,124
    Last modified:March 1, 2001 - v1
    Checksum:iB373143F2822DC94
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AE004437 Genomic DNA. Translation: AAG19208.1.
    PIRiD84230.
    RefSeqiNP_279728.1. NC_002607.1.
    WP_010902504.1. NC_002607.1.

    Genome annotation databases

    EnsemblBacteriaiAAG19208; AAG19208; VNG_0730C.
    GeneIDi1447514.
    KEGGihal:VNG0730C.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AE004437 Genomic DNA. Translation: AAG19208.1 .
    PIRi D84230.
    RefSeqi NP_279728.1. NC_002607.1.
    WP_010902504.1. NC_002607.1.

    3D structure databases

    ProteinModelPortali Q9HRF0.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 64091.VNG0730C.

    Proteomic databases

    PaxDbi Q9HRF0.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    EnsemblBacteriai AAG19208 ; AAG19208 ; VNG_0730C .
    GeneIDi 1447514.
    KEGGi hal:VNG0730C.

    Phylogenomic databases

    eggNOGi COG1893.
    KOi K00077.
    OMAi PGRVECT.
    PhylomeDBi Q9HRF0.

    Enzyme and pathway databases

    UniPathwayi UPA00028 ; UER00004 .

    Family and domain databases

    Gene3Di 1.10.1040.10. 1 hit.
    3.40.50.720. 1 hit.
    InterProi IPR008927. 6-PGluconate_DH_C-like.
    IPR003710. ApbA.
    IPR013328. DH_multihelical.
    IPR013752. KPA_reductase.
    IPR013332. KPR_N.
    IPR016040. NAD(P)-bd_dom.
    [Graphical view ]
    Pfami PF02558. ApbA. 1 hit.
    PF08546. ApbA_C. 1 hit.
    [Graphical view ]
    SUPFAMi SSF48179. SSF48179. 1 hit.
    TIGRFAMsi TIGR00745. apbA_panE. 1 hit.
    ProtoNeti Search...

    Publicationsi

    1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: ATCC 700922 / JCM 11081 / NRC-1.

    Entry informationi

    Entry nameiPANE_HALSA
    AccessioniPrimary (citable) accession number: Q9HRF0
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: February 21, 2002
    Last sequence update: March 1, 2001
    Last modified: October 1, 2014
    This is version 88 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programProkaryotic Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. PATHWAY comments
      Index of metabolic and biosynthesis pathways
    2. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3