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Protein

RNA 3'-terminal phosphate cyclase

Gene

rtcA

Organism
Halobacterium salinarum (strain ATCC 700922 / JCM 11081 / NRC-1) (Halobacterium halobium)
Status
Reviewed-Annotation score: -Protein inferred from homologyi

Functioni

Catalyzes the conversion of 3'-phosphate to a 2',3'-cyclic phosphodiester at the end of RNA. The mechanism of action of the enzyme occurs in 3 steps: (A) adenylation of the enzyme by ATP; (B) transfer of adenylate to an RNA-N3'P to produce RNA-N3'PP5'A; (C) and attack of the adjacent 2'-hydroxyl on the 3'-phosphorus in the diester linkage to produce the cyclic end product. The biological role of this enzyme is unknown but it is likely to function in some aspects of cellular RNA processing (By similarity).By similarity

Catalytic activityi

ATP + (RNA)-3'-(3'-phospho-ribonucleoside) = AMP + diphosphate + (RNA)-3'-(2',3'-cyclophospho)-ribonucleoside.

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Binding sitei109ATPBy similarity1
Active sitei310Tele-AMP-histidine intermediateBy similarity1

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Nucleotide bindingi286 – 290ATPBy similarity5

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionLigase
LigandATP-binding, Nucleotide-binding

Names & Taxonomyi

Protein namesi
Recommended name:
RNA 3'-terminal phosphate cyclase (EC:6.5.1.4)
Short name:
RNA cyclase
Short name:
RNA-3'-phosphate cyclase
Gene namesi
Name:rtcA
Synonyms:tpc
Ordered Locus Names:VNG_0732G
OrganismiHalobacterium salinarum (strain ATCC 700922 / JCM 11081 / NRC-1) (Halobacterium halobium)
Taxonomic identifieri64091 [NCBI]
Taxonomic lineageiArchaeaEuryarchaeotaHalobacteriaHalobacterialesHalobacteriaceaeHalobacterium
Proteomesi
  • UP000000554 Componenti: Chromosome

Subcellular locationi

GO - Cellular componenti

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001564241 – 339RNA 3'-terminal phosphate cyclaseAdd BLAST339

Proteomic databases

PaxDbiQ9HRE8

Interactioni

Protein-protein interaction databases

STRINGi64091.VNG0732G

Structurei

3D structure databases

ProteinModelPortaliQ9HRE8
SMRiQ9HRE8
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Phylogenomic databases

eggNOGiarCOG04125 Archaea
COG0430 LUCA
InParanoidiQ9HRE8
KOiK01974
OrthoDBiPOG093Z05RD
PhylomeDBiQ9HRE8

Family and domain databases

Gene3Di3.30.360.20, 1 hit
3.65.10.20, 2 hits
HAMAPiMF_00200 RTC, 1 hit
InterProiView protein in InterPro
IPR013791 RNA3'-term_phos_cycl_insert
IPR023797 RNA3'_phos_cyclase_dom
IPR037136 RNA3'_phos_cyclase_dom_sf
IPR000228 RNA3'_term_phos_cyc
IPR017770 RNA3'_term_phos_cyc_type_1
IPR013792 RNA3'P_cycl/enolpyr_Trfase_a/b
IPR036553 RPTC_insert
PANTHERiPTHR11096 PTHR11096, 1 hit
PTHR11096:SF0 PTHR11096:SF0, 1 hit
PfamiView protein in Pfam
PF01137 RTC, 1 hit
PF05189 RTC_insert, 1 hit
PIRSFiPIRSF005378 RNA3'_term_phos_cycl_euk, 1 hit
SUPFAMiSSF52913 SSF52913, 1 hit
SSF55205 SSF55205, 1 hit
TIGRFAMsiTIGR03399 RNA_3prim_cycl, 1 hit

Sequencei

Sequence statusi: Complete.

Q9HRE8-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MHVLDGSSGG GQLVRTALTC AAVSGESFRM RYVRRARSNP GLQAQHCAAV
60 70 80 90 100
NAVADICDAA TDGVEVGSEA FSFEPEVAAE EADDDEEPTL GGTTSVEVGT
110 120 130 140 150
AGSIPLVFDS LLPLAGALDE PITATLTGGT DAKWAPPMDY FQHVKLPLLR
160 170 180 190 200
EHGIDATVSV DRRGFYPRGG GEATLTVEPS TPTPITLTER GDREALTAYS
210 220 230 240 250
VAESSLADDE VAEQQATAAA PDAAHEIAYT DADSAGSAVV LAAEYEHSRA
260 270 280 290 300
GFAALGERGV SADAVGENAA DALAAFESGP GAVDSHLADQ LVPVVAVAGG
310 320 330
EVRAPEVTTH IETCVDLLAE FDYDIDIEHT DDGAVVLSA
Length:339
Mass (Da):34,879
Last modified:June 1, 2001 - v2
Checksum:i27B75201F22A61FE
GO

Sequence cautioni

The sequence AAG19210 differs from that shown. Reason: Erroneous initiation.Curated

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AE004437 Genomic DNA Translation: AAG19210.1 Different initiation.
PIRiF84230
RefSeqiWP_012289214.1, NC_002607.1

Genome annotation databases

EnsemblBacteriaiAAG19210; AAG19210; VNG_0732G
GeneIDi5952667
KEGGihal:VNG_0732G
PATRICifig|64091.14.peg.559

Similar proteinsi

Entry informationi

Entry nameiRTCA_HALSA
AccessioniPrimary (citable) accession number: Q9HRE8
Entry historyiIntegrated into UniProtKB/Swiss-Prot: June 1, 2001
Last sequence update: June 1, 2001
Last modified: May 23, 2018
This is version 102 of the entry and version 2 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

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