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Q9HR35 (DNLI_HALSA) Reviewed, UniProtKB/Swiss-Prot

Last modified December 14, 2011. Version 73. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (1) | Third-party data text xml rdf/xml gff fasta
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Names and origin

Protein namesRecommended name:
DNA ligase
EC=6.5.1.1
Alternative name(s):
Polydeoxyribonucleotide synthase [ATP]
Gene names
Name:lig
Ordered Locus Names:VNG_0881G
OrganismHalobacterium salinarium (strain ATCC 700922 / JCM 11081 / NRC-1) (Halobacterium halobium)
Taxonomic identifier64091 [NCBI]
Taxonomic lineageArchaea › Euryarchaeota › Halobacteria › Halobacteriales › Halobacteriaceae › Halobacterium

Protein attributes

Sequence length561 AA.
Sequence statusComplete.
Protein existenceInferred from homology

General annotation (Comments)

Function

DNA ligase that seals nicks in double-stranded DNA during DNA replication, DNA recombination and DNA repair By similarity. HAMAP MF_00407

Catalytic activity

ATP + (deoxyribonucleotide)(n) + (deoxyribonucleotide)(m) = AMP + diphosphate + (deoxyribonucleotide)(n+m). HAMAP MF_00407

Cofactor

Divalent metal cations By similarity. HAMAP MF_00407

Sequence similarities

Belongs to the ATP-dependent DNA ligase family.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 561561DNA ligase HAMAP MF_00407
PRO_0000059602

Sites

Active site2551N6-AMP-lysine intermediate By similarity
Binding site2531ATP By similarity
Binding site2601ATP By similarity
Binding site2751ATP By similarity
Binding site3041ATP By similarity
Binding site3441ATP By similarity
Binding site4211ATP By similarity
Binding site4271ATP By similarity

Sequences

Sequence LengthMass (Da)Tools
Q9HR35 [UniParc].

Last modified March 1, 2001. Version 1.
Checksum: 5BB30D3C1D106D2E

FASTA56159,620
        10         20         30         40         50         60 
MKFGSFATFA ADIEATDADL DVVALVAELF DAADSDLDVV ARFVQGRVFP AHSETKLDIG 

        70         80         90        100        110        120 
PQLCYTALSR AAGRNVDADD IEARLAETGD IGAVAGSLDL GGQTGLAAFG GGDDHADGLT 

       130        140        150        160        170        180 
VSGVADELAA LAAAAGDGSQ SEKVTLLFGL FNQCTSREAR YLARLVLGEM RIGVGEGAVR 

       190        200        210        220        230        240 
DAIAEAFDVP TAAVQRALQV SNDYGLVAET ARDSGTDALD AMGLEVGRPV QAMLAQAGTV 

       250        260        270        280        290        300 
TDALDEWHEA AVETKFDGAR VQVHYDGDDV VLYSRNMENV TGALPELVEF VENNVTAPVI 

       310        320        330        340        350        360 
IDGEAVAADE DGDPLPFQEI LKRFRRKHDV AAMREEISVE LHAFDCLHAP SADGGEDLLD 

       370        380        390        400        410        420 
APFSDRHRRL RSVVDDASAV SEVLVTDDAD EIAAFEATAL EGGHEGIMLK NPAAPYTPGD 

       430        440        450        460        470        480 
RGKDWLKRKP DVETLDLVVT GAEWGEGRRA SVLGTFLLSA RDAAGDGFET IGKVATGLTD 

       490        500        510        520        530        540 
EELAALSDRL EPHVRSEDGQ TVDIEPAVVL EVGYEEIQAS PTYSSGYALR FPRFVSVRED 

       550        560 
KTPTTADTIE RVERLAAQQQ Q

« Hide

Cross-references

Sequence databases

EMBL
GenBank
DDBJ		AE004437 Genomic DNA. Translation: AAG19323.1.
PIRG84244.
RefSeqNP_279843.1. NC_002607.1.

3D structure databases

ProteinModelPortalQ9HR35.
ModBaseSearch...

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

GeneID1447628.
GenomeReviewsGene locus VNG_0881G in contig AE004437_GR.
KEGGhal:VNG0881G.
NMPDRfig|64091.1.peg.859.

Phylogenomic databases

HOGENOMHBG570821.
OMAGRPRPFQ.
PhylomeDBQ9HR35.
ProtClustDBCLSK511253.

Enzyme and pathway databases

BioCycHSP64091:VNG0881G-MONOMER.

Family and domain databases

HAMAPMF_00407. DNA_ligase.
[Tree]
InterProIPR022865. DNA_ligae_ATP-dep_bac/arc.
IPR000977. DNA_ligase_ATP-dep.
IPR012309. DNA_ligase_ATP-dep_C.
IPR012310. DNA_ligase_ATP-dep_cent.
IPR016059. DNA_ligase_ATP-dep_CS.
IPR012308. DNA_ligase_ATP-dep_N.
IPR012340. NA-bd_OB-fold.
IPR016027. NA-bd_OB-fold-like.
[Graphical view]
Gene3DG3DSA:1.10.3260.10. DNA_ligase_ATP-dep_N. 1 hit.
G3DSA:2.40.50.140. OB_NA_bd_sub. 1 hit.
KOK10747.
PfamPF04679. DNA_ligase_A_C. 1 hit.
PF01068. DNA_ligase_A_M. 1 hit.
PF04675. DNA_ligase_A_N. 1 hit.
[Graphical view]
SUPFAMSSF50249. Nucleic_acid_OB. 1 hit.
SSF117018. SSF117018. 1 hit.
TIGRFAMsTIGR00574. Dnl1. 1 hit.
PROSITEPS00697. DNA_LIGASE_A1. 1 hit.
PS00333. DNA_LIGASE_A2. False negative.
PS50160. DNA_LIGASE_A3. 1 hit.
[Graphical view]
ProtoNetSearch...

Entry information

Entry nameDNLI_HALSA
AccessionPrimary (citable) accession number: Q9HR35
Entry history
Integrated into UniProtKB/Swiss-Prot: June 20, 2001
Last sequence update: March 1, 2001
Last modified: December 14, 2011
This is version 73 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families

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