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Protein

Type 2 DNA topoisomerase 6 subunit A

Gene

top6A

Organism
Halobacterium salinarum (strain ATCC 700922 / JCM 11081 / NRC-1) (Halobacterium halobium)
Status
Reviewed-Annotation score: -Protein inferred from homologyi

Functioni

Relaxes both positive and negative superturns and exhibits a strong decatenase activity.UniRule annotation

Catalytic activityi

ATP-dependent breakage, passage and rejoining of double-stranded DNA.UniRule annotation

Cofactori

Mg2+UniRule annotation

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Active sitei101NucleophileUniRule annotation1
Metal bindingi199MagnesiumUniRule annotation1
Metal bindingi251MagnesiumUniRule annotation1

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionDNA-binding, Isomerase, Topoisomerase
LigandATP-binding, Magnesium, Metal-binding, Nucleotide-binding

Names & Taxonomyi

Protein namesi
Recommended name:
Type 2 DNA topoisomerase 6 subunit AUniRule annotation (EC:5.99.1.3UniRule annotation)
Alternative name(s):
Type II DNA topoisomerase VI subunit AUniRule annotation
Gene namesi
Name:top6AUniRule annotation
Ordered Locus Names:VNG_0884G
OrganismiHalobacterium salinarum (strain ATCC 700922 / JCM 11081 / NRC-1) (Halobacterium halobium)
Taxonomic identifieri64091 [NCBI]
Taxonomic lineageiArchaeaEuryarchaeotaHalobacteriaHalobacterialesHalobacteriaceaeHalobacterium
Proteomesi
  • UP000000554 Componenti: Chromosome

Subcellular locationi

GO - Cellular componenti

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001454471 – 366Type 2 DNA topoisomerase 6 subunit AAdd BLAST366

Proteomic databases

PaxDbiQ9HR32

Interactioni

Subunit structurei

Homodimer. Heterotetramer of two Top6A and two Top6B chains.UniRule annotation

Protein-protein interaction databases

STRINGi64091.VNG0884G

Structurei

3D structure databases

ProteinModelPortaliQ9HR32
SMRiQ9HR32
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the TOP6A family.UniRule annotation

Phylogenomic databases

eggNOGiarCOG04143 Archaea
COG1697 LUCA
InParanoidiQ9HR32
KOiK03166
OMAiFTDGDPY
OrthoDBiPOG093Z03T5
PhylomeDBiQ9HR32

Family and domain databases

CDDicd00223 TOPRIM_TopoIIB_SPO, 1 hit
Gene3Di1.10.10.10, 1 hit
HAMAPiMF_00132 Top6A, 1 hit
InterProiView protein in InterPro
IPR002815 Spo11/TopoVI_A
IPR013049 Spo11/TopoVI_A_N
IPR036078 Spo11/TopoVI_A_sf
IPR004085 TopoVI_A
IPR034136 TOPRIM_Topo6A/Spo11
IPR036388 WH-like_DNA-bd_sf
PANTHERiPTHR10848 PTHR10848, 1 hit
PfamiView protein in Pfam
PF04406 TP6A_N, 1 hit
PRINTSiPR01550 TOP6AFAMILY
PR01552 TPISMRASE6A
SUPFAMiSSF56726 SSF56726, 1 hit

Sequencei

Sequence statusi: Complete.

Q9HR32-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MSETHTSDET EARDQLLAIA EQFYDQFADG DIPRMSLPTR SKSNIEYDED
60 70 80 90 100
ADVWVYGDSQ STRSANSVRG ARKLLKSVYT VDFLAQQLDE GRSSTLRELY
110 120 130 140 150
YLSESWDEAE AQFNDQSESD KLVEDLEIVS GVKREDFHMR PEESGAKVMG
160 170 180 190 200
PLRLREQTRR GDREIHCQED VGQGGYQIPN NPDTIDFLDT DADFVLCVET
210 220 230 240 250
GGMRDRLVEN GFDDDYNAIV VHLGGQPARA TRRLTKRLHD ELDLPVTVFT
260 270 280 290 300
DGDPWSYRIY GSVAYGSIKS AHLSEYLATP QAQFIGIRPQ DIVDYDLPTD
310 320 330 340 350
PLSDSDVNAL ESELEDPRFQ SDFWTEQIGL QLDIDKKAEQ QALASRGLDF
360
VTDTYLPERL AEMGVL
Length:366
Mass (Da):41,449
Last modified:February 21, 2001 - v1
Checksum:i21B08189088E768F
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AE004437 Genomic DNA Translation: AAG19326.1
PIRiB84245
RefSeqiWP_010902622.1, NC_002607.1

Genome annotation databases

EnsemblBacteriaiAAG19326; AAG19326; VNG_0884G
GeneIDi5952734
KEGGihal:VNG_0884G
PATRICifig|64091.14.peg.679

Similar proteinsi

Entry informationi

Entry nameiTOP6A_HALSA
AccessioniPrimary (citable) accession number: Q9HR32
Entry historyiIntegrated into UniProtKB/Swiss-Prot: February 21, 2001
Last sequence update: February 21, 2001
Last modified: May 23, 2018
This is version 102 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

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