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Protein

Type 2 DNA topoisomerase 6 subunit A

Gene

top6A

Organism
Halobacterium salinarum (strain ATCC 700922 / JCM 11081 / NRC-1) (Halobacterium halobium)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Protein inferred from homologyi

Functioni

Relaxes both positive and negative superturns and exhibits a strong decatenase activity.UniRule annotation

Catalytic activityi

ATP-dependent breakage, passage and rejoining of double-stranded DNA.UniRule annotation

Cofactori

Mg2+UniRule annotation

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Active sitei101NucleophileUniRule annotation1
Metal bindingi199MagnesiumUniRule annotation1
Metal bindingi251MagnesiumUniRule annotation1

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Isomerase, Topoisomerase

Keywords - Ligandi

ATP-binding, DNA-binding, Magnesium, Metal-binding, Nucleotide-binding

Names & Taxonomyi

Protein namesi
Recommended name:
Type 2 DNA topoisomerase 6 subunit AUniRule annotation (EC:5.99.1.3UniRule annotation)
Alternative name(s):
Type II DNA topoisomerase VI subunit AUniRule annotation
Gene namesi
Name:top6AUniRule annotation
Ordered Locus Names:VNG_0884G
OrganismiHalobacterium salinarum (strain ATCC 700922 / JCM 11081 / NRC-1) (Halobacterium halobium)
Taxonomic identifieri64091 [NCBI]
Taxonomic lineageiArchaeaEuryarchaeotaHalobacteriaHalobacterialesHalobacteriaceaeHalobacterium
Proteomesi
  • UP000000554 Componenti: Chromosome

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001454471 – 366Type 2 DNA topoisomerase 6 subunit AAdd BLAST366

Proteomic databases

PaxDbiQ9HR32.
PRIDEiQ9HR32.

Interactioni

Subunit structurei

Homodimer. Heterotetramer of two Top6A and two Top6B chains.UniRule annotation

Protein-protein interaction databases

STRINGi64091.VNG0884G.

Structurei

3D structure databases

ProteinModelPortaliQ9HR32.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the TOP6A family.UniRule annotation

Phylogenomic databases

eggNOGiarCOG04143. Archaea.
COG1697. LUCA.
InParanoidiQ9HR32.
KOiK03166.
OMAiWEEQIEL.
PhylomeDBiQ9HR32.

Family and domain databases

Gene3Di1.10.10.10. 1 hit.
HAMAPiMF_00132. Top6A. 1 hit.
InterProiIPR002815. Spo11/TopoVI_A.
IPR013049. Spo11/TopoVI_A_N.
IPR004085. TopoVI_A.
IPR011991. WHTH_DNA-bd_dom.
[Graphical view]
PANTHERiPTHR10848. PTHR10848. 1 hit.
PfamiPF04406. TP6A_N. 1 hit.
[Graphical view]
PRINTSiPR01550. TOP6AFAMILY.
PR01552. TPISMRASE6A.
SUPFAMiSSF56726. SSF56726. 1 hit.

Sequencei

Sequence statusi: Complete.

Q9HR32-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MSETHTSDET EARDQLLAIA EQFYDQFADG DIPRMSLPTR SKSNIEYDED
60 70 80 90 100
ADVWVYGDSQ STRSANSVRG ARKLLKSVYT VDFLAQQLDE GRSSTLRELY
110 120 130 140 150
YLSESWDEAE AQFNDQSESD KLVEDLEIVS GVKREDFHMR PEESGAKVMG
160 170 180 190 200
PLRLREQTRR GDREIHCQED VGQGGYQIPN NPDTIDFLDT DADFVLCVET
210 220 230 240 250
GGMRDRLVEN GFDDDYNAIV VHLGGQPARA TRRLTKRLHD ELDLPVTVFT
260 270 280 290 300
DGDPWSYRIY GSVAYGSIKS AHLSEYLATP QAQFIGIRPQ DIVDYDLPTD
310 320 330 340 350
PLSDSDVNAL ESELEDPRFQ SDFWTEQIGL QLDIDKKAEQ QALASRGLDF
360
VTDTYLPERL AEMGVL
Length:366
Mass (Da):41,449
Last modified:February 21, 2001 - v1
Checksum:i21B08189088E768F
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AE004437 Genomic DNA. Translation: AAG19326.1.
PIRiB84245.
RefSeqiWP_010902622.1. NC_002607.1.

Genome annotation databases

EnsemblBacteriaiAAG19326; AAG19326; VNG_0884G.
GeneIDi5952734.
KEGGihal:VNG_0884G.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AE004437 Genomic DNA. Translation: AAG19326.1.
PIRiB84245.
RefSeqiWP_010902622.1. NC_002607.1.

3D structure databases

ProteinModelPortaliQ9HR32.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi64091.VNG0884G.

Proteomic databases

PaxDbiQ9HR32.
PRIDEiQ9HR32.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaiAAG19326; AAG19326; VNG_0884G.
GeneIDi5952734.
KEGGihal:VNG_0884G.

Phylogenomic databases

eggNOGiarCOG04143. Archaea.
COG1697. LUCA.
InParanoidiQ9HR32.
KOiK03166.
OMAiWEEQIEL.
PhylomeDBiQ9HR32.

Family and domain databases

Gene3Di1.10.10.10. 1 hit.
HAMAPiMF_00132. Top6A. 1 hit.
InterProiIPR002815. Spo11/TopoVI_A.
IPR013049. Spo11/TopoVI_A_N.
IPR004085. TopoVI_A.
IPR011991. WHTH_DNA-bd_dom.
[Graphical view]
PANTHERiPTHR10848. PTHR10848. 1 hit.
PfamiPF04406. TP6A_N. 1 hit.
[Graphical view]
PRINTSiPR01550. TOP6AFAMILY.
PR01552. TPISMRASE6A.
SUPFAMiSSF56726. SSF56726. 1 hit.
ProtoNetiSearch...

Entry informationi

Entry nameiTOP6A_HALSA
AccessioniPrimary (citable) accession number: Q9HR32
Entry historyi
Integrated into UniProtKB/Swiss-Prot: February 21, 2001
Last sequence update: February 21, 2001
Last modified: November 30, 2016
This is version 97 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.