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Q9HQU4

- IMDH_HALSA

UniProt

Q9HQU4 - IMDH_HALSA

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Protein
Inosine-5'-monophosphate dehydrogenase
Gene
guaB, VNG_1001G
Organism
Halobacterium salinarum (strain ATCC 700922 / JCM 11081 / NRC-1) (Halobacterium halobium)
Status
Reviewed - Annotation score: 4 out of 5 - Protein inferred from homologyi

Functioni

Catalyzes the conversion of inosine 5'-phosphate (IMP) to xanthosine 5'-phosphate (XMP), the first committed and rate-limiting step in the de novo synthesis of guanine nucleotides, and therefore plays an important role in the regulation of cell growth By similarity.UniRule annotation

Catalytic activityi

Inosine 5'-phosphate + NAD+ + H2O = xanthosine 5'-phosphate + NADH.UniRule annotation

Cofactori

Potassium By similarity.UniRule annotation

Enzyme regulationi

Mycophenolic acid (MPA) is a non-competitive inhibitor that prevents formation of the closed enzyme conformation by binding to the same site as the amobile flap. In contrast, mizoribine monophosphate (MZP) is a competitive inhibitor that induces the closed conformation. MPA is a potent inhibitor of mammalian IMPDHs but a poor inhibitor of the bacterial enzymes. MZP is a more potent inhibitor of bacterial IMPDH By similarity.UniRule annotation

Pathwayi

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Binding sitei260 – 2601NAD By similarity
Metal bindingi310 – 3101Potassium; via carbonyl oxygen By similarity
Metal bindingi312 – 3121Potassium; via carbonyl oxygen By similarity
Binding sitei313 – 3131IMP By similarity
Active sitei315 – 3151Thioimidate intermediate By similarity
Metal bindingi315 – 3151Potassium; via carbonyl oxygen By similarity
Binding sitei425 – 4251IMP By similarity
Metal bindingi479 – 4791Potassium; via carbonyl oxygen; shared with tetrameric partner By similarity
Metal bindingi480 – 4801Potassium; via carbonyl oxygen; shared with tetrameric partner By similarity
Metal bindingi481 – 4811Potassium; via carbonyl oxygen; shared with tetrameric partner By similarity

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Nucleotide bindingi308 – 3103NAD By similarity

GO - Molecular functioni

  1. IMP dehydrogenase activity Source: UniProtKB-HAMAP
  2. adenyl nucleotide binding Source: InterPro
  3. metal ion binding Source: UniProtKB-HAMAP
Complete GO annotation...

GO - Biological processi

  1. GMP biosynthetic process Source: UniProtKB-HAMAP
Complete GO annotation...

Keywords - Molecular functioni

Oxidoreductase

Keywords - Biological processi

GMP biosynthesis, Purine biosynthesis

Keywords - Ligandi

Metal-binding, NAD, Potassium

Enzyme and pathway databases

UniPathwayiUPA00601; UER00295.

Names & Taxonomyi

Protein namesi
Recommended name:
Inosine-5'-monophosphate dehydrogenase (EC:1.1.1.205)
Short name:
IMP dehydrogenase
Short name:
IMPD
Short name:
IMPDH
Gene namesi
Name:guaB
Ordered Locus Names:VNG_1001G
OrganismiHalobacterium salinarum (strain ATCC 700922 / JCM 11081 / NRC-1) (Halobacterium halobium)
Taxonomic identifieri64091 [NCBI]
Taxonomic lineageiArchaeaEuryarchaeotaHalobacteriaHalobacterialesHalobacteriaceaeHalobacterium
ProteomesiUP000000554: Chromosome

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 499499Inosine-5'-monophosphate dehydrogenaseUniRule annotation
PRO_0000415692Add
BLAST

Proteomic databases

PaxDbiQ9HQU4.
PRIDEiQ9HQU4.

Interactioni

Subunit structurei

Homotetramer By similarity.UniRule annotation

Protein-protein interaction databases

STRINGi64091.VNG1001G.

Structurei

3D structure databases

ProteinModelPortaliQ9HQU4.

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini106 – 16560CBS 1
Add
BLAST
Domaini169 – 22557CBS 2
Add
BLAST

Region

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Regioni348 – 3503IMP binding By similarity
Regioni371 – 3722IMP binding By similarity
Regioni395 – 3995IMP binding By similarity

Sequence similaritiesi

Belongs to the IMPDH/GMPR family.
Contains 2 CBS domains.

Keywords - Domaini

CBS domain, Repeat

Phylogenomic databases

eggNOGiCOG0517.
KOiK00088.
OMAiNAIRGYT.
PhylomeDBiQ9HQU4.

Family and domain databases

Gene3Di3.20.20.70. 1 hit.
HAMAPiMF_01964. IMPDH.
InterProiIPR013785. Aldolase_TIM.
IPR000644. CBS_dom.
IPR005990. IMP_DH.
IPR015875. IMP_DH/GMP_Rdtase_CS.
IPR001093. IMP_DH_GMPRt.
[Graphical view]
PANTHERiPTHR11911:SF6. PTHR11911:SF6. 1 hit.
PfamiPF00571. CBS. 2 hits.
PF00478. IMPDH. 1 hit.
[Graphical view]
PIRSFiPIRSF000130. IMPDH. 1 hit.
SMARTiSM00116. CBS. 2 hits.
[Graphical view]
TIGRFAMsiTIGR01302. IMP_dehydrog. 1 hit.
PROSITEiPS51371. CBS. 2 hits.
PS00487. IMP_DH_GMP_RED. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q9HQU4-1 [UniParc]FASTAAdd to Basket

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MANDSSTDGR FSEKLRVPEA LTFDDVLLRP AESRVEPDDA DVATRVSTNV    50
ELEVPVLSAA MDTVTESRLA IAMAREGGLG VLHQNMDTDR VVAEVERVKR 100
ADELVIDREN VVTAAPEQTV EAVDEMMDRS DVSGAPVVDD DDTVRGIISA 150
TDIRPYLEVG ESDAVREAMT DEVITAPEDI TARDALELMY EHKIERVPIV 200
NDEQHLVGLV TMQGILERRE HGSAARDQNG RLRVGVAVGP FDTERATAVD 250
EAGADVLFID CAHAHNLNVI DSAREIKASV DADVVVGNVG TREAAEAVVD 300
FADGIKVGIG PGSICTTRVV TGSGMPQITA VSQVADVAAP AGVPVIADGG 350
IRYSGDAAKA IAAGADAVML GSYFAGTDEA PGRVITMNGK KYKQYRGMGS 400
VGAMQSGGSD RYLKDDDEDE EYVPEGVEAA TPYKGSLASE LHQLVGGIQS 450
GMGYVGAESI PAFKADAEFV RVSAAGQTEG HPHDVMITDE APNYSPQGE 499
Length:499
Mass (Da):52,767
Last modified:April 3, 2013 - v2
Checksum:i3A6C3B23A42B9D39
GO

Sequence cautioni

The sequence AAG19418.1 differs from that shown. Reason: Erroneous initiation. Translation N-terminally shortened.

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AE004437 Genomic DNA. Translation: AAG19418.1. Different initiation.
PIRiF84256.
RefSeqiNP_279938.1. NC_002607.1.

Genome annotation databases

EnsemblBacteriaiAAG19418; AAG19418; VNG_1001G.
GeneIDi1447720.
KEGGihal:VNG1001G.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AE004437 Genomic DNA. Translation: AAG19418.1 . Different initiation.
PIRi F84256.
RefSeqi NP_279938.1. NC_002607.1.

3D structure databases

ProteinModelPortali Q9HQU4.
ModBasei Search...

Protein-protein interaction databases

STRINGi 64091.VNG1001G.

Proteomic databases

PaxDbi Q9HQU4.
PRIDEi Q9HQU4.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai AAG19418 ; AAG19418 ; VNG_1001G .
GeneIDi 1447720.
KEGGi hal:VNG1001G.

Phylogenomic databases

eggNOGi COG0517.
KOi K00088.
OMAi NAIRGYT.
PhylomeDBi Q9HQU4.

Enzyme and pathway databases

UniPathwayi UPA00601 ; UER00295 .

Family and domain databases

Gene3Di 3.20.20.70. 1 hit.
HAMAPi MF_01964. IMPDH.
InterProi IPR013785. Aldolase_TIM.
IPR000644. CBS_dom.
IPR005990. IMP_DH.
IPR015875. IMP_DH/GMP_Rdtase_CS.
IPR001093. IMP_DH_GMPRt.
[Graphical view ]
PANTHERi PTHR11911:SF6. PTHR11911:SF6. 1 hit.
Pfami PF00571. CBS. 2 hits.
PF00478. IMPDH. 1 hit.
[Graphical view ]
PIRSFi PIRSF000130. IMPDH. 1 hit.
SMARTi SM00116. CBS. 2 hits.
[Graphical view ]
TIGRFAMsi TIGR01302. IMP_dehydrog. 1 hit.
PROSITEi PS51371. CBS. 2 hits.
PS00487. IMP_DH_GMP_RED. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: ATCC 700922 / JCM 11081 / NRC-1.

Entry informationi

Entry nameiIMDH_HALSA
AccessioniPrimary (citable) accession number: Q9HQU4
Entry historyi
Integrated into UniProtKB/Swiss-Prot: February 22, 2012
Last sequence update: April 3, 2013
Last modified: May 14, 2014
This is version 84 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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