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Q9HQT7 (GCH31_HALSA) Reviewed, UniProtKB/Swiss-Prot

Last modified May 1, 2013. Version 63. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (1) | Third-party data text xml rdf/xml gff fasta
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Names and origin

Protein namesRecommended name:
GTP cyclohydrolase III 1
EC=3.5.4.29
Gene names
Name:gch31
Ordered Locus Names:VNG_1011C
OrganismHalobacterium salinarum (strain ATCC 700922 / JCM 11081 / NRC-1) (Halobacterium halobium) [Reference proteome] [HAMAP]
Taxonomic identifier64091 [NCBI]
Taxonomic lineageArchaea › Euryarchaeota › Halobacteria › Halobacteriales › Halobacteriaceae › Halobacterium ›

Protein attributes

Sequence length255 AA.
Sequence statusComplete.
Protein existenceInferred from homology

General annotation (Comments)

Function

Catalyzes the formation of 2-amino-5-formylamino-6-ribofuranosylamino-4(3H)-pyrimidinone ribonucleotide monophosphate and inorganic phosphate from GTP. Also has an independent pyrophosphate phosphohydrolase activity By similarity. HAMAP-Rule MF_00608

Catalytic activity

GTP + 3 H2O = 2-amino-5-formylamino-6-(5-phospho-D-ribosylamino)pyrimidin-4(3H)-one + 2 phosphate. HAMAP-Rule MF_00608

Sequence similarities

Belongs to the archaeal-type GTP cyclohydrolase family.

Sequence caution

The sequence AAG19426.1 differs from that shown. Reason: Erroneous initiation.

Ontologies

Keywords
   LigandGTP-binding
Nucleotide-binding
   Molecular functionHydrolase
   Technical termComplete proteome
Reference proteome
Gene Ontology (GO)
   Biological_processbiosynthetic process

Inferred from electronic annotation. Source: InterPro

   Molecular_functionGTP binding

Inferred from electronic annotation. Source: UniProtKB-KW

GTP cyclohydrolase IIa activity

Inferred from electronic annotation. Source: EC

Complete GO annotation...

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 255255GTP cyclohydrolase III 1 HAMAP-Rule MF_00608
PRO_0000145752

Sequences

Sequence LengthMass (Da)Tools
Q9HQT7 [UniParc].

Last modified December 13, 2002. Version 2.
Checksum: 97C55FE6A7A46773

FASTA25527,498
        10         20         30         40         50         60 
MTNTQVTLVQ LDNYGPWTVT PSPRREVDLQ TLQSRLYADL SQAIGTRDGY VFFTRFDNMI 

        70         80         90        100        110        120 
AVTNGLDLEA HARVQESIRN RYPITASLSI GTGSTPADAL VGATGALQQQ GSAQDADRRE 

       130        140        150        160        170        180 
TLLGQPIPDA ERTDDDVQIA HFDVIDATGT YTDELDAFAS FTHIEAGYAA LMRHMHDAHD 

       190        200        210        220        230        240 
SLSFFVGGDN IIAVCPGLSD GDYEDAIAHV QDTADVALRV GVGRGASAHD AGMGAKHALE 

       250 
VAREHDTIVE RSGRQ

« Hide

Cross-references

Sequence databases

EMBL
GenBank
DDBJ		AE004437 Genomic DNA. Translation: AAG19426.1. Different initiation.
PIRF84257.
RefSeqNP_444206.1. NC_002607.1.

3D structure databases

ProteinModelPortalQ9HQT7.
ModBaseSearch...

Protein-protein interaction databases

STRING64091.VNG1011Cm.

Proteomic databases

PaxDbQ9HQT7.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaAAG19426; AAG19426; VNG_1011C.
GeneID1449034.
KEGGhal:VNG1011Cm.

Phylogenomic databases

eggNOGCOG2429.
KOK08096.
ProtClustDBPRK02240.

Family and domain databases

HAMAPMF_00608. GTP_cyclohydro_3.
InterProIPR007839. GTP_CycHdrlase_3.
[Graphical view]
PfamPF05165. GGDN. 1 hit.
[Graphical view]
PIRSFPIRSF009265. GTP_cyclohydro_3. 1 hit.
ProDomPD313320. GTP_CycHdrlase_3. 1 hit.
[Graphical view] [Entries sharing at least one domain]
ProtoNetSearch...

Entry information

Entry nameGCH31_HALSA
AccessionPrimary (citable) accession number: Q9HQT7
Entry history
Integrated into UniProtKB/Swiss-Prot: December 13, 2002
Last sequence update: December 13, 2002
Last modified: May 1, 2013
This is version 63 of the entry and version 2 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families

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